Journal
BIOLOGY OPEN
Volume 6, Issue 11, Pages 1720-1725Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/bio.029090
Keywords
Zebrafish; Histone modification; Atrophy; Autophagy; Myotube; Epigenetic
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Funding
- National Institute Of Diabetes And Digestive And Kidney Diseases [P30DK056336]
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The zebrafish (Danio rerio) remains the teleost fish of choice for biological investigations due to the vast array of molecular tools and resources available. To better understand the epigenetic regulation of autophagy, we utilized a primary myotube culture system generated from isolated myogenic precursor cells (MPCs) from zebrafish grown under starvation conditions using a media devoid of serum and amino acids. Here, we report starvation-induced regulation of several autophagy-related genes (atg) expression and profile the distribution of H3K27me3, H3K9me3, and H3K4me3 marks along lc3b, atg4b and p62lsqstm1 loci. These data support epigenetic regulation of autophagy in response to starvation that suggests a level of regulation that can be sustained for chronic conditions via chromatin modification.
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