Review
Microbiology
Anna A. A. Korchagina, Ekaterina Koroleva, Alexei V. V. Tumanov
Summary: Mucosal tissue homeostasis is regulated by innate lymphoid cells (ILCs) which can rapidly respond to environmental changes by producing effector cytokines. However, dysregulation of ILCs can lead to immunopathology. This review discusses recent advances in understanding the plasticity of ILCs in response to pathogens and the role of transcription factors, cytokines, tissue microenvironment, gut microbiota, and hypoxia in this process.
Article
Immunology
Evy E. Blomme, Sharen Provoost, Elise G. De Smet, Katrien C. De Grove, Hannelore P. Van Eeckhoutte, Joyceline De Volder, Philip M. Hansbro, Matteo Bonato, Marina Saetta, Sara R. A. Wijnant, Fien Verhamme, Guy F. Joos, Ken R. Bracke, Guy G. Brusselle, Tania Maes
Summary: ILC1 subset is increased in COPD patients and correlates with smoking and severity of respiratory symptoms. ILCs increase upon CS exposure in C57BL/6J mice. In the absence of adaptive immunity, ILCs contribute to CS-induced pro-inflammatory mediator release, but are redundant in CS-induced innate inflammation.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhiyu Ma, Jinsong Wang, Lei Hu, Songlin Wang
Summary: Periodontitis is an irreversible inflammatory response that occurs in periodontal tissues. Innate lymphoid cells (ILCs) have been found to play a crucial role in regulating immune responses in periodontitis. This review focuses on the intricate crosstalk between ILCs and the microenvironment in periodontal tissue homeostasis for the purpose of regulating or improving immune responses in periodontitis prevention and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Toshiaki Kogame, Gyohei Egawa, Takashi Nomura, Kenji Kabashima
Summary: Innate lymphoid cells (ILCs) possess tissue-resident properties and have a wide range of biological functions. The progenitor cells of ILCs can produce subsets that resemble T-cell subsets. ILC progenitors in different tissues undergo different modes of differentiation pathways. In addition, during the embryonic phase, progenitor cells give rise to unique immune cell spectra, replenishing immune cells in tissues. The concept of layered immunity may help unravel the complexity of ILC heterogeneity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ahmed Kabil, Samuel B. Shin, Michael R. Hughes, Kelly M. McNagny
Summary: ILCs are frontline immune effectors that play crucial roles in tissue homeostasis and diseases. They exhibit a degree of plasticity, allowing them to adapt to different tissue environments. The plasticity of ILCs is important for immune responses and therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Anna A. Korchagina, Ekaterina Koroleva, Alexei V. Tumanov
Summary: ILCs are a group of cytokine-producing lymphocytes located mainly at mucosal barrier surfaces, contributing to tissue homeostasis and protection against pathogens. They have the ability to alter their phenotype and function in response to changing environmental cues, quickly activating cytokine production to limit pathogen spread, but dysregulated responses may lead to tissue inflammation and damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Arlisa Alisjahbana, Yu Gao, Natalie Sleiers, Elza Evren, Demi Brownlie, Andreas von Kries, Carl Jorns, Nicole Marquardt, Jakob Michaelsson, Tim Willinger
Summary: This study reveals the uniqueness of CD5(+) ILCs in anatomical localization and developmental origin compared to well-studied CD5(-) ILCs, suggesting that they may play distinct roles in immune defense.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jan-Hendrik Schroeder, Gordon Beattie, Jonathan W. W. Lo, Tomasz Zabinski, Nick Powell, Joana F. F. Neves, Richard G. G. Jenner, Graham M. M. Lord
Summary: Significant progress has been made in understanding innate lymphoid cells (ILC) by applying concepts from T cell biology, such as flow cytometry gating strategies and CD90 markers. Surprisingly, a sub-population of ILC in the gut were found to have low or no expression of CD90, contrary to expectations. These CD90-negative and CD90-low CD127(+) ILC were influenced by stimulatory cues and dysbiosis, and could produce IL-13, IFN gamma and IL-17A in steady state and colitis conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Difeng Fang, Ayanna Healy, Jinfang Zhu
Summary: CD4 T helper (Th) cell subsets and their innate counterparts innate lymphoid cell (ILC) subsets display similar effector cytokine-producing capabilities during immune responses. The differentiation, development, and functions of these lymphoid cell subsets are regulated by lineage-determining transcription factors (LDTFs). This review discusses the functions of cis-regulatory elements in inducing LDTF expression during Th cell differentiation and ILC development, as well as the upstream signals involved in LDTF induction in vitro and in vivo. The possible mechanisms and physiological importance of regulating LDTF dynamic expression during ILC development and activation are also explored.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jing Xuan Lim, Chester Y. Lai, Grace E. Mallett, David McDonald, Gillian Hulme, Stephanie Laba, Andrew Shapanis, Megan Payne, Warren Patterson, Michael Alexander, Jonathan Coxhead, Andrew Filby, Ruth Plummer, Penny E. Lovat, Giuseppe Sciume, Eugene Healy, Shoba Amarnath
Summary: This study identifies a subset of Innate lymphoid cells (ILCs) expressing PD-1 in the tumor microenvironment (TME). PD-1 controls the metabolism and anti-tumor function of Tbet+NK1.1- ILCs. PD-1-deficient Tbet+NK1.1- ILCs contribute to reduced tumor growth. These findings reveal the regulatory role of PD-1 on Tbet+NK1.1- ILCs in the tumor microenvironment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Kathrin Warner, Maryam Ghaedi, Douglas C. C. Chung, Nicolas Jacquelot, Pamela S. Ohashi
Summary: Innate lymphoid cells (ILCs), the innate counterparts of T cells, play a crucial role in immune responses and have a profound impact on diseases like cancer. ILCs can influence early tumor development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Amy T. Hsu, Timothy A. Gottschalk, Evelyn Tsantikos, Margaret L. Hibbs
Summary: The lung is a vital mucosal organ constantly exposed to the external environment, with an evolved immune system that responds to danger signals and maintains tolerance to harmless aeroantigens. Innate lymphoid cells (ILCs) in the lung play important roles in early responses to pathogens and the development of adaptive immunity, but may also contribute to chronic lung diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Maryam Ghaedi, Fumio Takei
Summary: Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and play a regulatory role in tissue homeostasis and immunity. They are divided into 3 groups based on similar effector programs to T cells, and their development from lymphoid progenitors in adult mouse bone marrow has been extensively studied.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Julia M. Murphy, Louis Ngai, Arthur Mortha, Sarah Q. Crome
Summary: Tissue-resident immune cells, known as ILCs, play important roles in immune regulation and tissue homeostasis. ILCs have tissue-specific functions and can adapt to changes in the local microenvironment. Advancements in single cell platforms and patient-based data have provided new insights into the study of ILCs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Aurelie S. Clottu, Morgane Humbel, Natalia Fluder, Maria P. Karampetsou, Denis Comte
Summary: Innate lymphoid cells (ILC) are a group of immune cells similar to T cells in morphology and cytokine profile, but they lack clonally distributed diverse antigen receptors. ILC, especially ILC1, ILC2, and ILC3, express transcription factors and cytokines similar to T helper cells, and play an important role in innate immunity by responding rapidly to pathogens. Recent studies have shown that alterations in the number and function of ILC are associated with autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Cristina Belizna, Pier Luigi Meroni, Yehuda Shoenfeld, Katrien Devreese, Jaume Alijotas-Reig, Enrique Esteve-Valverde, Cecilia Chighizola, Francesca Pregnolato, Hannah Cohen, Celine Fassot, Patrick Martin Mattera, Pascale Peretti, Alexandre Levy, Laurence Bernard, Mathilde Saiet, Laurence Lagarce, Marie Briet, Marianne Riviere, Isabelle Pellier, Geraldine Gascoin, Jose Rakotonjanahary, Maria Orietta Borghi, Ljudmila Stojanovich, Aleksandra Djokovic, Natasa Stanisavljevic, Rebecca Bromley, Elisabeth Elefant-Amoura, Nadia Bahi Buisson, Taylor Pindi Sala, Hilde Kelchtermans, Alexander Makatsariya, Viktoria Bidsatze, Jamilya Khizroeva, Jose Omar Latino, Sebastian Udry, Daniel Henrion, Laurent Loufrani, Anne Laure Guihot, Christian Muchardt, Milena Hasan, Marie Noelle Ungeheuer, Jan Voswinkel, Laura Damian, Ingrid Pabinger, Johanna Gebhart, Rosario Lopez Pedrera, Jan Willem Cohen Tervaert, Angela Tincani, Laura Andreoli
AUTOIMMUNITY REVIEWS
(2020)
Article
Immunology
Antonia O. Cuff, Thibaut Perchet, Simone Dertschnig, Rachel Golub, Victoria Male
Review
Immunology
Marie Cherrier, Gayetri Ramachandran, Rachel Golub
MUCOSAL IMMUNOLOGY
(2020)
Article
Cell Biology
Milesa Simic, Iris Manosalva, Lionel Spinelli, Rebecca Gentek, Raheleh R. Shayan, Carole Siret, Mathilde Girard-Madoux, Shuaiwei Wang, Lauriane de Fabritus, Janneke Verschoor, Yann M. Kerdiles, Marc Bajenoff, Ralf Stumm, Rachel Golub, Serge A. van de Pavert
Article
Hematology
Ramy Elsaid, Sylvain Meunier, Odile Burlen-Defranoux, Francisca Soares-da-Silva, Thibaut Perchet, Lorea Iturri, Laina Freyer, Paulo Vieira, Pablo Pereira, Rachel Golub, Antonio Bandeira, Elisa Gomez Perdiguero, Ana Cumano
Summary: During embryonic development, multiple waves of hematopoietic progenitors are regulated differently, with the first wave of thymic progenitors comprising a unique population of bipotent T and innate lymphoid cells that play a crucial role in thymic organogenesis and the establishment of the immune system.
Letter
Rheumatology
Matheus Vieira, Georgina Maalouf, Milena Hasan, Alexandre Le Joncour, Esma Karkeni, Merwan Idir, Damien Amelin, Joe-Elie Salem, Paul Gougis, Jean-Marc Lacorte, Lucie Biard, Olivier Benveniste, Patrice Cacoub, David Saadoun, Yves Allenbach
Article
Immunology
Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B. Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L. Shorte, Brigitte David-Watine
Summary: The LabEx Milieu Interieur (MI) project focuses on characterizing immune responses in blood samples from healthy donors, providing insights into genetic and environmental factors influencing immune variation. The study developed in vitro methods for standardized quantification of fibroblast responses, showing variability in immune phenotype among donors. These findings establish a foundation for further experimental frameworks in high-throughput screening protocols.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rachel Golub
Summary: The Notch signaling pathway plays a crucial role in regulating the differentiation, plasticity, and functions of innate lymphoid cells (ILCs) by controlling the abundance and specificity of cytokine release, thus impacting both ILC cell fate decisions and immune responses.
BIOMEDICAL JOURNAL
(2021)
Article
Oncology
Soumaya Karaki, Charlotte Blanc, Thi Tran, Isabelle Galy-Fauroux, Alice Mougel, Estelle Dransart, Marie Anson, Corinne Tanchot, Lea Paolini, Nadege Gruel, Laure Gibault, Francoise Lepimpec-Barhes, Elizabeth Fabre, Nadine Benhamouda, Cecile Badoual, Diane Damotte, Emmanuel Donnadieu, Sebastian Kobold, Fathia Mami-Chouaib, Rachel Golub, Ludger Johannes, Eric Tartour
Summary: This study demonstrates the in vivo role of the CXCR6-CXCL16 axis in the migration of CD8(+) resident memory T cells in lung mucosa after intranasal vaccination, leading to tumor growth control. Intranasal vaccination induces higher and more sustained concentrations of CXCL16, compared with other chemokines, showing superior efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Alicia Bellomo, Rebecca Gentek, Rachel Golub, Marc Bajenoff
Summary: This article discusses how macrophages interact with their cellular niches, focusing on the cellular circuits formed by splenic macrophages and fibroblasts and their molecular signals. The study finds that these cellular circuits are crucial for maintaining splenic function, especially as they may be affected in the elderly.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Laura Rossmann, Katrin Bagola, Tharshana Stephen, Anna-Lisa Gerards, Bianca Walber, Anja Ullrich, Stefan Schulke, Christel Kamp, Ingo Spreitzer, Milena Hasan, Brigitte David-Watine, Spencer L. Shorte, Max Bastian, Ger van Zandbergen
Summary: Efficient and safe vaccine development is crucial during the COVID-19 pandemic, with the use of appropriate adjuvants being essential to boost and tailor the immune response. Toll-like receptor agonists activate dendritic cells and induce immune responses, while TLR7/8 agonists have a strong impact on antiviral immune responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Elsa Bourayou, Rachel Golub
Summary: Immune cells, including the innate lymphoid cells (ILCs), are important in the development and progression of hepatocellular carcinoma (HCC). ILCs are a family of lymphocytes, including Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s and lymphocytes tissue-inducer cells (LTi), that play significant roles in HCC. This overview highlights the importance of diverse signaling pathways in the regulation of ILCs' response to HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pietro Cacialli, Marie-Pierre Mailhe, Ingrid Wagner, Doron Merkler, Rachel Golub, Julien Y. Bertrand
Summary: This study reveals that the expansion of hematopoietic stem cells during vertebrate development is a result of the sequential and synergistic contribution of neutrophils, macrophages, and endothelial cells.
Article
Oncology
Nadine Benhamouda, Ikuan Sam, Nicolas Epaillard, Alain Gey, Letuan Phan, Hang Phuong Pham, Nadege Gruel, Antonin Saldmann, Josephine Pineau, Milena Hasan, Valentin Quiniou, Camille Nevoret, Virginie Verkarre, Valentina Libri, Sebastien Mella, Clemence Granier, Chloe Broudin, Patrice Ravel, Eleonore De Guillebon, Laetitia Mauge, Dominique Helley, Bernd Jabla, Nathalie Chaput, Laurence Albiges, Sandrine Katsahian, Julien Adam, Arnaud Mejean, Olivier Adotevi, Yann A. Vano, Stephane Oudard, Eric Tartour
Summary: This study found that the interaction between CD70 and CD27 in clear-cell renal cell carcinoma is associated with T-cell dysfunction in the tumor microenvironment. High levels of soluble CD27 (sCD27) were predictive of poor overall survival in patients treated with anti-programmed cell death protein 1 therapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Soraya Matczak, Valerie Bouchez, Pauline Leroux, Thibaut Douche, Nils Collinet, Annie Landier, Quentin Giai Gianetto, Sophie Guillot, Julia Chamot-Rooke, Milena Hasan, Mariette Matondo, Sylvain Brisse, Julie Toubiana
Summary: By comparing the microbiological characteristics and expressed protein profiles between FIM2 and FIM3 fimbrial serotypes and genomic clades, differences were found that may have implications on pathogenesis and epidemiological emergence.
MICROBES AND INFECTION
(2023)