Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Utpal Das, Binoy Kar, Sudhindra Pete, Priyankar Paira
Summary: Researchers are working on developing anticancer drugs with minimal toxicity and greater specificity for cancer cells. Metal-based complexes such as Ru(ii) and others have shown promising anticancer activity.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Yun-Qiong Gu, Wen-Ying Shen, Qi-Yuan Yang, Zhen-Feng Chen, Hong Liang
Summary: The study demonstrated that three ruthenium(III) complexes exhibit strong anticancer effects, showing high cytotoxicity against SK-OV-3 cells and effective in vivo anticancer activity. The complexes induced apoptosis, cell cycle arrest, and DNA damage in cancer cells, highlighting their potential as promising anticancer agents.
DALTON TRANSACTIONS
(2022)
Article
Pharmacology & Pharmacy
Gabriela Marinescu, Daniela C. Culita, Teodora Mocanu, Raul-Augustin Mitran, Simona Petrescu, Miruna S. Stan, Mariana C. Chifiriuc, Marcela Popa
Summary: A series of nanostructured materials were obtained by functionalizing SBA-15 mesoporous silica with Ru(II) and Ru(III) complexes bearing Schiff base ligands. The resulting materials showed antitumoral activity against lung tumor cells and inhibitory effects against bacteria.
Article
Chemistry, Medicinal
Yuliang Yang, Ya Gao, Yanyan Sun, Jian Zhao, Shaohua Gou
Summary: A series of novel ruthenium(II) and iridium(III) complexes with different ancillary ligands and a PARP-1-inhibitory chelating ligand were designed and synthesized. The complexes exhibited potent antiproliferative activity on cancer cell lines, with the ruthenium(II) complexes being more cytotoxic. The most active ruthenium complex induced apoptosis in cancer cells through multiple mechanisms.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Luca Conti, Eleonora Macedi, Claudia Giorgi, Barbara Valtancoli, Vieri Fusi
Summary: The increasing impact of cancer on mortality worldwide calls for the research and development of novel chemotherapeutic agents. Transition metal complexes, particularly Ru(II) polypyridyl complexes, have shown promise in photodynamic therapy and photochemotherapy, providing spatio-temporal control over drug activation. These complexes offer versatile options for both photosensitizer agents and photolabile complexes, addressing issues such as selectivity and oxygen-dependence. This review highlights the opportunities presented by RPCs in these treatment approaches, providing a comprehensive overview of their mechanisms of action.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Claudia Riccardi, Chiara Platella, Domenica Musumeci, Daniela Montesarchio
Summary: Recently, we have focused on the preparation of nucleolipid-based Ru(III) complexes that can form supramolecular aggregates under physiological conditions. These complexes can prevent metal deactivation and efficiently deliver Ru(III) into cells for its therapeutic activity.
Article
Chemistry, Inorganic & Nuclear
Li-Xiang Guo, Yao Gao, Pei Zhang, Jian-Hui Yang, Bin Liu
Summary: A family of edge-sharing bi-octahedral (ESBO) diruthenium(III,III) compounds has been prepared by reacting Ru-2(R'CO2) (+)(4). These compounds have a similar ESBO structure, with the Ru atoms bridged by two mu-O2CR' and two mu-OR in a trans manner, and each Ru atom coordinated with an eta(2)-L ligand. The Ru-Ru distances fall in the range of 2.4560(9)-2.4771(4) angstrom. The compounds exhibit strong absorption bands at around 345 cm(-1) in the Raman spectrum, which can be assigned to the stretching of the Ru-Ru single bond.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Andrea E. Gallio, Leonardo Brustolin, Nicolo Pettenuzzo, Dolores Fregona
Summary: Binuclear dithiocarbamate complexes of Ru(III) have shown promise as potential metal-based anticancer agents. This study proposes the use of heteroleptic ligands as tunable features to develop improved ruthenium-based antiproliferative agents. The cytotoxic activity of a selection of binuclear heteroleptic Ru(III) compounds towards MDA-MB-231 and PC3 cells was evaluated.
Article
Chemistry, Inorganic & Nuclear
Saumyaranjan Mishra, Suman Kumar Tripathy, Debasish Paul, Paltan Laha, Manas Kumar Santra, Srikanta Patra
Summary: In this study, a heterodinuclear complex was synthesized using terpyridyl/phenylpyridine and asymmetric phpy as ligands. The asymmetric binding mode of phpy in the complex was confirmed through various spectroscopy and crystallography techniques. The complex exhibited a broad low energy charge transfer band and showed anticancer activity and selectivity towards human breast cancer cells.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
M. Shahnawaz Khan, Mohd Umar Hayat, Madiha Khanam, Haris Saeed, Mohammad Owais, Mohd Khalid, M. Shahid, Musheer Ahmad
Summary: The study focuses on the design of new antimicrobial drugs using transition metals, specifically two mononuclear complexes, and evaluates their antimicrobial activity against both Gram-positive and Gram-negative bacteria. The compounds show promising bactericidal activity, ability to disrupt biofilms, and potential as anticancer agents. The role of imidazole in the biological activity of these complexes is highlighted, suggesting their potential clinical applications in treating bacterial and fungal infections.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Materials Science, Biomaterials
Md Saiful I. Chowdhury, Elizabeth A. Kras, Steven G. Turowski, Joseph A. Spernyak, Janet R. Morrow
Summary: Liposomes containing high-spin Fe(III) coordination complexes were prepared as T1 MRI probes with improved relaxivity. The liposomes with the amphiphilic Fe(III) complex had higher proton relaxivity values compared to the small hydrophilic analog. The biodistribution and clearance of the liposomes differed depending on the type of Fe(III) complex, with differences in stability and circulation time.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Claudia Riccardi, Antonella Campanella, Daniela Montesarchio, Pompea Del Vecchio, Rosario Oliva, Luigi Paduano
Summary: Ruthenium(III) complexes show promise as metal-based anticancer drugs. This study investigates the interaction of a Ru(III) complex embedded in a liposomal nanosystem with human serum proteins HSA and hTf, using fluorescence spectroscopy and circular dichroism. The results suggest that the nanosystem can interact with the serum proteins without affecting their secondary structures.
Article
Chemistry, Applied
Reem G. Deghadi, Gehad G. Mohamed, Nessma F. Mahmoud
Summary: In this study, bioactive complexes were synthesized and characterized. The complexes showed good anticancer and antibacterial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Joaquin Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, Jose Ruiz, Vicente Marchan
Summary: By encapsulating poorly soluble cyclometalated Ir(III) complexes using polyurethane-polyurea hybrid nanocapsules, their solubility is improved and the nanocapsules can enhance cellular uptake and cytotoxicity, leading to inhibition of tumor growth.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Ettore Napolitano, Claudia Riccardi, Rosa Gaglione, Angela Arciello, Valentina Pirota, Alice Triveri, Filippo Doria, Domenica Musumeci, Daniela Montesarchio
Summary: In order to develop efficient anticancer theranostic systems, the interaction between a cyanine dye (CyOH) and two G-quadruplex-forming aptamers (V7t1 and 3R02) was studied. These aptamers recognized the Vascular Endothelial Growth Factor 165 (VEGF165), which is overexpressed in cancer cells and responsible for the rapid growth and metastases of solid tumors. Biophysical techniques, such as gel electrophoresis, circular dichroism (CD), UV-vis spectroscopy and fluorescence spectroscopy, were used to demonstrate that the cyanine interacted with both aptamers, giving a fluorescence light-up when bound to their dimeric forms. The dimeric G-quadruplexes of the aptamers showed higher affinity for VEGF165 and the fluorescence light-up was maintained when the dimeric aptamer-CyOH complexes bound to the target protein. These complexes, tested on MCF-7 cancer cells with non-tumorigenic MCF-10A cells as control, were effectively internalized in cells and colocalized with a fluorescently-labeled anti-VEGF-A antibody, enabling recognition and detection of the target. The studied systems are promising tools for anticancer theranostic strategies, combining the therapeutic potential of the G4-forming anti-VEGF aptamers with the diagnostic efficacy of the cyanine selective fluorescence light-up.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Ester Colarusso, Sara Ceccacci, Maria Chiara Monti, Erica Gazzillo, Assunta Giordano, Maria Giovanna Chini, Maria Grazia Ferraro, Marialuisa Piccolo, Dafne Ruggiero, Carlo Irace, Stefania Terracciano, Ines Bruno, Giuseppe Bifulco, Gianluigi Lauro
Summary: Targeting bromodomain-containing protein 9 (BRD9), a set of 2,4,5-trisubstituted-2,4-dihydro-3H- 1,2,4-triazol-3-one-based compounds was investigated for the development of new anticancer agents. Through in silico studies, chemical synthesis, biophysical and biological evaluation, compounds with promising selectivity and binding affinity for BRD9 were identified. The multidisciplinary approach used in this study accelerated the selection process and provided insights for the synthesis of novel BRD9 binders.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maria Grazia Ferraro, Marco Bocchetti, Claudia Riccardi, Marco Trifuoggi, Luigi Paduano, Daniela Montesarchio, Gabriella Misso, Rita Santamaria, Marialuisa Piccolo, Carlo Irace
Summary: Based on strong preclinical evidence, this study focuses on the treatment of challenging indications, such as TNBC, using a novel ruthenium-based metallotherapeutics. An experimental model was used to validate the potential of the liposomal nanoformulation HoThyRu/DOTAP, which effectively delivered the antiproliferative compound AziRu to inhibit TNBC cell growth, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chiara Platella, Andrea Criscuolo, Claudia Riccardi, Rosa Gaglione, Angela Arciello, Domenica Musumeci, Marina DellaGreca, Daniela Montesarchio
Summary: Despite their well-known and various bioactivities, in-depth studies on the interaction of natural compounds with cancer-related G-quadruplex structures have only recently been undertaken. In this study, a mini-library of phenanthrenoid analogues was investigated for their selective recognition of G-quadruplexes. Compounds 3 and 6 emerged as the most selective and active ligands, targeting the grooves/flanking residues of G-quadruplex structures. These compounds showed a preference for the hybrid telomeric G-quadruplex and exhibited anticancer activity in human cancer cells. Overall, these compounds are promising starting scaffolds for the design of analogues with high and selective anticancer activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chiara Platella, Francesca Ghirga, Domenica Musumeci, Deborah Quaglio, Pasquale Zizza, Sara Iachettini, Carmen D'Angelo, Annamaria Biroccio, Bruno Botta, Mattia Mori, Daniela Montesarchio
Summary: In this study, five natural compounds were investigated as analogs of promising G-quadruplex-targeting ligands to identify highly effective and selective anticancer candidates. Among them, Dicentrine was found to be the most effective ligand for telomeric and oncogenic G-quadruplexes, showing good selectivity. In-depth studies demonstrated that Dicentrine thermally stabilizes G-quadruplexes without affecting the control duplex, with higher affinity for G-quadruplex structures. Molecular dynamics simulations indicated that Dicentrine preferentially binds the G-quadruplex groove or the outer G-tetrad. Biological assays confirmed that Dicentrine promotes potent and selective anticancer activity by inducing cell cycle arrest through apoptosis, targeting G-quadruplex structures at telomeres.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rodolfo Esposito, Immacolata Speciale, Cristina De Castro, Gerardino D'Errico, Irene Russo Krauss
Summary: To protect human and environmental health, researchers are focusing on discovering and developing new molecules with high biocompatibility and biodegradability. Surfactants are particularly urgent in this matter, and biosurfactants derived from microorganisms are a promising alternative. Rhamnolipids, a well-known family of biosurfactants, have been extensively studied for their production and physicochemical characterization, although a clear structure-function relationship is still lacking. This review aims to provide a comprehensive discussion of the physicochemical properties of rhamnolipids under different solution conditions and their structure, while also addressing unresolved issues for their potential replacement of conventional surfactants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Claudia Riccardi, Antonella Campanella, Daniela Montesarchio, Pompea Del Vecchio, Rosario Oliva, Luigi Paduano
Summary: Ruthenium(III) complexes show promise as metal-based anticancer drugs. This study investigates the interaction of a Ru(III) complex embedded in a liposomal nanosystem with human serum proteins HSA and hTf, using fluorescence spectroscopy and circular dichroism. The results suggest that the nanosystem can interact with the serum proteins without affecting their secondary structures.
Editorial Material
Biochemistry & Molecular Biology
Montserrat Terrazas, Ramon Eritja, Daniela Montesarchio
Article
Biochemistry & Molecular Biology
Claudia Riccardi, Chiara Platella, Domenica Musumeci, Daniela Montesarchio
Summary: Recently, we have focused on the preparation of nucleolipid-based Ru(III) complexes that can form supramolecular aggregates under physiological conditions. These complexes can prevent metal deactivation and efficiently deliver Ru(III) into cells for its therapeutic activity.
Article
Chemistry, Multidisciplinary
Pasqualina Liana Scognamiglio, Claudia Riccardi, Rosanna Palumbo, Thomas F. Gale, Domenica Musumeci, Giovanni N. Roviello
Summary: The design, synthesis and characterization of a novel nucleoamino acid derivative named TrpT were described. The self-assembly of TrpT into supramolecular networks in aqueous solution was demonstrated. TrpT nanoaggregates showed good stability, spherical-shaped assemblies, and the ability to bind curcumin. TrpT also interacted with the serum protein BSA and showed high stability in human serum.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)