Article
Agriculture, Multidisciplinary
Ruiqin Zhang, Dongxia Lin, Liang Zhang, Ruoting Zhan, Sidi Wang, Kui Wang
Summary: A novel trifunctional enzyme Bi76 with endoxylanase, endoglucanase, and feruloyl esterase activities was identified. It exhibited hydrolysis ability towards various substrates and showed great potential in agricultural residue utilization.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Boyun Kim, Victor Guaregua, Xuebo Chen, Chad Zhao, Wanyi Yeow, Nathaniel K. Berg, Holger K. Eltzschig, Xiaoyi Yuan
Summary: This study characterized the expression of miR-147, generated a transgenic mouse line with whole-body deletion of miR-147, and successfully demonstrated deletion of the target gene in different organs. The results showed that miR-147 (-/-) mice exhibited normal growth, development, and offspring, with similar baseline inflammatory gene expression compared to control mice except for elevated IL-6 expression in the spleen.
Article
Fisheries
Linwei Yang, Deyu Han, Zi-ang Wang, Nuo Chen, Hongliang Zuo, Zhixun Guo, Menghuang Xu, Shaoping Weng, Jianguo He, Xiaopeng Xu
Summary: This study reveals that Scalloped, as a downstream transcription factor of the Hippo signaling pathway, is upregulated in shrimp hemocytes and interacts with the Hippo pathway downstream transcriptional co-activator Yki. By inhibiting the Dorsal pathway, Scalloped reduces the expression of immune functional proteins and negatively regulates the immune response against bacterial infection in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hsiuying Wang, Ching Ho
Summary: MicroRNAs (miRNAs) play crucial roles in cell differentiation, development, gene regulation, and apoptosis. They have been identified as potential biomarkers for various diseases and can be used to explore disease associations. The phylogenetic tree analysis and distance distribution provide useful tools for investigating the similarity and association between different diseases and viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Eun Pyo Kim, Chae Young Kim, Min Young Heo, Sang Wha Kim, Geon A. Kim
Summary: This study analyzed the changes in miRNA expression in female reproductive organs of aging dogs and dogs with uteropathy. The results showed that the expression levels of certain miRNAs were significantly different in old dogs and dogs with uteropathy compared to young dogs. These miRNAs may serve as biological markers for aging and reproductive diseases in dogs.
Article
Environmental Sciences
Jiaqi Liu, Matthew Gibb, Sahar H. Pradhan, Christie M. Sayes
Summary: This study evaluated the cytotoxic interactions of regulated bromoacetic acid and emerging bromophenolic DBPs, revealing differences in cytotoxicity effects among four bromo-DBPs and synergistic cytotoxic effects in mixtures of these DBPs on human cells. The production of reactive oxidative species induced by DBP mixtures is suggested to be an important reason for the synergistic cytotoxicity.
Article
Plant Sciences
Kaichun Wang, Wei Liu, Qinfen Xu, Chao Gu, Daode Hu
Summary: This study found that Tenacissoside G (TG) exhibited dose-dependent growth inhibitory activity and cell cycle arrest induction in colorectal cancer cells, enhancing the anticancer effects of 5-fluorouracil (5-FU). The synergistic effects may be attributed to increased activation of caspase cascade, enhancement of DNA damage, and induction of p53 phosphorylation at Serine 46.
Article
Oncology
Guanglong Jiang, Jill L. Reiter, Chuanpeng Dong, Yue Wang, Fang Fang, Zhaoyang Jiang, Yunlong Liu
Summary: This study investigated the cis-regulation of isomiR biogenesis in human lymphoblastoid cell lines and identified significant associations between SNPs and 5'-isomiRs. The study also revealed the association between specific SNPs and the extensions and trimmings of certain isomiRs. Furthermore, the study showed that isomiR expression is correlated with breast cancer status and highlighted the role of isomiRs in biological processes.
Article
Chemistry, Multidisciplinary
Malcolm A. Kelland, Radhakanta Ghosh, Audun Undheim, Erik G. Dirdal, Hiroharu Ajiro
Summary: The deployment of kinetic hydrate inhibitors is a chemical method for preventing gas hydrate plugging in production flow lines. This study introduces oxyvinylenelactam polymers and copolymers as a new class of inhibitors, which show reasonable performance in preventing hydrate formation.
Article
Surgery
Joseph R. Scalea, Tony Pucciarella, Tara Talaie, Stephen Restaino, Cinthia Beskow Drachenberg, Charlie Alexander, Talal Al Qaoud, Rolf N. Barth, Norman M. Wereley, Matthew Scassero
Summary: The study successfully demonstrated the first human organ delivery using unmanned aircraft, with three experimental missions conducted over approximately 2.8 miles. Through collaboration of a multidisciplinary team, a uniquely designed organ drone was built, leading to the successful kidney transplant.
Review
Biochemistry & Molecular Biology
Adrianna Kondracka, Paulina Gil-Kulik, Bartosz Kondracki, Karolina Fraszczak, Anna Oniszczuk, Magda Rybak-Krzyszkowska, Jakub Staniczek, Anna Kwasniewska, Janusz Kocki
Summary: MicroRNAs are non-coding segments of RNA that modulate various biological processes. Their presence in biological fluids like blood, saliva, tears, and breast milk has raised interest in their potential impact on health and disease. Although hundreds of microRNAs have been found in breast milk, evidence on their function remains inconsistent. This scoping review aims to map the evidence on the occurrence, characterization techniques, and functional roles of microRNAs in breast milk. While methodological challenges need to be addressed, significant progress has been made in characterizing the microRNA profiles of human breast milk.
Review
Oncology
Kohei Taniguchi, Kazuhisa Uchiyama, Yukihiro Akao
Summary: Understanding the regulatory system of miRNAs is crucial for physiological and oncological research, especially in the context of cancer-specific energy metabolism and the Warburg effect. The organ-specific distribution of miRNAs and the regulation of PTBP1 on PKM2 are significant factors in cancer research, as dysregulation of PTBP1-targeting miRNAs can impact the Warburg effect.
Article
Energy & Fuels
Radhakanta Ghosh, Janronel Pomicpic, Malcolm A. Kelland
Summary: Kinetic hydrate inhibitors (KHIs) are used to prevent gas hydrates deposition and their performance is limited by subcooling and other factors. Poly(N-isopropyl methacrylamide) (PNIPMAm) blended with triisopentylamine oxide (TiPeAO) showed exceptional KHI performance. The performance decreased at higher concentrations, possibly due to polymer and amine oxide aggregation. Overdosing of components can have detrimental effects on KHI performance.
Article
Microbiology
Roberta Fais, Cosmeri Rizzato, Iacopo Franconi, Arianna Tavanti, Antonella Lupetti
Summary: This study describes a synergistic effect between the conventional antifungal drug caspofungin and a synthetic peptide derived from human lactoferrin, hLF1-11, against Candida species. These yeasts can cause severe systemic fungal infections in immunocompromised hosts and form biofilms in medical implanted devices. Caspofungin-resistant Candida strains have emerged, emphasizing the need for different therapeutic strategies. In vitro studies show that this drug combination is able to restore sensitivity to caspofungin in resistant strains of Candida species, both in free-living cells and in cells organized in biofilms. This synergism could represent a promising novel approach to target caspofungin-resistant Candida species infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Maurizio Viale, Giovanni Lentini, Rosaria Gangemi, Patrizio Castagnola, Gualtiero Milani, Silvia Ravera, Nadia Bertola, Antonio Carrieri, Maria Maddalena Cavalluzzi
Summary: This study investigated the potential of the anti-ischemic drug Lube S as an enhancer of anticancer chemotherapy. The results showed that Lube S can effectively improve the antitumor activity of doxorubicin through various mechanisms, including the inhibition of MDR1 gene expression and increased accumulation of doxorubicin in resistant cells.