Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Christa C. van Bunderen, Rick I. Meijer, Paul Lips, Mark H. Kramer, Erik H. Serne, Madeleine L. Drent
Summary: The study found that increasing IGF-1 levels had a beneficial effect on body composition but was detrimental to insulin resistance. At the same time, the contribution of the neurogenic vasomotion domain also increased.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nicholas A. Tritos, Beverly M. K. Biller
Summary: GH deficiency in adults is associated with various health issues, and diagnosis requires stimulation testing, evaluation of other pituitary hormone deficits, serum IGF-I levels, and multiple additional pituitary hormone deficiencies.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Paul Saenger, Reiko Horikawa
Summary: This study evaluated the efficacy, safety, and tolerability of once-weekly somapacitan treatment for GH deficiency in children over a three-year period. The results showed sustained efficacy in height-related outcomes with similar safety and tolerability to daily GH treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara
Summary: The mechanism of GH-induced hepatocyte DNA synthesis and proliferation is mainly mediated through the JAK2/PLC pathway leading to autocrine secretion of IGF-I, which then activates the IGF-I receptor tyrosine kinase signaling pathway. Blocking antibodies to IGF-I, but not transforming growth factor alpha, inhibit GH-induced hepatocyte DNA synthesis and proliferation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Hiroki Nishi, Kaito Uchida, Maki Saito, Daisuke Yamanaka, Haruka Nagata, Hinako Tomoshige, Ichiro Miyata, Koichi Ito, Yuka Toyoshima, Shin-Ichiro Takahashi, Fumihiko Hakuno, Asako Takenaka
Summary: This study evaluates the contribution of protein nutrition and the GH/IGF-I system to body growth regulation. The results show that a reduction in serum EAA concentration hinders Igf1 transcription and decreases serum IGF-I levels. Restoring serum IGF-I levels through recombinant IGF-I infusion rescues body growth, indicating the importance of EAAs for animal growth.
Article
Medicine, General & Internal
Agnieszka Lecka-Ambroziak, Marta Wysocka-Mincewicz, Katarzyna Dolezal-Oltarzewska, Agata Zygmunt-Gorska, Anna Wedrychowicz, Teresa Zak, Anna Noczynska, Dorota Birkholz-Walerzak, Renata Stawerska, Maciej Hilczer, Monika Obara-Moszynska, Barbara Rabska-Pietrzak, Elzbieta Golebiowska, Adam Dudek, Elzbieta Petriczko, Mieczyslaw Szalecki
Summary: The study revealed that rhGH treatment is most effective in younger patients with PWS, promoting growth and improving body composition, without observing worsening of metabolic parameters or advancement of bone age/chronological age index in older patients during a comparable time of treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Bradley S. Miller, Joanne C. Blair, Michael Hojby Rasmussen, Aristides Maniatis, Jun Mori, Volker Boettcher, Ho-Seong Kim, Rikke Beck Bang, Michel Polak, Reiko Horikawa
Summary: This study evaluated the efficacy and tolerability of somapacitan in children with growth hormone deficiency (GHD) for 2 years and after switching from daily growth hormone treatment. The results showed that somapacitan was effective and well-tolerated during the 2-year period, and patients and caregivers preferred once-weekly somapacitan treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Kangkang Chen, Xiaoyi Dou, Jai Hoon Eum, Ruby E. Harrison, Mark R. Brown, Michael R. Strand
Summary: This study assessed the expression of insulin-like peptides (ILPs) and ovary ecdysteroidogenic hormone (OEH) in Aedes aegypti during a gonadotrophic cycle and further functionally characterized these peptides to understand their roles in regulating egg formation. The results showed that all ILPs and OEH were expressed during the cycle, and there were differences in their biological activities and insulin- insulin growth factor signaling (IIS) phosphorylation levels.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yiyi Zhu, Min Nie, Xi Wang, Qibin Huang, Bingqing Yu, Rui Zhang, Junyi Zhang, Bang Sun, Jiangfeng Mao, Xueyan Wu
Summary: Recombinant human growth hormone (rhGH) effectively induces spermatogenesis in patients with congenital combined pituitary hormone deficiency (CCPHD). Combination treatment with rhGH and gonadotropins leads to higher spermatogenesis rate, shorter time for initial sperm appearance, and higher serum testosterone level.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Haim Werner, Zvi Laron
Summary: The GH-IGF1 signaling pathway plays a key role in aging and longevity. Patients with LS, a congenital IGF1 deficiency, seem to be protected from cancer. Aging and cancer may be different manifestations of the same underlying processes. Genome-wide screenings have identified genes associated with aging and longevity in LS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Martin Bidlingmaier, Beverly M. K. Biller, David Clemmons, Jens Otto L. Jorgensen, Hiroshi Nishioka, Yutaka Takahashi
Summary: Adult growth hormone deficiency (AGHD) is a rare endocrine disorder that affects body composition, metabolism, and quality of life. Long-acting growth hormone (LAGH) preparations are being developed to reduce treatment burden for patients. Understanding the differences between LAGH preparations is important for physicians planning to treat AGHD with these therapies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Martin O. Savage, Helen L. Storr, Philippe F. Backeljauw
Summary: The continuum of growth hormone (GH)-IGF-I axis defects ranges from severe to mild GH deficiency, including GH insensitivity, with various endocrine, biochemical, phenotypic and genetic abnormalities. While extreme cases are easily diagnosed, milder cases are less well defined and may overlap with idiopathic short stature conditions.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Endocrinology & Metabolism
Carolyn T. Bramante, Sarah Raatz, Eric M. Bomberg, Megan M. Oberle, Justin R. Ryder
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Stephen J. Molitor, Claudia K. Fox, Megan O. Bensignor, Amy C. Gross
Summary: The study with 280 adolescents in a pediatric weight management clinic found that the seven-factor structure of AEBQ had a marginally acceptable fit for obese patients, with Food Approach scales showing better convergent validity and some clinical utility in identifying patients at increased risk for binge eating.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Pediatrics
Megan O. Bensignor, Eric M. Bomberg, Carolyn T. Bramante, T. V. S. Divyalasya, Paula M. Hale, Chethana K. Ramesh, Kyle D. Rudser, Aaron S. Kelly
Summary: Liraglutide was associated with significant reductions in BMI/weight parameters at week 52, but not at week 26, in children and adolescents with T2D. Dose-dependent effects were not observed for liraglutide vs placebo for all BMI/weight parameters.
Article
Pediatrics
Claudia K. Fox, Elise F. Northrop, Kyle D. Rudser, Justin R. Ryder, Aaron S. Kelly, Megan O. Bensignor, Eric M. Bomberg, Carolyn T. Bramante, Amy C. Gross
Summary: This study found that in youth, the association between hedonic hunger and obesity is independent of binge eating. However, when considering binge eating, the relationship between hedonic hunger and obesity is no longer significant.
Article
Endocrinology & Metabolism
Carolyn T. Bramante, Elise F. Palzer, Kyle D. Rudser, Justin R. Ryder, Claudia K. Fox, Eric M. Bomberg, Megan O. Bensignor, Amy C. Gross, Nancy E. Sherwood, Aaron S. Kelly
Summary: The study found that %BMIp95 and %BMIp50 were the most strongly correlated with measures of adiposity in youth, while BMIp consistently had the lowest correlations.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Public, Environmental & Occupational Health
Megan O. Bensignor, Rebecca L. Freese, Nancy E. Sherwood, Jerica M. Berge, Alicia Kunin-Batson, Sara Veblen-Mortenson, Simone A. French
Summary: The study found that factors such as food insecurity may influence parental feeding styles and child eating behaviors, rather than SNAP participation. Screening by healthcare providers is recommended to address these issues.
JOURNAL OF HUNGER & ENVIRONMENTAL NUTRITION
(2021)
Letter
Endocrinology & Metabolism
Megan O. Bensignor, Jack M. Wolf, Kyle D. Rudser, Aaron S. Kelly, Silva Arslanian
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Claudia K. Fox, Justin M. Clark, Kyle D. Rudser, Justin R. Ryder, Amy C. Gross, Brandon M. Nathan, Muna Sunni, Donald R. Dengel, Charles J. Billington, Megan O. Bensignor, Aaron S. Kelly
Summary: This study evaluated the effect of exenatide extended release (XR) in adolescents with severe obesity who achieved BMI reduction with meal replacement therapy (MRT). The results showed that although not statistically significant, exenatide XR may partly mitigate BMI rebound in these adolescents.
Review
Endocrinology & Metabolism
Megan O. O. Bensignor, Aaron S. S. Kelly, Silva Arslanian
Summary: Type 2 diabetes mellitus (T2DM) in adolescents is a rapidly progressive disease with higher rates of microvascular complications compared to adults. Anti-obesity medications (AOMs) are recommended as adjuvant therapy for adults with T2DM and overweight/obesity, but their use in adolescents is not clearly mentioned in the updated guidelines. However, there are three FDA-approved AOMs available for chronic use in adolescents with obesity, and more options are being developed. Adding AOMs to diabetes regimen in adults can improve glycemic control, reduce weight, and decrease anti-diabetes medication use.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Megan O. Bensignor, Carolyn T. Bramante, Eric M. Bomberg, Claudia K. Fox, Paula M. Hale, Aaron S. Kelly, Rashmi Mamadi, Nandana Prabhu, Nina M. Harder-Lauridsen, Amy C. Gross
Summary: In the SCALE Teens trial, the effectiveness of liraglutide in reducing BMI in adolescents with obesity varied among individuals. However, baseline characteristics such as age, pubertal stage, and obesity category did not predict BMI reduction. Early response to liraglutide treatment may be indicative of better long-term response.
Article
Public, Environmental & Occupational Health
Megan M. Oberle, Eliza Whiteman Kinsey, Terri H. Lipman, Carolyn Cannuscio, Amy Hillier, Virginia A. Stallings
Summary: Participation in the Supplemental Nutrition Assistance Program (SNAP) is associated with obesity in women, but caloric intake and dietary quality did not significantly differ among food insecure, African-American female head-of-households with overweight/obesity in this pilot study. The study also found a positive association between the appetite-stimulating hormone neuropeptide Y concentrations and the percent of Estimated Energy Requirements (%EER) consumed.
JOURNAL OF HUNGER & ENVIRONMENTAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Megan M. Oberle, Katie A. Loth, Anne Schendel, Claudia K. Fox, Amy C. Gross
Article
Endocrinology & Metabolism
Megan M. Oberle, Elise F. Northrop, Carolyn T. Bramante, Kyle D. Rudser, Amy C. Gross, Aaron S. Kelly
OBESITY SCIENCE & PRACTICE
(2020)
Article
Public, Environmental & Occupational Health
Megan M. Oberle, Rebecca Freese, Justine Shults, Virginia A. Stallings, Senbagam Virudachalam
JOURNAL OF HUNGER & ENVIRONMENTAL NUTRITION
(2020)
Article
Public, Environmental & Occupational Health
Eliza Whiteman Kinsey, Megan Oberle, Roxanne Dupuis, Carolyn C. Cannuscio, Amy Hillier
SSM-POPULATION HEALTH
(2019)