Article
Biochemistry & Molecular Biology
Federica Tonolo, Alessandra Folda, Valeria Scalcon, Oriano Marin, Alberto Bindoli, Maria Pia Rigobello
Summary: This study found that the bioactive peptides K-8-K and S-10-S, derived from milk and soy, have both antioxidant and anti-inflammatory effects in human cells. They exert antioxidant effects through activation of the Keap1/Nrf2 pathway and exert anti-inflammatory effects by inhibiting the NF-κB pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Wenzhen Xu, Han Lu, Yuan Yuan, Zeyuan Deng, Liufeng Zheng, Hongyan Li
Summary: This study found that propolis and its main flavonoids have good antioxidant and anti-inflammatory effects. The flavonoids and propolis extract regulate cellular ROS levels, antioxidant enzyme activities, and inhibit the activation of NO, NOS, and NF-κB signaling pathways.
Article
Biochemistry & Molecular Biology
Hail Kim, Sanghee Han, Kwangho Song, Min Young Lee, BeumJin Park, In Jin Ha, Seok-Geun Lee
Summary: The study identified ethyl acetate (EtOAc) fractions of Papaver nudicaule and Papaver rhoeas as having lower toxicity and stronger activity in anti-inflammatory and antioxidant processes, inhibiting LPS-induced inflammation. By modulating oxidative stress pathways, the EtOAc fractions exhibited significant free radical scavenging activity.
Review
Biochemistry & Molecular Biology
Maja Jazvinscak Jembrek, Nada Orsolic, Lucija Mandic, Anja Sadzak, Suzana Segota
Summary: Neurodegenerative diseases are a major cause of disability and death worldwide, with pathways involving transcription factors playing a critical role in the pathological changes associated with oxidative stress and neuroinflammation. This review focuses on the role of transcription factor p53 in coordinating cellular response and potential therapeutic interventions using natural polyphenolic compounds with anti-oxidative, anti-inflammatory and anti-apoptotic effects. Further research is needed to fully understand the cellular and molecular mechanisms of these compounds for potential new treatments for neurodegenerative diseases.
Article
Nutrition & Dietetics
Wenxiu Ba, Wenzhen Xu, Zeyuan Deng, Bing Zhang, Liufeng Zheng, Hongyan Li
Summary: The study investigated the antioxidant and anti-inflammatory effects of tomato extract and its carotenoids lutein and lycopene. It was found that these compounds exhibited dose-dependent antioxidant effects but showed pro-oxidation effects at higher concentrations. The anti-inflammatory effects were enhanced at high concentrations and potentially mediated through the inhibition of the NF-kappa B signaling pathway.
Article
Pharmacology & Pharmacy
Catia Sousa, Bruno Miguel Neves, Alcino Jorge Leitao, Alexandrina Ferreira Mendes
Summary: In this study, the anti-inflammatory activity of (R)-(-)-carvone was explored. The results showed that (R)-(-)-carvone could inhibit the signaling pathways involving MAPKs and NF-kappa B. It was found that (R)-(-)-carvone significantly decreased the phosphorylation of JNK1 and inhibited the transcriptional activity of NF-kappa B. Moreover, (R)-(-)-carvone might exert its anti-inflammatory effect through the activation of Nrf2.
Article
Neurosciences
Mohamed H. Yousef, Mohamed Salama, Hassan A. N. El-Fawal, Anwar Abdelnaser
Summary: This study aims to explore the therapeutic utility of GSK3 inhibition in multimodal disease modification and emphasizes the difference in therapeutic value between selective isoform inhibition. The results reveal that GSK3 beta-selective inhibition has superior anti-inflammatory and anti-oxidative efficacy compared to GSK3 alpha-selective and non-selective pan-inhibition.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Biochemistry & Molecular Biology
Shuaishuai Du, Hongwei Wang, Jiaming Li, Weijun Huang, Xueyang Jiang, Enjing Cui, Le Du, Yang Wang
Summary: This study synthesized several novel compounds and identified compound 8s as a potential treatment for stroke due to its anti-inflammatory and antioxidant properties, and its protective effects on neuronal cells.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen, Kun Gao
Summary: This study isolated three unreported ent-abietane-type norditerpene lactones, named euphohelides A-C (1-3), from the whole plants of Euphorbia helioscopia L. The structures of euphohelides A-C were established using spectroscopic methods, computational ECD, and X-ray crystallographic analyses. Euphohelide A (1) is a novel 2-nor-ent-abietane lactone with a unique 5/6/6/5 tetracyclic system.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Medicinal
Wei Xu, Ming Bai, Ning-Ning Du, Shao-Jiang Song, Bin Lin, Xiao-Xiao Huang
Summary: Four undescribed compounds were isolated from Elephantopus scaber L., including one germacrane-type sesquiterpene lactone (1), alkaloid (2), and two neolignans (3-4). Their structures and absolute configurations were elucidated through various analytic methods. Compound 2 showed significant inhibitory activity against tyrosinase. Molecular docking was performed to study the interaction between compound 2 and tyrosinase.
Review
Biochemistry & Molecular Biology
Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: This review highlights the importance of ascorbate as a strong antioxidant and its various mechanisms of action. It also emphasizes the interaction of ascorbate with other antioxidants and its role in promoting antioxidant proteins and transcription factors.
Article
Chemistry, Medicinal
Fatma H. Al-Awadhi, Emily F. Simon, Na Liu, Ranjala Ratnayake, Valerie J. Paul, Hendrik Luesch
Summary: This study identified monounsaturated fatty acids and their analogues with antioxidant and detoxification enzyme activation activities. Further investigations demonstrated the anti-inflammatory potential of one of the compounds, which may be involved in the regulation of inflammation-related diseases such as multiple sclerosis. Additionally, the widespread occurrence of these compounds in marine algal samples from different locations suggests their important ecological roles in marine ecosystems.
Article
Medicine, Research & Experimental
Bee Kee Ooi, Su Wen Phang, Phelim Voon Chen Yong, Dinesh Kumar Chellappan, Kamal Dua, Kooi-Yeong Khaw, Bey Hing Goh, Priyia Pusparajah, Wei Hsum Yap
Summary: The study aimed to investigate the role of Nrf2 in the anti-inflammatory effects of MA in atheroma pathogenesis. Opposing effects of MA on Nrf2 expression were observed in HUVECs and THP-1 macrophages. Combined effects of MA and Nrf2 inhibitor ML385 suppressed the expression of MCP-1, VCAM-1, and SR-A.
Article
Plant Sciences
Yanhua Wu, Junfeng Shen, Liyan Wang, Yinzhi Lin, Shiori Kojima, Shoshiro Okada, Kazuo Umezawa
Summary: Safe and effective nonsteroidal anti-inflammatory drugs are necessary, and adding amino acids to cultures of microorganisms may increase the likelihood of discovering new secondary metabolites. Two new compounds, myceliostatins A and B, with the myceliothermophin structure were isolated from a methionine-enriched culture of Myceliophthora thermophila. Both compounds exhibited inhibition of LPS-induced NO production and had anti-inflammatory and antioxidant effects by suppressing NF-KB activity and reactive oxygen species production.
JOURNAL OF NATURAL PRODUCTS
(2023)
Review
Food Science & Technology
Ting Yi Heung, Jessica Yue Shuen Huong, Wan Yeng Chen, Yi Wen Loh, Kooi Yeong Khaw, Bey-Hing Goh, Yong Sze Ong
Summary: Papaya extracts or their bioactive compounds may serve as a potential broad-spectrum therapy for cancer by targeting multiple characteristics of cancer development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biology
Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen-Nee Tan, Kooi Yeong Khaw
Summary: Plant-derived terpenes have shown potential as cholinesterase inhibitors, making them a promising target for the treatment of Alzheimer's disease. Various terpenoids have been found to inhibit cholinesterase activity, with their chemical structures playing a role in this inhibition. This research encourages further exploration of terpenes for drug discovery and development in treating Alzheimer's disease.
Review
Food Science & Technology
Omar Belmehdia, Naoual El Menyiy, Abdelhakim Bouyahya, Aicha El Baaboua, Nasreddine El Omari, Monica Gallo, Domenico Montesano, Daniele Naviglio, Gokhan Zengin, Nadia Skali Senhaji, Bey Hing Goh, Jamal Abrini
Summary: This review discusses the recent advances in the chemical composition and biological activities of propolis. It highlights the various important bioactive properties of propolis, including antibacterial, antioxidant, and anticancer effects. Data shows that propolis has low toxicity even at high doses, making it a promising source of bioactive compounds for drug development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Pathology
Kar-Yan Su, Jie-Yi Koh Kok, Yie-Wei Chua, Shearn-Dior Ong, Hooi Leng Ser, Priyia Pusparajah, Pui San Saw, Bey Hing Goh, Wai-Leng Lee
Summary: Extracellular vesicles (EVs) are membrane-derived lipid bilayers released by cells. Bacterial EVs (BEVs) have attracted interest as potential diagnostic markers due to their differential bacterial composition in biofluids between patients and healthy controls. This review outlines the commonly used approach for investigating BEVs in biofluids, including 16S ribosomal RNA gene sequencing, and discusses the potential of BEVs as biomarkers for various diseases.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Nutrition & Dietetics
Shu Chyi Wong, Muhamad Noor Alfarizal Kamarudin, Rakesh Naidu
Summary: High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult tumors of the central nervous system. Introducing dietary flavonoids to the current high-grade adult-type diffuse glioma treatment strategies is crucial to overcome the challenge of intra-tumor heterogeneity. Flavonoids have the potential to target multiple molecules associated with high-grade adult-type diffuse glioma cell proliferation, apoptosis, oxidative stress, and other key processes.
Review
Medicine, General & Internal
Le-Wei Wong, Siow-Hui Mak, Bey-Hing Goh, Wai-Leng Lee
Summary: In conjunction with imaging analysis, pathology-based assessments of biopsied tissue are the gold standard for diagnosing solid tumors. However, the disadvantages of tissue biopsies have led to the development of liquid biopsy, which involves sampling and clinical assessment of bodily fluids for cancer diagnosis. Extracellular vesicles (EVs), carrying molecular profiles of their cell or tissue origins, have emerged as one of the most promising biomarkers for cancer, allowing for non-invasive and rapid diagnosis with the help of Fourier-transform infrared spectroscopy (FTIR).
Article
Health Care Sciences & Services
Qais Jarrar, Rami Ayoub, Kawther Alhussine, Khang Wen Goh, Said Moshawih, Chrismawan Ardianto, Bey Hing Goh, Long Chiau Ming
Summary: This study aimed to investigate the behavioral effects of prolonged maternal separation (MS) in the offspring of mice. The results showed that prolonged MS caused the adult offspring to exhibit anxiolytic-like behaviors and increased compulsive burying activity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Bingpeng Lin, Hooi Leng Ser, Lijing Wang, Jiang Li, Kok-Gan Chan, Learn-Han Lee, Loh Teng-Hern Tan
Summary: This review provides a comprehensive overview of the role of MMP12 in various oral diseases, including periodontitis, temporomandibular joint dysfunction, orthodontic tooth movement, and oral squamous cell carcinoma. Studies have shown the association of MMP12 expression with the pathogenesis of these oral diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Shahdadi, Maliheh Faryabi, Haroon Khan, Ali Salehi Sardoei, Bahman Fazeli-Nasab, Bey Hing Goh, Khang Wen Goh, Ching Siang Tan
Summary: This study examined the antibacterial effects of Mentha longifolia essential oil and pulegone in edible coatings on the growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli in cheese. The results showed that the addition of these compounds significantly reduced bacterial growth during storage. Increasing the concentration of chitosan, M. longifolia, and pulegone in the coatings further decreased the bacterial population, with pulegone exhibiting a stronger effect. Overall, the findings suggest that M. longifolia essential oil and pulegone, combined with alginate and chitosan coatings, have antibacterial effects against S. aureus, L. monocytogenes, and E. coli in cheese.
Article
Medicine, General & Internal
Najwa Hazwani Muhammad Haskani, Long Chiau Ming, Jagjit Singh Dhaliwal, Daniel Vui Teck Wee, Bey Hing Goh, Majid Ali, Shazwani Shaharuddin, Khang Wen Goh, Hui Poh Goh
Summary: This study aimed to identify and review research related to the practice of patients with DM in Brunei Darussalam in order to identify associated factors influencing diabetic medication knowledge and adherence. The results revealed relatively poor medication knowledge and inappropriate diabetes-related practices in studies conducted in Brunei Darussalam. However, no study has directly measured both medication awareness and compliance among Brunei Darussalam T2DM patients. Future studies can focus on the relation between these two factors in different geographical locations characterized by different diabetes-related practices and culture.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Editorial Material
Pharmacology & Pharmacy
Kah Hui Wong, Lee Wei Lim, Nur Shahirah Mohd Hisam, Muhamad Noor Alfarizal Kamarudin, Hariprasath Lakshmanan
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Brandon Wee Siang Phon, Saatheeyavaane Bhuvanendran, Qasim Ayub, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Summary: This study investigated the suitability of 3D cultures as cell-based models for GBM by leveraging genomic data. Genes related to pathways such as epithelial-to-mesenchymal transition, angiogenesis/migration, hypoxia, stemness, and the Wnt signalling pathway were found to be upregulated in both brain samples from GBM patients and 3D GBM cells. These findings support the use of 3D GBM cultures as reliable preclinical models for studying GBM.
Review
Biology
Dexter Hoi Long Leung, Brandon Wee Siang Phon, Mageswary Sivalingam, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Summary: In this scoping review, we identified a range of lncRNAs that play a regulatory role in GBM cells by modulating EMT markers, transcription factors, and the affiliated signalling pathways associated with MES transition. These findings provide an update on the complex interplays between lncRNAs, EMT markers, TFs, and signalling pathways in GBM cell studies.
Article
Biochemistry & Molecular Biology
Wei Hsum Yap, Bey Hing Goh
Review
Food Science & Technology
Wei-Shan Ang, Jodi Woan-Fei Law, Vengadesh Letchumanan, Kar Wai Hong, Sunny Hei Wong, Nurul Syakima Ab Mutalib, Kok-Gan Chan, Learn-Han Lee, Loh Teng-Hern Tan
Summary: A new probiotic, Christensenella minuta, was discovered in 2012 from healthy human stool. It is a subdominant commensal bacterium with highly heritable properties and has mutual interactions with other heritable microbiomes. Its relative abundance is positively correlated with the lean host phenotype. Various studies have shown its potential in managing metabolic diseases such as obesity, inflammatory bowel disease, and type 2 diabetes.