Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 4, Pages 601-607Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00084
Keywords
microfluidic paper-based analytical devices (mu PADs); continuous perfusion; paper-based biofluidics; concentration gradient; cell culture; drug screening
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Funding
- National Nature Science Foundation of China [51622510, U1609207]
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China [51521064]
- Nature Science Foundation of Zhejiang Province, China [LR17E050001]
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As a kind of facile tool, microfluidic paper-based analytical devices (mu PADs) have been widely used in analytical and biomedical fields. However, because we lack the ability to control the continuous perfusion of these devices, they are not generally used in fields that require continuous flow, especially biofluidics fields such as cell culturing, drug screening, and organs on chips. In this study, we designed a novel, low-cost, and compact platform that can be used to control the continuous perfusion of mu pPADs. As most of the parts of this platform can be created using a three-dimensional (3D) desktop printer, our platform can be easily duplicated by other researchers. We demonstrate that with our system, mu PADs can be promising paper-based biofluidic platforms for cell culturing and drug screening.
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