Article
Oncology
Siddhartha Devarakonda, Yize Li, Fernanda Martins Rodrigues, Sumithra Sankararaman, Humam Kadara, Chandra Goparaju, Irena Lanc, Kymberlie Pepin, Saiama N. Waqar, Daniel Morgensztern, Jeffrey Ward, Ashiq Masood, Robert Fulton, Lucinda Fulton, Michael A. Gillette, Shankha Satpathy, Steven A. Carr, Ignacio Wistuba, Harvey Pass, Richard K. Wilson, Li Ding, Ramaswamy Govindan
Summary: The study analyzed genomic and transcriptomic data from never-smoker lung adenocarcinoma samples, finding a high prevalence of clinically actionable driver alterations and potential role of germline variants in DNA repair genes and passive exposure to cigarette smoke in the pathogenesis of a subset of never-smoker LUADs. The findings also highlight the importance of obtaining biopsies with adequate cellularity for clinical genomic testing in these patients.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
M. Torres-Duran, M. T. Curiel-Garcia, A. Ruano-Ravina, M. Provencio, I Parente-Lamelas, J. Hernandez-Hernandez, A. Fernandez-Villar, J. M. Barros-Dios, M. Perez-Rios
Summary: Characteristics of SCLC in never-smokers were not associated with indoor radon exposure, and the survival rate of this aggressive lung cancer in never-smokers remains low.
Article
Public, Environmental & Occupational Health
Maria Teresa Landi, Naoise C. Synnott, Jennifer Rosenbaum, Tongwu Zhang, Bin Zhu, Jianxin Shi, Wei Zhao, Michael Kebede, Jian Sang, Jiyeon Choi, Laura Mendoza, Marwil Pacheco, Belynda Hicks, Neil E. Caporaso, Mustapha Abubakar, Dmitry A. Gordenin, David C. Wedge, Ludmil B. Alexandrov, Nathaniel Rothman, Qing Lan, Montserrat Garcia-Closas, Stephen J. Chanock
Summary: The Sherlock-Lung study investigates cancer etiology by studying somatic mutational signatures imprinted on the cellular genome. By integrating various data sources, the study aims to classify LCINS into subtypes that could reveal distinct risk factors. Challenges and potential for this approach in future epidemiologic studies are discussed.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Immunology
Piotr Kusnierczyk
Summary: Smoking is a major risk factor for lung cancer, and the trends of lung cancer epidemiology largely reflect past trends of cigarette smoking. The geographic patterns of mortality closely follow those of incidence. While lung cancer is strongly associated with cigarette smoking, it is important to note that only a small percentage of smokers develop the disease and there is also lung cancer in never-smokers. Lung cancer in never-smokers, though less common, is still a significant cause of cancer deaths globally. The genetic differences between lung cancer in smokers and never-smokers, including gene expression, gene mutations, and ethnic and gender differences, will be the focus of this review, along with a brief overview of treatment options for both groups.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Timo B. Trefzer, Marc A. Schneider, Katharina Jechow, Robert Lorenz Chua, Thomas Muley, Hauke Winter, Mark Kriegsmann, Michael Meister, Roland Eils, Christian Conrad
Summary: Lung cancer, the leading cause of cancer-related death worldwide, is not only highly associated with smoking status but also occurs in a significant proportion of non-smokers, particularly female non-smokers. This study used single-cell transcriptomics to analyze surgical lung adenocarcinoma (LUAD) and normal lung tissue samples from smokers and non-smokers, revealing different cell populations and immune interactions between the two groups. The findings provide important insights into lung cancer heterogeneity and immune involvement, which can guide future therapeutic strategies.
Article
Cell Biology
Wenxin Luo, Zhen Zeng, Yang Jin, Lan Yang, Ting Fan, Zhoufeng Wang, Yitong Pan, Ying Yang, Menglin Yao, Yangqian Li, Xue Xiao, Gang Wang, Chengdi Wang, Shuai Chang, Guowei Che, Li Zhang, Yalun Li, Yong Peng, Weimin Li
Summary: By studying the differences in tumor microenvironment (TME) between lung cancer in never-smokers and smokers, it was found that dysfunction of alveolar cells induced by cigarette smoking contributes more to the aggressiveness of smoker lung cancer, while the immunosuppressive TME exerts more effects on never-smoker lung cancer's aggressiveness. The study also identified SPP1hi pro macrophage as another independent source of monocyte-derived macrophage. Furthermore, higher expression of immune checkpoint CD47 and lower expression of major histocompatibility complex (MHC)-I in cancer cells of never-smoker lung cancer imply that CD47 may be a better immunotherapy target for lung cancer in never-smokers (LCINS).
CELL REPORTS MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Hamouz, Raneem Y. Hammouz, Muhammad Ahmed Bajwa, Abdelrahman Waleed Alsayed, Magdalena Orzechowska, Andrzej K. Bednarek
Summary: There is a lack of information about lung cancer in never smokers (LCINS), and there are differences in genetic mutations and other characteristics between smokers and never smokers, suggesting a different form of the disease in LCINS. Understanding the genetic alterations in LCINS and the overall genomic landscape will help identify new treatment targets and improve outcomes. Differences in treatment response and tumor characteristics between never smokers and smokers highlight the need for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Tongwu Zhang, Philippe Joubert, Naser Ansari-Pour, Wei Zhao, Phuc H. Hoang, Rachel Lokanga, Aaron L. Moye, Jennifer Rosenbaum, Abel Gonzalez-Perez, Francisco Martinez-Jimenez, Andrea Castro, Lucia Anna Muscarella, Paul Hofman, Dario Consonni, Angela C. Pesatori, Michael Kebede, Mengying Li, Bonnie E. Gould Rothberg, Iliana Peneva, Matthew B. Schabath, Maria Luana Poeta, Manuela Costantini, Daniela Hirsch, Kerstin Heselmeyer-Haddad, Amy Hutchinson, Mary Olanich, Scott M. Lawrence, Petra Lenz, Maire Duggan, Praphulla M. S. Bhawsar, Jian Sang, Jung Kim, Laura Mendoza, Natalie Saini, Leszek J. Klimczak, S. M. Ashiqul Islam, Burcak Otlu, Azhar Khandekar, Nathan Cole, Douglas R. Stewart, Jiyeon Choi, Kevin M. Brown, Neil E. Caporaso, Samuel H. Wilson, Yves Pommier, Qing Lan, Nathaniel Rothman, Jonas S. Almeida, Hannah Carter, Thomas Ried, Carla F. Kim, Nuria Lopez-Bigas, Montserrat Garcia-Closas, Jianxin Shi, Yohan Bosse, Bin Zhu, Dmitry A. Gordenin, Ludmil B. Alexandrov, Stephen J. Chanock, David C. Wedge, Maria Teresa Landi
Summary: Whole-genome sequencing of lung cancer in never smokers identifies different copy number subtypes and shows a lack of tobacco smoking signatures, even in cases exposed to secondhand smoke.
Review
Immunology
Viviane Teixeira L. de Alencar, Amanda B. Figueiredo, Marcelo Corassa, Kenneth J. Gollob, Vladmir Cordeiro C. de Lima
Summary: Lung cancer is the second most common and the most lethal malignancy worldwide, with lung cancer in never smokers accounting for 10-25% of cases. These tumors have a better prognosis but poor response to immune therapy, possibly due to factors like low immunogenicity and constitutive PD-L1 expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Renelle Myers, Michael Brauer, Trevor Dummer, Sukhinder Atkar-Khattra, John Yee, Barbara Melosky, Cheryl Ho, Anna L. McGuire, Sophie Sun, Kyle Grant, Alexander Lee, Martha Lee, Weiran Yuchi, Martin Tammemagi, Stephen Lam
Summary: The study revealed that non-smokers with lung cancer, especially females and Asians, had higher exposure to outdoor air pollution, indicating a significant association between air pollution and lung cancer risk for this group.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Immunology
Anna Andrzejczak, Anna Partyka, Andrzej Wisniewski, Irena Porebska, Konrad Pawelczyk, Kuba Ptaszkowski, Piotr Kusnierczyk, Monika Jasek, Lidia Karabon
Summary: This study aimed to analyze the impact of BTLA polymorphic variants on the susceptibility to non-small cell lung cancer (NSCLC) and NSCLC patients' overall survival (OS). The results showed that the rs1982809 variant within the BTLA gene is associated with NSCLC risk. Furthermore, BTLA polymorphic variants are associated with smoking history, gender, tumor type, and disease stage in NSCLC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew Tang, Usman Ahmad, Andrew J. Toth, Natalie Bourdakos, Siva Raja, Daniel P. Raymond, Eugene H. Blackstone, Sudish C. Murthy
Summary: The study found that NSCLC in never-smokers is more common in women, with differences in tumor location and histopathological cell type compared to ever-smokers. Never-smokers had similar postoperative complications as ever-smokers, but lower rates of non-lung cancer deaths. In pathological stage I, never-smokers had better overall survival, but lower in stage II.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Ryan J. Langdon, Paul Yousefi, Caroline L. Relton, Matthew J. Suderman
Summary: The study shows that DNA methylation can classify smoking status with close to 65% accuracy, especially in distinguishing between current and former smokers. Different DNAm models demonstrate reasonable accuracy in smoking status classification, contributing to better representation of real-world populations.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Zheng Wu, Shuanghua Xie, Fei Wang, Shuohua Chen, Kai Su, Fang Li, Hong Cui, Wei Cao, Yiwen Yu, Chao Qin, Yadi Zheng, Xuesi Dong, Zhuoyu Yang, Zilin Luo, Liang Zhao, Yongjie Xu, Hongda Chen, Jiang Li, Gang Wang, Shouling Wu, Min Dai, Ni Li, Jie He
Summary: Short-term dramatic changes in body weight, both gain and loss, may increase the risk of lung cancer in male never-smokers, suggesting that weight control could be a potential way for lung cancer prevention.
Article
Oncology
Chong Kin Liam, Chian Yih Yew, Yong Kek Pang, Chee Kuan Wong, Mau Ern Poh, Jiunn Liang Tan, Chun Ian Soo, Thian Chee Loh, Ka Kiat Chin, Vijayan Munusamy, Yong Sheng Liam, Nur Husna Ibrahim
Summary: This study investigated the relationship between PD-L1 expression, driver mutations, and cigarette smoking in non-small cell lung cancer (NSCLC). The results showed that high PD-L1 expression was more common in smokers, EGFR wild-type tumors, and heavy smokers.
Article
Radiology, Nuclear Medicine & Medical Imaging
K. Kamakshi, Arvind Krishnamurthy, V. Karthik, Preetha Vinodkumar, R. Krishna Kumar, K. M. Lakshmipathy
WORLD JOURNAL OF NUCLEAR MEDICINE
(2020)
Review
Oncology
Arvind Krishnamurthy, Vijayalakshmi Ramshankar
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2020)
Letter
Oncology
Ramachandran Krishna Kumar, Arvind Krishnamurthy, Gomadam Kuppusamy Rangarajan, Nagarathinam Anandi, Namasivayam Parvathnathan
INDIAN JOURNAL OF CANCER
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Veeraraghavan Krishnamurthy, Thirumoorthi Natarajan, Arvind Krishnamurthy
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Veeraraghavan Krishnamurthy, Thirumoorthi Natarajan, Arvind Krishnamurthy
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arvind Krishnamurthy, Saket Mittel, Krishna Kumar Ramachandran
INDIAN JOURNAL OF NUCLEAR MEDICINE
(2019)
Article
Obstetrics & Gynecology
Manikandan Dhanushkodi, Shirley Sundersingh, Arvind Krishnamurthy
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Arvind Krishnamurthy
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Taha Sethjiwala, Manikandan Dhanushkodi, Venkatraman Radhakrishnan, Jayachandran Perumal Kalaiarasi, Nikita Mehra, Archit Joshi, Arun Kumar Rajan, Gangothri Selvarajan, Balasubramanian Ananthi, Priya Iyer, Geetha Senguttuvan, Bharathi Srilatha, Rama Ranganathan, Shirley Sundersingh, Arvind Krishnamurthy, Sridevi Velusamy, Hemanth Raj, Selvaluxmy Ganesarajah, Tenali Gnana Sagar, Trivadi S. Ganesan
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
Meeting Abstract
Oncology
P. Iyer, V. Radhakrishnan, A. Balasubramanian, V. Sridevi, A. Krishnamurthy, S. Ganesharaja
ANNALS OF ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Manikandan Dhanushkodi, Priya Iyer, Balasubramanian Ananthi, Arvind Krishnamurthy, K. M. Lakshmipathy
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
Letter
Oncology
Arvind Krishnamurthy
INDIAN JOURNAL OF CANCER
(2019)
Article
Obstetrics & Gynecology
Taha Sethjiwala, Manikandan Dhanushkodi, Venkatraman Radhakrishnan, Jayachandran Perumal Kalaiarasi, Nikita Mehra, Archit Joshi, Arun Kumar Rajan, Gangothri Selvarajan, Balasubramanian Ananthi, Priya Iyer, Geetha Senguttuvan, Bharathi Srilatha, Arvind Krishnamurthy, Sridevi Velusamy, Selvaluxmy Ganesarajah, Trivadi S. Ganesan, Tenali Gnana Sagar
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Priya Iyer, Ananthi Balasubramanian, Ganesarajah Selvaluxmy, V Sridevi, Arvind Krishnamurthy, Venkatraman Radhakrishnan
INDIAN JOURNAL OF CANCER
(2019)
Article
Obstetrics & Gynecology
Manikandan Dhanushkodi, Priya Iyer, Balasubramanian Ananthi, Arvind Krishnamurthy
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)