Editorial Material
Computer Science, Artificial Intelligence
Tim Verdonck, Bart Baesens, Maria Oskarsdottir, Seppe vanden Broucke
Summary: Feature engineering aims to improve the performance of machine learning models by cleverly adjusting data features while maintaining interpretability. It can be used with simple techniques or to enhance complex techniques by adjusting existing features or creating new meaningful ones.
Editorial Material
Chemistry, Multidisciplinary
Neill J. Turner
Summary: This Special Issue explores the various applications of extracellular matrix (ECM) in regenerative medicine, including manufacturing scaffold materials, understanding the impact of changes in ECM composition on disease development, and utilizing decellularization techniques to develop tissue-derived ECM scaffolds. Overall, the articles in this issue cover a wide range of research and applications of ECM in the field of regenerative medicine.
APPLIED SCIENCES-BASEL
(2021)
Editorial Material
Computer Science, Theory & Methods
Kirstie L. Bellman, Ada Diaconescu, Sven Tomforde
Summary: SISSY is a research initiative that aims to address the changing demands of system organization in dynamic environments, promoting automated integration decisions during runtime. Systems must self-integrate and self-improve internally, while also being able to cooperate or coexist with other autonomous systems.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2021)
Editorial Material
Engineering, Electrical & Electronic
Qiyin Fang, Charles Kervrann, David Nolte, Oxana Semyachkina-Glushkovskaya, Shuo Tang, Yuji Matsuura, Zachary Smith
Summary: Biophotonics is an interdisciplinary field that combines photonics and biomedical applications. It has made significant advancements in clinical diagnosis, therapeutics, biotechnology, and environmental studies. The integration of optics and biology has led to quick adoption of photonics technologies in medicine due to its compatibility with minimally invasive procedures.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Editorial Material
Engineering, Biomedical
Chung-Chih Hung, Mohamed Atef, Vanessa Chen
Summary: The 16 papers in this special issue were presented at the 2022 IEEE Biomedical Circuits and Systems Conference (BioCAS) in Taipei, Taiwan, from October 13-15, 2022. BioCAS 2022 was jointly sponsored by the IEEE Circuits and Systems (CAS) Society, IEEE Solid-State Circuits (SSC) Society, and the IEEE Engineering in Medicine and Biology (EMB) Society.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj, Rajamanikkam Yuvashree, Gopal Hariprabu, Raghunandhakumar Subramanian, Palraju Murali, Deepak Nallaswamy Veeraiyan, Lakshmi Thangavelu
Summary: Zebrafish serves as an excellent biomaterial testing platform for rapid characterization of the biological properties of new biomaterials, particularly in bone tissue engineering applications, surpassing technical difficulties and cost issues associated with rodent models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Editorial Material
Chemistry, Multidisciplinary
Ivan Shtepliuk, Rositsa Yakimova
Summary: This Special Issue aims to provide a scientific platform for experts in epitaxial graphene on SiC to present their recent studies on growth mechanisms, property engineering, and device processing. The issue offers readers new insights into buffer layer formation, control of electronic properties of graphene, and the use of epitaxial graphene as a substrate for deposition of different substances. The papers published in this Special Issue contribute to advancing knowledge on device-quality epitaxial graphene on SiC, making it more suitable for practical applications.
APPLIED SCIENCES-BASEL
(2021)
Editorial Material
Engineering, Multidisciplinary
Eric Severson, Akira Chiba
Summary: Magnetic levitated motor systems offer potential improvements in lifetime and efficiency, solve critical challenges,and feature prognostic capabilities. However, historical limitations due to cost, design complexity, and low force density have hindered acceptance. Recent technological advances are enabling new approaches to address these challenges.
IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS
(2021)
Review
Pharmacology & Pharmacy
Saman Naghieh, Xiongbiao Chen
Summary: Printability assessment of 3D extrusion-based bioprinting is crucial for creating reproducible 3D scaffolds, and it can be influenced by various factors related to bioink, printing process, and scaffold design. This review explores the definition, measurements, and factors affecting printability, as well as strategies for improving it in extrusion-based bioprinting.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Editorial Material
Chemistry, Multidisciplinary
Stefano Mariani, Andrea Omicini
Summary: Multi-agent systems (MAS) are collections of autonomous computational entities capable of proactively pursuing goals and reactively adapting to environment change. MAS agents exploit social abilities and situated capabilities to interact with peers and perceive and act on the world around them. MAS is increasingly used to model and build heterogeneous systems in various application scenarios, from industrial manufacturing to robotics, social simulation and more, with recent focus on the cognitive capabilities of agents in the context of AI.
APPLIED SCIENCES-BASEL
(2023)
Review
Materials Science, Ceramics
Sikta Panda, Chandan Kumar Biswas, Subhankar Paul
Summary: Hydroxyapatite has been widely used in bone tissue engineering due to its similarity to human bone, with the possibility of enhancing its properties by replacing calcium with other dopants. The review discusses various coating agents and methods for HAP, as well as different doping materials, effects, and applications in medical procedures. Research articles are analyzed to provide a detailed overview of the topic.
CERAMICS INTERNATIONAL
(2021)
Editorial Material
Business
Madeleine Rauch, Moritz Loock, Wolfgang H. Guettel
Summary: This introduction examines the relationship between heuristics, technological forecasting, and social change. It introduces five articles included in the Special Issue on 'Heuristics in Technological Forecasting and Social Change' and proposes directions for further research. The authors highlight important, yet unexplored research questions that could enhance the study of heuristics in the context of social and technological change.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Editorial Material
Computer Science, Artificial Intelligence
Jie Lu, Joao Gama, Xin Yao, Leandro Minku
Summary: In recent years, stream learning has significantly developed in both conceptual and application levels, becoming a hot research direction in machine learning and data science. Advancements include detecting concept drift, adapting to drifts, and utilizing online, active, incremental, and reinforcement learning in data streaming scenarios.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Review
Biotechnology & Applied Microbiology
Hamidreza Tolabi, Negar Bakhtiary, Shaghayegh Sayadi, Maryam Tamaddon, Farnaz Ghorbani, Aldo R. Boccaccini, Chaozong Liu
Summary: This review summarizes the recent discoveries and applications of polydopamine as a surface coating material for tackling musculoskeletal disorders. Polydopamine, with its adhesive properties to various substrates, has shown potential in creating pro-healing interfaces and personalized scaffolds. The review also highlights the potential applications of polydopamine in bioengineering, such as carriers and nanoparticles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Computer Science, Artificial Intelligence
Vaishak Belle, Thomas Bolander, Andreas Herzig, Bernhard Nebel
Summary: Epistemic planning combines automated planning with cognitive concepts such as knowledge and belief. Single-agent epistemic planning deals with how an agent moves from its current knowledge state to a desired one. Multi-agent epistemic planning extends this to consider the knowledge states of other agents, including higher-order knowledge. Both types of planning are important in various AI applications and require integrating different sub-areas of AI research. The importance of epistemic planning is reflected in its relevance to mobile service robots, game playing, human-robot interaction, and other areas. Rating: 9 out of 10.
ARTIFICIAL INTELLIGENCE
(2023)
Article
Materials Science, Biomaterials
Holly D. Sparks, Taisiya Sigaeva, Samar Tarraf, Serena Mandla, Hannah Pope, Olivia Hee, Elena S. Di Martino, Jeff Biernaskie, Milica Radisic, W. Michael Scott
Summary: The study identified significant differences in skin thickness, collagen engagement, wound contraction, and granulation tissue production in different locations of the equine distal limb, impacting healing outcomes. Furthermore, the peptide-modified collagen-chitosan hydrogel was found to accelerate wound closure and improve biomechanical function of healed tissue effectively.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Biochemical Research Methods
Benjamin Fook Lun Lai, Rick Xing Ze Lu, Locke Davenport Huyer, Sachiro Kakinoki, Joshua Yazbeck, Erika Yan Wang, Qinghua Wu, Boyang Zhang, Milica Radisic
Summary: The study presents an alternative method for cultivating millimeter-scale functional vascularized tissues on a biofabricated platform, facilitating the easy integration of organoid technology. By utilizing 3D stamping with a synthetic polymeric elastomer, a scaffold called 'AngioTube' is generated to support a perfusable vascular system and the self-assembly of various parenchymal tissues. The platform allows easy connection of two or more tissue compartments through a common vasculature, with built-in micropores for studying cell invasion.
Article
Chemistry, Multidisciplinary
Aixiang Ding, Oju Jeon, David Cleveland, Kaelyn L. Gasvoda, Derrick Wells, Sang Jin Lee, Eben Alsberg
Summary: 4D bioprinting is a promising technique for creating complex cell-laden constructs for tissue/organ regeneration. This study introduces a new single-component micro-flake hydrogel (MFH) system as a bioink for 4D bioprinting. The MFH exhibits scalable production, simple composition, and shear-thinning, shear-yielding, and rapid self-healing properties.
ADVANCED MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Roberta Lock, Hadel Al Asafen, Sharon Fleischer, Manuel Tamargo, Yimu Zhao, Milica Radisic, Gordana Vunjak-Novakovic
Summary: Sex-related differences in health and disease are often overlooked in tissue engineering, particularly in cardiovascular research. These differences involve the nature of the heart muscle and cardiovascular disease research, which can be advanced by implementing sex-specific features at the cellular and tissue levels for disease treatment.
NATURE REVIEWS MATERIALS
(2022)
Review
Materials Science, Biomaterials
Sargol Okhovatian, Mohammad Hossein Mohammadi, Naimeh Rafatian, Milica Radisic
Summary: Developing an artificial heart for transplantation has been a challenging goal for scientists, with recent studies focusing on functional left ventricular (LV) models. These models, utilizing various techniques and materials, aim to mimic the native LV's functionality and have shown promising results. However, challenges such as vascularization and cell composition still need to be addressed for further advancements in the field.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Aixiang Ding, Sang Jin Lee, Rui Tang, Kaelyn L. Gasvoda, Felicia He, Eben Alsberg
Summary: This study demonstrates a simple 4D bioprinting approach for the formation of shape-morphing cell condensate-laden bilayer systems with predefined complex shapes, broadening the applications of cell condensation-based 4D bioprinting.
Article
Engineering, Biomedical
Chuan Liu, Scott B. Campbell, Jianzhao Li, Dawn Bannerman, Simon Pascual-Gil, Jennifer Kieda, Qinghua Wu, Peter R. Herman, Milica Radisic
Summary: This study presents a high throughput omnidirectional printing approach for fabricating microtubes of elastomers, which can be used in biomedical applications. The method allows for the printing of microtubes with small inner diameter and wall thickness that can be tuned to match the dimensions and stiffness of rat vasculature. The approach also enables the fabrication of biomimetic shapes and the tuning of microstructure permeability through laser micromachining. Compared to traditional methods, this approach offers faster printing speed, completing the process in minutes.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biophysics
Rui Tang, Kaelyn L. Gasvoda, Jacob Rabin, Eben Alsberg
Summary: Thermally stable proteins are important for resisting irreversible denaturation during thermal stress. In this study, the conformational and thermal stability of TGF-beta 1 were investigated, revealing its ability to recover native folding after thermal treatment. Further studies demonstrated the maintenance of its bioactive properties and potential applications in biomedicine and nutrition.
BIOPHYSICAL JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Yimu Zhao, Erika Yan Wang, Fook B. L. Lai, Krisco Cheung, Milica Radisic
Summary: This article reviews the emergence of organ-on-a-chip (OOAC) engineering, which derives from the fields of tissue engineering and microfluidics. The tools and capabilities brought into the OOAC field by early tissue engineers and microfluidics experts are discussed. Two case studies, liver-on-a-chip and heart-on-a-chip, are highlighted as early implementations of OOAC models heavily reliant on tissue engineering techniques, driven by the need for improved toxicity assessment in preclinical drug development. Current challenges in OOAC, such as stable vascularization and drug absorption, are also reviewed, stemming from challenges in the parent fields.
TRENDS IN BIOTECHNOLOGY
(2023)
Editorial Material
Materials Science, Biomaterials
Neelkanth M. Bardhan, Milica Radisic, Md Nurunnabi
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Sung-Won Hwang, Chung-Man Lim, Cong Truc Huynh, Hossein Moghimianavval, Nicholas A. Kotov, Eben Alsberg, Allen P. Liu
Summary: This study presents a strategy to confer mechano-responsive behavior on hydrogels by embedding hybrid vesicles. Under mechanical stress, these vesicles release encapsulated compounds that control the hydrogel network, offering promise for diverse biomedical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Sargol Okhovatian, Amid Shakeri, Locke Davenport Huyer, Milica Radisic
Summary: Cardiovascular tissue constructs have unique design requirements and require the use of durable elastic materials. Polyester synthesis methods provide an opportunity to develop biocompatible, elastic, and immunomodulatory cardiovascular polymers. These elastomeric polyester materials have the capability to reduce inflammatory response and better support tissue maturation. This review discusses the underlying chemistry and design strategies of polyester elastomers optimized for cardiac tissue scaffolds, as well as the unique fabrication methods and applications of these biomaterials in cardiovascular devices.
Review
Engineering, Biomedical
Jennifer Kieda, Amid Shakeri, Shira Landau, Erika Yan Wang, Yimu Zhao, Benjamin Fook Lai, Sargol Okhovatian, Ying Wang, Richard Jiang, Milica Radisic
Summary: Recent advances in cardiac tissue engineering and hearts-on-a-chip have been made possible through the development of new biomaterials and innovative fabrication techniques. These allow for precise control of the mechanical, electrical, and structural properties of simulated cardiac tissues. Notably, induced pluripotent stem cell-derived cardiac patches have achieved significant progress and entered human testing. Heart-on-a-chip platforms are now widely used by pharmaceutical and biotechnology companies. However, both fields face common challenges related to tissue fabrication, cellular fidelity, tissue maturation, and cryopreservation protocols.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Biotechnology & Applied Microbiology
Rick Xing Ze Lu, Yimu Zhao, Milica Radisic
Summary: Coronavirus disease 2019 (COVID-19) has become a major global health concern since 2019, with over 680 million confirmed cases as of April 2023. The specific mechanisms by which viral infection induces myocardial dysfunction in COVID-19 patients are still controversial. Studies have shown that severe acute respiratory syndrome coronavirus-2 can cause heart failure directly by damaging heart cells and indirectly by triggering systemic inflammation.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Kari Martyniak, Sean Kennedy, Makan Karimzadeh, Maria A. Cruz, Oju Jeon, Eben Alsberg, Thomas J. Kean
Summary: In this study, a high-throughput human articular chondrocyte reporter system was used to optimize the combination of GelMA and OMA for lubricin expression. The 14% GelMA / 2% OMA formulation was identified as the optimal one for lubricin secretion. This strategy allows for rapid analysis of the effects of biomaterial composition and cell manipulation on lubricin expression, which could enhance therapeutic strategies for cartilage regeneration.
BIOENGINEERING-BASEL
(2023)
