Article
Critical Care Medicine
Jarrod E. Dalton, Paul R. Gunsalus, Carli J. Lehr, Johnie Rose, Belinda L. Udeh, Maryam Valapour
Summary: The current U.S. lung transplant mortality risk models do not consider the disease progression of patients over time. This study investigated the impact of accrued waitlist time on mortality in lung transplant candidates and recipients beyond clinical deterioration and proposed a new framework for conceptualizing mortality risk in end-stage lung disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Surgery
Sarah Tsou, Joy Chen, Marek Brzezinski, Steven Hays, Lorriana Leard, Jonathan P. Singer, Binh Trinh, Jasleen Kukreja
Summary: The use of donor lungs from victims of drowning is rare and there is limited literature on the outcomes, with most focusing on cases from natural bodies of water. However, three cases of successful bilateral lung transplantation from donors who drowned in swimming pools demonstrate the potential for good short- and long-term outcomes, suggesting that drowned donor lungs may offer a feasible solution to the growing demand for donor organs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Michael Z. L. Zhu, Bronwyn J. Levvey, David C. McGiffin, Gregory Snell
Summary: This study evaluated the outcomes of lung transplantation for patients with interstitial lung disease. The results showed that despite the need for rapid transplantation, the majority of patients were able to achieve good early and midterm outcomes posttransplant.
Article
Surgery
Stefan Schwarz, Nina Rahimi, Daria Kifjak, Moritz Muckenhuber, Martin Watzenboeck, Alberto Benazzo, Peter Jaksch, Sylvia Knapp, Walter Klepetko, Konrad Hoetzenecker
Summary: This study retrospectively evaluated 2201 donor lungs offered to a lung transplant program, finding that the Oto score was superior in predicting acceptance and utilization of donor lungs, while the MALT score and UMN-DLQI score were effective in predicting outcomes after lung transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Syed A. Husain, Kristen L. King, David C. Cron, Nikole A. Neidlinger, Han Ng, Sumit Mohan, Joel T. Adler
Summary: This study investigated the impact of local market competition and/or organ availability on kidney procurement and utilization. The results showed that lower competition was associated with higher export, while market monopoly was weakly associated with lower discard. Higher organ availability was associated with both export and discard.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Marian Urban, Anthony W. Castleberry, Nicholas W. Markin, Megan M. Chacon, Heather M. Strah, John Y. Um, David Berkheim, Shaheed Merani, Aleem Siddique
Summary: Lung transplantation from donors after circulatory death is now seen as a viable alternative to traditional brain death donation. The emergence of TA-NRP as a technique for cardiac allograft procurement from circulatory death cases allows for in situ organ assessment, potentially impacting lung allograft quality. However, successful cases of transplantation using this method have been reported.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Emmanouil Giorgakis, Shirin E. Khorsandi, Amit K. Mathur, Lyle Burdine, Wayel Jassem, Nigel Heaton
Summary: The study findings suggest that using older grafts from donors aged 70 years and above can lead to acceptable outcomes in a highly selected cohort at experienced transplant centers. Advanced age should not be considered an absolute contraindication for utilizing DCD grafts from donors aged 70 years and older.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medical Informatics
Darren E. Stewart, Dallas W. Wood, James B. Alcorn, Erika D. Lease, Michael Hayes, Brett Hauber, Rebecca E. Goff
Summary: The study demonstrated that converting match run data into composite scores can closely reflect current lung allocation policy, providing a potential policy option that optimizes the limited supply of donor lungs in alignment with the priorities of the transplant community.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Cardiac & Cardiovascular Systems
Ashley Y. Choi, Oliver K. Jawitz, Vignesh Raman, Michael S. Mulvihill, Samantha E. Halpern, Yaron D. Barac, Jacob A. Klapper, Matthew G. Hartwig
Summary: The study found that nontransplantation of donation after circulatory death lungs was associated with potentially modifiable factors such as smoking history, clinical infection, and low PaO2/FiO(2) ratio. Furthermore, interventions to increase consent and standardize donation after circulatory death donor management, including selective use of ex vivo lung perfusion, may increase use and the donor pool.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Brendan T. Heiden, Zhizhou Yang, Yun Zhu Bai, Yan Yan, Su-Hsin Chang, Yikyung Park, Graham A. Colditz, Hank Dart, Ramsey R. Hachem, Chad A. Witt, Rodrigo Vazquez Guillamet, Derek E. Byers, Gary F. Marklin, Michael K. Pasque, Daniel Kreisel, Ruben G. Nava, Bryan F. Meyers, Benjamin D. Kozower, Varun Puri
Summary: We developed the LUNDON score to predict the acceptability of lung donors in pulmonary transplantation. This score utilizes readily available donor characteristics and shows high discriminatory power. Adoption of this model may standardize donor evaluation and improve lung utilization rates.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Carli J. Lehr, Melissa A. Skeans, Erika D. Lease, Maryam Valapour
Summary: The US lung transplant policy changed on November 24, 2017, expanding the geographic organ distribution to a 250-nautical-mile radius. This change resulted in increased travel distance and time for organ procurement, leading to higher travel costs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jay M. Brahmbhatt, Travis Hee Wai, Christopher H. Goss, Erika D. Lease, Christian A. Merlo, Siddhartha G. Kapnadak, Kathleen J. Ramos
Summary: Improved predictive models are needed for lung transplantation in the United States to accurately predict long-term post-transplant survival and fairly allocate organs. The existing models show poor accuracy in predicting 1-year and 3-year post-transplant mortality, and tend to overestimate the risk of death in patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Surgery
Naissa Abdoul, Camille Legeai, Christelle Cantrelle, Olaf Mercier, Anne Olland, Pierre Mordant, Pascal Alexandre Thomas, Jacques Jougon, Adrien Tissot, Jean-Michel Maury, Edouard Sage, Richard Dorent
Summary: Donors whose lungs were transplanted after EVLP had similar profiles to those whose lungs were declined, but were quite different from donors with lungs transplanted without EVLP. Predictors for graft nonuse included age ≥ 50 years, smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, abnormal chest imaging, and purulent secretions. EVLP was found to increase the utilization of lungs from donors with a smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, and abnormal chest imaging.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
Olivier Aubert, Daniel Yoo, Dina Zielinski, Emanuele Cozzi, Massimo Cardillo, Michael Durr, Beatriz Dominguez-Gil, Elisabeth Coll, Margarida Ivo Da Silva, Ville Sallinen, Karl Lemstrom, Karsten Midtvedt, Camilo Ulloa, Franz Immer, Annemarie Weissenbacher, Natalie Vallant, Nikolina Basic-Jukic, Kazunari Tanabe, Georgios Papatheodoridis, Georgia Menoudakou, Martin Torres, Carlos Soratti, Daniela Hansen Krogh, Carmen Lefaucheur, Gustavo Ferreira, Helio Tedesco Silva, David Hartell, John Forsythe, Lisa Mumford, Peter P. Reese, Francois Kerbaul, Christian Jacquelinet, Serge Vogelaar, Vassilios Papalois, Alexandre Loupy
Summary: The study evaluated the impact of the COVID-19 pandemic on worldwide organ transplantation activities and found an overall decrease in transplant activity in all countries studied. Kidney transplantation was most affected, followed by lung, liver, and heart transplants. There was a marked reduction in transplant activity during the first 3 months of the pandemic, with losses stabilizing after June 2020 but decreasing again from October to December 2020.
LANCET PUBLIC HEALTH
(2021)
Review
Surgery
Kristopher P. Croome, Andrew S. Barbas, Bryan Whitson, Ali Zarrinpar, Timucin Taner, Denise Lo, Malcolm MacConmara, Jim Kim, Peter T. Kennealey, Jonathan S. Bromberg, Kenneth Washburn, Vatche G. Agopian, Mark Stegall, Cristiano Quintini
Summary: The American Society of Transplant Surgeons supports increasing organ availability for transplantation. Variability in the utilization and practices of donation after circulatory death (DCD) transplantation exists. To improve DCD organ utilization, a work group has proposed recommendations on controversial or lacking standardized topics in DCD procurement.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Public, Environmental & Occupational Health
Benjamin Seeliger, Moritz Z. Kayser, Nora Drick, Jan Fuge, Christina Valtin, Mark Greer, Jens Gottlieb
Summary: This study investigated the effects of supplementing standard informed consent with a graphic narrative on patient satisfaction, periprocedural anxiety, and experience. The results showed that the addition of a graphic narrative improved patient satisfaction with informed consent but did not influence pre-procedural anxiety and adverse experience during the procedure.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Immunology
Moritz Z. Kayser, Benjamin Seeliger, Christina Valtin, Jan Fuge, Stefan Ziesing, Tobias Welte, Mathias W. Pletz, Patrick Chhatwal, Jens Gottlieb
Summary: The study showed that BFPPp offered faster test results compared to conventional tests, which led to quicker clinical decisions. BFPPp demonstrated high accuracy in diagnosing viral LRTI, non-viral LRTI, and combined viral and non-viral LRTI. Additionally, preliminary therapies based on BFPPp results were upheld in 90% of cases.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Respiratory System
Jens Gottlieb, Philipp Capetian, Uwe Hamsen, Uwe Janssens, Christian Karagiannidis, Stefan Kluge, Marco Koenig, Andreas Markewitz, Monika Nothacker, Sabrina Roiter, Susanne Unverzagt, Wolfgang Veit, Thomas Volk, Christian Witt, Rene Wildenauer, Heinrich Worth, Thomas Fuehner
Summary: Background Oxygen (O-2) is a drug with specific biochemical and physiologic properties, a range of effective doses and may have side effects. In 2015, 14% of over 55 000 hospital patients in the UK were using oxygen. 42% of patients received this supplemental oxygen without a valid prescription. Healthcare professionals are frequently uncertain about the relevance of hypoxemia and have low awareness about the risks of hyperoxemia. Numerous randomized controlled trials about targets of oxygen therapy have been published in recent years. A national guideline is urgently needed. Methods A S3-guideline was developed and published within the Program for National Disease Management Guidelines (AWMF) with participation of 10-medical associations. Literature search was performed until Feb 1st 2021 to answer 10 key questions. The Oxford Centre for Evidence- Based Medicine (CEBM) System (The Oxford 2011 Levels of Evidence) was used to classify types of studies in terms of validity. Grading of Recommendations, Assessment, Development and Evaluation (GRADE) was used and for assessing the quality of evidence and for grading guideline recommendation and a formal consensus-building process was performed. Results The guideline includes 34 evidence-based recommendations about indications, prescription, monitoring and discontinuation of oxygen therapy in acute care. The main indication for O-2 therapy is hypoxemia. In acute care both hypoxemia and hyperoxemia should be avoided. Hyperoxemia also seems to be associated with increased mortality, especially in patients with hypercapnia. The guideline provides recommended target oxygen saturation for acute medicine without differentiating between diagnoses. Target ranges for oxygen saturation are depending on ventilation status risk for hypercapnia. The guideline provides an overview of available oxygen delivery systems and includes recommendations for their selection based on patient safety and comfort. Conclusion This is the first national guideline on the use of oxygen in acute care. It addresses healthcare professionals using oxygen in acute out-of-hospital and in- hospital settings. The guideline will be valid for 3 years until June 30, 2024.
Article
Critical Care Medicine
Oana Joean, Tobias Welte, Jens Gottlieb
Summary: Despite progress in follow-up strategies, lung transplant recipients still face high morbidity and mortality due to infection risks and chronic lung allograft dysfunction. Quick diagnosis, early treatment, and follow-up are crucial but challenging due to a wide range of pathogens and compromised immune responses in transplant recipients.
Article
Medicine, General & Internal
Oana Joean, Maria Petronella Van't Klooster, Moritz Z. Kayser, Christina Valtin, Raphael Ewen, Heiko Golpon, Thomas Fuehner, Jens Gottlieb
Summary: Background Oxygen therapy is widely used in German hospitals and rescue services, but there is a lack of reliable data on its use, documentation, and surveillance. In a study conducted in three hospitals in Hannover, Germany, it was found that 20% of patients received oxygen therapy, with 29% of them at risk of hypercapnia. Only 68% of patients had a standard operating procedure for oxygen therapy, and only 22% received appropriate therapy based on documented vital parameters. Complete documentation of vital parameters was conducted in only 30% of all patients and 41% of patients receiving oxygen therapy.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Letter
Medicine, General & Internal
Jens Gottlieb, Heinrich Worth, Thomas Volk, Thomas Fuehner
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Maximilian Franz, Thierry Siemeni, Khalil Aburahma, Pavel Yablonski, Reza Poyanmehr, Murat Avsar, Dmitry Bobylev, Wiebke Sommer, Dietmar Boethig, Mark Greer, Jens Gottlieb, Igor Tudorache, Marius M. Hoeper, Gregor Warnecke, Axel Haverich, Christian Kuehn, Fabio Ius, Jawad Salman
Summary: The presence of severe coronary artery disease does not affect the survival rate after lung transplantation. Coronary artery bypass graft surgery and pretransplant percutaneous transluminal coronary angioplasty can be used for revascularization in these patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan Schwarz, Christian Lang, Matevz Harlander, Tomaz Stupnik, Jan Van Slambrouck, Laurens J. Ceulemans, Fabio Ius, Jens Gottlieb, Stefan Kuhnert, Matthias Hecker, Clemens Aigner, Nikolaus Kneidinger, Erik AM. Verschuuren, Jacqueline M. Smits, Edda Tschernko, Eva Schaden, Peter Faybik, Klaus Markstaller, Michael Trauner, Peter Jaksch, Konrad Hoetzenecker
Summary: SSC-CIP is a severe late complication after lung transplantation for COVID-19 ARDS, leading to significant morbidity and mortality. GGT appears to be a sensitive parameter able to predict SSC-CIP even at the time of listing.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Surgery
Amelie Riviere, Clement Picard, Cristina Berastegui, Victor Manuel Mora, Vincent Bunel, Laurent Godinas, Elena Salvaterra, Valeria Rossetti, Laurent Savale, Dominique Israel-Biet, Xavier Demant, Julien Bermudez, Federica Meloni, Peter Jaksch, Jesper Magnusson, Laurence Beaumont, Michael Perch, Jean-Francois Mornex, Christiane Knoop, John-David Aubert, Baptiste Hervier, Hilario Nunes, Marc Humbert, Jens Gottlieb, Yurdagul Uzunhan, Jerome Le Pavec
Summary: This study aimed to evaluate the survival rate and prognostic factors in lung transplant recipients with interstitial lung disease complicating idiopathic inflammatory myopathy (IIM-ILD). The study found that the post-transplant survival rate in IIM-ILD was similar to that in international all-cause transplantation registries and worse in patients with classical IIM. Muscle involvement was identified as the main factor associated with worse survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Infectious Diseases
Nikolaus Kneidinger, Matthias Hecker, Vasiliki Bessa, Ina Hettich, Alexandra Wald, Sabine Wege, Anna-Barbara Nolde, Maike Oldigs, Zulfiya Syunyaeva, Heinrike Wilkens, Jens Gottlieb
Summary: This study aims to assess the outcome and associated factors in lung transplant recipients during the Omicron era of COVID-19, and found that age and glomerular filtration rate < 30 ml/min/1.73m(2) were independent risk factors for severe or critical COVID-19.
Article
Multidisciplinary Sciences
Jens Gottlieb, Bettina Fischer, Jonas Schupp, Heiko Golpon
Summary: This study investigated the effectiveness of CNI-free immunosuppression using mTOR inhibitors in lung transplant recipients. The results showed that the 1-year survival rate was 36% in patients with malignancy who were converted to CNI-free immunosuppression, while the 1-year survival rate was 100% in other patients. Additionally, patients who received this immunosuppression showed improvement in glomerular filtration rate.
Article
Respiratory System
Geert M. Verleden, Jens Gottlieb
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Jens Gottlieb, Fernando Torres, Tarik Haddad, Gundeep Dhillon, Daniel F. Dilling, Christiane Knoop, Reinaldo Rampolla, Rajat Walia, Vivek Ahya, Romain Kessler, Marie Budev, Claus Neurohr, Allan R. Glanville, Robert Jordan, Danielle Porter, Matt McKevitt, Polina German, Ying Guo, Jason W. Chien, Timothy R. Watkins, Martin R. Zamora
Summary: This study evaluated the efficacy of the RSV fusion inhibitor presatovir in RSV-infected lung transplant recipients. The results showed that presatovir did not significantly improve nasal RSV load, symptoms, or lung function in lung transplant recipients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Respiratory System
Jens Gottlieb, Thomas Fuehner, Patrick Zardo
Summary: This study investigated the management and outcome of obstructive airway complications (OACs) after lung transplantation. The results showed that bilateral OACs impose a high burden on patients and are associated with early and late graft loss. Patients with bilateral OACs had reduced graft function and impaired quality of life.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Gottlieb, C. Valtin, B. Fischer, J. Schupp, H. Golpon.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)