Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 3, Pages 370-380Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00670
Keywords
CHPOA; nanogel; pH sensitive; hybrid hydrogel; drug delivery; pregabalin
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Funding
- Koc University seed grant
- [FP7-IRG-239471]
- Grants-in-Aid for Scientific Research [16K01387, 16H03842] Funding Source: KAKEN
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A novel pH-sensitive hydrogel system consisting of poly(methacrylic acid-g-ethylene glycol) (P(MAA-gEG)) and acryloyl group modified-cholesterol-bearing pullulan (CHPOA) nanogels was developed for the controlled delivery of an anticonvulsant drug, pregabalin (PGB). Here, the hydrophilic hydrogel network provides the pH-sensitive swelling behavior, whereas nanogel components form separate reservoirs for the delivery of drugs with different hydro-phobicities. These nanocarrier-integrated hybrid gels were synthesized through both surface-initiated and bulk photo polymerization approaches. The swelling and drug release behavior of these pH-responsive hydrogels synthesized by different photopolymerization approaches at visible and UV light wavelenghts were studied at acidic and basic pH values. Nanogel-integrated hydrogels exhibited higher swelling behavior compared to plain hydrogels in reversible swelling experiments. Similarly, the presence of nanogels in hydrogel network enhanced the loading and release percentages of PGB and the release was analyzed to describe the mode of transport through the network. In vitro cytotoxicity assay suggests that hydrogels in altered groups are nontoxic. This is the first report about the visible light-induced synthesis of a pH-responsive network incorporated CHPOA nanogels. Responsive and multifunctional properties of this system could be used for pH-triggered release of therapeutic molecules for clinical applications.
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