Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins

Purification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum Strain

(2016) Sabine Pellett et al.   mSphere

Functional Characterization of Botulinum Neurotoxin Serotype H as a Hybrid of Known Serotypes F and A (BoNT F/A)

(2015) Suzanne R. Kalb et al.   ANALYTICAL CHEMISTRY

A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin

(2015) Susan E. Maslanka et al.   JOURNAL OF INFECTIOUS DISEASES

Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons

(2015) Phillip H. Beske et al.   TOXICOLOGICAL SCIENCES

High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays

(2015) Kristin H. Gilchrist et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing

(2015) Phillip H. Beske et al.   Frontiers in Cellular Neuroscience

Botulinum Neurotoxin Vaccines:  Past history and recent developments

(2014) Janice M. Rusnak et al.   Human vaccines & immunotherapeutics

Validity of Botulinum Neurotoxin Serotype H

(2014) E. A. Johnson   JOURNAL OF INFECTIOUS DISEASES

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

High-Throughput Multi-Parameter Profiling of Electrophysiological Drug Effects in Human Embryonic Stem Cell Derived Cardiomyocytes Using Multi-Electrode Arrays

(2014) Mike Clements et al.   TOXICOLOGICAL SCIENCES

A Novel Strain of Clostridium botulinum That Produces Type B and Type H Botulinum Toxins

(2013) Jason R. Barash et al.   JOURNAL OF INFECTIOUS DISEASES

Network activity and spike discharge oscillations in cortical slice cultures from neonatal rat

(2012) Antonny Czarnecki et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity

(2012) Jasmin Strotmeier et al.   FEBS LETTERS

Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set

(2012) Emma R. McConnell et al.   NEUROTOXICOLOGY

Botulinum Neurotoxin Serotype a Specific Cell-Based Potency Assay to Replace the Mouse Bioassay

(2012) Ester Fernández-Salas et al.   PLoS One

Novel Application of Human Neurons Derived from Induced Pluripotent Stem Cells for Highly Sensitive Botulinum Neurotoxin Detection

(2012) Regina C. M. Whitemarsh et al.   TOXICOLOGICAL SCIENCES

Embryonic stem cell-derived neurons are a novel, highly sensitive tissue culture platform for botulinum research

(2011) Patrick McNutt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteomic assessment of a cell model of spinal muscular atrophy

(2011) Chia-Yen Wu et al.   BMC NEUROSCIENCE

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

(2011) Erkan Kiris et al.   Stem Cell Research

Botulinum Neurotoxin: A Marvel of Protein Design

(2010) Mauricio Montal   Annual Review of Biochemistry

The Case of Botulinum Toxin in Milk: Experimental Data

(2010) O. G. Weingart et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells

(2010) Sabine Pellett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century☆

(2010) Andrew F.M. Johnstone et al.   NEUROTOXICOLOGY

Effects of A2 type botulinum toxin on spontaneous miniature and evoked transmitter release from the rat spinal excitatory and inhibitory synapses

(2010) Norio Akaike et al.   TOXICON

Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination

(2010) Sabine Pellett et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Derivation of homogeneous GABAergic neurons from mouse embryonic stem cells

(2009) Christina Chatzi et al.   EXPERIMENTAL NEUROLOGY

Neural Differentiation of Embryonic Stem Cells In Vitro: A Road Map to Neurogenesis in the Embryo

(2009) Elsa Abranches et al.   PLoS One

Receptor and substrate interactions of clostridial neurotoxins

(2009) Axel T. Brunger et al.   TOXICON

Cortical Networks Grown on Microelectrode Arrays As a Biosensor for Botulinum Toxin

(2008) A. Scarlatos et al.   JOURNAL OF FOOD SCIENCE

Assessment: Botulinum neurotoxin in the treatment of autonomic disorders and pain (an evidence-based review)

(2008) M. Naumann et al.   NEUROLOGY