Article
Rheumatology
Francesca Faustini, Helena Idborg, Enrico Fuzzi, Anders Larsson, Wen-Rong Lie, Sven Poetzsch, Shinji L. Okitsu, Elisabet Svenungsson, Iva Gunnarsson
Summary: This study investigated the role of urinary galectin-3 binding protein (u-Gal-3BP) as a candidate biomarker for renal disease in Lupus nephritis (LN). The results showed that u-Gal-3BP levels were higher in LN patients and correlated with the activity index in renal biopsies. After treatment, u-Gal-3BP levels decreased. Therefore, u-Gal-3BP shows promise as a non-invasive urinary biomarker to help detect and monitor renal involvement in Lupus erythematosus patients.
Article
Biology
Raouia Fakhfakh, Emna Bouallegui, Hana Houssaini, Nesrine Elloumi, Fatma Dhafouli, Olfa Abida, Hend Hachicha, Sameh Marzouk, Zouhir Bahloul, Khawla Kammoun, Tahia Boudawara, Hatem Masmoudi
Summary: Lupus nephritis (LN) is an immune complex glomerulonephritis, and the mechanisms of its pathogenesis are related to the expression and regulation of RNA-binding proteins (RBPs). Studying the differential expression of RBPs and their regulatory effects on target genes can help identify new therapeutic targets for LN.
Review
Medicine, Research & Experimental
Emily Capone, Stefano Iacobelli, Gianluca Sala
Summary: LGALS3BP, a secreted protein expressed in most human cells, has been identified as a potential therapeutic target for cancer treatment. Studies have shown that LGALS3BP plays a significant role in cancer, potentially impacting prognosis and functionality.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Soraia R. Mendes, F. Xavier Gomis-Rueth, Theodoros Goulas
Summary: Human alpha(2)-macroglobulin (h alpha M-2) is a large homotetrameric protein involved in the broad inhibition of endopeptidases. After cleavage, h alpha M-2 undergoes conformational changes and eventually entraps the peptidase through a Venus flytrap mechanism. Biochemical and biophysical characterization of purified h alpha M-2 from fresh or frozen plasma showed no differences in molecular or functional properties, indicating that native h alpha M-2 remains functional despite freezing.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Huihua Ding, Yiwei Shen, Cheng Lin, Ling Qin, Shijun He, Min Dai, Shinji L. Okitsu, Julie A. DeMartino, Qiang Guo, Nan Shen
Summary: Urinary G3BP levels are associated with renal disease activity in lupus nephritis patients and could serve as a non-invasive biomarker when renal biopsy is impractical.
ARTHRITIS RESEARCH & THERAPY
(2022)
Review
Immunology
Haeun Ko, Chan Johng Kim, Sin-Hyeog Im
Summary: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. Type 2 immune responses are involved during the pathology of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrew Beenken, Gabriele Cerutti, Julia Brasch, Yicheng Guo, Zizhang Sheng, Hediye Erdjument-Bromage, Zainab Aziz, Shelief Y. Robbins-Juarez, Estefania Y. Chavez, Goran Ahlsen, Phinikoula S. Katsamba, Thomas A. Neubert, Anthony W. P. Fitzpatrick, Jonathan Barasch, Lawrence Shapiro
Summary: In this study, high-resolution cryoelectron microscopy structures of LRP2 were analyzed, revealing that LRP2 is a molecular machine capable of binding ligands at the cell surface and releasing them in the endosome. LRP2 forms a homodimer and its conformational transformation is regulated by pH-sensitive sites. Deleterious missense variants of LRP2 appear to impair homodimer assembly. These observations provide insights into the function and mechanism of LDL receptors and suggest that homodimerization is a conserved feature of the LRP receptor subfamily.
Article
Multidisciplinary Sciences
Kawin Tangvoraphonkchai, Tanita Suttichaimongkol, Churairat Kularbkaew, Prakasit Sangaimwibool, Wattana Sukeepaisarnjaroen
Summary: This study evaluates the application of a novel serum marker M2BPGi in fibrosis staging. By comparing the M2BPGi levels among healthy donors and hepatitis C patients, it is found that M2BPGi shows superior performance in distinguishing between liver disease populations and healthy controls.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Wenyan Fu, Yu Liu, Fangjie Liu, Chenghua Liu, Jingjing Li, Jiali Niu, Peng Han, Dan Xu, Jiaojiao Hou, Yuanfang Ma, Jiannan Feng, Zhanguo Li, Rong Mu, Guang Yang
Summary: A conserved peptide HU1 from bacterial biofilms was specifically recognized by approximately 47% of SLE patients' sera, showing a significant positive correlation with lupus nephritis development. Antibodies against HU1 aggravated lupus nephritis in mice and inhibited the activity of protein disulfide isomerase on renal cells. These findings reveal a novel mechanism linking bacterial biofilms to the development of lupus nephritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroyuki Kobayashi, Satoru Joshita, Yuki Akahane, Katsuhiko Matsuzaki, Hiromi Yamada, Daiki Aomura, Nao Joshita, Hajime Midorikawa, Kazuhiro Suyama, Masao Ota, Shun-ichi Wakabayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Hiromichi Misawa, Takeji Umemura
Summary: This study aims to achieve HCV micro-elimination in Nagawa, Japan by conducting HCV screening and treatment among local residents. Through systematic efforts, the goal of HCV eradication can be achieved in this region.
Article
Biochemistry & Molecular Biology
Milos Sunderic, Tamara Vasovic, Milos Milcic, Cedo Miljevic, Olgica Nedic, Milan R. Nikolic, Nikola Gligorijevic
Summary: The study revealed moderate binding affinity between alpha M-2 and clozapine, without significant conformational changes in the protein. Both substances were found to shield each other from the deleterious influence of strong oxidants, suggesting a potential synergistic protective effect against neural tissue injury caused by disturbed proteostasis or oxidative stress.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Rheumatology
Amany M. Ebaid, Nillie Ezzeldin, Enas Abdelhady, Heba A. Mohammed, Alshimaa L. Abdallah
Summary: This study evaluated the relationship between serum IGBP1 and SLE disease activity and renal activity, and found that serum IGBP1 is a valid biomarker for detecting active nephritis. Clinicians are recommended to monitor the serum IGBP1 levels of patients with SLE to detect LN.
Article
Multidisciplinary Sciences
Ayaka Tomihari, Mako Kiyota, Akira Matsuura, Eisuke Itakura
Summary: Proteostasis is crucial for stress resistance and aging. In this study, the degradation pathway of alpha 2-macroglobulin (alpha M-2) was identified, showing its role in lysosomal degradation of extracellular misfolded proteins. Comparative analysis with clusterin revealed that alpha M-2 selectively targets aggregation-prone proteins. These findings shed light on the understanding of protein degradation pathways for extracellular proteins.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
A. S. R. Peretz, N. S. Rasmussen, S. Jacobsen, C. Sjowall, C. T. Nielsen
Summary: In patients with SLE, serum G3BP has been identified as a novel predictor of VTE. Further studies are necessary to better understand the role of G3BP in VTE and its clinical implications.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Jeanne Perpetue Vincent, Gibril Ndow, Shintaro Ogawa, Amie Ceesay, Ramou Njie, Bakary Sanneh, Ignatius Baldeh, Umberto D'Alessandro, Maimuna Mendy, Mark Thursz, Isabelle Chemin, Yasuhito Tanaka, Maud Lemoine, Yusuke Shimakawa
Summary: In low-income countries, access to liver histopathology is limited, making it necessary to find a cheap and accurate serum biomarker for staging liver fibrosis and predicting HCC in HBV-infected patients.
JOURNAL OF GLOBAL HEALTH
(2022)
Letter
Rheumatology
Sindhu R. Johnson, Martin Aringer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sindhu R. Johnson, Dafna D. Gladman, Hermine Brunner, David Isenberg, Ann E. Clarke, Megan R. W. Barber, Laurent Arnaud, Paul R. Fortin, Marta Mosca, Alexandre E. Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S. Alarcon, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica A. English, Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Rebecca Gilman, Ellen M. Ginzler, John G. Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L. Kamen, Chynace Lambalgen, Alexandra Legge, S. Sam Lim, Anselm Mak, Eric F. Morand, Christine A. Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A. Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F. van Vollenhoven, Heather Waldhauser, Daniel J. Wallace, Asad Zoma, Ian N. Bruce
Summary: The SLICC, ACR, and Lupus Foundation of America are developing a revised SLE damage index (SDI) due to shifts in the concept of damage in SLE. A qualitative study was conducted to evaluate contemporary constructs in SLE damage and develop a conceptual framework for the revised SDI.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Immunology
Katrine A. Myhr, Amanda H. Zinglersen, Marie-Louise F. Hermansen, Mathies M. Jepsen, Katrine K. Iversen, Anh T. Ngo, Redi Pecini, Soren Jacobsen
Summary: This study aimed to investigate the factors associated with cardiac size and function in SLE patients, and found that the presence of lupus anticoagulant is associated with diastolic dysfunction and left ventricular dilatation during a 5-year follow-up.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Biochemical Research Methods
Anders H. Kverneland, Ole Ostergaard, Kristina Bennet Emdal, Inge Marie Svane, Jesper Velgaard Olsen
Summary: This study demonstrates that enrichment of extracellular vesicles (EVs) by ultracentrifugation can significantly increase the depth of the plasma proteome analysis. By optimizing the workflow, over two thousand proteins can be quantified in a short time using label-free quantification and data independent acquisition (DIA), enabling high-throughput analysis of plasma samples and supporting potential biomarker discovery in the future.
Article
Rheumatology
Ann E. Clarke, John G. Hanly, Murray B. Urowitz, Yvan St. Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Vernon Farewell
Summary: The objective of this study was to estimate the costs associated with neuropsychiatric events in SLE. The study found that new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs. Indirect costs exceeded direct costs by 3.0 to 5.2 fold.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Renata Baronaite Hansen, Titilola Falasinnu, Mikkel Faurschou, Soren Jacobsen, Julia F. Simard
Summary: This study aimed to determine whether diabetes mellitus (DM) increases the risk of end-stage renal disease (ESRD) in patients with systemic lupus erythematosus (SLE). The findings show that SLE patients with DM have a 3 times higher risk of developing ESRD compared to SLE patients without DM.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Clinical Neurology
Louise Pyndt Diederichsen, Line Vinderslev Iversen, Christoffer Tandrup Nielsen, Soren Jacobsen, Marie-Louise Hermansen, Nanna Witting, Rikke Cortes, Sine Sondergaard Korsholm, Markus Engebaek Krogager, Tina Friis
Summary: This study aimed to determine the prevalence and clinical associations of cN-1A autoantibodies in patients with connective tissue diseases. The results showed that cN-1A autoantibodies were predominantly found in patients with idiopathic inflammatory myopathies (IIM) and were associated with dysphagia in sporadic inclusion body myositis (sIBM) patients. Additionally, cN-1A positive non-IBM IIM patients had a milder disease course.
Article
Virology
Julie Knudsen, Nicole Hartwig Trier, Anette Holck Draborg, Christoffer Tandrup Nielsen, Soren Jacobsen, Peter Hojrup, Gunnar Houen
Summary: SLE and DIL are autoimmune diseases associated with EBV and CMV infections, but they differ in onset and clinical symptoms. This study found significantly elevated IgG titers to EBV and CMV antigens in serum samples from SLE and DIL patients, as well as reduced total IgG titers, which may be related to lymphocytopenia commonly seen in SLE.
Article
Microbiology
Rosa Maja Mohring Gynthersen, Mette Frimodt Hansen, Lukas Frans Ocias, Andreas Kjaer, Randi Fons Petersen, Sisse Rye Ostrowski, Lene Harritshoj, Soren Jacobsen, Ulrik Overgaard, Karen Angeliki Krogfelt, Anne-Mette Lebech, Helene Mens
Summary: The presence of N. mikurensis DNA was detected in immunocompromised patients in Denmark, highlighting the potential underdiagnosis of this bacterium in Danish patients.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Medicine, General & Internal
Simon Jonck, Malte Lund Adamsen, Pil Hojgaard, Iben Elmerdahl Rasmussen, Helga Ellingsgaard, Morten Asp Vonsild Lund, Peter Godsk Jorgensen, Soren Jacobsen, Lars Kober, Niels Vejlstrup, Lene Dreyer, Bente Klarlund Pedersen, Ronan M. G. Berg, Regitse Hojgaard Christensen
Summary: The chronic inflammatory state in rheumatoid arthritis (RA) increases the risk of cardiovascular disease (CVD), with pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin 6 (IL-6) playing a vital role. Biological disease-modifying antirheumatic drugs (bDMARDs) may attenuate that risk. IL-6 is also a myokine, secreted from exercising skeletal muscles, where it exhibits anti-inflammatory effects that may mitigate the risk of CVD. We hypothesize that inhibiting IL-6 signaling will impair the cardiac and metabolic adaptations to exercise training compared to TNF inhibition in RA patients.
Article
Rheumatology
Yann Nguyen, Benoit Blanchet, Murray B. Urowitz, John G. Hanly, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Ann E. Clarke, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Joensen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Veronique Le Guern, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Jill Buyon, Nathalie Costedoat-Chalumeau
Summary: The study aimed to assess the association between severe nonadherence to hydroxychloroquine (HCQ), analyzed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates. Severe nonadherence was found to be independently associated with increased risk of SLE flares, early damage, and five-year mortality.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
R. Talarico, G. A. Ramirez, S. C. Barreira, C. Cardamone, P. Triggianese, S. Aguilera, J. Andersen, T. Avcin, K. Benistan, G. Bertsias, A. Bortoluzzi, C. Bouillot, I. Bulina, G. R. Burmester, S. Callens, P. E. Carreira, R. Cervera, M. Cutolo, L. Damian, E. Della Torre, R. Faria, J. E. Fonseca, I. Galetti, E. Hachulla, L. Iaccarino, S. Jacobsen, N. Khmelinskii, M. Limper, D. Marinello, A. Meyer, G. Moroncini, G. Nagy, M. Olesinska, C. Pamfil, M. Pileckyte, M. Pistello, S. Rednic, C. Richez, V. C. Romao, M. Schneider, S. Sciascia, C. A. Scire, G. Simonini, V. Smith, A. Sulli, C. Tani, S. W. Tas, A. Tincani, M. C. Vonk, M. Tektonidou, M. Mosca
Summary: Recent studies have shown that immunocompromised individuals may inadvertently contribute to the mutations of the virus that lead to new variants. This aspect should be carefully considered as immunocompromised individuals remain at risk of COVID-19 despite vaccination, experience more severe disease, and can be contagious for longer. The European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ReCONNET) addressed this issue by forming a multidisciplinary Task Force to develop guidelines for treating immunocompromised patients with COVID-19. The final principles and points-to-consider were agreed upon by the Task Force.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katrine A. Myhr, Amanda H. Zinglersen, Redi Pecini, Soren Jacobsen
Summary: This study aimed to investigate the prevalence and degree of myocardial fibrosis in SLE patients. The results showed that SLE patients displayed signs of myocardial fibrosis on CMR, which were associated with the presence of lupus anticoagulant (LAC).
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Rheumatology
Ann E. Clarke, Manuel Ugarte-Gil, Megan Barber, John Hanly, Murray Urowitz, Yvan St. Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel Wallace, David Isenberg, Anisur Rahman, Joan Merrill, Paul R. Fortin, Dafna Gladman, N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Ronald Van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane Kamen, Anca Askanase, Bernardo Pons-Estel, Graciela Alarcon
ARTHRITIS & RHEUMATOLOGY
(2022)