HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner

Spatial confinement of active microtubule networks induces large-scale rotational cytoplasmic flow

(2017) Kazuya Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell mass spectrometry with multi-solvent extraction identifies metabolic differences between left and right blastomeres in the 8-cell frog (Xenopus) embryo

(2016) Rosemary M. Onjiko et al.   ANALYST

On chirality of slime mould

(2016) Alice Dimonte et al.   BIOSYSTEMS

Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog

(2016) Angus Davison et al.   CURRENT BIOLOGY

Actomyosin-driven left-right asymmetry: from molecular torques to chiral self organization

(2016) Sundar Ram Naganathan et al.   CURRENT OPINION IN CELL BIOLOGY

Conserved roles for cytoskeletal components in determining laterality

(2016) Gary S. McDowell et al.   Integrative Biology

From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left–right patterning

(2016) Gary McDowell et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ion Channels in Development and Cancer

(2015) Emily Bates   Annual Review of Cell and Developmental Biology

Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current

(2015) Arie Verkerk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endogenous Gradients of Resting Potential Instructively Pattern Embryonic Neural Tissue via Notch Signaling and Regulation of Proliferation

(2015) V. P. Pai et al.   JOURNAL OF NEUROSCIENCE

Cellular chirality arising from the self-organization of the actin cytoskeleton

(2015) Yee Han Tee et al.   NATURE CELL BIOLOGY

Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration

(2014) Michael Levin   JOURNAL OF PHYSIOLOGY-LONDON

Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo

(2014) Michael Levin   MOLECULAR BIOLOGY OF THE CELL

Active torque generation by the actomyosin cell cortex drives left–right symmetry breaking

(2014) Sundar Ram Naganathan et al.   eLife

A unified model for left–right asymmetry? Comparison and synthesis of molecular models of embryonic laterality

(2013) Laura N. Vandenberg et al.   DEVELOPMENTAL BIOLOGY

Integration of Left-Right Pitx2 Transcription and Wnt Signaling Drives Asymmetric Gut Morphogenesis via Daam2

(2013) Ian C. Welsh et al.   DEVELOPMENTAL CELL

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells

(2013) Daniela Später et al.   NATURE CELL BIOLOGY

Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities

(2013) Michael Levin   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Regulation of Cell Behavior and Tissue Patterning by Bioelectrical Signals: Challenges and Opportunities for Biomedical Engineering

(2012) Michael Levin et al.   Annual Review of Biomedical Engineering

Molecular bioelectricity in developmental biology: New tools and recent discoveries

(2012) Michael Levin   BIOESSAYS

Endogenous voltage gradients as mediators of cell-cell communication: strategies for investigating bioelectrical signals during pattern formation

(2012) Dany S. Adams et al.   CELL AND TISSUE RESEARCH

Left-Right Symmetry Breaking in Tissue Morphogenesis via Cytoskeletal Mechanics

(2012) Ting-Hsuan Chen et al.   CIRCULATION RESEARCH

The Impact of Mechanical Forces in Heart Morphogenesis

(2012) Javier T. Granados-Riveron et al.   Circulation-Cardiovascular Genetics

DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment

(2012) A. G. Petzoldt et al.   DEVELOPMENT

Left-right patterning: conserved and divergent mechanisms

(2012) T. Nakamura et al.   DEVELOPMENT

Serotonin has early, cilia-independent roles in Xenopus left-right patterning

(2012) L. N. Vandenberg et al.   Disease Models & Mechanisms

HCN Channels and Heart Rate

(2012) Pietro Scicchitano et al.   MOLECULES

Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms

(2012) M. Lobikin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reciprocal Signaling between the Ectoderm and a Mesendodermal Left-Right Organizer Directs Left-Right Determination in the Sea Urchin Embryo

(2012) Nathalie Bessodes et al.   PLoS Genetics

Is Pitx2 Growing Up?

(2011) Sebastian Clauss et al.   Circulation-Cardiovascular Genetics

Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis

(2011) V. P. Pai et al.   DEVELOPMENT

Laterality defects are influenced by timing of treatments and animal model

(2011) Laura N. Vandenberg   DIFFERENTIATION

Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heart

(2011) Rebecca Vicente-Steijn et al.   HEART RHYTHM

Low Frequency Vibrations Disrupt Left-Right Patterning in the Xenopus Embryo

(2011) Laura N. Vandenberg et al.   PLoS One

Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry

(2011) L. Q. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of the Pacemaker Tissues of the Heart

(2010) Vincent M. Christoffels et al.   CIRCULATION RESEARCH

The ATP-sensitive K+-channel (KATP) controls early left–right patterning in Xenopus and chick embryos

(2010) Sherry Aw et al.   DEVELOPMENTAL BIOLOGY

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chiral blastomere arrangement dictates zygotic left–right asymmetry pathway in snails

(2009) Reiko Kuroda et al.   NATURE

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS

Cell Movements at Hensen's Node Establish Left/Right Asymmetric Gene Expression in the Chick

(2009) J. Gros et al.   SCIENCE

HCN channels: Structure, cellular regulation and physiological function

(2008) C. Wahl-Schott et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

KCNQ1 and KCNE1 K+ Channel Components are Involved in Early Left-Right Patterning in Xenopus laevis Embryos

(2008) Junji Morokuma et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pitx2

(2008) Robert E. Poelmann et al.   CIRCULATION RESEARCH

A ryanodine receptor-dependent Cai2+ asymmetry at Hensen's node mediates avian lateral identity

(2008) A. Garic-Stankovic et al.   DEVELOPMENT

The development and evolution of left-right asymmetry in invertebrates: Lessons fromDrosophilaand snails

(2008) Takashi Okumura et al.   DEVELOPMENTAL DYNAMICS

Left–right asymmetry in Drosophila

(2008) J.B. Coutelis et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hyperpolarization-activated cyclic nucleotide-modulated ‘HCN’ channels confer regular and faster rhythmicity to beating mouse embryonic stem cells

(2007) Yang Qu et al.   JOURNAL OF PHYSIOLOGY-LONDON

H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left–right asymmetry

(2007) Sherry Aw et al.   MECHANISMS OF DEVELOPMENT