Article
Biochemistry & Molecular Biology
Mingming Teng, Yuan Luo, Chan Wang, Anmin Lei
Summary: In assisted reproduction, DSF can increase the antioxidant capacity of oocytes and the ovulation rate, and promote early pregnancy by increasing the degree and volume of uterine vascularization. These effects are achieved through the regulation of gene expression related to antioxidation, follicular development, ovulation, and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Kosta J. Popovic, Dusica J. Popovic, Dejan Miljkovic, Jovan K. Popovic, Dusan Lalosevic, Mihalj Posa, Ivan Capo
Summary: The combination of disulfiram and metformin showed significant inhibition of fibrosarcoma growth in hamsters without toxicity, while single treatments did not have a significant anti-tumor effect. Nitroglycerin partially rescued tumor progression, possibly through ROS inhibition, while mebendazole completely blocked the anticancer activity of the disulfiram and metformin combination.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Xiaochun Hu, Yonglin Lu, Wenrong Zhao, Menglin Sun, Ruihao Li, Lei Feng, Tianming Yao, Chunyan Dong, Shuo Shi
Summary: A multi-functional nanoplatform (PDA-DTC/Cu-MnO2) was developed for MR imaging-guided multi-therapy (CDT, PTT, and chemotherapy) in cancer treatment. Both in vitro and in vivo results confirmed the biocompatible nanoplatform's ability to significantly induce tumor cell death and inhibit tumor growth.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Meixu Chen, Zeqian Huang, Meng Xia, Yaqing Ding, Ting Shan, Zilin Guan, Xiuling Dai, Xiaoyu Xu, Yanjuan Huang, Min Huang, Chunshun Zhao
Summary: The FDA-approved drug Disulfiram has been found to have potent antitumor therapeutic effect by generating Cu(DTC)2, but its poor tumor selectivity and lack of sufficient endogenous Cu2+ concentration within the tumor site hinder its application. A GSH-responsive coordination nanoparticles (Cu-IXZ@DSF) was established to achieve selective triggered tumor in situ Cu(DTC)2 generation for antitumor therapy, showing good biosafety and excellent antitumor effect via endoplasmic reticulum stress (ERS) and reactive oxygen species (ROS) generation pathway. This nanocarrier provides a specific-triggered antitumor Cu(DTC)2 generation for DSF-based chemotherapy with high therapeutic effect and biosafety, showing great potential of treating cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Multidisciplinary
Xinyu Peng, Qingqing Pan, Jing Li, Wangwei Zhu, Nan Zhang, Yuji Pu, Kui Luo, Bin He
Summary: The study focused on the polymer-directed J-aggregation of cationic photosensitizers, allowing for enhanced photothermal effect and singlet oxygen generation upon irradiation of an 808 nm laser. This approach provided a strategy for robust drug carriers with fascinating optical properties for enhanced phototherapy in vivo.
APPLIED MATERIALS TODAY
(2021)
Article
Psychology, Clinical
Daniel Freeman, Laina Rosebrock, Felicity Waite, Bao Sheng Loe, Thomas Kabir, Ariane Petit, Robert Dudley, Kate Chapman, Anthony Morrison, Eileen O'Regan, Charlotte Aynsworth, Julia Jones, Elizabeth Murphy, Rosie Powling, Heather Peel, Harry Walker, Rory Byrne, Jason Freeman, Aitor Rovira, Ushma Galal, Ly-Mee Yu, David M. Clark, Sinead Lambe
Summary: This study assessed the experience of patients with psychosis receiving virtual reality therapy and found that the majority of patients were very satisfied with the therapy, experienced few side effects, and the occurrence of side effects did not impact therapy outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Aoibheann C. Rainford, Gerard T. Flaherty, Brian Hallahan
Summary: ‘Dark tourism’ is the travel to destinations and sites associated with death, tragedy, and the macabre, with vampire tourism gaining popularity in the past 20 years. Further investigation is needed to understand the psychological coping abilities of travelers, especially those with mental disorders, when visiting emotionally challenging destinations.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Infectious Diseases
Claire N. Shanholtzer, Cameron Rice, Katherine Watson, Hannah Carreon, Timothy E. Long
Summary: This study evaluated the impact of copper on the antifungal activity of disulfiram against fluconazole-resistant Candida species. The results showed that copper addition enhanced the inhibitory effects of disulfiram on Candida cultures, but it also antagonized the fungicidal activity of disulfiram.
Article
Biochemistry & Molecular Biology
Ziad Omran
Summary: ALDH1a1 is a key therapeutic target for treating debilitating disorders such as cancer, obesity, and inflammation. Drugs like disulfiram can inhibit ALDH1a1, and introducing aromatic rings into the structure of disulfiram can lead to the synthesis of new selective ALDH1a1 inhibitors.
Article
Oncology
Hao-Zhe Cao, Wen-Ting Yang, Peng-Sheng Zheng
Summary: The study found that the disulfiram/copper complex has strong cytotoxicity against cervical cancer cells, disrupting the S phase, inhibiting the expression of stemness markers, and reducing the number of cancer stem cell-like LGR5(+) cells, thereby enhancing the anti-tumor effect.
News Item
Multidisciplinary Sciences
Gretchen Vogel, Kai Kupferschmidt
Summary: Some countries are limiting vaccine shots to older individuals as investigations into clotting disorders continue.
Article
Materials Science, Multidisciplinary
Liping Zhao, Xiaoxia Wang, Mingxia Jiang, Xinghan Wu, Mogen Zhang, Xiuwen Guan, Jinlong Ma, Weifen Zhang
Summary: This research has successfully developed an effective and highly selective cancer treatment using CuET-ZIFCu@HA nano system, which has high biocompatibility, targets CD44 overexpressed cancer cells, and responds to acidic environments. Both in vivo and in vitro experiments have shown that CuET-ZIF(Cu)@HA has strong anti-tumor properties without evident side effects, providing a promising strategy for DSF nanosystems with simple preparation and high efficacy.
FRONTIERS OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Medicinal
Ziad Omran
Summary: Disulfiram is a drug approved by the FDA for treating chronic alcoholism, acting by inhibiting ALDH2. It also inhibits ALDH1a1, a key therapeutic target for diseases like cancer and obesity. The study successfully synthesized a derivative, 2b, which showed comparable activity to Disulfiram against ALDH1a1 but no inhibitory activity against ALDH2.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Cell Biology
Anna Taranta, Mohamed A. Elmonem, Francesco Bellomo, Ester De Leo, Sara Boenzi, Manoe J. Janssen, Amer Jamalpoor, Sara Cairoli, Anna Pastore, Cristiano De Stefanis, Manuela Colucci, Laura R. Rega, Isabella Giovannoni, Paola Francalanci, Lambertus P. van den Heuvel, Carlo Dionisi-Vici, Bianca M. Goffredo, Rosalinde Masereeuw, Elena Levtchenko, Francesco Emma
Summary: Nephropathic cystinosis is a rare disease caused by mutations of the CTNS gene, leading to cystine accumulation in tissues. Treatment with DSF shows partial reversal of the disease, but high dosage inhibits growth, while low dosage fails to reduce cystine accumulation and causes adverse effects.
Article
Public, Environmental & Occupational Health
L. Bernasconi, M. Carnovale, D. Lonati, V. M. Petrolini, A. Schicchi, B. Brolli, V. M. Negrini, C. Grazioli, O. Maystrova, E. Buscaglia, Giulia Scaravaggi, F. Crema, C. A. Locatelli
Summary: Hydrogen cyanamide, a plant growth regulator recalled from the market, can cause severe clinical manifestations. This study retrospectively evaluated hydrogen cyanamide exposures referred to a Poison Control Centre, highlighting the importance of monitoring exposure to agricultural products and increasing awareness of its potential toxicity.
OCCUPATIONAL MEDICINE-OXFORD
(2023)
