Review
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Jessica Pepe, Nicola Napoli, Andrea Palermo, Christos Magopoulos, Aliya A. Khan, M. Carola Zillikens, Jean-Jacques Body
Summary: This study evaluates the differences of MRONJ among different patient categories and provides recommendations on how to mitigate the risk and optimally manage MRONJ. The results indicate that patients with advanced malignancies are at a higher risk for MRONJ compared to those with benign bone diseases, but the overall risk is considerably lower than the benefits of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Camille Gaudet, Stephane Odet, Christophe Meyer, Brice Chatelain, Elise Weber, Anne-Laure Parmentier, Stephane Derruau, Sebastien Laurence, Cedric Mauprivez, Esteban Brenet, Halima Kerdjoudj, Mathilde Fenelon, Jean-Christophe Fricain, Narcisse Zwetyenga, David Hoarau, Remi Curien, Eric Gerard, Aurelien Louvrier, Florelle Gindraux
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a complication caused by anti-resorptive agents and anti-angiogenesis drugs. We reviewed the literature and designed a questionnaire to collect information on clinical practices. However, we found missing data and a lack of consensus.
Article
Endocrinology & Metabolism
Judith Everts-Graber, Daniel Lehmann, John-Patrik Burkard, Benoit Schaller, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study aimed to determine the risk of ONJ in a real-world population, showing a higher incidence rate in patients receiving denosumab therapy compared to those receiving BPs, with previous BP therapy potentially being an additional risk factor for ONJ development.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Geriatrics & Gerontology
Bridget Boston, Deepak Ipe, Bogdan Capitanescu, Andrei Gresita, Stephen Hamlet, Robert Love, Michael Hadjiargyrou, Chien-Ling Huang, Iulian Nusem, Rodica Ileana Miroiu, Aurel Popa-Wagner, Patrick Hans-Heinrich Warnke, Eugen Bogdan Petcu
Summary: Medication-related osteonecrosis of the jaw (MRONJ) refers to the non-healing jawbone ulcerative-necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with certain medications. Studies have been conducted to explore MRONJ's classification, clinical features, and pathophysiology, as well as its management and new trends in treatment. Conservative therapy may not be effective for severe cases of MRONJ, but new methods that promote local angiogenesis and vascularization show promise in limited trials.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Oncology
Raiza Querrer, Nathalia Ferrare, Nilce Melo, Cristine Miron Stefani, Paula Elaine Diniz dos Reis, Carla Ruffeil Moreira Mesquita, Gabriel Alvares Borges, Andre Ferreira Leite, Paulo Tadeu Figueiredo
Summary: Bisphosphonate-related ONJ and denosumab-related ONJ exhibit differences in imaging characteristics, with the former showing bone sequestra increase, cortical bone lysis, and bone density increase, while the latter showing larger bone sequestra, more frequent periosteal reactions, and mandibular canal enhancement.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Paola Bracchi, Ernesto Zecca, Cinzia Brunelli, Rosalba Miceli, Gabriele Tine, Massimo Maniezzo, Silvia Lo Dico, Mariangela Caputo, Morena Shkodra, Augusto T. T. Caraceni
Summary: This study aimed to assess the incidence of Medication Related Osteonecrosis of the Jaw (MRONJ) in cancer patients with bone metastases receiving Denosumab (Dmab) and identify potential risk factors. The results showed that middle-aged patients, dental treatments, and previous bisphosphonates administration were associated with a higher incidence of MRONJ.
Article
Biotechnology & Applied Microbiology
Stephane Odet, Christophe Meyer, Camille Gaudet, Elise Weber, Julie Quenot, Stephane Derruau, Sebastien Laurence, Lisa Bompy, Marine Girodon, Brice Chatelain, Cedric Mauprivez, Esteban Brenet, Halima Kerdjoudj, Narcisse Zwetyenga, Philippe Marchetti, Anne-Sophie Hatzfeld, David Toubeau, Fabienne Pouthier, Xavier Lafarge, Heinz Redl, Mathilde Fenelon, Jean-Christophe Fricain, Roberta Di Pietro, Charlotte Ledouble, Thomas Gualdi, Anne-Laure Parmentier, Aurelien Louvrier, Florelle Gindraux
Summary: The use of human amniotic membrane (hAM) can promote tissue regeneration and healing in patients with medication-related osteonecrosis of the jaw (MRONJ). By using cryopreserved hAM, MRONJ can be effectively treated, leading to improved quality of life for patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Guillermo Pardo-Zamora, Yanet Martinez, Jose Antonio Moreno, Antonio J. Ortiz-Ruiz
Summary: MRONJ is a rare and severe disease with unclear exact cause and potential multifactorial origins. A case series of three stage 2 MRONJ patients showed complete healing within 12 months of therapeutic protocol application, with radiography demonstrating slow but progressive healing with normal bone structure. Conservative treatment and minimally invasive surgical intervention are effective for stage 2 MRONJ, while application of PRF-L in refractory cases can improve outcomes in soft tissue healing and bone regeneration, though further research is needed to confirm effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Oncology
Akanksha Srivastava, Graciela M. Nogueras Gonzalez, Yimin Geng, Alexander M. Won, Maria E. Cabanillas, Aung Naing, Jeffrey N. Myers, Yisheng Li, Mark S. Chambers
Summary: This study investigated the prevalence of MRONJ in patients receiving two or more sequential ARDs compared to a single antiresorptive drug. The results showed an increased prevalence of MRONJ associated with sequential ARD therapy, such as pamidronate-zoledronate and bisphosphonate-denosumab, when compared to single ARD therapy.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alexander Wick, Philipp Bankosegger, Sven Otto, Bettina Hohlweg-Majert, Timm Steiner, Florian Probst, Oliver Ristow, Christoph Pautke
Summary: This study identified several risk factors significantly increasing the onset of MRONJ in patients treated with DNO, including chemotherapy/hormonal therapy, DNO dosage, breast cancer, corticosteroid intake, hypertension, diabetes mellitus, periodontal disease, apical ostitis, and denture use. Switching medications did not affect the development of MRONJ.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Immunology
Weidong Zhang, Ling Gao, Wenhao Ren, Shaoming Li, Jingjing Zheng, Shasha Li, Chunmiao Jiang, Shuying Yang, Keqian Zhi
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug effect, with hypotheses involving reduced bone remodeling, infection, inflammation, and bisphosphonates-induced immune dysfunction. Treatment with bisphosphonates disrupts mucosal and osteo immune homeostasis, impairing the body's ability to resist infection and repair from injury, contributing to the development of MRONJ.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Article
Endocrinology & Metabolism
Fang-Chun Liu, Kwing-Chi Luk, Yung-Chih Chen
Summary: In this retrospective cohort study, the long-term risk of osteonecrosis of the jaw was compared between osteoporotic patients treated with denosumab and bisphosphonates. After 2 years of use, the likelihood of osteonecrosis of the jaw is lower with denosumab compared to bisphosphonates, and the difference increases with time.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Gabor Kammerhofer, Daniel Vegh, Dorottya Banyai, Adam Vegh, Arpad Joob-Fancsaly, Peter Hermann, Zoltan Geczi, Tamas Hegedus, Kata Sara Somogyi, Bulcsu Bencze, Zita Biczo, Donat Huba Juhasz, Peter Zaborszky, Marta Ujpal, Mihaly Tamas Vaszilko, Zsolt Nemeth
Summary: This study aimed to evaluate the association between hyperglycemia and medication-related osteonecrosis of the jaw (MRONJ). The results showed a significant association between hyperglycemia and MRONJ, suggesting that hyperglycemia may lead to vascular anomaly and immune dysfunction, resulting in necrosis after tooth extraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
K. H. J. Lim, K. Murali, E. Thorne, K. Punie, K. Kamposioras, C. Oing, M. O'Connor, E. Elez, T. Amaral, P. Garrido, M. Lambertini, B. Devnani, C. B. Westphalen, G. Morgan, J. B. A. G. Haanen, C. Hardy, S. Banerjee
Summary: COVID-19 has significantly impacted the well-being and job performance of oncology professionals globally. Despite improved job performance, there is still a high risk of poor well-being, distress, and burnout among oncology professionals. They are also facing issues of overwhelming workload and concerns about career development, job security, and international fellowship opportunities.
Review
Oncology
Diogo Martins-Branco, Guilherme Nader-Marta, Ana Tecic Vuger, Veronique Debien, Lieveke Ameye, Mariana Brandao, Kevin Punie, Angela Loizidou, Karen Willard-Gallo, Chloe Spilleboudt, Ahmad Awada, Martine Piccart, Evandro de Azambuja
Summary: This systematic review and meta-analysis evaluated the immune response to anti-SARS-CoV-2 vaccination in cancer patients. The results showed that cancer patients had sustained humoral and adaptive immune responses for at least 2 months after complete prime-vaccination. However, patients with hematological malignancies had lower immune responses.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Vibeke K. J. Vergote, Gregor Verhoef, Ann Janssens, F. J. Sherida H. Woei-A-Jin, Annouschka Laenen, Thomas Tousseyn, Daan Dierickx, Christophe M. Deroose
Summary: Multiple studies have demonstrated the predictive value of pretreatment [F-18]FDG-PET/CT metabolic parameters in various lymphoma subtypes. However, there is limited research on the role of metabolic parameters in mantle cell lymphoma (MCL). In this retrospective study, we investigated the prognostic value of baseline metabolic tumor volume (MTV) and lesion dissemination in untreated MCL. We found that higher baseline MTV was associated with worse overall survival, progression-free survival, and disease-specific survival in univariate analysis. Furthermore, MTV was significantly associated with disease-specific survival in multivariate analysis. However, there was no correlation between lesion dissemination and outcome. Overall, these findings suggest that MTV is an important prognostic tool and can improve risk stratification for untreated MCL at staging.
LEUKEMIA & LYMPHOMA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luc Vrielinck, Catalina Moreno-Rabie, Wim Coucke, Reinhilde Jacobs, Constantinus Politis
Summary: This study reported on the survival rate and complications of zygomatic implants (ZIs) through a longitudinal retrospective cohort assessment. The survival rate of ZI was found to be 89.9%, and the most frequently observed complication was sinusitis. The study also found that most ZI losses occur within the first 5 years after implant placement.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Anatomy & Morphology
Maria Piagkou, Michael Kostares, Fabrice Duparc, Panagiotis Papanagiotou, Constantinus Politis, George Tsakotos, Nikos Pantazis, Konstantinos Natsis
Summary: The purpose of this study was to estimate the prevalence of the sphenoidal emissary foramina (SEF) and investigate the factors that may affect it. A systematic online literature search was conducted, and meta-analysis was performed. The overall estimated prevalence of SEF was 38.1%. The results showed that unilateral dominance was associated with a decrease in the reported SEF prevalence.
SURGICAL AND RADIOLOGIC ANATOMY
(2023)
Article
Cardiac & Cardiovascular Systems
Lauranne Van Assche, Bart Peeters, Anne Vorlat, Koen Monsieurs, Hein Heidbuchel, Marc J. Claeys
Summary: This study evaluates the safety and effectiveness of the 0-1h hs-cTn algorithm compared to the standard 0-3h cTn protocol for diagnosing AMI. The results show that the 0-1h hs-cTn protocol has a sensitivity of 100% and a negative predictive value of 100% for ruling out AMI.
Article
Oncology
Lize Vanaken, F. J. Sherida H. Woei-A-Jin, Rita Van Ginderdeuren, Christophe M. Deroose, Annouschka Laenen, Guy Missotten, Dietmar R. Thal, Oliver Bechter, Patrick Schoffski, Paul Clement
Summary: This study aimed to investigate the efficacy of immune checkpoint inhibitors (ICI) in patients with metastatic uveal melanoma (MUM). The results showed that ICI did not improve overall survival in MUM patients. Local treatment options may be more beneficial compared to ICI.
Article
Oncology
Lorenz Haaker, Marcella Baldewijns, Liesbeth De Wever, Maarten Albersen, Philip R. Debruyne, Wim Wynendaele, Gert De Meerleer, Benoit Beuselinck
Summary: The outcome of renal cell carcinoma has significantly improved with the use of immune checkpoint inhibitors, but atypical responses such as mixed response and pseudoprogression are observed. In a retrospective analysis of 94 patients, we found 8.5% to be pseudoprogressors with similar outcomes to responders. This study adds to the limited evidence in this area, aiding clinicians in the treatment of patients with immune checkpoint inhibitors.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Surgery
Jiqing Li, Sohaib Shujaat, Eman Shaheen, Constantinus Politis, Reinhilde Jacobs
Summary: Autoimmune diseases involve the immune system attacking native cells and tissues mistakenly, resulting in increased risk of complications after surgical interventions. This study found that patients with autoimmune diseases who undergo orthognathic surgery have a higher risk of postoperative complications, highlighting the importance of careful patient selection and risk stratification before surgery.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tim Van Cleemput, Xander Jackers, Maria Piagkou, Constantinus Politis
Summary: The study aimed to identify the recurrence patterns of odontogenic keratocysts (OKCs) and the onset of second primary OKCs in non-syndromic and syndromic patients. Retrospective evaluation of patients with OKCs from 1998 to 2021 revealed a recurrence rate of 15.8% in the non-syndromic group and 21.4% in the syndromic group. No second primary OKCs were observed in the non-syndromic group, while 76.9% of the patients in the syndromic group developed at least one.
JOURNAL OF MAXILLOFACIAL & ORAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Julie Adriaenssens, Hannah Vaesen Bentein, Reinhilde Jacobs, Constantinus Politis, Frederic van der Cruyssen
Summary: Quantitative sensory testing (QST) is a valuable tool in assessing orofacial somatosensory function and dysfunction by applying thermal and mechanical stimuli in a noninvasive way. This dataset includes orofacial QST gathered from ten healthy volunteers, comparing different regions innervated by the trigeminal nerve, and can be used for future studies on orofacial sensory function, pain, and pharmacological trials.
Article
Engineering, Biomedical
Shengping Zhong, Qimin Shi, Jeroen Van Dessel, Yifei Gu, Heinz-Theo Luebbers, Shoufeng Yang, Yi Sun, Constantinus Politis
Summary: The use of the non-locking system is feasible for patient-specific mandibular reconstruction with fibular free flaps. The non-locking system can be matched with customized bone plates, providing adequate safety and stability, and its biomechanics are similar to the locking system.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jorunn Eyfjoro, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad A. Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc Van de Vijver, Steven Van Laere, Laura van't Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke T. Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek D. Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, Francois Richard, Christine Desmedt
Summary: Obesity is associated with an increased risk of developing breast cancer and worse prognosis in breast cancer patients. This study investigates the biological differences in untreated primary breast cancer according to patients' body mass index (BMI). The study finds several genomic alterations that are differentially prevalent in overweight or obese patients compared to lean patients. It also reveals an elevated and unresolved inflammation of the breast cancer tumor microenvironment associated with obesity. The findings suggest that patient adiposity may play a significant role in the heterogeneity of breast cancer and should be considered for tailored treatment.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Yentl Lambrechts, Abhishek D. Garg, Giuseppe Floris, Kevin Punie, Patrick Neven, Ines Nevelsteen, Jannes Govaerts, Francois Richard, Annouschka Laenen, Christine Desmedt, Hans Wildiers, Sigrid Hatse
Summary: There is an urgent need for new and improved biomarker modalities to estimate the risk of recurrence in breast cancer patients. This study provides proof of concept that various liquid biopsy read-outs could be used to build a multi-modal biomarker model that can distinguish between early metastasizing and non-metastasizing patients.
GENES AND IMMUNITY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Katrien Brijs, Hilde Peeters, Constantinus Politis
Summary: This study reviewed the experience of orthognathic surgery in patients with systemic diseases, syndromic conditions, or a history of oncological disease. The findings suggest that complications during and after surgery are uncommon in patients with an underlying disorder, and contraindications for surgery due to medical conditions are very rare.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2023)