Journal
ALLERGOLOGY INTERNATIONAL
Volume 66, Issue 3, Pages 382-391Publisher
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.1016/j.alit.2017.04.007
Keywords
Basophil; IgE-mediated chronic allergic inflammation; IL-4; Protease; Th2 differentiation
Categories
Funding
- Japanese Ministry of Education, Culture, Sports, Science and Technology [15H05786]
- Grants-in-Aid for Scientific Research [15H05786] Funding Source: KAKEN
Ask authors/readers for more resources
Basophils have long been neglected in immunological studies because they were regarded as only minor relatives of mast cells. However, recent advances in analytical tools for basophils have clarified the non redundant roles of basophils in allergic inflammation. Basophils play crucial roles in both IgE-dependent and-independent allergic inflammation, through their migration to the site of inflammation and secretion of various mediators, including cytokines, chemokines, and proteases. Basophils are known to produce large amounts of IL-4 in response to various stimuli. Basophil-derived IL-4 has recently been shown to play versatile roles in allergic inflammation by acting on various cell types, including macrophages, innate lymphoid cells, fibroblasts, and endothelial cells. Basophil-derived serine proteases are also crucial for the aggravation of allergic inflammation. Moreover, recent reports suggest the roles of basophils in modulating adaptive immune responses, particularly in the induction of Th2 differentiation and enhancement of humoral memory responses. In this review, we will discuss recent advances in understanding the roles of basophils in allergic inflammation. Copyright (C) 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available