Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2017.00214
Keywords
AMPA receptors; GluA1; GluA2; Gria1 knockout mice; Gria2 knockout mice; long-term potentiation (LTP); spatial working memory (SWM); spatial reference memory (SRM)
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Funding
- German Research Foundation (DFG) [SFB636/A4, SFB1134/B01]
- Max Planck Society
- EU Grant [QLRT-1999-01022]
- Letten Foundation
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Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LIP) at hippocampal CA3/CA1 synapses are dependent on L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout mice LTP and SWM deficits could be partially recovered by transgenic re-installation of full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site truncated GFP-GluA1(TG). In none of these three mouse lines, the partial LIP recovery improved the SWM performance of GluA1-deficient mice suggesting a specific function of intact GluA1/2 receptors and the GluA1 intracellular carboxyl-terminus in SWM and its associated behavior.
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