Review
Oncology
Caichen Li, Huiting Wang, Yu Jiang, Wenhai Fu, Xiwen Liu, Ran Zhong, Bo Cheng, Feng Zhu, Yang Xiang, Jianxing He, Wenhua Liang
Summary: Lung cancer screening is burdened with physical and mental health issues for patients worldwide. This review summarizes recent studies on lung cancer screening from the US, Europe, and Asia, and discusses risk-based selection for screening, novel techniques for differential diagnosis of pulmonary nodules, and current strategies for suspected malignancy.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wonchan Park, Seong-Woo Maeng, Jee Won Mok, Minji Choi, Hyung Joon Cha, Choun-Ki Joo, Sei Kwang Hahn
Summary: A facile method for early diagnosis of tumors is developed by extracting exosomes from interstitial fluid using hydrogel microneedles. The hydrogel MNs expand in the skin to absorb the ISF, and the tumor exosomes bind with the glypican-1 antibodies inside the hydrogel. Exosomes are separately purified from the ISF to analyze tumor-related biomarkers, and colorectal cancer can be diagnosed by ELISA for model mice. This noninvasive hydrogel MN system plays an important role in early cancer diagnosis.
Article
Biochemistry & Molecular Biology
Erika Bandini, Tania Rossi, Emanuela Scarpi, Giulia Gallerani, Ivan Vannini, Samanta Salvi, Irene Azzali, Mattia Melloni, Sara Salucci, Michela Battistelli, Patrizia Serra, Roberta Maltoni, William C. Cho, Francesco Fabbri
Summary: Breast cancer is the most commonly diagnosed malignant tumor in women, and the leading cause of cancer death. Studies suggest that extracellular vesicles could be important tools for diagnosing and monitoring the progression of breast cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Lukas Kalinke, Ricky Thakrar, Sam M. Janes
Summary: Survival rates for lung cancer are poor despite advances in targeted therapies and immunotherapies, but there is hope with improvements in early detection tools such as low-dose CT screening and biomarker research. However, challenges remain with LDCT screening primarily targeting high-risk individuals, suggesting a need for a synergistic, multimodal approach in the future for early lung cancer diagnosis.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Ruiyang Zou, Sau Yeen Loke, Yew Chung Tang, Heng-Phon Too, Lihan Zhou, Ann S. G. Lee, Mikael Hartman
Summary: This study conducted the largest comprehensive multi-center research to date and identified 30 dysregulated miRNAs associated with breast cancer. An optimized eight-miRNA panel was successfully validated in diverse ethnic groups and showed consistent performance. The panel has the potential to be used for breast cancer screening in conjunction with mammography.
BRITISH JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Sneha S. S. Pillai, Duane G. G. Pereira, Gloria Bonsu, Hibba Chaudhry, Nitin Puri, Hari Vishal Lakhani, Maria Tria Tirona, Komal Sodhi, Ellen Thompson
Summary: This study aims to develop a panel of novel biomarkers and circulating miRNAs for early screening of trastuzumab-induced cardiotoxicity in breast cancer patients. The results showed significant upregulation of biomarkers and circulating miRNAs specific to cardiac injury and remodeling at 3- and 6-months post trastuzumab therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna Daily, Prashanth Ravishankar, Steve Harms, V. Suzanne Klimberg
Summary: This study identified protein biomarkers with altered expression levels in tear samples from women diagnosed with breast cancer. Through LC-MS/MS analysis, 14 potential biomarkers were identified and validated by ELISA. The results showed significantly higher expression of S100A8 and S100A9 in breast cancer patients, while Galectin-3 binding protein had increased expression in the control group. These findings support the use of tear proteins in detecting systemic diseases such as breast cancer.
Review
Cell Biology
Tiago Brito-Rocha, Vera Constancio, Rui Henrique, Carmen Jeronimo
Summary: Cancer is a major cause of death worldwide due to late detection and limited therapeutic options. Existing screening procedures for most cancers have drawbacks, leading to low patient compliance and increased costs. Multi-cancer early detection (MCED) tests, combining molecular analysis and artificial intelligence, have emerged as a promising tool for early cancer detection.
Article
Materials Science, Multidisciplinary
X. Wu, Y. Li, M. Y. Yang, C. B. Mao
Summary: An ultrasensitive sensing system based on FRET effect was developed for simultaneous detection of two miRNAs, showing high sensitivity and good compatibility. The system utilized core@shell UCNPs and MoS2 nanosheets to achieve fluorescence recovery dependent on miRNA concentration, allowing accurate measurement of miRNA levels.
MATERIALS TODAY ADVANCES
(2021)
Review
Oncology
Jie Qiu, Da Qian, Yuancong Jiang, Liwei Meng, Liming Huang
Summary: Breast cancer is the most common form of cancer in women, and there is a need for more accurate and effective methods to detect it in the early stages. Blood-based biomarkers derived from the tumor microenvironment have emerged as potential targets for detecting breast tumors at various stages of progression. This review provides a comprehensive overview of the characteristics of early breast cancer and current approaches to detecting blood-based biomarkers.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Margarita Posso, Rodrigo Alcantara, Ivonne Vazquez, Laura Comerma, Marisa Bare, Javier Louro, M. Jesus Quintana, Marta Roman, Rafael Marcos-Gragera, Maria Vernet-Tomas, Francina Saladie, Carmen Vidal, Xavier Bargallo, Lupe Penalva, Maria Sala, Xavier Castells
Summary: This study evaluated mammographic features in women with benign breast disease (BBD) and their risk of subsequent breast cancer. Different BBD subtypes showed distinct mammographic findings, with women showing architectural distortion, multiple findings, asymmetries, and calcifications having a higher risk of subsequent breast cancer compared to those with masses.
EUROPEAN RADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shuyan Zhang, Qing Yang Steve Wu, Yi Fan Chen, Melissa Hum, Dave Chi Lok Wong, Ern Yu Tan, Ann Siew Gek Lee, Jinghua Teng, U. S. Dinish, Malini Olivo
Summary: In this study, a label-free detection method based on broadband multi-resonant infrared metasurface for surface-enhanced infrared absorption (SEIRA) spectroscopy was used to detect miRNAs as biomarkers for breast cancer. The SEIRA resonances were optimized and showed a simulated resonance enhancement of up to 10(3) times. Testing on nine patient samples demonstrated good linear correlation with industry standards and introduced a novel analysis method. The findings pave the way for routine cancer diagnosis and have the potential for application in other biosensing activities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marta Roman, Javier Louro, Margarita Posso, Rodrigo Alcantara, Lupe Penalva, Maria Sala, Javier del Riego, Miguel Prieto, Carmen Vidal, Mar Sanchez, Xavier Bargallo, Ignasi Tusquets, Xavier Castells
Summary: The study shows that breast density and benign breast disease have independent effects on the risk of breast cancer, with women with benign breast disease and extremely dense breasts having a significantly higher risk of developing breast cancer.
EUROPEAN RADIOLOGY
(2021)
Review
Oncology
Karen Pinilla, Lynsey M. Drewett, Rebecca Lucey, Jean E. Abraham
Summary: Personalised approaches to the management of triple-negative breast cancers (TNBC) are important due to the disease's heterogeneity and distinct molecular alterations. Historically, cytotoxic chemotherapy has been the mainstay of treatment for TNBC, but it is associated with off-target tissue toxicity and drug resistance. Neoadjuvant chemotherapy is commonly used and provides valuable prognostic information. Platinum chemotherapy, DNA damage response (DDR) inhibitors, immune checkpoint inhibitors, inhibitors of the PI3K-AKT-mTOR, and androgen receptor (AR) pathways are increasingly studied therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jonine D. Figueroa, Ewan Gray, Nora Pashayan, Silvia Deandrea, Andre Karch, Diama Bhadra Vale, Kenneth Elder, Pietro Procopio, Nicolien T. van Ravesteyn, Miriam Mutabi, Karen Canfell, Carolyn Nickson
Summary: The COVID-19 pandemic has disrupted access to cancer-related services, including timely breast cancer screening and treatment, which may lead to increased mortality and more intensive treatment requirements. Modelled evaluations can help estimate short- and long-term outcomes and inform international priorities for recovery efforts in the face of the pandemic. Collaborations from the Covid and Cancer Modelling Consortium (CCGMC) Working Group 2 (Breast Cancer) aim to mitigate the impact of the pandemic on early diagnosis and treatment of breast cancer through analysis and modelling studies.
PREVENTIVE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Marcella Marinelli, Anne-Elie Carsin, Michelle C. Turner, Ana Fernandez-Somoano, Ana Cristina Rodriguez-Dehli, Mikel Basterrechea, Loreto Santa-Marina, Carmen Iniguez, Maria-Jose Lopez-Espinosa, Jordi Sunyer, Jordi Julvez
Summary: The study found that for mothers who slept less than 7 hours a day before pregnancy, each additional hour of sleep increased neonate birth weight score by 44.7 g. However, for mothers who slept more than 9 hours a day during pregnancy, each additional hour of sleep decreased birth weight score by 39.2 g.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Oncology
Jose M. Quintana, Ane Anton-Ladislao, Santiago Lazaro, Nerea Gonzalez, Marisa Bare, Nerea Fernandez de Larrea, Maximino Redondo, Antonio Escobar, Cristina Sarasqueta, Susana Garcia-Gutierrez, Urko Aguirre, Eduardo Briones
Summary: According to this study, proper implementation of quality indicators in patients with colorectal cancer can reduce mortality but increase the risk of adverse outcomes.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Environmental Sciences
Miguel Garcia-Villarino, Antonio J. Signes-Pastor, Margaret R. Karagas, Isolina Riano-Galan, Cristina Rodriguez-Dehli, Joan O. Grimalt, Eva Junque, Ana Fernandez-Somoano, Adonina Tardon
Summary: This study found that exposure to metal mixtures impacts growth indicators in children, with negative associations between cadmium and arm circumference, head circumference, and standing height, as well as lead and cobalt with reduced standing height and head circumference, and a positive association between molybdenum and head circumference.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Mireia Utzet, Fernando G. Benavides, Rocio Villar, Andrea Buron, Maria Sala, Luis-Eugenio Lopez, Pau Gomar, Xavier Castells, Pilar Diaz, Jose Maria Ramada, Consol Serra
Summary: This study assessed the impact of non-pharmacological preventive measures against COVID-19 on healthcare workers and found that these measures significantly reduced the incidence rate of COVID-19. It is necessary to identify which measures were more effective and strengthen preventive efforts for young workers and those with replacement contracts.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Merce Comas, Laia Domingo, Anna Jansana, Elisabeth Lafuente, Anna Civit, Lidia Garcia-Perez, Carmen Lasso de la Vega, Francesc Cots, Maria Sala, Xavier Castells
Summary: This study evaluated the cost-effectiveness of using PICCs by a VAT compared to CVCs for in-hospital TPN. The results showed that PICCs had a longer average duration, lower infection rate, and lower overall costs compared to CVCs. Therefore, PICCs may be a more cost-effective choice.
JOURNAL OF PATIENT SAFETY
(2022)
Article
Medicine, General & Internal
Laia Domingo, Merce Comas, Anna Jansana, Javier Louro, Helena Tizon-Marcos, Maria Lourdes Cos, Jaume Roquer, Juan Jose Chillaron, Isabel Cirera, Sergi Pascual-Guardia, Maria Sala, Xavier Castells
Summary: This study assessed the impact of the COVID-19 pandemic on non-COVID diseases and healthcare quality. The results showed a decrease in hospitalization rates during the pandemic, with reductions in admissions related to respiratory and circulatory diseases and an increase in admissions for endocrine and metabolic diseases. Complication rates increased, but in-hospital mortality rates remained steady. Overall, the study highlights the potential public health consequences of reduced hospitalizations for conditions requiring timely treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Guillermo Bosch, Merce Comas, Laia Domingo, Anna Guillen-Sola, Esther Duarte, Xavier Castells, Maria Sala
Summary: This study characterized dysphagia and its association with aspiration pneumonia and mortality in a tertiary hospital in Barcelona, Spain. The results showed that dysphagia was present in 2.4% of all hospital discharges and was more frequent in older patients and in men. The most common diagnoses associated with dysphagia were aspiration pneumonia (48.2%) and stroke (14%). Dysphagia was associated with a higher risk of aspiration pneumonia and increased mortality among hospitalized patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Health Care Sciences & Services
Carme Miret, Miren Orive, Maria Sala, Susana Garcia-Gutierrez, Cristina Sarasqueta, Maria Jose Legarreta, Maximino Redondo, Amado Rivero, Xavier Castells, Jose M. Quintana, Olatz Garin, Montse Ferrer
Summary: The purpose of this study is to obtain reference norms for EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L based on a population of Spanish non-metastatic breast cancer patients. The study found independent associations between age, comorbidity, and tumor stage with health-related quality of life (HRQoL). These reference norms can be useful for interpreting scores of non-metastatic breast cancer patients and comparing them with country-specific reference values.
QUALITY OF LIFE RESEARCH
(2023)
Article
Health Care Sciences & Services
Daniel G. Abietar, Laia Domingo, Laura Medina-Perucha, Nuria Saavedra, Anna Berenguera, Laia Lacueva, Marta Hurtado, Xavier Castells, Maria Sala
Summary: This study aimed to explore patients' and companions' perceptions, attitudes, and experiences of patient safety, taking into account contextual factors such as cultural background. The study found that good communication, a calm environment, and patient education were important factors. Different cultural backgrounds led to different attitudes towards patient safety. The findings of this study could enrich interventions in areas with diverse cultural backgrounds.
HEALTH EXPECTATIONS
(2023)
Article
Multidisciplinary Sciences
Rocio Fernandez-Iglesias, Ana Fernandez-Somoano, Cristina Rodriguez-Dehli, Rafael Venta-Obaya, Isolina Riano-Galan, Adonina Tardon
Summary: This study aimed to investigate subgroups of children with different clusters of cardiovascular disease (CVD) risk factors at 4 and 8 years of age, and their patterns of change between these two time points. At 4 years, three subgroups were identified: no disorders (55.9%); some disorders (21.2%), and central obesity (22.9%). At 8 years, three subgroups were identified: no disorders (59.8%); hypertension (17.9%), and central obesity (22.3%). Children who did not present any disorder at 4 years tend to remain in that state at 8 years. Central obesity may play a major role in the development of other disorders.
Article
Environmental Sciences
L. Notario-Barandiaran, A. Irizar, M. Begona-Zubero, R. Soler-Blasco, G. Riutort-Mayol, A. Fernandez-Somoano, A. Tardon, M. Casas, M. Vrijheid, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J. O. Grimalt, J. Vioque, A. J. Signes-Pastor
Summary: In this study, the association between adherence to the Mediterranean diet (MD) and urinary metal concentrations in children was evaluated. It was found that high adherence to MD was associated with increased urinary levels of arsenic and copper, but also an increase in non-toxic arsenobetaine concentrations.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Elba Mauriz, Jose P. Fernandez-Vazquez, Cristina Diez-Flecha, Sofia Reguero-Celada, Tania Fernandez-Villa, Ana Fernandez-Somoano, Joan A. Cayla, Jesus A. Lozano-Garcia, Ana M. Vazquez-Casares, Vicente Martin-Sanchez
Summary: This study investigated the impact of a COVID-19 outbreak in a long-term care facility for the elderly after the initial vaccination. The results showed that 75.0% of residents and 56.3% of workers tested positive 4 days after vaccination. Among the 68 vaccinated individuals, 95.58% of the elderly residents were infected with symptoms, with 34.9% requiring hospitalization and 25.8% dying.
Article
Mathematics
Rocio Fernandez-Iglesias, Pablo Martinez-Camblor, Adonina Tardon, Ana Fernandez-Somoano
Summary: This study presents an analysis of cardiovascular measures in children, discussing the challenges in dealing with missing data and selecting the appropriate regression model. It also explores the impact of different decisions on the results.
