Article
Pharmacology & Pharmacy
Catarina Abrantes, Fernanda S. Tonin, Joana Reis-Pardal, Margarida Castel-Branco, Claudia Furtado, Isabel V. Figueiredo, Fernando Fernandez-Llimos
Summary: The study found that changes in DDD in 2009 led to decreases in the consumption of certain statins using the DDDYEAR approach, while gradual changes in overall statin consumption were indicated using the DDDLAST and PDDYEAR approaches in Portugal. Before 2009, the utilization of certain statins was greatly overestimated using the DDDYEAR/1000 inhabitants/day method.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Furqan A. Maulvi, Kiran H. Shetty, Ditixa T. Desai, Dinesh O. Shah, Mark D. P. Willcox
Summary: The human eye is a complex organ with unique anatomy and physiology that restricts drug delivery. Recent advances in pharmacy, biotechnology and material science have led to the development of novel ophthalmic dosage forms, improving drug delivery, reducing dosing frequency and enhancing ocular bioavailability. Different routes of drug administration and their advancements and limitations have been discussed in ophthalmic preparations from 2016 to 2020.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Eugenia Moreno-Dominguez, Ana Borrego-Sanchez, Rita Sanchez-Espejo, Cesar Viseras, Claro Ignacio Sainz-Diaz
Summary: In this study, the interaction between sulfathiazole and montmorillonite mineral was investigated experimentally and computationally to improve the drug's biopharmaceutical profile. The results showed that the inclusion of sulfathiazole in the interlayer space of montmorillonite significantly enhanced the drug's solubility. The experimental and theoretical results were in agreement.
Article
Pharmacology & Pharmacy
Patricia Helena Castro Nunes, Jessica Pronestino de Lima Moreira, Alessandra de Figueiredo Thompson, Thalita Lyrio da Silveira Machado, Jose Cerbino-Neto, Fernando Augusto Bozza
Summary: This study investigated the prevalence of antibiotic consumption and the deviation of prescribed daily dose (PDD) from defined daily dose (DDD) in Brazilian ICUs. The study found a high prevalence of antibiotic use, predominantly in empirical regimens and antibiotics belonging to the WHO Watch classification. The most prescribed antibiotics exhibited high variability of doses and large deviations of PDD from DDD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Nakirekanti Laxmi, J. Mohana
Summary: The transparency of blockchain technology allows for shared access to all the data on the blockchain, which can be valuable for managing diabetes. A hybrid algorithm is proposed to classify diabetic disorders and accurately calculate the ideal medicine dosage for diabetic patients. The proposed method achieves higher accuracy compared to other methods, reaching about 94%.
Article
Biotechnology & Applied Microbiology
Katherine C. Fein, John P. Gleeson, Kyle Cochran, Nicholas G. Lamson, Rose Doerfler, Jilian R. Melamed, Kathryn A. Whitehead
Summary: This study investigated the effects of chronic use of permeation enhancers on intestinal health in mice. Results showed that the mice gained weight and there was no increase in intestinal permeability after 30 days of treatment. Gene expression and protein localization did not show significant differences between treated and untreated mice. These findings suggest that some permeation enhancers may be therapeutically viable from a safety standpoint.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Joachim Kloehn, Clare R. Harding, Dominique Soldati-Favre
Summary: The Apicomplexa phylum relies on heme as cofactor for enzymes, obtaining it through de novo synthesis or uptake mechanisms. Different stages of the parasites have varying heme uptake strategies, with a synthesis pathway spanning three cellular compartments. Loss of certain heme synthesis enzymes is costly, indicating the parasites' ability to salvage heme precursors.
Review
Pharmacology & Pharmacy
Oyku Simsekli, Irfan Bilinmis, Sumeyye Celik, Gizem Arik, Abdullah Yucel Baba, Alptug Karakucuk
Summary: Biofilms are complex microbial communities that are highly resistant to conventional treatments. Nanotechnological drug delivery systems can enhance the efficacy of antimicrobial agents and allow targeted drug delivery. The route of administration and choice of dosage forms also play a crucial role in biofilm management.
JOURNAL OF DRUG TARGETING
(2023)
Article
Pharmacology & Pharmacy
Elin Dahlen, Jenny Marianne Kindblom, Elin Eyfells Kimland
Summary: A better measure of drug utilization in children, taking body weight into account, was proposed as the defined daily dose for children (cDDD) instead of the World Health Organization's DDD. There is currently no global definition of DDDs for children, and the appropriate standard doses for children in drug utilization studies remain unclear. Calculation of theoretical cDDD for three common medicines in Swedish children using authorized medical product information and body weight from national pediatric growth curves showed that cDDD may not be optimal for drug utilization studies in children, especially for younger children and when dosing is based on weight. Validation of cDDD with real-world data is necessary, and access to individual-level data on body weight, age, and dosing information is crucial for pediatric drug utilization studies.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Environmental Studies
Eliska Fnukalova, Vladimir Zyka, Dusan Romportl
Summary: This study aims to identify the green infrastructure network in Central Europe to improve ecological connectivity, promote species migration and dispersal, covering approximately 15% of the landscape and providing high levels of various ecosystem services.
Review
Pharmacology & Pharmacy
Jan Schjott, Lillan Mo Andreassen, Gro Helen Dale, Charlotte Lorentze Stokes
Summary: Patient-centric care aims to optimize healthcare services based on patients' needs and characteristics, but faces challenges in the older population due to physiological changes, comorbidity, and a high proportion of patients with dementia and frailty. Decision support regarding appropriate medication for older patients, including indication, formulation, dose, administration, and length of treatment, is frequently in demand.
Article
Chemistry, Medicinal
Christina Karavasili, Paola Zgouro, Natalia Manousi, Athina Lazaridou, Constantinos K. Zacharis, Nikolaos Bouropoulos, Thomas Moschakis, Dimitrios G. Fatouros
Summary: This study proposes a solution for medication administration in hospitalized pediatric patients by using semi-solid extrusion 3D printing. The study utilizes cereal as a carrier for drugs and evaluates the dispersion and dissolution enhancement of the drugs in the cereal through microscopy and dissolution studies.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Environmental Studies
Qingxiang Meng, Likun Zhang, Hejie Wei, Enxiang Cai, Dong Xue, Mengxue Liu
Summary: The study found that there was a mismatch in the spatial distribution of supply and demand for ecosystem services in the Yihe River Basin. While water yield and carbon sequestration decreased, food production and soil conservation increased from 2000 to 2018. Water yield faced considerable supply-demand risks, while the other three services were at low-risk levels. The Yihe River Basin was divided into eight types of supply-demand risk spatial management zones, which will help promote refined regional ecosystem management and sustainable development.
Article
Ecology
Niyati Naudiyal, Joachim Schmerbeck
Summary: Using niche modelling, the potential distribution of oak forests in Uttarakhand, India was identified, and the possible changes in ecosystem services without human disturbance were estimated. It was found that the region has a higher potential to support oak forests than its current distribution, and the best-suited course of action to increase ecosystem services is to support the succession of current forests to late-successional dense-oak forest community.
ECOSYSTEM SERVICES
(2021)
Article
Pharmacology & Pharmacy
Katarzyna Dettlaff, Aleksandra Gostynska, Natalia Ziolkowska, Maciej Stawny
Summary: In this study, the compatibility of KTF with eight commercial PN admixtures was investigated. The results showed that three of the mixtures were incompatible with KTF and should not be co-administered.
Review
Biochemistry & Molecular Biology
Sara Aboulaghras, Daniela Piancatelli, Khalid Taghzouti, Abdelaali Balahbib, Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh, Khang Wen Goh, Long Chiau Ming, Abdelhakim Bouyahya, Khadija Oumhani
Summary: Although HLA DQ2 and/or DQ8 genes increase the risk of developing celiac disease (CD), other factors such as genetics, the environment, and the immune system also play a role in the genesis of the disease. A comprehensive and meta-analytical study of adult CD patients was conducted to gain insight into the assessment and distribution of HLA class II (HLA-DQ2/DQ8) and explore screening techniques. DQ2/DQ2 homozygotes have the highest risk of developing CD, and DQ2/DQ8 typing is an effective test for differential diagnosis. The inclusion of non-HLA genes in diagnosis is limited due to their low contribution to the heritability of CD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Faiza Riaz, Md. Sanower Hossain, Miah Roney, Yousaf Ali, Saira Qureshi, Riaz Muhammad, Said Moshawih, Shafida Abd Hamid, Veronique Seidel, Haroon Ur Rashid, Long Chiau Ming
Summary: Antimicrobial drug resistance poses a serious threat to global public health, and the discovery of new antibacterial agents is urgently needed. Quinoline derivatives have shown a range of pharmacological properties, including potential antibacterial effects. This study evaluated the binding affinity of three newly designed hydroxyquinoline compounds to multiple bacterial protein targets, and identified two compounds that may serve as new antibiotic scaffolds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Prerana B. B. Jadhav, Shailaja B. B. Jadhav, Mehrukh Zehravi, Mohammad S. S. Mubarak, Fahadul Islam, Philippe Jeandet, Sharuk L. L. Khan, Nazmul Hossain, Salma Rashid, Long Chiau Ming, Md. Moklesur Rahman Sarker, Mohd Fahami Nur Azlina
Summary: The aim of this study was to synthesize carbohydrazide derivatives as DPP-IV inhibitors and evaluate their antidiabetic activity. Molecular docking, ADMET analysis, and drug-likeness guidelines were used for simulations. The synthesized compounds showed excellent hypoglycemic potential both in vitro and in vivo, and could be used as leads in developing novel antidiabetic agents.
Article
Infectious Diseases
Mohd Sayeed Shaikh, Mayura A. Kale, V. Muralidharan, T. Venkatachalam, Syed Sarfaraz Ali, Fahadul Islam, Sharuk L. Khan, Falak A. Siddiqui, Humaira Urmee, Ganesh G. Tapadiya, Sachin A. Dhawale, Long Chiau Ming, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Md. Moklesur Rahman Sarker, Mohd Fahami Nur Azlina
Summary: Thiazole and oxazole analogues of diaminopimelic acid (DAP) showed significant antibacterial efficacy, with MICs of 70-80 μg/mL against all tested bacteria. The docking scores revealed that the synthesized compounds interact more precisely with dapF than LL-DAP, suggesting their potential as inhibitors of bacterial cell wall synthesis. The structure-based drug design approach was used to synthesize these compounds.
Article
Medicine, General & Internal
Najwa Hazwani Muhammad Haskani, Long Chiau Ming, Jagjit Singh Dhaliwal, Daniel Vui Teck Wee, Bey Hing Goh, Majid Ali, Shazwani Shaharuddin, Khang Wen Goh, Hui Poh Goh
Summary: This study aimed to identify and review research related to the practice of patients with DM in Brunei Darussalam in order to identify associated factors influencing diabetic medication knowledge and adherence. The results revealed relatively poor medication knowledge and inappropriate diabetes-related practices in studies conducted in Brunei Darussalam. However, no study has directly measured both medication awareness and compliance among Brunei Darussalam T2DM patients. Future studies can focus on the relation between these two factors in different geographical locations characterized by different diabetes-related practices and culture.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Review
Public, Environmental & Occupational Health
Qlaementine Ng Xue Qin, Long Chiau Ming, Mohd Shahezwan Abd Wahab, Ching Siang Tan, Ana Yuda, Andi Hermansyah
Summary: This systematic review examined drug-related problems (DRPs) among patients with dementia or cognitive impairments, specifically focusing on medication misadventures such as adverse drug reactions (ADRs) and inappropriate drug use. The findings indicate a high prevalence of DRPs among dementia patients, especially older individuals. Medication misadventures, ADRs, and potentially inappropriate medication use were identified as the most common types of DRPs among older people with dementia.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2023)
Article
Multidisciplinary Sciences
Roheena Zafar, Inayat Ur Rehman, Yasar Shah, Long Chiau Ming, Hui Poh Goh, Khang Wen Goh
Summary: Patients with chronic kidney disease (CKD) in Pakistan, especially those in private hospitals, face a higher risk of potential drug-drug interactions (pDDIs). Older age and a higher number of prescribed drugs are independent risk factors for pDDIs.
Review
Multidisciplinary Sciences
Hui Ming Chua, Said Moshawih, Hui Poh Goh, Long Chiau Ming, Nurolaini Kifli
Summary: This article describes the application of computer-aided drug design and discovery based on anthraquinone scaffold in cancer treatment. Through a systematic review, it provides insights and trends in using this method to search for anti-cancer drugs. The study aims to support further research in similar areas and provide evidence-based guidance for the design of new drugs.
Article
Health Policy & Services
Roheena Zafar, Inayat Ur Rehman, Yasar Shah, Zahid Ali, Long Chiau Ming, Tahir Mehmood Khan
Summary: This study aimed to evaluate the knowledge, attitudes, and perceptions of pharmacists in the Khyber Pakhtunkhwa province and Islamabad regarding renal dose adjustments. The results showed that pharmacists had a relatively high level of knowledge and positive attitudes but a lower level of perception. The study highlights the importance of targeted training programs for pharmacists, access to reliable resources, and promoting research and dissemination of results in renal pharmacotherapy to improve public health outcomes.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Kaoshik Sureshkumar, Mahesh Durairaj, Kaviya Srinivasan, Khang Wen Goh, Krishna Undela, Vijayakumar Thangavel Mahalingam, Chrismawan Ardianto, Long Chiau Ming, Rajanandh Muhasaparur Ganesan
Summary: The aim of this review was to evaluate the efficacy of L-carnosine in patients with age-related diseases. Clinical studies showed that L-carnosine has potential therapeutic activity in age-related diseases such as diabetes mellitus and neurodegenerative disorders.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Biochemistry & Molecular Biology
Arab Gul, Haroon Khan, Sayyed Ibrahim Shah, Khalaf F. Alsharif, Safa H. Qahl, Inayat Ur Rehman, Khang Wen Goh, Chrismawan Ardianto, Long Chiau Ming
Summary: This study aims to investigate the potential protective mechanisms of peanut methanolic crude extract and n-hexane oil fraction against gentamycin-induced nephrotoxicity. The results show that both the crude extract and the oil fraction have significant reversal effects on gentamycin-induced nephrotoxicity.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Review
Oncology
Farheen Badrealam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah, Shahab Uddin, Qamar Zia, Manoj Kumar Jena, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Venkatesh Chanukuppa, Chrismawan Ardianto, Long Chiau Ming, Waqas Alam, Haroon Khan, Mohammad Akli Ayoub
Summary: This article reviews the use of proteomics to study the molecular details of phytochemicals such as curcumin, genistein, and tanshinone IIA. These phytochemicals have various pharmacological properties that are extensively studied to understand their mechanisms of action. Proteomics technology has proved to be a reliable approach to unravel the molecular intricacies of phytochemicals.
Article
Education, Scientific Disciplines
Rebecca Shin-Yee Wong, Long Chiau Ming, Raja Affendi Raja Ali
Summary: This viewpoint article presents the authors' perspective on the integration of AI models like ChatGPT in clinical medicine and medical education and highlights the ethical considerations. It emphasizes the potential of AI to reshape pedagogical methodologies in medical education and its significance in knowledge creation and dissemination. The importance of maintaining academic integrity and establishing clear guidelines is emphasized.
JMIR MEDICAL EDUCATION
(2023)
Review
Integrative & Complementary Medicine
Siti Raudhah Noor Shifa Putri Mohidin, Said Moshawih, Andi Hermansyah, Mohd Ikmal Asmuni, Naeem Shafqat, Long Chiau Ming
Summary: This systematic review provides a comprehensive summary of the nutritional and therapeutic properties of cassava, highlighting its diverse pharmacological activities and potential role in addressing global food crises.
JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Asif Massud, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Nafees Ahmad, Muhammad Shafqat, Long Chiau Ming
Summary: This study aimed to evaluate treatment outcomes and predictors of poor outcomes among drug-resistant tuberculosis patients in Punjab, Pakistan. The study found a treatment success rate below the WHO target, emphasizing the importance of special attention and timely intervention for high-risk patients.