The Evaluation of Pharmacodynamics and Pharmacokinetics of Anti-thrombin DNA Aptamer RA-36

Effect of thrombin inhibitors on positive feedback in the coagulation cascade

(2016) N. B. Ustinov et al.   BIOCHEMISTRY-MOSCOW

G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants

(2016) Elena Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

Development of Antithrombotic Aptamers: From Recognizing Elements to Drugs

(2016) Elena Zavyalova et al.   CURRENT PHARMACEUTICAL DESIGN

Specific antidotes against direct oral anticoagulants: A comprehensive review of clinical trials data

(2016) Ramyashree Tummala et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Translation and Clinical Development of Antithrombotic Aptamers

(2016) Shahid M. Nimjee et al.   Nucleic Acid Therapeutics

Modulation of the Coagulation Cascade Using AptamersSignificance

(2015) Rebecca S. Woodruff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evaluation of Antithrombotic Activity of Thrombin DNA Aptamers by a Murine Thrombosis Model

(2014) Elena Zavyalova et al.   PLoS One

Development and validation of a highly sensitive LC-MS/MS method for quantitation of bivalirudin in human plasma: application to a human pharmacokinetic study

(2013) Dong Chai et al.   BIOMEDICAL CHROMATOGRAPHY

Module-Activity Relationship of G-quadruplex Based DNA Aptamers for Human Thrombin

(2013) E. Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

Investigational anticoagulants for hematological conditions: a new generation of therapies

(2013) Gentian Denas et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Selection of an Aptamer Antidote to the Anticoagulant Drug Bivalirudin

(2013) Jennifer A. Martin et al.   PLoS One

A new paradigm shift in antithrombotic therapy

(2013) Anita Pudusseri et al.   Frontiers in Pharmacology

Population pharmacokinetics and pharmacodynamics of bivalirudin in young healthy Chinese volunteers

(2012) Dong-mei Zhang et al.   ACTA PHARMACOLOGICA SINICA

DNA Aptamers for Human Thrombin with High Anticoagulant Activity Demonstrate Target- and Species-Specificity

(2012) E. Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

Novel Modular DNA Aptamer for Human Thrombin with High Anticoagulant Activity

(2011) E. Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

Leech-Derived Thrombin Inhibitors: From Structures to Mechanisms to Clinical Applications

(2010) María Ángeles Corral-Rodríguez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY