Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Erratum: Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells

(2015) R S Watnick et al.   ONCOGENE

Molecular mechanism matters: Benefits of mechanistic computational models for drug development

(2015) Lindsay E. Clegg et al.   PHARMACOLOGICAL RESEARCH

Anti-VEGF Therapy and the Retina: An Update

(2015) Vikas Tah et al.   Journal of Ophthalmology

Targeting Receptor Tyrosine Kinases and Their Downstream Signaling with Cell-Penetrating Peptides in Human Pulmonary Artery Smooth Muscle and Endothelial Cells

(2014) Jun Yu et al.   Chemical Biology & Drug Design

CD47 Signaling Regulates the Immunosuppressive Activity of VEGF in T Cells

(2014) Sukhbir Kaur et al.   JOURNAL OF IMMUNOLOGY

Thrombospondin-1 Activation of Signal-Regulatory Protein-  Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury

(2014) M. Yao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice

(2014) David R. Soto-Pantoja et al.   MATRIX BIOLOGY

VEGFR2 trafficking: Speed doesn’t kill

(2013) Xi Zhang et al.   CELL CYCLE

Therapeutic angiogenesis for critical limb ischaemia

(2013) Brian H. Annex   Nature Reviews Cardiology

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

A Mathematical Model of T Lymphocyte Calcium Dynamics Derived from Single Transmembrane Protein Properties

(2013) Christine Schmeitz et al.   Frontiers in Immunology

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Vascular Endothelial Growth Factor A in Intraocular Vascular Disease

(2012) Joan W. Miller et al.   OPHTHALMOLOGY

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

(2012) Matthew W. Parker et al.   PLoS One

Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome

(2012) Marija Milacic et al.   Cancers

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

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Orai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation

(2011) Jing Li et al.   CIRCULATION RESEARCH

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium

(2011) Michael T. Dellinger et al.   PLoS One

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

(2011) Pipsa Saharinen et al.   TRENDS IN MOLECULAR MEDICINE

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

(2010) Eileen M. Bauer et al.   CARDIOVASCULAR RESEARCH

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts

(2009) Jeff S. Isenberg et al.   ANNALS OF SURGERY

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Complexity of Cell Signaling and the Need for a New Mechanics

(2009) W. S. Hlavacek et al.   Science Signaling

Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis

(2009) Alexander F. Bruns et al.   TRAFFIC

Inhibition of Vascular Endothelial Growth Factor-A Signaling Induces Hypertension: Examining the Effect of Cediranib (Recentin; AZD2171) Treatment on Blood Pressure in Rat and the Use of Concomitant Antihypertensive Therapy

(2008) J. O. Curwen et al.   CLINICAL CANCER RESEARCH

The Role of Vascular Endothelial Growth Factor in Wound Healing

(2008) Philip Bao et al.   JOURNAL OF SURGICAL RESEARCH

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival

(2008) C. Chabot et al.   MOLECULAR AND CELLULAR BIOLOGY

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE