Article
Psychology, Clinical
Simon Schmitt, Tina Meller, Frederike Stein, Katharina Brosch, Kai Ringwald, Julia-Katharina Pfarr, Clemens Bordin, Nina Peusch, Olaf Steinstrater, Dominik Grotegerd, Katharina Dohm, Susanne Meinert, Katharina Foerster, Ronny Redlich, Nils Opel, Tim Hahn, Andreas Jansen, Andreas J. Forstner, Fabian Streit, Stephanie H. Witt, Marcella Rietschel, Bertram Mueller-Myhsok, Markus M. Noethen, Udo Dannlowski, Axel Krug, Tilo Kircher, Igor Nenadic
Summary: The study found an association between polygenic risk for depression and cortical complexity in the right orbitofrontal cortex. While there was no association with grey matter volume or cortical thickness, the changes in cortical complexity related to depression risk might affect established brain structural changes.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Baihan Wang, Haritz Irizar, Johan H. Thygesen, Eirini Zartaloudi, Isabelle Austin-Zimmerman, Anjali Bhat, Jasmine Harju-Seppaenen, Oliver Pain, Nick Bass, Vasiliki Gkofa, Behrooz Z. Alizadeh, Therese van Amelsvoort, Maria J. Arranz, Stephan Bender, Wiepke Cahn, Maria Stella Calafato, Benedicto Crespo-Facorro, Marta Di Forti, Ina Giegling, Lieuwe de Haan, Jeremy Hall, Mei-Hua Hall, Neeltje van Haren, Conrad Iyegbe, Rene S. Kahn, Eugenia Kravariti, Stephen M. Lawrie, Kuang Lin, Jurjen J. Luykx, Ignacio Mata, Colm McDonald, Andrew M. McIntosh, Robin M. Murray, Marco Picchioni, John Powell, Diana P. Prata, Dan Rujescu, Bart P. F. Rutten, Madiha Shaikh, Claudia J. P. Simons, Timothea Toulopoulou, Matthias Weisbrod, Ruud van Winkel, Karoline Kuchenbaecker, Andrew McQuillin, Elvira Bramon
Summary: This study aims to identify biological mechanisms relevant to endophenotypes by partitioning polygenic risk scores into specific gene sets. The results show that a reduced P300 amplitude is associated with a higher schizophrenia polygenic risk score of the forebrain regionalization gene set. This finding suggests that certain genetic variants influence early brain development and increase the risk of schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Yann Quide, Oliver J. Watkeys, Leah Girshkin, Manreena Kaur, Vaughan J. Carr, Murray J. Cairns, Melissa J. Green
Summary: This study found a significant relationship between interact effects of cognitive subtypes and PRS-SZ and regional GMV changes in psychosis spectrum cases with cognitive deficits, but not in cases cognitively spared. Two distinct cognitive subtypes were evident: a 'cognitive deficit' group and a 'cognitively spared' group.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Jinyu Zang, Yuanyuan Huang, Lingyin Kong, Bingye Lei, Pengfei Ke, Hehua Li, Jing Zhou, Dongsheng Xiong, Guixiang Li, Jun Chen, Xiaobo Li, Zhiming Xiang, Yuping Ning, Fengchun Wu, Kai Wu
Summary: This study utilized various brain atlases, classifiers, cross validation methods, and dimensionality reduction algorithms to analyze MRI data of SZ patients. Results showed that the whole-brain atlas with 268 ROIs outperformed others, while different classifiers and dimensionality reduction algorithms had similar classification performances. Features of GMV and ReHo in prefrontal and temporal regions made higher contributions to the classifiers.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Eva-Maria Stauffer, Richard A. Bethlehem, Varun Warrier, Graham K. Murray, Rafael Romero-Garcia, Jakob Seidlitz, Edward T. Bullmore
Summary: The study found associations between polygenic risk scores and neuroimaging phenotypes, suggesting genetic effects on brain structure at global and regional scales. Results indicate a link between genetic risk for schizophrenia and altered neurite density index in the brain.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Emiliana Tonini, Oliver Watkeys, Yann Quide, Thomas J. Whitford, Murray J. Cairns, Melissa J. Green
Summary: Recent research has found a correlation between genetic and environmental risk factors for psychotic disorders and higher levels of schizotypy in the general population. This study aimed to investigate the moderating effect of genetic loading for schizophrenia on the association between childhood trauma severity and schizotypy. The results showed a significant interaction between genetic loading and childhood trauma in relation to interpersonal and disorganised dimensions of schizotypy, as well as the total score. This suggests that trauma may increase the risk for psychosis independently of any genetic vulnerability.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Igor Nenadic, Tina Meller, Simon Schmitt, Frederike Stein, Katharina Brosch, Johannes Mosebach, Ulrich Ettinger, Phillip Grant, Susanne Meinert, Nils Opel, Hannah Lemke, Stella Fingas, Katharina Foerster, Tim Hahn, Andreas Jansen, Till F. M. Andlauer, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Alisha S. M. Hall, Swapnil Awasthi, Stephan Ripke, Stephanie H. Witt, Marcella Rietschel, Bertram Mueller-Myhsok, Markus M. Noethen, Udo Dannlowski, Axel Krug, Fabian Streit, Tilo Kircher
Summary: This study found that schizotypy may share less genetic risk with schizophrenia and is not significantly associated with the genetic risk of affective disorders.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Trisha Chakrabarty, Sophia Frangou, Ivan J. Torres, Ruiyang Ge, Lakshmi N. Yatham
Summary: This study investigated the association between accelerated or delayed age-related brain structural changes and cognition in early-stage BDI patients. The results showed that patients with delayed or accelerated brain changes had lower global cognitive scores and verbal memory scores compared to patients with age-congruent brain changes. These findings suggest a link between cognitive dysfunction and apparent delay in typical age-related brain changes in the early stage of BDI.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsae, Nina Lindberg, Minna Torniainen-Holm, Markku Laehteenvuo, Kaisla Lahdensuo, Martta Kerkelae, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppae, Tuomas Jukuri, Katja Haekkinen, Erik Cederloef, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Maennynsalo, Jussi Niemi-Pynttaeri, Kimmo Suokas, Jouko Loennqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelae, Jaana Suvisaari, Juha Veijola
Summary: This study aimed to investigate the association between hazardous drinking Polygenic Scores (PGS) and cognition in patients with schizophrenia, schizoaffective disorder, and bipolar disorder in Finland. The results showed that hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients after controlling for various factors.
Article
Clinical Neurology
Zongchang Li, David Li, Xiaogang Chen
Summary: This study shows differences in genetic association between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) with schizophrenia (SCZ) and major depressive disorder (MDD). The study finds that BD-II is more polygenic compared to BD-I, SCZ, and MDD, and there is substantial polygenic overlap between BD-I and SCZ, as well as between BD-I and MDD. The study also identifies specific shared genetic loci between BD subtypes and SCZ or MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Pavol Mikolas, Michael Marxen, Philipp Riedel, Kyra Broeckel, Julia Martini, Fabian Huth, Christina Berndt, Christoph Vogelbacher, Andreas Jansen, Tilo Kircher, Irina Falkenberg, Martin Lambert, Vivien Kraft, Gregor Leicht, Christoph Mulert, Andreas J. Fallgatter, Thomas Ethofer, Anne Rau, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Felix Bermpohl, Jana Fiebig, Thomas Stamm, Christoph U. Correll, Georg Juckel, Vera Flasbeck, Philipp Ritter, Michael Bauer, Andrea Pfennig
Summary: Machine learning using structural magnetic resonance imaging can aid in early recognition of bipolar disorder risk and reduce disease burden.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Qingxia Yang, Qiaowen Xing, Qingfang Yang, Yaguo Gong
Summary: Schizophrenia, bipolar disorder, and major depressive disorder are the most common psychiatric disorders. Diagnosing these disorders is difficult due to overlaps in genetic epidemiology and molecular genetics. This study used transcriptomic data to identify key genes and construct a classification model for differentiating these disorders. The model showed potential for improving the diagnoses of these psychiatric disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Clinical Neurology
Kai Yao, Tracey van der Veen, Johan Thygesen, Nick Bass, Andrew Mcquillin
Summary: This study explores the interaction between adverse childhood experiences and genetic risk for bipolar disorder and its impact on symptom outcomes. The findings emphasize the importance of considering multiple psychiatric polygenic risk scores in predicting symptom outcomes among bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Michael D. E. Sewell, Lorena Jimenez-Sanchez, Xueyi Shen, Amelia J. Edmondson-Stait, Claire Green, Mark J. Adams, Olivia M. Rifai, Andrew M. McIntosh, Donald M. Lyall, Heather C. Whalley, Stephen M. Lawrie
Summary: Major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD) share both common and distinct genetic risk factors, which are associated with peripheral abnormalities. Peripheral markers associated with these disorders are both shared and disorder-specific, suggesting potential underlying pathophysiological mechanisms in major psychiatric disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Psychiatry
Zsofia B. Dombi, Istvan Szendi, Philip W. J. Burnet
Summary: This study found that circulating BDNF levels are significantly reduced in patients experiencing an acute episode of schizophrenia or bipolar disorder, and cognitive function is significantly worse in these patients. However, the correlation between BDNF levels and cognitive impairment is not always significant. Pharmacotherapy appears to improve cognitive function and increase BDNF levels.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Akiah Ottesen, W. T. Hegelstad, Inge Joa, Stein E. Opjordsmoen, Bjorn Rishovd Rund, Jan Ivar Rossberg, Erik Simonsen, Jan Olav Johannessen, Tor K. Larsen, Ulrik Helt Haahr, Thomas H. McGlashan, Svein Friis, Ingrid Melle
Summary: This longitudinal study compares symptom trajectories and remission in first-episode psychosis (FEP) with and without a history of childhood interpersonal trauma (CIT) over the first 2 years of treatment. The results indicate that antipsychotic medication is equally beneficial in achieving symptomatic remission, regardless of CIT. However, FEP patients with CIT experience more severe positive, depressive, and excited symptoms throughout the disease.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Camilla Barthel Flaaten, Ingrid Melle, Erlend Gardsjord, Thomas Bjella, Magnus Johan Engen, Anja Vaskinn, Gina Asbo, Kristin Fjelnseth Wold, Line Widing, Siv Hege Lyngstad, Beathe Haatveit, Carmen Simonsen, Torill Ueland
Summary: IQ levels in schizophrenia and bipolar disorder patients show changes before and after illness onset, with steeper declines in schizophrenia patients and milder declines in bipolar patients. Over time, all groups showed increases in IQ. However, patients still lag behind healthy controls in terms of IQ levels.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Mashhood A. Sheikh, Kevin S. O'Connell, Tove Lekva, Attila Szabo, Ibrahim A. Akkouh, Jordi Requena Osete, Ingrid Agartz, John A. Engh, Dimitrios Andreou, Birgitte Boye, Erlend Boen, Torbjorn Elvsashagen, Sigrun Hope, Maren Caroline Frogner Werner, Inge Joa, Erik Johnsen, Rune A. Kroken, Trine Vik Lagerberg, Ingrid Melle, Ole Kristian Drange, Gunnar Morken, Terje Naerland, Kjetil Sorensen, Arne E. Vaaler, Melissa Authen Weibell, Lars T. Westlye, Pal Aukrust, Srdjan Djurovic, Nils Eiel Steen, Ole A. Andreassen, Thor Ueland
Summary: This study investigates the dysregulation of cell adhesion molecules (CAMs) in severe mental illness (SMI), particularly in schizophrenia (SCZ) patients. The researchers found increased soluble ICAM-1 expression in plasma, leukocytes, and induced pluripotent stem cell-derived neurons from SMI patients, indicating both systemic and cerebral dysregulation of ICAM-1 in SMI.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Andre C. Sahl, Henning F. Rognlien, Ole A. Andreassen, Ingrid Melle, Torill Ueland, Anja Vaskinn
Summary: This study compared theory of mind in schizophrenia participants with high or low IQ to healthy controls. The results showed that low IQ schizophrenia patients had impaired theory of mind, while high IQ patients had better performance in certain aspects. High IQ patients had deficits in lower-level theory of mind, while low IQ patients also had impaired higher-level theory of mind.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Christina Bell, Natalia Tesli, Tiril P. Gurholt, Jaroslav Rokicki, Gabriela Hjell, Thomas Fischer-Vieler, Ingrid Melle, Ingrid Agartz, Ole A. Andreassen, Petter Andreas Ringen, Kirsten Rasmussen, Hilde Dahl, Christine Friestad, Unn K. Haukvik
Summary: Violence in psychosis has been associated with antisocial behavior and psychopathy traits. This study examined psychopathy subdomains among violent offenders with and without a psychotic disorder. The findings suggest that individuals with a psychotic disorder and a history of severe violence have lower affective psychopathy scores compared to violent offenders without psychotic disorders, which may indicate different underlying mechanisms for violence.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Kimberly Blake, Ziphozihle Ntwatwa, Tobias Kaufmann, Dan J. Stein, Jonathan C. Ipser, Nynke A. Groenewold
Summary: The study suggests that psychopathology is related to an advanced brain aging process, and machine learning models can predict an individual's age based on brain imaging data. The meta-analysis found that there is a larger brain age difference in psychotic disorders and a smaller difference in mood disorders. Clinical factors, such as symptom severity, may be associated with a larger brain age difference in psychopathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Aili R. Lochen, Knut K. Kolskar, Ann-Marie G. de Lange, Markus H. Sneve, Beathe Haatveit, Trine V. Lagerberg, Torill Ueland, Ingrid Melle, Ole A. Andreassen, Lars T. Westlye, Dag Alnaes
Summary: The objective of this study was to compare visual discrimination performance in patients with schizophrenia spectrum disorder or bipolar disorder with healthy controls, and investigate associations with clinical symptoms and IQ. The results showed that patients with schizophrenia spectrum or bipolar disorders exhibited higher visual discrimination thresholds than healthy controls. Furthermore, there were negative associations between IQ and discrimination threshold among healthy controls and bipolar disorder patients.
Article
Psychiatry
Claudia Barth, Stener Nerland, Kjetil N. Jorgensen, Beathe Haatveit, Laura A. Wortinger, Ingrid Melle, Unn K. Haukvik, Torill Ueland, Ole A. Andreassen, Ingrid Agartz
Summary: This study examined sex and diagnostic group differences in hippocampal subfield volumes in individuals with schizophrenia spectrum disorder, bipolar disorders, and healthy controls. The results showed a larger volumetric deficit in male patients compared to female patients when compared with same-sex controls. There were no significant sex differences in the associations between hippocampal volumes and clinical or cognitive measures in schizophrenia and bipolar disorder.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Rune Boen, Tobias Kaufmann, Oleksandr Frei, Dennis van der Meer, Srdjan Djurovic, Ole A. Andreassen, Kaja K. Selmer, Dag Alnaes, Ida E. Sonderby
Summary: The study investigates the differences in brain morphology and ageing process between 15q11.2 BP1-BP2 CNV carriers and non-carriers. Despite the alterations in brain structure, there is no apparent effect on ageing in terms of brain structure and motor, lung, and heart function.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Anja Torsvik, Hans-Richard Brattbakk, Andrea Trentani, Rita Holdhus, Christine Stansberg, Christoffer A. Bartz-Johannessen, Timothy Hughes, Nils Eiel Steen, Ingrid Melle, Srdjan Djurovic, Ole A. Andreassen, Vidar M. Steen
Summary: This study identified differential gene expression patterns in peripheral blood cells of patients with schizophrenia (SCZ) or bipolar disorder (BD) compared to healthy controls (HC). Both SCZ and BD showed altered expression of genes related to immune pathways and lipid changes.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cell Biology
Hao Wang, Carolina Makowski, Yanxiao Zhang, Anna Qi, Tobias Kaufmann, Olav B. Smeland, Mark Fiecas, Jian Yang, Peter M. Visscher, Chi-Hua Chen
Summary: The study investigates the impact of chromosomal inversions on human brain morphology by analyzing genotypes of adults with European ancestry. Several common inversions, including 2p22.3, 16p11.2, and 17q21.31, show significant associations with cortical and subcortical morphology. The inverted orientations of these regions have a noticeable effect on brain size and motor cortex. These findings contribute to understanding the role of inversions in shaping human brain phenotypes.
Article
Psychology, Developmental
Irene Voldsbekk, Rikka Kjelkenes, Andreas Dahl, Madelene C. Holm, Martina J. Lund, Tobias Kaufmann, Christian K. Tamnes, Ole A. Andreassen, Lars T. Westlye, Dag Alnaes
Summary: By investigating the association between functional connectivity and psychopathology in children and adolescents, five latent variables related to the hierarchy of psychopathology were identified. These variables included a general psychopathology factor and dimensions of internalizing-externalizing, neurodevelopment, somatic complaints, and thought problems. A unique connectivity pattern for autism spectrum disorder was also discovered.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Max Korbmacher, Meng-Yun Wang, Rune Eikeland, Ralph Buchert, Ole A. Andreassen, Thomas Espeseth, Esten Leonardsen, Lars T. Westlye, Ivan I. Maximov, Karsten Specht
Summary: This study shows that there is a small correlation between brain age predictions and actual age, and the prediction can be influenced by factors such as field strength and scan quality. Therefore, the clinical applications of brain age models should be carefully validated and take into account potential biases in the data acquisition process.
BRAIN AND BEHAVIOR
(2023)
Article
Psychiatry
Kristin Fjelnseth Wold, Akiah Ottesen, Barthel Flaaten Camilla, Erik Johnsen, Trine Vik Lagerberg, Kristin Lie Romm, Carmen Simonsen, Torill Ueland, Line Widing, Gina Asbo, Ingrid Melle
Summary: This study investigates whether an adaptation of consensus criteria can be used to identify individuals with early signs of treatment resistance in first-episode psychosis, and examines the impact of different antipsychotic treatments on treatment outcomes. The findings suggest that the prevalence of early treatment resistance may be underestimated when using consensus criteria. Only a small proportion of patients classified as non-early clinical recovery met the full criteria for treatment resistance.
EUROPEAN PSYCHIATRY
(2023)