Article
Gastroenterology & Hepatology
Susrutha Puthanmadhom Narayanan, Daniel R. O'Brien, Mayank Sharma, Thomas C. Smyrk, Rondell P. Graham, Madhusudan Grover, Adil E. Bharucha
Summary: In patients with functional dyspepsia (FD), there is a modest reduction in the expression of several duodenal epithelial barrier proteins, possibly due to the up-regulation of regulatory miRNAs, along with increased small intestinal permeability measured in vivo.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lucas Wauters, Matthias Ceulemans, Dennis Frings, Maarten Lambaerts, Alison Accarie, Joran Toth, Raf Mols, Patrick Augustijns, Gert De Hertogh, Lukas Van Oudenhove, Jan Tack, Tim Vanuytsel
Summary: This study found that the numbers of eosinophils and immune cells in the duodenum, as well as permeability, were significantly higher in patients with functional dyspepsia, and decreased after PPI therapy. In contrast, immune cells and permeability increased in healthy volunteers on PPIs.
Article
Immunology
Yi-Feng Zheng, Shu-Ping Liang, Zi-Shao Zhong, Wang Zhang, Yu-Yao Wu, Jia-Bin Liu, Sui-Ping Huang
Summary: There is a significant difference in duodenal mucosal microflora between patients with functional dyspepsia and healthy individuals, including differences in microflora diversity, structure, composition, and function.
MICROBIAL PATHOGENESIS
(2022)
Article
Medicine, General & Internal
Duc Trong Quach, Quoc Van Ha, Chuyen Thi-Ngoc Nguyen, Quang Dinh Le, Doan Thi-Nha Nguyen, Nhu Thi-Hanh Vu, Ngoc Le-Bich Dang, Nhan Quang Le
Summary: This study aimed to assess the overlap rate of gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) and the yield of esophagogastroduodenoscopy in patients clinically presenting with FD. The results showed that GERD-FD overlap was more common than each disorder alone, with postprandial distress syndrome being significantly prominent. Organic dyspepsia was uncommon in patients clinically fulfilling the Rome IV criteria for FD.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Catherine G. Tran, Scott K. Sherman, Mohammed O. Suraju, Apoorve Nayyar, Henning Gerke, Rami G. El Abiad, Chandrikha Chandrasekharan, Po Hien Ear, Thomas M. O'Dorisio, Joseph S. Dillon, Andrew M. Bellizzi, James R. Howe
Summary: The management of duodenal neuroendocrine tumors (DNETs) varies depending on the size of the lesion, with smaller ones typically treated by endoscopic mucosal resection (EMR) and larger ones by surgical resection (SR). A study comparing outcomes between patients who underwent EMR and SR showed that there was no significant difference in survival rates, particularly in 1-2 cm DNETs. However, surgically resected DNETs had improved progression-free survival (PFS) and overall survival (OS) compared to jejunoileal NETs.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucas Wauters, Raul Y. Tito, Matthias Ceulemans, Maarten Lambaerts, Alison Accarie, Leen Rymenans, Chloe Verspecht, Joran Toth, Raf Mols, Patrick Augustijns, Jan Tack, Tim Vanuytsel, Jeroen Raes
Summary: The study found differential mucus-associated genera between FD patients and controls, with Streptococcus positively correlating with duodenal eosinophils in controls. While short-term PPI therapy effects were unrelated to changes in the gut microbiota for FD patients, increased Streptococcus in controls was associated with duodenal PPI effects, even after long-term therapy withdrawal in FD stoppers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Shuai Ji, Yanting You, Baizhao Peng, Tianyu Zhong, Yuxiang Kuang, Shasha Li, Lijing Du, Liqian Chen, Xiaomin Sun, Jiaojiao Dai, Suiping Huang, Yuyao Wu, Yanyan Liu
Summary: This study conducted a multi-omics analysis in a rat model of functional dyspepsia (FD) and found that differential microbiomes in the duodenum were significantly correlated with the biosynthesis of lipopolysaccharide and peptidoglycan. Innate immune response-related genes in the duodenum were upregulated and associated with the TLR2/TLR4-NF kappa B signaling pathway. Furthermore, the study revealed a linear relationship between arachidonyl ethanolamide (anandamide, AEA) and FD phenotypes, suggesting its potential role in regulating duodenal low-grade inflammation in FD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Lucas Wauters, Matthias Ceulemans, Jolien Schol, Ricard Farre, Jan Tack, Tim Vanuytsel
Summary: This review discusses the issue of increased intestinal permeability in patients with functional dyspepsia, as well as the factors and techniques associated with it. Although there is currently a lack of definitive clinical evidence, studying these changes is crucial for improving the management of functional dyspepsia.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Giovanni Sarnelli, Marcella Pesce, Luisa Seguella, Jie Lu, Eleonora Efficie, Jan Tack, Fatima Domenica Elisa De Palma, Alessandra D'Alessandro, Giuseppe Esposito
Summary: The study found that patients with functional dyspepsia show an enhanced response of increased mast cells and their mediators in acidic environment. By modulating TRPV receptors and mast cell activation, PEA could be considered an attractive therapeutic strategy for treating FD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Susrutha Puthanmadhom Narayanan, David R. Linden, Stephanie A. Peters, Anshuman Desai, Saatchi Kuwelker, Daniel O'Brien, Thomas J. Smyrk, Rondell P. Graham, Madhusudan Grover, Adil E. Bharucha
Summary: It is increasingly recognized that duodenal disturbances play a role in functional dyspepsia (FD), affecting mucosal ion transport and gene expression. In this study, duodenal mucosal ion transport and associated gene expression were found to be altered in FD patients compared to healthy controls. The findings suggest that upregulated miRNAs may contribute to the downregulation of genes involved in ion transport in FD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Yosuke Toya, Masaki Endo, Masanao Yamazato, Shun Yamada, Tomo Kumei, Minami Hirai, Makoto Eizuka, Toshifumi Morishita, Risaburo Akasaka, Shunichi Yanai, Noriyuki Uesugi, Tamotsu Sugai, Takayuki Matsumoto
Summary: This study compared treatment outcomes between underwater endoscopic mucosal resection (U-EMR) and conventional endoscopic mucosal resection (C-EMR) for patients with nonampullary duodenal epithelial tumors (NADETs) and found that the resectability was comparable. Despite no significant differences in adverse events and en bloc resection rates between the two groups, the U-EMR group had significantly shorter procedure time.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhiming Wang, Menghao Hao, Liping Wu, Yumei He, Xiaobin Sun
Summary: This study found that changes in intestinal barrier and tight junction proteins may be associated with the occurrence and development of functional dyspepsia (FD). Mast cells may play a crucial role in the development of FD by disrupting duodenal barrier function through modulating the levels of tight junction proteins. The PAR-2 and ERK1/2 signaling pathways may mediate the pathogenesis of FD.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Gastroenterology & Hepatology
Lucas Wauters, Paul R. Harris, Marjorie M. Walker, Carolina A. Serrano, Andrea Villagran, Gurpreet S. Rakhra, Jean E. Crabtree, Nicholas J. Talley
Summary: This article is connected to the paper by Broeders et al. To access this article, visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Brototo Deb, Daniel R. O'Brien, Zainali S. Chunawala, Adil E. Bharucha
Summary: This study compared the expression of SARS-CoV-2 and inflammation-related genes in the duodenal mucosa of patients with diabetes gastroenteropathy (DGE), functional dyspepsia (FD), and healthy controls. The results showed that there were several SARS-CoV-2-related genes that were upregulated in DGE patients, and these gene expressions were related to diabetes per se. The upregulation of CTSL and CTSB genes in the gastrointestinal tract of patients with diabetes may predispose to SARS-CoV-2 infection.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Tomoki Okata, Kiyotaka Asanuma, Kenichiro Nakagawa, Waku Hatta, Tomoyuki Koike, Akira Imatani, Atsushi Masamune
Summary: An unidentified cause of functional dyspepsia (FD) is closely associated with medication resistance. Acid suppression is a traditional and preferential method for treating FD, but its efficacy varies between epigastric pain syndrome (EPS) and postprandial syndrome (PDS). This study found that the duodenal mucosal transepithelial electrical resistance (TEER) in EPS patients decreased when exposed to acidic solutions, even under weak acidic conditions. The decrease in TEER was correlated with the severity of epigastric pain. Additionally, EPS patients had an increase in mast cells and plasma cells expressing Ig-E in the duodenal mucosa, suggesting that duodenal mucosal vulnerability to acid may contribute to the development of EPS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hang Viet Dao, Tomoaki Matsumura, Tatsuya Kaneko, Satsuki Takahashi, Mamoru Tokunaga, Hirotaka Oura, Kentaro Ishikawa, Naoki Akizue, Atsuko Kikuchi, Mai Fujie, Keiko Saito, Kenichiro Okimoto, Daisuke Maruoka, Tomoo Nakagawa, Makoto Arai, Jun Kato, Naoya Kato
DISEASES OF THE ESOPHAGUS
(2020)
Article
Gastroenterology & Hepatology
Kentaro Ishikawa, Kenichiro Okimoto, Tomoaki Matsumura, Yosuke Hirotsu, Kenji Amemiya, Takashi Kishimoto, Naoki Akizue, Yuki Ohta, Keiko Saito, Daisuke Maruoka, Motoi Nishimura, Kazuyuki Matsushita, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Osamu Yokosuka, Masao Omata, Naoya Kato
Summary: The study clarified the malignant potential of patients with CLE without intestinal metaplasia and/or less than 1 cm, suggesting the need for follow-up in these patients similar to those with BE.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mamoru Tokunaga, Tomoaki Matsumura, Kentaro Ishikawa, Tatsuya Kaneko, Hirotaka Oura, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Kenichiro Okimoto, Naoki Akizue, Daisuke Maruoka, Yuki Ohta, Keiko Saito, Tomoo Nakagawa, Tetsuhiro Chiba, Makoto Arai, Jun Kato, Naoya Kato
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2020)
Article
Multidisciplinary Sciences
Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Mamoru Tokunaga, Tatsuya Kaneko, Hirotaka Oura, Naoki Akizue, Yuki Ohta, Keiko Saito, Makoto Arai, Jun Kato, Naoya Kato
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Naoki Akizue, Kenichiro Okimoto, Makoto Arai, Yosuke Hirotsu, Kenji Amemiya, Hirotaka Oura, Tatsuya Kaneko, Mamoru Tokunaga, Kentaro Ishikawa, Yuki Ohta, Takashi Taida, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Tomoo Nakagawa, Motoi Nishimura, Tetsuhiro Chiba, Kazuyuki Matsushita, Hitoshi Mochizuki, Osamu Yokosuka, Masao Omata, Naoya Kato
Summary: The study evaluated somatic mutations in the background mucosa of patients with Lugol-voiding lesions (LVLs), finding TP53 as the most dominant mutation in LVLs and NOTCH1 as the dominant mutation in the background mucosa. TP53 mutation could be the main target gene in the carcinogenesis of esophageal squamous cell carcinoma.
Article
Gastroenterology & Hepatology
Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Kengo Kanayama, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Yosuke Inaba, Yohei Kawasaki, Makoto Arai, Jun Kato, Naoya Kato
Summary: The study validated the significant advantages of underwater EMR over conventional EMR and cap-assisted EMR in treating superficial nonampullary duodenal epithelial tumors, indicating the potential value of underwater EMR in the treatment of SNADETs measuring <= 20 mm.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Wataru Shiratori, Ariki Nagashima, Tsubasa Ishikawa, Mamoru Tokunaga, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Makoto Arai, Jun Kato, Naoya Kato
Summary: This study aimed to investigate the long-term outcomes of cold snare polypectomy for superficial non-ampullary duodenal epithelial tumors (SNADETs). The results showed that CSP is a safe and effective procedure with a high en-bloc resection rate and long-term local control capability.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Kengo Kanayama, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Yosuke Inaba, Yohei Kawasaki, Jun Kato, Naoya Kato
Summary: This study investigated the utility and short-term outcomes of different endoscopic resection techniques for relatively small superficial non-ampullary duodenal adenomas (SNADAs). The results showed that there was no significant difference in recurrence risk among the different techniques, and underwater endoscopic resection appeared to be a simple and safe option for these lesions.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Satsuki Takahashi, Tomoaki Matsumura, Tatsuya Kaneko, Mamoru Tokunaga, Hirotaka Oura, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Naoki Akizue, Yuki Ohta, Atsuko Kikuchi, Mai Fujie, Keiko Saito, Kenichiro Okimoto, Daisuke Maruoka, Tomoo Nakagawa, Makoto Arai, Jun Kato, Naoya Kato
Summary: This study found that different types of EMDs have distinct characteristics. Cigarette smoking and high body mass index were associated with esophageal hypermotility. Assessment of dysphagia symptom scores may help identify patients with EMDs.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Multidisciplinary Sciences
Kenichiro Okimoto, Tomoaki Matsumura, Daisuke Maruoka, Akane Kurosugi, Wataru Shiratori, Ariki Nagashima, Tsubasa Ishikawa, Tatsuya Kaneko, Kengo Kanayama, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Jun Kato, Naoya Kato
Summary: This pilot study investigated the use of texture and color enhancement imaging (TXI) with magnified endoscopy (ME) for the preoperative diagnosis of superficial nonampullary duodenal epithelial tumors (SNADETs). The results showed that ICME-TXI can improve the visibility of the surface structure (SS) of SNADETs and may contribute to their preoperative diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Tomoaki Matsumura, Alanna Ebigbo, Christoph Roemmele, Hiroaki Ikematsu, Hideaki Ishigami, Takuto Suzuki, Hideaki Harada, Tomoyuki Yada, Yusaku Takatori, Manabu Takeuchi, Kenichiro Okimoto, Naoki Akizue, Daisuke Maruoka, Yoshiyasu Kitagawa, Tatsunori Minamide, Tomoyuki Iwaki, Yuji Amano, Keisuke Matsusaka, Kengo Nagashima, Tadateru Maehata, Naohisa Yahagi, Helmut Messmann, Naoya Kato
Summary: This study aimed to explore the additional value of magnifying chromoendoscopy (MCE) in the optical diagnosis of colorectal polyps. The results showed that MCE had higher sensitivity for predicting colorectal cancer with deep invasion. It is recommended to perform additional MCE in lesions with low confidence or diagnosed as deep invasion colorectal cancer by M-NBI.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Kengo Kanayama, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Jun Kato, Naoya Kato
GASTROINTESTINAL ENDOSCOPY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Tsubasa Ishikawa, Kenichiro Okimoto, Tomoaki Matsumura, Mamoru Tokunaga, Hirotaka Oura, Yuya Yokoyama, Tsubasa Oike, Yushi Imai, Naoki Akizue, Yuki Ohta, Daisuke Maruoka, Makoto Arai, Jun Kato, Naoya Kato
GASTROINTESTINAL ENDOSCOPY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Mamoru Tokunaga, Hirotaka Oura, Tatsuya Kaneko, Yuya Yokoyama, Tsubasa Oike, Yushi Imai, Naoki Akizue, Yuki Ohta, Makoto Arai, Jun Kato, Naoya Kato
GASTROINTESTINAL ENDOSCOPY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Hirotaka Oura, Tomoaki Matsumura, Tatsuya Kaneko, Mamoru Tokunaga, Yushi Imai, Tsubasa Oike, Yuya Yokoyama, Naoki Akizue, Yuki Ohta, Kenichiro Okimoto, Daisuke Maruoka, Makoto Arai, Mai Fujie, Kazuya Yamaguchi, Jun Kato, Naoya Kato
GASTROINTESTINAL ENDOSCOPY
(2020)
