Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 124, Issue 3, Pages 247-252Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2017.1392580
Keywords
Cancer; DMBA; immunity; melatonin; zinc
Funding
- Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK) [16202034]
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Objective: The aim of the study was to determine the effects of zinc and melatonin supplements on the immunity parameters of female rats with breast cancer induced by DMBA. Methods: Group 1; Control, Group 2; 7,12-dimethylbenz[a]anthracene (DMBA), Group 3; DMBA + zinc, Group 4; DMBA + melatonin, Group 5; DMBA + zinc + melatonin. The rats' breast cancer was induced by DMBA 80 mg/kg. Groups 3-5 received daily 5 mg/kg doses of zinc, melatonin, and zinc + melatonin, respectively. Lymphocyte rates, T-lymphocyte subgroups, B-lymphocyte and natural killer cells (NK), and natural killer T (NKT) were evaluated. Results: The most significant increase in lymphocyte, T-lymphocyte, and CD4 lymphocyte rates was found in Group 5. The highest NKT cell rates were found in Group 3. Conclusions: Findings show that zinc and melatonin supplements have led to an increase in the immunity parameters of rats with breast cancer.
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