Article
Orthopedics
Dmitry Skvortsov, Sergey Kaurkin, Alexey Prizov, Alyona Altukhova, Evgeny Goncharov, Artem Nikitin
Summary: In this study, the mid-term changes in gait biomechanics and clinical symptoms of patients with varus deformity (VD) of the knee joint (KJ) and osteoarthritis (OA) were investigated before and six months after surgical correction. The results showed that the knee extension amplitude increased significantly in female patients after surgery, while the increase in male patients was not significant. The kinematics of walking movements were restored to a nearly normal gait after valgus osteotomy, with increased first and second flexion amplitudes. The non-operative leg functioned less efficiently than required by the walking pace.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Agriculture, Dairy & Animal Science
H. van den Brand, R. Molenaar, M. Klaasen
Summary: This study investigated the effects of different protocols on the angulation of the tibiotarsal-tarsometatarsal joint in broiler chickens with valgus-varus deformity. It was found that fixation of the femorotibiotarsal joint was essential in determining the angulation accurately.
Article
Orthopedics
Kai Ding, Weijie Yang, Haicheng Wang, Shi Zhan, Pan Hu, Junsheng Bai, Chuan Ren, Qi Zhang, Yanbin Zhu, Wei Chen
Summary: This study demonstrated that varus/valgus deformity of the femur has a significant impact on the contact area and stress distribution of the knee joint, providing biomechanical evidence for orthopedic trauma surgery or surgical correction of existing varus/valgus deformities.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Biophysics
Shivangi Giri, Ravi Prakash Tewari, Asma Salhi, Matthieu Lempereur, Bhushan Borotikar
Summary: Current lower limb musculoskeletal models mainly focus on sagittal plane kinematics, limiting their use in abnormal gait where motions cross into other planes. This study extends a full-body musculoskeletal model to include frontal knee plane kinematics during healthy gait and proposes a realistic muscle discretization technique. The results show that the new model accurately predicts knee varus-valgus trajectories and improves muscle mechanics predictions, leading to better simulation of muscle activations.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Agriculture, Dairy & Animal Science
Chunxia Cai, Lujie Zhang, Xinxin Liu, Jianzeng Li, Yanchao Ma, Ruirui Jiang, Zhuanjian Li, Guoxi Li, Yadong Tian, Xiangtao Kang, Ruili Han
Summary: Valgus-varus deformity is a common leg disease in commercial broilers, causing animal welfare issues and economic losses. This study examined the effects of VVD on broiler growth by analyzing carcass composition and meat quality of normal and VVD broilers. The results showed that VVD broilers had lower shear force, protein content, water content, cooking loss, and darker meat color compared to normal broilers. Additionally, VVD broilers had lower skeletal muscle weight and smaller myofibrils. Gene expression analysis revealed higher expression of muscle atrophy and apoptosis-related genes in VVD broilers. Overall, VVD negatively affects broiler growth characteristics, slaughter characteristics, and meat quality, potentially leading to muscle atrophy.
Article
Orthopedics
Mitsuyuki Nagashima, Shohei Omokawa, Yasuaki Nakanishi, Pasuk Mahakkanukrauh, Hideo Hasegawa, Takamasa Shimizu, Kenji Kawamura, Yasuhito Tanaka
Summary: Ulnar nerve strain significantly increases during elbow flexion. The contribution of elbow deformity to ulnar nerve strain remains unclear.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Itaru Kawashima, Ryosuke Kawai, Shinya Ishizuka, Hideki Hiraiwa, Takashi Tsukahara, Shiro Imagama
Summary: Delayed surgical treatment for ACL injuries in patients aged 16 and below with varus knee alignment may lead to an increased risk of secondary medial meniscal tears. Therefore, early ACL reconstruction should be considered for patients with varus-aligned knees after ACL injury.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Agriculture, Dairy & Animal Science
Y. Ma, C. Cai, J. Li, L. Zhang, J. Ma, R. Jiang, Y. Zhang, Y. Tian, X. Kang, R. Han
Summary: Valgus-varus deformity (VVD) is a common leg bone problem in broilers. This study used whole-genome bisulphite sequencing to describe the unique DNA methylation profile of VVD broilers. The analysis identified differentially methylated regions (DMRs) and differentially methylated genes (DMGs), including the potential role of the ESPL1 gene in VVD.
BRITISH POULTRY SCIENCE
(2023)
Article
Orthopedics
Yanfeng Jia, Leilei Zhai, Shiqi Qin, Juncai Xu, Wei Gao, Boxuan Zhang, Xiaofeng Wang, Kezhen Zhou, Zhiwen Sun, Yingzhen Niu, Hongwei Bao, Ran Sun
Summary: This study aimed to investigate the relationship between lower limb alignment and soft tissue balance after total knee arthroplasty (TKA). The results showed that the relaxation of soft tissues around the knee joint changed over time after TKA, but this change did not significantly affect the alignment of the lower limbs.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biotechnology & Applied Microbiology
Yaping Guo, Hetian Huang, Zhenzhen Zhang, Yanchao Ma, Jianzeng Li, Hehe Tang, Haoxiang Ma, Zhuanjian Li, Wenting Li, Xiaojun Liu, Xiangtao Kang, Ruili Han
Summary: This study investigated the genetic basis of Valgus-varus deformity (VVD) leg disease in broilers. Through a genome-wide association study, several candidate genes and pathways associated with VVD, growth performance, and serum indicators were identified. Functional enrichment analysis revealed the involvement of these genes in bone development and skeletal development pathways. The findings provide insights into the metabolic mechanism of alkaline phosphatase (ALP) and the pathogenesis of VVD, which can contribute to disease-resistant breeding of chicken leg soundness.
Article
Orthopedics
Heiko Graichen, Kreangsak Lekkreusuwan, Kim Eller, Thomas Grau, Michael T. Hirschmann, Wolfgang Scior
Summary: The study aimed to analyze the gap widths and differences in varus knees in different flexion angles, finding a high variability among individuals. While varus deformity correlated with medio-lateral gap difference in extension, no correlation was found in flexion. Women tended to have larger gap sizes, while age and BMI had no significant effect. Individualized balancing techniques are necessary for treating varus knees effectively.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Yasuhiko Kokubu, Shinya Kawahara, Satoshi Hamai, Yukio Akasaki, Hidetoshi Tsushima, Shinji Miyachika, Yasuharu Nakashima
Summary: The purpose of this study was to investigate the shape of the anterior femoral resection surface in varus and valgus knees. Virtual TKA was performed using three different anterior flange flexion angles. The study found that the variation in the anterior femoral resection surface with malrotation was smaller in valgus knees.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Medicine, General & Internal
Eugenio Cammisa, Iacopo Sassoli, Matteo La Verde, Stefano Fratini, Vito Gaetano Rinaldi, Giada Lullini, Vittorio Vaccari, Stefano Zaffagnini, Giulio Maria Marcheggiani Muccioli
Summary: This review discusses the outcomes of bilateral knee arthroplasty in patients with windswept deformity (WSD). The results show that knee replacement surgery improves knee function and reduces axial deviation in both valgus and varus knees. Unicompartmental knee arthroplasty (UKA) allows for limited axial correction, while kinematic alignment (KA) provides similar results in both knees. The choice of implant is important for functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Kilian Rueckl, Armin Runer, Anna Jungwirth-Weinberger, Maximilian F. Kasparek, Martin Faschingbauer, Friedrich Boettner
Summary: The study found that the degree of valgus deformity and the grade of osteoarthritis do not predict the outcome of total knee arthroplasty in patients with advanced valgus osteoarthritis. Surgery appears to be justified in patients who failed nonoperative treatment, regardless of the degree of deformity.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Edoardo Bori, Bernardo Innocenti
Summary: This study used finite element analysis to investigate the effects of different interventions on bone stress, tibio-femoral contact pressure, and force when treating varus and valgus deformities with hinged total knee arthroplasty. The results showed that changes in the varus or valgus deformity degrees altered the distribution of medio-lateral stress and force, as well as the contact area. The interventions and cement had no effect on the tibio-femoral contact biomechanics, but mainly affected the distal femoral region and had negligible effect in the proximal regions.
APPLIED SCIENCES-BASEL
(2023)
Article
Orthopedics
Achim Benditz, Svenja Sprenger, Luise Rauch, Markus Weber, Joachim Grifka, Rainer H. Straub
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Orthopedics
A. Benditz, J. Grifka
Article
Biotechnology & Applied Microbiology
Achim Benditz, Florian Faber, Gabriela Wenk, Tina Fuchs, Natalie Salak, Joachim Grifka, Matthias Vogl, Matthias Menke, Petra Jansen
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Orthopedics
Florian Voellner, Florian Herl, Felix Greimel, Achim Benditz, Tobias Renkawitz, Joachim Grifka, Benjamin Craiovan, Markus Weber
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2020)
Article
Rheumatology
F. Faber, A. Benditz, D. Boluki, J. Grifka
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2020)
Article
Multidisciplinary Sciences
Franziska Leiss, Julia Sabrina Goetz, Guenther Maderbacher, Florian Zeman, Winfried Meissner, Joachim Grifka, Achim Benditz, Felix Greimel
SCIENTIFIC REPORTS
(2020)
Article
Orthopedics
Matthias Meyer, Tobias Renkawitz, Florian Voellner, Achim Benditz, Joachim Grifka, Markus Weber
Summary: Both imageless navigation and conventional total knee arthroplasty enable accurate postoperative leg alignment with low complication rates and equally successful patient-reported outcome measures (PROMs) and responder rates one year postoperatively.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moritz Kaiser, Tobias Renkawitz, Achim Benditz, Matthias Koenig, Max Thieme, Markus Weber
Summary: This study evaluated the influence of pelvic tilt on cup measurements in postoperative CT scans for total hip arthroplasty, finding that standard CT planes should be corrected for pelvic tilt before measurements to avoid errors.
Article
Clinical Neurology
Raffael Peteler, Paul Schmitz, Martin Loher, Petra Jansen, Joachim Grifka, Achim Benditz
Summary: This study found sex-dependent differences in symptom-related disability in patients with lumbar spinal stenosis, with female patients showing higher scores in RMDQ and ODI, as well as significantly higher intermediate depression scores. The findings also suggest that variables such as age, pain chronicity, psychological symptoms, pain level, and paresis are influenced by patient sex.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Orthopedics
Achim Benditz, Loreto C. Pulido, Joachim Grifka, Fabian Ripke, Petra Jansen
Summary: The aim of this study is to show the concordance between an app-based decision support system and the diagnosis given by spinal surgeons in cases of back pain. The results demonstrated a strong relation between the tool and the doctor's diagnosis, with a concordance rate of 67.4% in the cases studied.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Clinical Neurology
Matthias A. Koenig, Joachim Grifka, Achim Benditz
Summary: The study established a new radiological classification for surgical decision-making in coccygodynia cases, which could help facilitate the surgical treatment for patients with displaced os coccyx. Subtypes III and IV were more likely to require surgery.
EUROPEAN SPINE JOURNAL
(2022)
Article
Medicine, General & Internal
Julia Sabrina Goetz, Achim Benditz, Jan Reinhard, Melanie Schindler, Florian Zeman, Joachim Grifka, Felix Greimel, Franziska Leiss
Summary: Preoperative anxiety/depression symptoms lead to worse clinical outcomes 1 year postoperatively after total joint arthroplasty, along with higher age and ASA 2 or 3 influencing the outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Melanie Schindler, Stephanie Schmitz, Jan Reinhard, Petra Jansen, Joachim Grifka, Achim Benditz
Summary: This study assessed pain development within the first 4 weeks after total knee arthroplasty (TKA) and found that increased pain scores after the first postoperative week were likely due to more intensive mobilization and physiotherapy in the rehabilitation department. Female patients, those with low BMI, and a preoperative valgus leg axis showed significantly higher postoperative pain scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jan Reinhard, Loreto C. Pulido, Melanie Schindler, Amadeus Schraag, Felix Greimel, Joachim Grifka, Achim Benditz
Summary: This study retrospectively compared postoperative pain, side effects, and functional outcomes in patients who underwent primary total hip arthroplasty in 2015 and 2021. The results showed that patients in 2021 experienced more severe pain symptoms and required higher opioid usage. Despite a decrease in patient participation in pain management, patient satisfaction remained high.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Armin Keshmiri, Guenther Maderbacher, Clemens Baier, Achim Benditz, Joachim Grifka, Felix Greimel
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2019)