Article
Engineering, Electrical & Electronic
Shuang Chen, Zongqian Shi, Jiajia Sun, Shenli Jia, Mingjie Zhong, Yuxin Ma
Summary: Inertial microfluidic is a widely applied technology that uses inertial lift force and Dean Vortices to manipulate particles or bio-samples. This study introduces a split-recombination microchannel for high flow rate particle focusing and separation, utilizing the combined effects of inertial lift force, curvature-induced Dean drag force, and the structure of split and recombination. The designed microchannel not only enhances particle focusing but also enables the separation of different-sized particles with high throughput.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Simon Dumas, Mathilde Richerd, Marco Serra, Stephanie Descroix
Summary: This study presents a method using microfabricated NiFe structures, called magnetic microtweezers, to trap and extract magnetic particles from droplets and enable physical separation of single cells. The results show high extraction efficiency and applicability in capturing particles and extracting mRNA.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Analytical
Zhenna Chen, Beibei Chen, Man He, Bin Hu
Summary: A negative magnetophoresis focusing microchip was developed and coupled to ICP-MS for single-cell analysis, achieving high sample throughput. Study on uptake behaviors revealed that MCF-7 cells exhibited more remarkable heterogeneity when treated with ZnO NPs, with lower uptake content compared to Zn2+.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Weihan Li, Mikinori Kuwata
Summary: Acidity is an important property of atmospheric aerosol particles, but there is currently no method available for measuring the pH of submicron particles in suspension. This study developed a fluorescence-based method using an aerosol fluorescence cell (AFC) to quantify the pH of aerosol particles in a continuous flow. The AFC method showed good agreement with pH indicator papers and can be applied to submicron particles of 80 nm in diameter.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Mechanics
Xiao Hu, Jianzhong Lin, Yu Guo, Xiaoke Ku
Summary: The inertial focusing of elliptical particles and the formation of self-organizing trains in a channel flow are studied using the lattice Boltzmann method. Different particle characteristics such as aspect ratio, concentration, Reynolds number, and blockage ratio affect the formation and stability of the particle trains.
Article
Biotechnology & Applied Microbiology
Fang Xu, Yan Shen, Lufeng Ding, Chao-Yu Yang, Heng Tan, Hao Wang, Qingyuan Zhu, Rui Xu, Fengyi Wu, Yanyang Xiao, Cheng Xu, Qianwei Li, Peng Su, Li I. Zhang, Hong-Wei Dong, Robert Desimone, Fuqiang Xu, Xintian Hu, Pak-Ming Lau, Guo-Qiang Bi
Summary: This study introduces a new method combining primate-optimized tissue sectioning and clearing with high-speed fluorescence microscopy to achieve high-resolution imaging of the entire rhesus monkey brain. Researchers have also developed an efficient method for tracing sparse axonal fibers in large datasets, enabling connectome-scale mapping of large primate brains.
NATURE BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Xiaoyi Sun, Yuqi Ma, Chunyang Lu, Ziwei Cai, Jintao Han, Zhigang Wang, Gen Yang
Summary: In this study, a simply structured microfluidic chip based on the principle of inertial focusing was designed to separate circulating tumor cells (CTCs) from blood with high efficiency. The chip showed excellent separation efficiency, robustness, and low velocity sensitivity across a broad range of velocities. It can be integrated with other functional modules, making it a promising tool for cancer diagnosis and therapeutics.
Article
Chemistry, Multidisciplinary
Yao Chen, Chen Ni, Lin Jiang, Zhonghua Ni, Nan Xiang
Summary: An inertial multi-force deformability cytometry (IMFDC) is developed for high-throughput, high-accuracy, and high-applicability tumor cell mechanotyping. The IMFDC is able to evaluate the deformability of different cells and identify cell types. The multiple-parameters-based machine learning model achieves high discrimination accuracy and throughput. The IMFDC has important applications in clinical cancer diagnosis.
Article
Multidisciplinary Sciences
Tharagan Kumar, Harisha Ramachandraiah, Sharath Narayana Iyengar, Indradumna Banerjee, Gustaf Martensson, Aman Russom
Summary: In this study, high Reynolds number viscoelastic particle focusing and separation in spiral channels was explored. The balance between dominant inertial lift force, dean drag force, and elastic force enables stable 3D particle focusing at dynamically high Reynolds numbers. Effective separation based on size was achieved with high precision.
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Wenjun Ma, Dong Liu, Sida Ling, Jingwei Zhang, Zhuo Chen, Yuan Lu, Jianhong Xu
Summary: By improving the structure of microfluidic devices, high-throughput fabrication of helical microfibers has been achieved, solving the previous issues of channel blockage and spinning instability, and providing more possibilities for the application of helical microfibers.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Jung Yeon Han, Joseph N. La Fiandra, Don L. DeVoe
Summary: This paper presents a microfluidic vortex focusing technique for mass production of liposomes with controlled size and low variability, addressing the trade-offs between size uniformity and mass production in liposome synthesis.
NATURE COMMUNICATIONS
(2022)
Article
Nuclear Science & Technology
M. M. Wang, H. W. Deng, H. Wang, Z. M. Xie, T. Zhang, X. P. Wang, Q. F. Fang, C. S. Liu, X. Liu
Summary: An ultrafine ZrC nanoparticles dispersion strengthened sub-micrometer grained W-0.5 wt% ZrC alloy was successfully fabricated using an improved ball milling and spark plasma sintering (SPS) process. The alloy exhibits high thermal stability and thermal shock resistance, with a higher grain growth temperature compared to rolled specimens, as well as a crack threshold at room temperature similar to most carbide dispersion strengthening tungsten alloys. Additionally, a quantitative relationship between Vickers micro-hardness and grain size of sintered W-based alloys has been proposed.
FUSION ENGINEERING AND DESIGN
(2021)
Article
Optics
Yuhan Zhou, Takatoshi Seto, Yuhua Wang
Summary: Phosphors are widely used in high-quality white light emitting diodes (W-LEDs) and display technology. This paper presents a strategy to improve the luminescence intensity of sub-micrometer narrow-band red phosphors by increasing the doping concentration of rare-earth ions and reducing the nonradiative transition. The results show that this strategy greatly enhances the luminescence intensity of the phosphors.
LASER & PHOTONICS REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Shigeru Tanaka, Kouki Hasegawa, Ivan Bataev, Akihisa Kubota, Kazuyuki Hokamoto
Summary: This study proposes using underwater shockwaves as an alternative method for high-quality imprinting on thin metal foils, achieving nanoscale reliefs that match the depth of the grooves on the mold and improving mold filling efficiency. Additionally, underwater shockwaves allow imprinting over a large area in a single shot, which could be beneficial for future applications in the fields of plasmonics and metasurfaces.
MATERIALS & DESIGN
(2021)
Article
Multidisciplinary Sciences
Javier Cruz, Klas Hjort
Summary: Microfluidics utilizing inertial focusing phenomenon has been a focus of attention in the past decade for facilitating the detection and analysis of rare particles in complex fluids. Although many interesting applications have been demonstrated, these systems remain challenging to engineer. The High Aspect Ratio Curved microfluidics technology of inertial focusing presents the potential to make the benefits of inertial focusing more accessible.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Robert B. Channon, Yuanyuan Yang, Kristen M. Feibelman, Brian J. Geiss, David S. Dandy, Charles S. Henry
ANALYTICAL CHEMISTRY
(2018)
Article
Biophysics
Lei Wang, Jessica E. Filer, Meghan M. Lorenz, Charles S. Henry, David S. Dandy, Brian J. Geiss
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Chemistry, Analytical
Robert B. Channon, Michael P. Nguyen, Charles S. Henry, David S. Dandy
ANALYTICAL CHEMISTRY
(2019)
Article
Plant Sciences
Bjorn Andersson, Chen Shen, Michael Cantrell, David S. Dandy, Graham Peers
Article
Biochemical Research Methods
Eka Noviana, Sidhartha Jain, Josephine Hofstetter, Brian J. Geiss, David S. Dandy, Charles S. Henry
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Electrochemistry
Tugba Ozer, Cynthia McCord, Brian J. Geiss, David Dandy, Charles S. Henry
Summary: A new amine functionalized electrochemical immunosensor for label-free detection of Escherichia coli using modified thermoplastic electrodes was reported, with successful application in urine samples for selective and sensitive detection of the bacteria. The sensor showed high specificity and sensitivity, making it suitable for accurate detection of different pathogenic bacteria.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Isabelle C. Samper, Ana Sanchez-Cano, Wisarut Khamcharoen, Ilhoon Jang, Weena Siangproh, Eva Baldrich, Brian J. Geiss, David S. Dandy, Charles S. Henry
Summary: A novel low-cost electrochemical capillary-flow device was developed for rapid detection of SARS-CoV-2 antibodies within 20 minutes without the need for sample preparation. The device integrates blood-filtration membrane for plasma extraction and automated steps of an ELISA, providing accurate and reliable results for point-of-care testing. The novelty lies in the integration of sensitive electrochemical detection with capillary-flow immunoassay, showing potential for aiding the diagnosis of infectious diseases at the point of care.
Article
Chemistry, Analytical
Isabelle C. Samper, Catherine J. McMahon, Melissa S. Schenkel, Kaylee M. Clark, Wisarut Khamcharoen, Loran B. R. Anderson, James S. Terry, Emily N. Gallichotte, Gregory D. Ebel, Brian J. Geiss, David S. Dandy, Charles S. Henry
Summary: A highly sensitive electrochemical immunoassay has been developed for quantitatively detecting the presence of SARS-CoV-2 virus in patient nasopharyngeal samples. The assay demonstrates high specificity and sensitivity, meeting the criteria for POC COVID-19 diagnostic tests set by the World Health Organization.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zachary D. Call, Ilhoon Jang, Brian J. Geiss, David S. Dandy, Charles S. Henry
Summary: Urinary tract infections (UTIs) are a common and potentially serious condition. Current diagnostic methods are expensive and time-consuming. Magnetophoresis, a method for separating and analyzing cells of interest, has been combined with paper-based microfluidic devices to enable low-cost and simple operation. This study successfully detected E. coli using this hybrid method.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chen Shen, Kevin H. Dunn, Susan R. Woskie, James S. Bennett, Michael J. Ellenbecker, David S. Dandy, Candace Su-Jung Tsai
Summary: Understanding airflow dynamics is crucial for controlling exposure to toxic airborne substances in the nanoparticle size range. Chemical fume hoods are commonly used to control worker exposure, and this study evaluates the impact of human body motion on the containment performance of conventional and nano ventilated enclosing hoods.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Chemistry, Analytical
Cody Carrell, Ilhoon Jang, Jeremy Link, James S. Terry, Zachary Call, Yosita Panraksa, Orawon Chailapakul, David S. Dandy, Brian J. Geiss, Charles S. Henry
Summary: A capillary-driven microfluidic sequential flow device was developed for at-home or doctor's office use, to perform enzyme-linked immunosorbent assay (ELISA) for serology testing. This device provides critical information for managing COVID-19 infections, immunity status, and vaccination status.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Sidhartha Jain, David S. Dandy, Brian J. Geiss, Charles S. Henry
Summary: The sensitive nucleic acid detection method based on padlock probe rolling circle amplification, nuclease protection, and lateral flow detection has been developed for use in resource-limited settings. By combining these techniques, the method allows for detection of antimicrobial resistance genes and specific pathogens such as SARS-CoV-2 with high sensitivity.
Article
Chemistry, Analytical
Ilhoon Jang, Hyunwoong Kang, Simon Song, David S. Dandy, Brian J. Geiss, Charles S. Henry
Summary: Capillary-driven microfluidic devices made from paper and polyester film are commonly used due to their low cost and lack of external pumps. However, controlling flow in these devices can be challenging due to the sole reliance on capillary forces. This study introduces new flow control methods, such as push and burst valve systems, for increased functionality in laminate capillary-driven microfluidic devices. These methods enable precise control of flow direction, concentration, and velocity, ultimately offering new design possibilities for on-site analysis in various fields.
Article
Chemistry, Analytical
Zachary D. Call, Cody S. Carrell, Ilhoon Jang, Brian J. Geiss, David S. Dandy, Charles S. Henry
ANALYTICAL METHODS
(2020)