Article
Endocrinology & Metabolism
Elena Flowers, Bradley E. Aouizerat, Alka M. Kanaya, Jose C. Florez, Xingyue Gong, Li Zhang
Summary: This study identified 5 miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that can effectively predict the incidence of type 2 diabetes. After adjusting for covariates, the HR for the highest quartile risk group compared with the lowest quartile risk group was 5.91. There was significant interaction between the intensive lifestyle and metformin groups compared with placebo. These findings may have potential clinical utility for risk stratification of individuals with prediabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Sofie Dinesen, Alisar El-Faitarouni, Nanna Lond Skov Frisk, Anja Elaine Sorensen, Louise Torp Dalgaard
Summary: Gestational diabetes mellitus (GDM) is a severe complication during pregnancy, and identifying potential biomarkers for its early detection is crucial. This study conducted a systematic review and meta-analysis to investigate miRNAs associated with GDM. The findings suggest that certain miRNAs show altered expression in GDM, indicating their potential as biomarkers for early GDM detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Parkinson's disease (PD) and Diabetes Mellitus (DM) have been shown to have a connection in recent studies. This link has been discussed in the literature in relation to different mechanisms. miRNAs play a crucial role in regulating insulin pathways, glucose absorption, and PD-related genes, making them a potential therapeutic target for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Zhu-Qiu Jin
Summary: Cardiac fibrosis, a main characteristic of diabetic cardiomyopathy, is influenced by multiple signaling pathways, with TGF-beta/Smad2/3 pathway playing a central role. miRNAs, stable molecules involved in gene silencing, are dysregulated in the diabetic heart, promoting or inhibiting cardiac fibrosis by targeting various pathways in different cardiac cells. Detection of miRNAs in plasma or serum could potentially serve as biomarkers for diabetes mellitus or heart failure diagnosis, providing insight into the pathogenesis of cardiac fibrosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Xinyang Yu, Zhengfei Liu, Jie Fang, Hongbo Qi
Summary: miR-96-5p plays a significant role in diagnosing gestational diabetes mellitus (GDM), with decreased levels in both placenta and plasma samples of patients with GDM. It can serve as a diagnostic biomarker for GDM with high sensitivity and specificity, and may participate in the pathogenesis of GDM by affecting the viability of trophoblasts.
Article
Endocrinology & Metabolism
Tingting Lin, Shuyu Zhang, Yuchuan Zhou, Ligang Wu, Xinmei Liu, Hefeng Huang
Summary: The study found that physical exercise can effectively improve the negative impact of obesity on male fertility. Small noncoding RNAs, especially microRNAs in germ cells, may play a critical role in the effects of obesity and physical exercise on spermatozoa.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Yang Liu, Libo He, Wang Wang
Summary: The importance of physical exercise in reducing cancer risk and improving treatment efficacy in tumor patients, especially those with lung cancer, has long been known. Though several molecular mechanisms have been identified, the role of microRNAs (miRNAs) in relation to these processes is still unclear. This study aimed to identify and analyze miRNAs associated with lung cancer and exercise intervention. The results identified 42 marker miRNAs, of which three core miRNAs (has-miR-195, has-miR-26b, and has-miR-126) were found to be co-regulated by exercise and cancer, with involvement in cell cycle and immunity. This study supports the potential of exercise intervention as adjuvant therapy for lung cancer patients, with the identified core miRNAs potentially serving as non-invasive biomarkers for cancer prevention.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen
Summary: This study found that specific miRs were associated with coronary plaque components in patients with coronary artery disease. After aerobic exercise intervention, changes in miR levels were associated with a regression of coronary plaque burden. These findings may contribute to the development of biomarkers for coronary artery disease and coronary plaque composition.
PHYSIOLOGICAL GENOMICS
(2022)
Review
Biochemistry & Molecular Biology
Tingting Shi, Asahiro Morishita, Hideki Kobara, Tsutomu Masaki
Summary: miRNAs play crucial roles in the pathogenesis of cholangiocarcinoma, their potential as biomarkers for diagnosis and prognosis, and their utilization as novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Katarina Soltys, Leonard Lendvorsky, Ivan Hric, Eva Baranovicova, Adela Penesova, Ivan Mikula, Miroslav Bohmer, Jaroslav Budis, Silvia Vavrova, Jozef Grones, Marian Grendar, Martin Kolisek, Viktor Bielik
Summary: The study found that regular physical activity in elderly individuals has a positive effect on the microbiota composition, but little is known about the additional benefits of strenuous endurance training. By combining different omics approaches, the research aimed to analyze the physiology of elderly endurance athletes and identify biomarkers associated with endurance training. Strenuous athletic training was associated with higher cardiorespiratory fitness, lower body fat, and some favorable gut microbiota composition, all factors linked to slowing the rate of biological aging.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
H. M. Dumidu A. B. Attanayake, Adrian Barnett, Nicola W. Burton, Wendy J. Brown, Susanna M. Cramb
Summary: This study investigated the relationship between diabetes and physical activity in middle-aged adults. The findings suggest that BMI and gender have a stronger influence on physical activity than diabetes status.
Article
Microbiology
Galina S. S. Shepelkova, Vladimir V. V. Evstifeev, Ruslan V. V. Tarasov, Anush E. E. Ergeshova, Mamed A. A. Bagirov, Vladimir V. V. Yeremeev
Summary: This study focuses on finding biomarkers that can characterize the disease course in surgical tuberculosis patients. They examined a number of serum microRNAs as potential biomarkers for inflammation and fibrosis in tuberculosis, and used quantitative real time polymerase chain reaction and receiver operating curves to verify the data. The study identified several microRNAs that showed differential expression between different groups of patients, and further research is needed to validate these findings on a larger population.
Article
Biotechnology & Applied Microbiology
Lin Li, Andre Gorgens, Veronika Mussack, Elena Pepeldjiyska, Anne Sophie Hartz, Andreas Rank, Jorg Schmohl, Doris Kra''mer, Samir El Andaloussi, Michael W. Pfaffl, Helga Schmetzer
Summary: Extracellular Vesicles (EVs) play a crucial role in hematological malignancies, affecting bone marrow environment, immune system, drug resistance, and therapies. EVs collected from serum of leukemia samples have potential as biomarkers for disease pattern distinctions. This study aims to investigate the potential role and methodology of serum-derived EVs as biomarkers in leukemic versus healthy samples.
CANCER GENE THERAPY
(2022)
Article
Sport Sciences
Bok Sil Hong
Summary: Exercise-induced alterations in miRNAs can significantly influence the progression of breast cancer, with the expression of miRNAs being closely associated with patient prognosis. However, the prognostic value of different miRNAs varies depending on tumor stages and subtypes.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Green & Sustainable Science & Technology
Eeva Kettunen, Tuomas Kari, Lauri Frank
Summary: This study focuses on the experiences of young elderly individuals with a sport and wellness technology digital coach and finds that digital coaching has the potential to motivate them towards physical activity and improve their exercise self-efficacy. However, digital coaching devices need to be tailored and easy to learn to attract their interest.
Article
Hospitality, Leisure, Sport & Tourism
Alisson Gomes da Silva, Maicon Rodrigues Albuquerque, Ciro Jose Brito, Guilherme Martins Stroppa, Samuel Angelo Ferreira Oliveira, Manuel Sillero-Quintana, Joao Carlos Bouzas Marins
Summary: This study analyzed the skin temperature response of the same muscle groups undergoing different exercise demands in rowing. The results showed that manipulating the muscle groups involved in rowing altered the skin temperature response. These exercise-induced skin temperature changes can reflect local hemodynamic and thermoregulatory adjustments.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Ellen Caroline M. Silva, Luciana L. S. Barboza, Larissa Gandarela, Julian Tejada, Heike Schmitz, Thayse Natacha Gomes, Roberto Jeronimo S. Silva, Luis B. Sardinha, Danilo R. Silva
Summary: The aim of this study was to evaluate the effectiveness of a two-year intervention with physically active lessons on sedentary behavior and physical activity in elementary school children. The results showed a reduction in sedentary behavior and an increase in light physical activity over the two-year period. However, the effects observed in the first year were not maintained in the second year, and there were no differences in sitting time and moderate to vigorous physical activity.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Letter
Nutrition & Dietetics
Claudio Cordova, Ciro Jose Brito, Otavio Toledo Nobrega
CLINICAL NUTRITION ESPEN
(2023)
Article
Multidisciplinary Sciences
David N. Oliveira, Ellen Caroline M. Silva, Luciana L. S. Barboza, Mabliny Thuany, Raphael Henrique O. Araujo, Roberto Jeronimo S. Silva, Thayse Natacha Gomes, Heike Schmitz, Julian Tejada, Danilo R. Silva
Summary: The purpose of this study was to evaluate the impact of physically active lessons (PAL) on the cognitive performance of children. The intervention group showed improved cognitive performance in all tasks over the two-year follow-up, except for visual search. PAL was found to have modest improvements on various cognitive functions in children.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Geraldo Magela Fernandes, Lizandra Moura Paravidine Sasaki, Gabriela Profirio Jardim-Santos, Heidi Luise Schulte, Felipe Motta, Angelo Pereira da Silva, Aleida Oliveira de Carvalho, Yacara Ribeiro Pereira, Caroline de Oliveira Alves, David Alves de Araujo Junior, Dayde Lane Mendonca-Silva, Karina Nascimento Costa, Maria Eduarda Canellas de Castro, Lucas Lauand, Rodrigo de Resende Nery, Rosana Tristao, Patricia Shu Kurizky, Otavio de Toledo Nobrega, Laila Salmen Espindola, Luiz Claudio Goncalves de Castro, Patricia Nessralla Alpoim, Lara Carvalho Godoi, Luci Maria Sant Ana Dusse, Jordana Grazziela Alves Coelho-dos-Reis, Laurence Rodrigues do Amaral, Matheus de Souza Gomes, Pedro Luiz Lima Bertarini, Joaquim Pedro Brito-de-Sousa, Ismael Artur da Costa-Rocha, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhaes, Andrea Teixeira-Carvalho, Alberto Moreno Zaconeta, Alexandre Anderson de Sousa Munhoz Soares, Valeria Valim, Ciro Martins Gomes, Cleandro Pires de Albuquerque, Olindo Assis Martins-Filho, Licia Maria Henrique da Mota
Summary: This study aimed to characterize the immunological status of pregnant women with convalescent COVID-19 at different pregnancy trimesters. The results showed that pregnant women with COVID-19 had higher levels of chemokines, cytokines, and growth factors compared to the control group. The study suggests an imbalanced immune response during convalescent COVID-19 infection in pregnant women, which may contribute to late complications in the post-symptomatic phase.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
David Alves de Araujo Jr, Felipe Motta, Geraldo Magela Fernandes, Maria Eduarda Canellas De Castro, Lizandra Moura Paravidine Sasaki, Licia Pacheco Luna, Thalys Sampaio Rodrigues, Patricia Shu Kurizky, Alexandre Anderson De Sousa Munhoz Soares, Otavio de Toledo Nobrega, Laila Salmen Espindola, Alberto Moreno Zaconeta, Ciro Martins Gomes, Olindo Assis Martins-Filho, Cleandro Pires de Albuquerque, Licia Maria Henrique da Mota
Summary: This longitudinal prospective cohort study aimed to characterize the consequences of maternal and fetal inflammatory states in the central nervous system of newborns following maternal SARS-CoV-2 infection. Neuroimaging evaluation at 6 months revealed hyperechogenicity of deep brain white matter and basal ganglia, reduction in intracranial arterial flow indices, and decreased stiffness values in the SARS-CoV-2 exposed group compared to the control group.
FRONTIERS IN PEDIATRICS
(2023)
Article
Social Sciences, Interdisciplinary
Fabricia Silva de Lima, Marco Aurelio Oliveira Santos, Maria Creuziane Cardoso do Nascimento Ramos, Roberto Junio do Nascimento Silva, Silvan Mota Araujo
Summary: The State of Para has the worst municipal development indicators. The municipality of Alenquer in the State of Para is politically and economically unstable, which affects the coordination of public policies. This study analyzes intra-organizational relationships and their impact on the coordination of the Municipal Secretariat of Social Assistance of Alenquer.
REVISTA CIENTIFICA DA FACULDADE DE EDUCACAO E MEIO AMBIENTE
(2023)
Review
Biochemistry & Molecular Biology
Victor M. Baiao, Vinicius A. Cunha, Marvery P. Duarte, Francini P. Andrade, Aparecido P. Ferreira, Otavio T. Nobrega, Joao L. Viana, Heitor S. Ribeiro
Summary: Individuals with chronic kidney disease (CKD) show systemic inflammation. Exercise interventions significantly reduce levels of inflammatory markers and increase levels of IL-10 in individuals with CKD. Resistance interventions have greater anti-inflammatory effects compared to aerobic interventions. Combined exercise interventions do not lead to significant changes in inflammatory markers.
Article
Ergonomics
Juliana Lima Quintas, Isabela Oliveira Azevedo Trindade, Keli Silva Duarte Gameiro, Leonardo Santos Rocha Pitta, Einstein Francisco Camargos, Otavio Toledo Nobrega
Summary: This integrative review examined the cognitive deficits associated with mild cognitive impairment (MCI) or Alzheimer's disease (AD) that can impact driving. The review found that attentional capacity, processing speed, executive functions, and visuospatial skills were the most frequently reported functions declining in the context of unsafe driving by older adults with MCI or AD. The studies had heterogeneous methodological aspects and were limited in cross-cultural coverage and sample recruitment, suggesting a need for further research.
ACCIDENT ANALYSIS AND PREVENTION
(2023)
Article
Multidisciplinary Sciences
Lindsei Brabec Mota Barreto, Esteban Ariel Aedo-Munoz, Bianca Miarka, Dany Alexis Sobarzo Soto, Roberto Jeronimo dos Santos Silva, Felipe J. Aidar, Andreia Cristiane Carrenho Queiroz, Otavio de Toledo Nobrega, Ciro Jose Brito
Summary: This study compares the technical-tactical actions of female judokas in the approach and gripping phases between the 2016 and 2020 Olympic cycles, which had different rules. The findings reveal significant differences in the behavior of athletes between the two cycles, highlighting the importance of considering these changes in specialized training for female judo.
Article
Critical Care Medicine
Luciana Vieira, Paulo Eugenio Silva, Priscilla Flavia de Melo, Vinicius Maldaner, Joao Q. Durigan, Rita de Cassia Marqueti, Otavio Nobrega, Sunita Mathur, Chris Burtin, Fabricio Barin, Wilcelly Machado-Silva, Sergio Ramalho, Gaspar R. Chiappa, Nadia Oliveira Gomes, Celso R. F. Carvalho, Graziella F. B. Cipriano, Gerson Cipriano
Summary: This study aimed to investigate the effects of early neuromuscular electrical stimulation (NMES) on muscle quality and size in patients with traumatic brain injury (TBI). The results showed that NMES intervention preserved muscle size and quality and maintained normal levels of signaling mediators of muscle growth and inflammation in TBI patients. Therefore, early NMES can be beneficial for TBI patients.
CRITICAL CARE RESEARCH AND PRACTICE
(2023)
Review
Geriatrics & Gerontology
Wannessa Martins de Almeida, Juliana Lima Quintas, Isabela Oliveira Azevedo Trindade, Leonardo Santos Rocha Pitta, Luciana Lilian Louzada, Otavio Toledo Nobrega, Einstein Francisco Camargos
Summary: There are doubts about vehicle driving restriction for patients with Alzheimer's disease. There is no psychometric test sensitive enough to assess driving competence in older adults with cognitive deficits. There is no robust evidence to recommend or against stopping driving for patients with mild cognitive decline or mild dementia. Stopping driving can impact patients and their families, and there is a scarcity of legal regulations regarding driving for older adults and people with dementia worldwide.
Article
Geriatrics & Gerontology
Victor M. Baiao, Marvery P. Duarte, Vinicius A. Cunha, Gustavo i. Dourado, Diogo V. Leal, Joao L. Viana, Antonio J. Inda-Filho, Otavio T. Nobrega, Aparecido P. Ferreira, Heitor S. Ribeiro
Summary: The study showed that intradialytic resistance training can lead to modest improvements in body mass index, basal metabolic rate, and physical function performance in hemodialysis patients on short daily treatment.
FRONTIERS IN AGING
(2023)
