Article
Behavioral Sciences
Fumiaki Yokoi, Huan-Xin Chen, Janneth Oleas, Mai Tu Dang, Hong Xing, Kelly M. Dexter, Yuqing Li
Summary: DYT1 dystonia is mainly caused by a trinucleotide deletion in the DYT1 gene, resulting in decreased activities to dopamine receptors. Both D1R and D2R antagonists showed reduced responsiveness in Dyt1 KI mice, while Dyt1 d1KO mice exhibited behavioral abnormalities and defective striatal D1R-expressing medium spiny neurons. This suggests that torsinA plays a crucial role in electrophysiological function and motor performance in D1R-expressing cells, with potential implications for medical interventions targeting the direct pathway.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Xiaoying Tan, Cynthia M. Ingraham, William J. McBride, Zheng-Ming Ding
Summary: The study demonstrates that cotinine can be self-administered by activating the mesolimbic dopamine system, which may represent one cellular mechanism underlying cotinine self-administration. The shared activation mechanism between cotinine and nicotine suggests that cotinine may play a role in nicotine reinforcement.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Riccardo Viaro, Francesco Longo, Fabrizio Vincenzi, Katia Varani, Michele Morari
Summary: Previous studies have demonstrated that L-DOPA can enhance dopamine release through SCH23390-sensitive D1 receptors and potentially promote dopamine efflux via conversion to dopamine and reversal of the DA transporter.
Article
Behavioral Sciences
Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Summary: Multiple neural systems, including dopamine D1 receptors and glutamate NMDA receptors, are involved in nicotine reinforcement. Acute blockade of D1 receptors decreases nicotine self-administration, while acute blockade of NMDA receptors increases it. Chronic blockade of NMDA receptors decreases nicotine self-administration. Memantine attenuates the decrease in nicotine self-administration caused by chronic D1 antagonist SCH-23390.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2024)
Article
Neurosciences
Madeleine Cleal, Barbara D. Fontana, Matthew O. Parker
Summary: Zebrafish are increasingly used as a model for understanding drug dependence and addiction. Chronic treatment with drugs like AMPH or NIC boosts cognitive performance in adult zebrafish, leading to enhanced working memory. However, repeat exposure to AMPH may inhibit cognitive flexibility, while repeat exposure to NIC does not have the same effect.
PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Anne-Emilie Allain, Oceane Aribo, Maria-Carmen Medrano, Marie-Line Fournier, Sandrine S. Bertrand, Stephanie Caille
Summary: The deletion of TRPV1Rs gene reduces nicotine-induced locomotor sensitization and acts as a regulator of inhibitory synaptic transmission in ventral tegmental area (VTA) neurons.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Douglas Asede, Divyesh Doddapaneni, M. McLean Bolton
Summary: Generating adaptive behavioral responses to emotionally salient stimuli requires evaluation of complex associations between multiple sensations, the surrounding context, and current internal state. Neural circuits within the amygdala parse this emotional information and evoke appropriate responses through their projections to the brain regions orchestrating these behaviors. Intercalated cells (ITCs) within the amygdala regulate information flow and play a key role in emotional learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Lufei Wang, Lichi Han, Peng Xue, Xiangxiang Hu, Sing-Wai Wong, Meng Deng, Henry C. Tseng, Bo-Wen Huang, Ching-Chang Ko
Summary: The study found that dopamine inhibits osteoclast differentiation through the D2R/cAMP/PKA/CREB pathway. This reveals a potential mechanism for how the nervous system impacts bone remodeling and suggests future research directions for understanding bone development, repair, aging, and degenerative diseases.
CELLULAR SIGNALLING
(2021)
Article
Clinical Neurology
Jillian J. Weeks, Anthony A. Grace, Alan F. Sved
Summary: The study showed that both acute and chronic administration of nicotine improved deficits in schizophrenia-like behaviors and normalized neuronal activity in specific brain regions in the schizophrenia rodent model. These findings support the self-medication hypothesis for smoking in schizophrenia and suggest the potential of nicotinic modulation in future pharmacotherapies.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jie Zhou, Cheng Peng, Qiuju Li, Xiaoyu Yan, Liang Yang, Mengting Li, Xiaoyu Cao, Xiaofang Xie, Dayi Chen, Chaolong Rao, Sizhou Huang, Fu Peng, Xiaoqi Pan
Summary: Aconitine exposure induces neurotoxicity and affects the dopaminergic system. Aconitine alters dopamine levels and activates the AC/cAMP/PKA pathway through dopamine receptors, disrupting intracellular calcium homeostasis and resulting in nerve cell damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Constanza Garcia-Keller, Jordan S. Carter, Anna Kruyer, Angela M. Kearns, Jordan L. Hopkins, Ritchy Hodebourg, Peter W. Kalivas, Carmela M. Reichel
Summary: Exposure to acute stress can lead to enduring plasticity in the nucleus accumbens of rats, affecting both behavior and neuroplasticity. The stress-induced behavioral changes are correlated with dendritic spine morphology, and stressed female rats exhibit a preference for sweet solutions and higher motivation to seek sucrose.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Wesley Drew Gill, Katherine C. Burgess, Cynthia Vied, Russell W. Brown
Summary: Administration of neonatal quinpirole (NQ) to rats results in transgenerational effects of increased dopamine D-2 (DAD(2)) receptor sensitivity, sensorimotor gating deficits, and enhanced behavioral responses to nicotine in the F1 generation. RNA-Seq analysis revealed significant gene expression changes associated with stress hormones and cell signaling pathways. These findings provide insights into the hereditary transmission of altered dopamine signaling and associated behaviors in rodents.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Kruyer, Jeffrey Parrilla-Carrero, Courtney Powell, Lasse Brandt, Stefan Gutwinski, Ariana Angelis, Reda M. Chalhoub, Thomas C. Jhou, Peter W. Kalivas, Davide Amato
Summary: Antipsychotic-induced dopamine supersensitivity is a problematic consequence of long-term antipsychotic treatment, characterized by motor abnormalities, refractory symptoms, and rebound psychosis. This phenomenon is associated with long-lasting synaptic plasticity and hyperexcitability in a subpopulation of D2 receptor-expressing neurons, leading to behavioral endophenotypes of treatment resistance and substance use disorder. Chemogenetic restoration of inhibitory postsynaptic currents may offer a novel therapeutic direction for preventing antipsychotic-induced supersensitivity.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Renan dos Santos-Baldaia, Raphael Wuo-Silva, Viviam Sanabria, Marilia A. Baldaia, Thais S. Yokoyama, Antonio Augusto Coppi, Andre W. Hollais, Eduardo A. V. Marinho, Alexandre J. Oliveira-Lima, Beatriz M. Longo
Summary: The present study aimed to characterize behavioral sensitization to cocaine and identify the neuroanatomical structures involved in its induction and expression phases. Mice were treated with saline or cocaine every second day for 15 days during the conditioning period (experiment 1) in either the open-field or their home-cages for the induction phase, and then not manipulated for 10 days followed by cocaine challenge for the expression phase (experiment 2). Stereological quantification of c-Fos staining in different brain regions revealed higher expression in the dorsomedial prefrontal cortex (dmPFC), nucleus accumbens core (NAc core), basolateral amygdala (BLA), and ventral tegmental area (VTA) during the induction phase, and higher expression in almost all areas except VTA during the expression phase. Hence, environmental context and specific brain structures play important roles in the induction and expression of behavioral sensitization.
Article
Neurosciences
Yukari Nakamura, Sophie Longueville, Akinori Nishi, Denis Herve, Jean-Antoine Girault, Yuki Nakamura
Summary: The study indicates that chemogenetic inhibition of D1-neurons reduces both spontaneous and cocaine-induced locomotor activity, prevents sensitization induction, and blocks sensitized locomotion in a two-injection protocol of sensitization, but does not reverse established sensitization.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
John Kealy, Sean Commins, John P. Lowry
Article
Optics
Zhengyuan Tang, Sinead J. Barton, Tomas E. Ward, John P. Lowry, Michelle M. Doran, Hugh J. Byrne, Bryan M. Hennelly
Article
Biochemical Research Methods
J. J. O'Connor, K. M. O'Boyle, J. P. Lowry
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Neurosciences
Sinead M. Lanigan, John J. O'Connor
Article
Neurosciences
Sinead Lanigan, Alan E. Corcoran, Audrey Wall, Gatambwa Mukandala, John J. O'Connor
Article
Chemistry, Analytical
Keeley L. Baker, Fiachra B. Bolger, Michelle M. Doran, John P. Lowry
Review
Neurosciences
Sinead M. Lanigan, John J. O'Connor
Article
Neurosciences
John Kealy, Carol Murray, Eadaoin W. Griffin, Ana Belen Lopez-Rodriguez, Daire Healy, Lucas Silva Tortorelli, John P. Lowry, Leiv Otto Watne, Colm Cunningham
JOURNAL OF NEUROSCIENCE
(2020)
Article
Chemistry, Analytical
Kobi P. Bermingham, Michelle M. Doran, Fiachra B. Bolger, John P. Lowry
Summary: The performance optimization of a polymer/enzyme composite biosensor for monitoring glutamate was conducted in vitro. The biosensor displayed appropriate sensitivity, stability, and biocompatibility, and reliably detected glutamate in neurological monitoring. Implantation experiments in rats demonstrated stable recording and reliable detection of physiological changes in glutamate in response to behavioral/neuronal activation.
ANALYTICA CHIMICA ACTA
(2022)
Article
Neurosciences
Niamh Moreton, Martina Puzio, John J. O'Connor
Summary: This study investigated the effects of the ROS scavenger MnTMPyP on synaptic transmission in hypoxia and OGD models, revealing a modulatory effect specific to the CA1 region of the hippocampus and a protective role in cell viability post hypoxia and OGD.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Martina Puzio, Niamh Moreton, Mairead Sullivan, Caitriona Scaife, Jeffrey C. Glennon, John J. O'Connor
Summary: Metabolic stress and ROS production contribute to neuronal damage and synaptic plasticity in acute ischemic stroke. MnTMPyP has a neuroprotective effect in hippocampal slices and regulates synaptic transmission during hypoxia and OGD. This study investigates the molecular changes and mechanisms involved in the effect of MnTMPyP, revealing impairments in vesicular trafficking and cell differentiation signaling. These findings provide insights into the role of MnTMPyP in synaptic transmission and plasticity during ischemia.
Article
Chemistry, Analytical
Gama Theophile Gnahore, Jack L. Kelly, Saidhbhe L. O'Riordan, Fiachra B. Bolger, Michelle M. Doran, Michelle Sands, John P. Lowry
ANALYTICAL METHODS
(2020)
Article
Behavioral Sciences
John Kealy, Rachel Bennett, Barbara Woods, John P. Lowry
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Chemistry, Analytical
Saidhbhe L. O'Riordan, John P. Lowry
ANALYTICAL METHODS
(2017)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)