Journal
MATERIALS HORIZONS
Volume 4, Issue 3, Pages 431-436Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6mh00571c
Keywords
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Funding
- 973 project [2013CB733700]
- National Natural Science Foundation of China [21572058, 21576088]
- Science and Technology Commission of Shanghai Municipality [15540723800]
- Knowledge Innovation Program [Y014P31503]
- Fundamental Research Funds for the Central Universities
- Chinese Academy of Sciences [Y316P11503]
- Shanghai Rising-Star Program [16QA1401400]
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The switch in glycan-receptor specificity of influenza viruses may cause their interspecies transmission. However, tools that can simultaneous unveil the different receptor specificities of a single virus strain, in a homogeneous solution, have been elusive. Here we show a simple yet effective 2D glycosheet that is capable of simultaneously identifying the human-and avian-glycan-receptor specificity of influenza viruses. Two fluorophores with different emission colors are coupled with avian-or human-glycan receptors. Then, the glycan-fluorophore conjugates with different receptors and emission colors are co-assembled on a 2D molybdenum disulfide platform, producing a duplexed, fluorogenic 2D glycosheet. While the system shows a single emission color with viruses containing a single receptor specificity, in the presence of a virus (H7N9) containing dual (human- and avian-) receptor specificity the system produces both emission colors. Interestingly, the use of graphene oxide and carbon nanotubes as the material substrate also produces dual emission with H7N9, thus enabling a new generation of low-dimensional glyco-materials for effectively probing the switch in receptor-specificity of influenza viruses.
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