Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII

PSMA-targeted imaging of prostate cancer: the best is yet to come

(2016) Michael A. Gorin et al.   BJU INTERNATIONAL

Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities

(2016) Michal Navrátil et al.   FEBS Journal

Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA)

(2016) Pavel Majer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systemic Radioligand Therapy with 177Lu Labeled Prostate Specific Membrane Antigen Ligand for Imaging and Therapy in Patients with Metastatic Castration Resistant Prostate Cancer

(2016) Matthias M. Heck et al.   JOURNAL OF UROLOGY

Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine

(2015) Jan Tykvart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

[18F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)

(2015) Xing Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of Highly Potent Urea-Based, Exosite-Binding Inhibitors Selective for Glutamate Carboxypeptidase II

(2015) Jan Tykvart et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury

(2015) Yang Gao et al.   JOURNAL OF NEUROCHEMISTRY

Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery

(2014) Jan Tykvart et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Detection and quantitation of glutamate carboxypeptidase II in human blood

(2014) Tomáš Knedlík et al.   PROSTATE

Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA)

(2014) J. Tykvart et al.   PROSTATE

PSMA-Targeted Theranostic Nanoplex for Prostate Cancer Therapy

(2012) Zhihang Chen et al.   ACS Nano

68Ga-Complex Lipophilicity and the Targeting Property of a Urea-Based PSMA Inhibitor for PET Imaging

(2012) Matthias Eder et al.   BIOCONJUGATE CHEMISTRY

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Molecular Identification of β-Citrylglutamate Hydrolase as Glutamate Carboxypeptidase 3

(2011) François Collard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient and versatile one-step affinity purification of in vivo biotinylated proteins: Expression, characterization and structure analysis of recombinant human glutamate carboxypeptidase II

(2011) J. Tykvart et al.   PROTEIN EXPRESSION AND PURIFICATION

A low molecular weight PSMA-based fluorescent imaging agent for cancer

(2009) Ying Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods

(2009) Vojtěch Klusák et al.   BIOCHEMISTRY

Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II

(2009) Liqun Han et al.   SYNAPSE

Radiohalogenated Prostate-Specific Membrane Antigen (PSMA)-Based Ureas as Imaging Agents for Prostate Cancer

(2008) Ying Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs

(2008) Cyril Barinka et al.   JOURNAL OF MOLECULAR BIOLOGY