Article
Cell Biology
Minhao Chen, Longfei Xiao, Guangchun Dai, Panpan Lu, Yuanwei Zhang, Yingjuan Li, Ming Ni, Yunfeng Rui
Summary: Aging leads to an accumulation of senescent TSPCs in tendon tissue, with an increase in the activity of the JAK-STAT signaling pathway. Genetic knockdown of JAK2 or STAT3 significantly reduces cellular senescence in aged TSPCs. Pharmacological inhibition of JAK-STAT signaling pathway with AG490 also alleviates cellular senescence and age-related dysfunctions in TSPCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Fei Tang, Liu-yao Zhou, Ping Li, Ling-ling Jiao, Kang Chen, Yu-jie Guo, Xu-long Ding, Si-yu He, Biao Dong, Ru-xiang Xu, Huan Xiong, Peng Lei
Summary: This study found that ACSL4 expression is increased in Parkinson's disease and is associated with dopaminergic neuronal death. Inhibition of ACSL4 activity improves Parkinson's symptoms. These findings suggest ACSL4 as a therapeutic target associated with lipid peroxidation in Parkinson's disease.
Article
Biochemistry & Molecular Biology
Weihua Wu, Qian Chai, Ziying Zhang
Summary: This study found that glycemic variability aggravates cardiac fibrosis in patients with diabetes mellitus by activating cardiac fibroblasts and promoting M1 polarization of macrophages. In addition, glycemic variability also promotes the expression of fibrogenic cytokines and extracellular matrix proteins. SGLT1 plays an important regulatory role in this process.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Janos Borbas, Mate Vamos, Lidia Hategan, Lilla Hanak, Nelli Farkas, Zsolt Szakacs, Dezso Csupor, Balint Tel, Peter Kupo, Beata Csanyi, Viktoria Nagy, Andras Komocsi, Tamas Habon, Peter Hegyi, Robert Sepp
Summary: Mutations in the CACNA1C gene can result in various clinical manifestations. Timothy syndrome is associated with the most severe clinical phenotype and the highest risk of morbidity and mortality. However, our data does not support distinguishing subtypes of TS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Zhi-Teng Chen, Qing-Yuan Gao, Mao-Xiong Wu, Meng Wang, Run-Lu Sun, Yuan Jiang, Qi Guo, Da-Chuan Guo, Chi-Yu Liu, Si-Xu Chen, Xiao Liu, Jing-Feng Wang, Hai-Feng Zhang, Yang-Xin Chen
Summary: The study demonstrated the significant role of glycolysis in cardiac fibrosis post-myocardial infarction, with glycolysis inhibition showing potential in reducing cardiac fibroblast activation and fibrosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xiyue Zhang, Yihua Zhang, Qing Miao, Zhiguang Shi, Lulu Hu, Shangmin Liu, Jie Gao, Shuang Zhao, Hongshan Chen, Zhengrong Huang, Yi Han, Yong Ji, Liping Xie
Summary: Inhibition of SNO-HSP90 can alleviate cardiac fibrosis, potentially through blocking the TGF beta/SMAD3 signaling pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Junjun Zhang, Yujuan Zhang, Meiling Xu, Zhigang Miao, Ye Tian
Summary: This study investigated the protective effects of inhibiting the Cdk5/caspase-3 pathway on radiation-induced cognitive dysfunction using p5-TAT, which was found to reduce Cdk5 hyperactivity, prevent inhibition of hippocampal neurogenesis and proliferation, and improve cognitive function.
Article
Cell Biology
Xiaoyuan Xu, Xinli Song, Xiaohua Xu, Yanluan Zheng, Lan Xu, Ling Shen
Summary: PCOS is the most common endocrine disorder in women of reproductive age, but the molecular mechanisms underlying its etiology remain unclear. This study identified differentially expressed genes in adipose tissue of PCOS patients and explored the effects of Sestrin 1 on granulosa-like tumor cells. Downregulation of Sestrin 1 may present a potential novel treatment strategy for PCOS.
Article
Hematology
Cristina Caescu, Jens Hansen, Brittany Crockett, Wenzhen Xiao, Pauline Arnaud, Bart Spronck, Alan Weinberg, Takeshi Hashimoto, Sae-Il Murtada, Roshan Borkar, James M. Gallo, Guillaume Jondeau, Catherine Boileau, Jay D. Humphrey, John Cijiang He, Ravi Iyengar, Francesco Ramirez
Summary: HIPK2 has been identified as a key determinant in aneurysmal disease, showing potential as a new target for multidrug therapy against thoracic aortic aneurysm and acute aortic dissection. Gene inactivation of Hipk2 has been found to extend survival in MFS mice by slowing aneurysm growth, indicating its significance in disease progression. Additionally, HIPK2 may act through the TGF-beta/Smad3 signaling pathway to mitigate aortic pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Qianru Mei, Zhenhua Yang, Zhengkai Xiang, He Zuo, Zijing Zhou, Xiaochuan Dong, Ludan Zhang, Wenhui Song, Yi Wang, Qinghua Hu, Yong Zhou, Jing Qu
Summary: This study evaluated the efficacy of XI-011, a small molecular inhibitor of MDM4, for treating lung fibrosis. XI-011 significantly reduced MDM4 expression and increased the expression of p53. XI-011 treatment resulted in the resolution of lung fibrosis in mice with no notable impact on normal fibroblast death or the morphology of healthy lungs. Therefore, XI-011 might be a promising therapeutic drug candidate for treating pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Michishige Terasaki, Hironori Yashima, Yusaku Mori, Tomomi Saito, Yoshie Shiraga, Raichi Kawakami, Makoto Ohara, Tomoyasu Fukui, Tsutomu Hirano, Yuichiro Yamada, Yutaka Seino, Sho-ichi Yamagishi
Summary: The study suggests that GIP may inhibit foam cell formation of macrophages by suppressing the Cdk5-CD36 pathway via GIP receptor.
Article
Endocrinology & Metabolism
Xuejiao Wang, Ting Xu, Rui Liu, Guojun Wu, Liping Gu, Yahui Zhang, Feng Zhang, Huaqing Fu, Yunxia Ling, Xiaohui Wei, Yunchen Luo, Jian Shen, Liping Zhao, Yongde Peng, Chenhong Zhang, Xiaoying Ding
Summary: This study aimed to evaluate the effects of high-fiber diet or combined with acarbose on the clinical phenotypes of PCOS. The results showed that high-fiber diet could alleviate metabolic inflammation, reproductive function, and brain-gut peptides secretion in PCOS patients, and the combination with acarbose had better clinical improvements. The remodeling of gut microbiota may play an important role in these improvements.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jong Bin Choi, Dong-Won Seol, Hyo-Sang Do, Hee-Young Yang, Taek-Min Kim, Youkyeong Gloria Byun, Jinhyuk Choi, Seon Pyo Hong, Won-Suk Chung, Jae Myoung Suh, Gou Young Koh, Beom Hee Lee, Gabbine Wee, Yong -Mahn Han
Summary: Fabry disease is a lysosomal storage disorder caused by defective a-galactosidase activity, leading to the accumulation of Gb3 in endothelial cells and resulting in life-threatening complications. Enzyme replacement therapy (ERT) has limited effectiveness, but the chemical compound fasudil has shown promise in downregulating TSP1 and SMAD2 signaling, improving endothelial function, and alleviating FD symptoms in mice. Fasudil may be a novel candidate for FD therapy.
Article
Neurosciences
Jennifer L. Sanderson, Ronald K. Freund, Anna M. Castano, Timothy A. Benke, Mark L. Dell 'Acqua
Summary: This study provides insights into how alterations in CaV1.2 channel function disrupt basal transmission and plasticity, which are relevant for neurobehavioral alterations in Autism Spectrum Disorders (ASD). Individuals with Timothy Syndrome (TS) and TS2-neo mice exhibit social deficits and cognitive impairments similar to ASD. The synaptic function in the hippocampal CA1 region of TS2-neo mice shows slightly increased excitatory transmission and strongly decreased inhibitory transmission, potentially related to the synaptic dysfunction caused by CaV1.2 channel mutations.
Article
Biochemistry & Molecular Biology
Xinxin Zhang, Huiping Tang, Sitong Li, Yueqin Liu, Wei Wu, Yue Li, Chenchen Ma, Xiao Ma, Lin Chen, Yupeng Yang
Summary: The study demonstrates that Cdk5 in PV interneurons plays a crucial role in modulating the excitatory-inhibitory balance to control the plasticity of the visual cortex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
LouJin Song, Daniel W. Awari, Elizabeth Y. Han, Eugenia Uche-Anya, Seon-Hye E. Park, Yoko A. Yabe, Wendy K. Chung, Masayuki Yazawa
STEM CELLS TRANSLATIONAL MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Jose R. Quejada, Seon-Hye E. Park, Daniel W. Awari, Fan Shi, Hannah E. Yamamoto, Fuun Kawano, Juergen C. Jung, Masayuki Yazawa
NUCLEIC ACIDS RESEARCH
(2017)
Article
Multidisciplinary Sciences
Kumi Morikawa, Kazuhiro Furuhashi, Carmen De Sena-Tomas, Alvaro L. Garcia-Garcia, Ramsey Bekdash, Alison D. Klein, Nicholas Gallerani, Hannah E. Yamamoto, Seon-Hye E. Park, Grant S. Collins, Fuun Kawano, Moritoshi Sato, Chyuan-Sheng Lin, Kimara L. Targoff, Edmund Au, Michael C. Salling, Masayuki Yazawa
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
F. Garcia-Oscos, T. M. Koch, H. Pancholi, M. Trusel, V Daliparthi, M. Co, S. E. Park, F. Ayhan, D. H. Alam, J. E. Holdway, G. Konopka, T. F. Roberts
Summary: The disrupted expression of the ASD gene FOXP1 affects the cultural transmission of birdsong in zebra finches, leading to selective learning deficits in forming memories of adult song models. This learning deficit is associated with disruptions to experience-dependent structural and synaptic plasticity in mirror neurons. FoxP1 plays a role in regulating the ability to form memories essential for the cultural transmission of behavior.
Article
Oncology
Elizabeth Louie, Sara Nik, Juei-suei Chen, Marlies Schmidt, Bo Song, Christine Pacson, Xiu Fang Chen, Seonhye Park, Jingfang Ju, Emily I. Chen
BREAST CANCER RESEARCH
(2010)