Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

(2017) Michael K. Pugsley et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Measuring kinetics and potency of hERG block for CiPA

(2017) Monique J. Windley et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

(2017) Hiroyuki Ando et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

(2017) Oliver J. Britton et al.   Frontiers in Physiology

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

(2017) Jose Vicente et al.   PLoS One

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

(2016) Luca Sala et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human pluripotent stem cell-derived cardiomyocyte based models for cardiotoxicity and drug discovery

(2016) Yimu Zhao et al.   Expert Opinion On Drug Safety

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease

(2016) Berend J. van Meer et al.   STEM CELLS

Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

(2016) Ksenia Blinova et al.   TOXICOLOGICAL SCIENCES

Human ex-vivo action potential model for pro-arrhythmia risk assessment

(2016) Guy Page et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

(2016) William J. Crumb et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials

(2016) C. Kang et al.   Scientific Reports

Transmural APD gradient synchronizes repolarization in the human left ventricular wall

(2015) Bastiaan J. Boukens et al.   CARDIOVASCULAR RESEARCH

Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial

(2015) L Johannesen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Assessing drug safety in human tissues — what are the barriers?

(2015) Anthony Holmes et al.   NATURE REVIEWS DRUG DISCOVERY

Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?

(2015) Christiaan C. Veerman et al.   STEM CELLS AND DEVELOPMENT

Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform

(2015) Yusheng Qu et al.   TOXICOLOGICAL SCIENCES

Enhanced Characterization of Contractility in Cardiomyocytes During Early Drug Safety Assessment

(2015) Larissa Butler et al.   TOXICOLOGICAL SCIENCES

Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2015) J. Vicente et al.   Journal of the American Heart Association

Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2014) L Johannesen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

(2014) Raffaele Coppini et al.   Jove-Journal of Visualized Experiments

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Preservation of cardiomyocytes from the adult heart

(2013) Najah Abi-Gerges et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay

(2013) Yusheng Qu et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Validation of an in vitro contractility assay using canine ventricular myocytes

(2012) A.R. Harmer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

On the relationship between block of the cardiac Na+channel and drug-induced prolongation of the QRS complex

(2011) AR Harmer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Organotypic slice culture from human adult ventricular myocardium

(2011) Matthias Brandenburger et al.   CARDIOVASCULAR RESEARCH

Transmural Heterogeneity and Remodeling of Ventricular Excitation-Contraction Coupling in Human Heart Failure

(2011) Qing Lou et al.   CIRCULATION

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

(2010) CE Pollard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Domperidone and Ventricular Arrhythmia or Sudden Cardiac Death

(2010) Charlotte van Noord et al.   DRUG SAFETY

Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study

(2010) Catherine B. Johannes et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative

(2009) Jonathan P. Piccini et al.   AMERICAN HEART JOURNAL

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long QT syndrome, a purely electrical disease? Not anymore

(2009) G. M. De Ferrari et al.   EUROPEAN HEART JOURNAL

Abnormal left ventricular relaxation in patients with long QT syndrome

(2009) L. Belardinelli et al.   EUROPEAN HEART JOURNAL

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

(2009) A. R. Lyon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome

(2008) K. H. Haugaa et al.   EUROPEAN HEART JOURNAL

Ranolazine Shortens Repolarization in Patients with Sustained Inward Sodium Current Due to Type-3 Long-QT Syndrome

(2008) ARTHUR J. MOSS et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY