Article
Biochemistry & Molecular Biology
Neha Kukreti, Havagiray R. Chitme, Vinay K. Varshney, Basel A. Abdel-Wahab, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb
Summary: This study examined the antioxidant activities of Skimmia anquetilia using in vitro and in vivo models. The plant was found to contain multiple important active constituents with strong antioxidant, hepatoprotective, and nephroprotective activities. Further research on specific active constituents is recommended.
Article
Food Science & Technology
Ida Madiha Yusoff, Lee Suan Chua, Zarani Mat Taher
Summary: The study aimed to investigate the bioactive compounds and antioxidant activities in watermelon and wintermelon rinds using ultrasound-assisted extraction technique. The results showed that ultrasound-assisted extraction had higher total phenolic and total flavonoid content, as well as stronger antioxidant activity. The findings are important for the development and utilization of watermelon and wintermelon rinds as income-generating resources in agriculture and the food industry.
Article
Food Science & Technology
Mumtaz Ali, Habib Ullah, Wasim Ul Bari, Noor Ul Islam, Muhammad Zahoor, Riaz Ullah, Ahmed Bari
Summary: Extracts from Cotoneaster microphyllus showed good antioxidant, anticholinesterase, anthelmintic, and antimicrobial activities. The ethyl acetate fraction exhibited the highest activity and could be a potential candidate for further research.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2021)
Review
Biochemistry & Molecular Biology
Yoko Matsumura, Masahiro Kitabatake, Shin-ichi Kayano, Toshihiro Ito
Summary: Oxidative stress can cause diseases, but antioxidants in foods can prevent diseases and delay aging. Phenolic compounds, such as flavonoids, are present in plants and contribute to the bitterness and color of foods. Dietary phenolic compounds exhibit antioxidant activity and can prevent cell aging and diseases. The structures of these compounds can be changed by intestinal bacteria metabolism, and the resulting metabolites exert effects in vivo.
Review
Food Science & Technology
Zilanir Carvalho Pereira, Josias Martins dos Anjos Cruz, Renilto Frota Correa, Edgar Aparecido Sanches, Pedro Henrique Campelo, Jaqueline de Araujo Bezerra
Summary: This review focuses on the chemical composition, health benefits, and products derived from the pulps of Passiflora spp. over the last 5 years. Phenolic acids and polyphenols were among the major organic compounds found in the pulps of Passiflora spp. The fruits demonstrated antioxidant properties as well as inhibition of alpha-amylase and alpha-glucosidase enzymes. These findings indicate the potential use of Passiflora spp. in developing a variety of products, especially non-dairy beverages, to meet consumer demand for alternatives. Sensory analysis and in vivo tests are encouraged to further explore the development of pharmaceutical and food products with high value. Patents also show considerable interest in research and product development in various food technology areas, as well as biotechnology, pharmacy, and materials engineering.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Tawanda Tayengwa, Obert C. Chikwanha, Jeannine Neethling, Michael E. R. Dugan, Timothy Mutsvangwa, Cletos Mapiye
Summary: Feeding dried grape pomace (DGP) or citrus pulp (DCP) increased CLA, n-3 and n-6 PUFA, and reduced concentrations of aldehydes, ketones, and alcohols in beef, while also resulting in less tender meat compared to control diet.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Kristyna St'astna, Daniela Sumczynski, Erkan Yalcin
Summary: The study investigated the changes in nutritional composition, phenolic compounds, and antioxidant activity in free and bound fractions of shortcrust cookies by incorporating ingredients such as kamut, matcha tea, dried mango, and jasmine flowers. The contents of crude and neutral-detergent fibre, phenolic compound contents, and antioxidant activity values increased significantly in cookies supplemented with matcha tea. The main phenolic compounds identified in all supplemented cookies were neochlorogenic, gallic, and vanillic acids.
Article
Plant Sciences
Nusrat Bibi, Munir H. Shah, Nadeem Khan, Abdulrahman Al-Hashimi, Mohamed Soliman Elshikh, Akhtar Iqbal, Shakeel Ahmad, Arshad Mehmood Abbasi
Summary: The study aimed to evaluate the impact of growing conditions on total phenolic and total flavonoid contents, and in vitro antioxidant potential in different onion varieties. The results showed that the cultivation location, climatic conditions, and soil properties significantly affected the nutritional composition and antioxidant capacity of onions.
Article
Chemistry, Applied
Benjaporn Pawin, Ratchuporn Suksathan, Ratchadawan Puangpradab, Apinya Rachkeeree, Kuttiga Kantadoung
Summary: In this study, five selected medicinal plants from the ginger family were collected from Thailand. The content of phenolic compounds in their ethanolic extracts was determined, and their antioxidant and anticholinesterase activities were evaluated. The results showed that Meistera koenigii exhibited higher total phenolic contents, stronger antioxidant activity, and mild acetylcholinesterase effects, indicating its potential as a natural source of antioxidants and anticholinesterase agents in the pharmaceutical industry.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Chen Hsu, Hsin-Ya Tsai, Chi-Fon Chang, Chien-Chih Yang, Nan-Wei Su
Summary: Flavonoid O-phosphorylation provides a potent modification to enhance the oral bioavailability of flavonoids. The enzyme BsFPS, discovered in this study, efficiently catalyzes the phosphorylation of structurally-diverse flavonoids. The findings highlight the potential for developing biosynthetic platforms to obtain new phosphorylated flavonoids for pharmaceutical and nutraceutical applications.
Article
Plant Sciences
Dong-Jie Yin, Shi-Jie Ye, Xiao-Yan Sun, Qin-Yi Chen, Ting Min, Hong-Xun Wang, Li-Mei Wang
Summary: The biosynthesis pathways of phenolics in Trapa bispinosa were examined through transcriptome and metabolome analyses. Comparison of different tissues revealed up-regulation of genes related to phenolics synthesis in Trapa bispinosa shell. Metabolome analysis identified 202 differentially accumulated metabolites in different tissues.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Suwannee Sriyab, Nachtharinee Laosirisathian, Chanun Punyoyai, Songyot Anuchapreeda, Singkome Tima, Sawitree Chiampanichayakul, Wantida Chaiyana
Summary: This study investigated the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were extracted successively with 95% ethanol. Drying temperature and duration significantly affected the chemical composition and biological activity of A. officinalis extract. A. officinalis spear extract showed the highest MMP-1, elastase, and hyaluronidase inhibition rates, making it a potent source of natural anti-skin-wrinkle ingredients.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Fhatuwani Thovhogi, Godwin Richard Ainamensa Mchau, Eastonce Tendayi Gwata, Nombasa Ntushelo
Summary: Spider plant is an important leafy vegetable rich in minerals and phenolic compounds, with exotic genotypes generally superior to local genotypes in terms of mineral composition. Swiss chard has significantly higher levels of certain minerals, while spider plant genotypes vary in antioxidant capacity and phenolic content. The main flavonoid in spider plant leaves is quercetin-3-rutinoside, with a positive correlation between total phenolic content and flavonoids.
Article
Multidisciplinary Sciences
Ali Akbar, Zareen Gul, Nadia Hussain, Amal H. I. Al Haddad, Nazir Ahmad Khan, Muhammad Bilal Sadiq, Hassan Sher
Summary: This study evaluated the biochemical constituents, antioxidant, and antimicrobial potential of ethanolic grape peduncles (EGP) extract. The results showed the presence of various phytochemicals with antioxidant and antimicrobial activities. This suggests that grape peduncles could be a promising source of bioactive medicinal components.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Zongde Jiang, Zisheng Han, Mengting Zhu, Xiaochun Wan, Liang Zhang
Summary: This review summarizes the isomerization, degradation and polymerization products of polyphenols (PP) in food during thermal processing, as well as their interaction with other food components. The formation of new adducts and their contribution to flavor quality of food are also discussed. This review provides a new strategy for using PP to regulate food flavor in the future.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Pharmacology & Pharmacy
B. M. Gupta, K. K. Mueen Ahmed
Summary: This study conducted a bibliometric assessment of COVID-19 vaccine research publications in 2020, revealing that the USA, UK, and China were the most productive countries, with China, South Korea, and the USA having the highest impact. Top productive organizations included Harvard Medical School, University of Washington, and Fudan University, while the most impactful organizations were Tongji Medical College, Shanghai Medical College, and Chinese Center for Disease Control and Prevention from China.
JOURNAL OF YOUNG PHARMACISTS
(2022)
Article
Pharmacology & Pharmacy
Mallikarjun Kappi, Murthy Chavali, Chaman M. Sab, K. K. Mueen Ahmed
Summary: This study aims to compare the research output of nanocellulose in the world and India. The methodology involved data extraction from the Science Citation Index of Web of Science, analyzing research productivity, authorship pattern, collaboration, preferred sources, prolific authors, organizations, countries, and keywords. The results showed that multi-authored documents had a greater research impact, and the journal Carbohydrate Polymers had a significant influence in the field.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Editorial Material
Pharmacology & Pharmacy
Mueen K. K. Ahmed
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Article
Chemistry, Medicinal
Maged E. Mohamed, Nora Tawfeek, Samar S. Elbaramawi, Mahmoud H. Elbatreek, Eman Fikry
Summary: In this study, the chemical composition of ARBE was identified and the interaction between the major components of ARBE and RIRI-related targets was investigated using network pharmacology. The experimental results demonstrated the nephroprotective effect of ARBE in a rat model of RIRI.
Article
Biology
Maged E. Mohamed, Nancy S. Younis
Summary: The study found that pretreatment with D-carvone can protect the liver against damage induced by hepatic ischemia-reperfusion. D-carvone downregulates the expression of HMGB1, TLR4, NF kappa B, and NLP3, leading to a reduction in adhesion molecules, neutrophil infiltration, inflammatory mediators, and apoptotic markers.
Article
Biochemistry & Molecular Biology
Manar K. Alomair, Lama S. Alabduladheem, Marwah A. Almajed, Amjad A. Alobaid, Essraa A. R. Alkhalifah, Nancy S. Younis, Maged E. Mohamed
Summary: The study revealed that yarrow essential oil has a protective effect on the gastric mucosa, reducing ethanol-induced gastric ulcers and inflammation. This protective effect may be attributed to the antioxidant, anti-inflammatory, and anti-apoptotic actions of yarrow essential oil, as well as the activation of the Nrf2/HO-1 pathway.
Article
Biochemistry & Molecular Biology
Emad A. Ahmed, Hamad Abu Zahra, Rebai Ben Ammar, Maged Elsayed Mohamed, Hairul-Islam M. Ibrahim
Summary: β-Caryophyllene (BCP) enhances the anti-tumor activity of cisplatin (CDDP) on lung cancer cells by regulating the cell cycle, apoptosis, and EMT signaling molecules. BCP is non-toxic at moderate doses and can prevent lung cancer progression. The combination of BCP and CDDP upregulates the levels of CDKN1A and BCL-xl2, and downregulates the level of BCL-2, enhancing the chemotherapeutic function of CDDP.
Article
Biochemistry & Molecular Biology
Maged E. Mohamed, Nancy S. Younis, Hossam S. El-Beltagi, Omar M. Mohafez
Summary: This study demonstrates the superior hepatoprotective activity of curcumin and rosemary essential oil, as evidenced by reduced liver enzymes, lipid peroxidation, inflammatory and apoptotic biomarkers, and enhanced antioxidant activities. The combination of curcumin and rosemary essential oil also leads to increased plasma levels of curcumin, indicating a synergistic activity between these natural products.
Article
Nutrition & Dietetics
Rebai Ben Ammar, Maged Elsayed Mohamed, Manal Alfwuaires, Sarah Abdulaziz Alamer, Mohammad Bani Ismail, Vishnu Priya Veeraraghavan, Ashok Kumar Sekar, Riadh Ksouri, Peramaiyan Rajendran
Summary: This study aimed to investigate the impact of geraniol on Ox-LDL-induced stress and inflammation in human umbilical vein endothelial cells. The results show that geraniol pre-incubation ameliorates Ox-LDL-mediated HUVECs cytotoxicity and DNA fragmentation. Geraniol inhibited the production of pro-inflammatory cytokines by Ox-LDL and suppressed the nuclear translocation and activity of NF-ᴋB. Moreover, geraniol activated the PI3K/AKT/NRF2 pathway in HUVECs, resulting in an increase in the expression of HO-1.
Article
Green & Sustainable Science & Technology
Maged E. Mohamed, Ibrahim Abdelhamid Elshaer, Alaa M. S. Azazz, Nancy S. Younis
Summary: This study aimed to measure entrepreneurial intentions among junior healthcare students and fresh graduates in Saudi Arabia and identify their characteristics and personality dimensions. The results showed that healthcare students' entrepreneurial intentions were influenced by their proactiveness, innovativeness, internal locus of control, problem-solving, and autonomy, while risk-taking propensity had no significant effect on entrepreneurial intention.
Review
Food Science & Technology
Sarah F. Al-Subaie, Abdullah M. Alowaifeer, Maged E. Mohamed
Summary: Pyrrolizidine alkaloids are natural secondary metabolites found in many plants, which can be toxic to humans and mammals. Detecting these alkaloids in food is crucial for food security. This review summarizes the latest advances in extraction and analysis methods, with a focus on chromatographic-based analysis and determinations in food.
Article
Chemistry, Applied
Rebai Ben Ammar, Sarah Abdulaziz Alamer, Maged Elsayed Mohamed, Duaa Althumairy, Saeed Y. Al-Ramadan, Manal Alfwuaires, Nancy S. Younis, Thnaian A. Althnaian, R. I. H. Ibrahim, Peramaiyan Rajendran
Summary: An experimental study investigated the efficacy of geraniol (GNL) in protecting against cardiac toxicity induced by tilmicosin (TIL) in albino mice. The study found that supplementation with GNL resulted in thicker left ventricular walls and smaller ventricular cavities compared to TIL-treated mice. GNL also reduced the expression levels of pro-hypertrophy and fibrosis biomarkers.
NATURAL PRODUCT RESEARCH
(2023)
Article
Food Science & Technology
Nashi K. Alqahtani, Hisham A. Mohamed, Mahmoud E. Moawad, Nancy S. Younis, Maged E. Mohamed
Summary: This study aimed to optimize the extraction method for two cultivars of date palm fruits and investigate their protective effect against CCl4-induced liver toxicity. The optimized extracts showed enhanced antioxidant capacity, reduced inflammation and apoptosis, and improved DNA integrity, thus mitigating liver damage caused by CCl4.
Article
Chemistry, Medicinal
Nancy S. Younis, Maged E. Mohamed
Summary: This study aimed to explore the preventive actions of anethole (AN) in ameliorating cerebral ischemia/reperfusion-induced brain damage and BBB permeability leakage, as well as its potential mechanisms of action. The results showed that AN enhanced blood-brain barrier integrity, reduced oxidative stress, inflammation, and apoptosis through modulating MMPs, JNK/p38 pathway. This study revealed the neuroprotective ability of AN against cerebral ischemia/reperfusion in rats.
Article
Chemistry, Medicinal
Manar Khalid Alomair, Amjad Abdullah Alobaid, Marwah Abdulaziz Ali Almajed, Lama Salman Alabduladheem, Essraa Abdulrahman Alkhalifah, Maged Elsayed Mohamed, Nancy Safwat Younis
Summary: This study evaluated the anti-urolithic effect of grape seed extract (GSE) on ethylene glycol and ammonium chloride-induced urolithiasis in rats. The results showed that GSE could reduce urinary stone formation and increase the activity of urolithiasis inhibitors and antioxidant enzymes.
PHARMACOGNOSY MAGAZINE
(2023)