Article
Cell Biology
Xiaoyu Wang, Naifeng Kuang, Yuexia Chen, Guifeng Liu, Nan Wang, Fan'er Kong, Shouwei Yue, Zuncheng Zheng
Summary: Co-transplantation of olfactory ensheathing cells (OECs) with neural stem cells (NSCs) can enhance the survival and therapeutic effects of NSCs in rats with spinal cord injury (SCI). OECs promote neuroprotection, inhibit programmed necrosis of NSCs, and increase NSC proliferation and differentiation, making co-transplantation a promising strategy for SCI treatment.
Review
Biochemistry & Molecular Biology
Gang-Un Kim, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, Minkyoung Sung, Seung Yun Yang, Seul-Ki Kim, Young In Kim, Ju-Hyeon Lim, Min-Soo Seo, Gun Woo Lee
Summary: Spinal cord injury (SCI) is a serious condition that leads to permanent disability. Research on SCI treatment focuses on reducing neuroinflammation, with Mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (EVs) showing potential therapeutic effects but inconsistent results in animal models. Development of novel agents for regenerative medicine is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Young-Ju Lim, Gyeong Na Jung, Wook-Tae Park, Min-Soo Seo, Gun Woo Lee
Summary: There are various approaches to control neuroinflammatory cascades, including traditional mesenchymal stem cells (MSCs), but their effectiveness remains debated. To overcome these issues, researchers are now turning to extracellular vesicles (EVs) as potential therapeutic agents for neural pathologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Susan L. Lindsay, Susan C. Barnett
Summary: The use of MSCs for transplant-mediated repair after SCI is promising, but different tissue sources of MSCs may have varying biological properties. The importance of identifying the appropriate niche-specific MSC type for SCI repair is highlighted.
Review
Immunology
Yizhen Jiang, Jianbin Guo, Xiangwen Tang, Xiaohui Wang, Dingjun Hao, Hao Yang
Summary: Spinal cord injury is a devastating neurological disorder with high mortality and disability. Secondary injury, caused by infection and inflammation, exacerbates the initial injury and leads to severe consequences. Olfactory ensheathing cells, with their anti-inflammatory properties, have potential as cell-based therapy for spinal cord injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Chao Jiang, Xiaohui Wang, Yizhen Jiang, Zhe Chen, Yongyuan Zhang, Dingjun Hao, Hao Yang
Summary: Neural regeneration has been a challenge for researchers worldwide. Cell transplantation, particularly olfactory ensheathing cells (OECs), has emerged as a promising strategy for neural regeneration, as OECs possess unique regenerative properties. Studies have shown that OEC transplantation plays a vital role in neural repair and functional recovery, especially in the central and peripheral nervous system. OECs can improve the adverse microenvironment for neural regeneration, particularly by reducing overwhelming inflammatory responses.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Lijian Zhang, Xiaoqing Zhuang, Paivi Kotitalo, Thomas Keller, Anna Krzyczmonik, Merja Haaparanta-Solin, Olof Solin, Sarita Forsback, Tove J. Gronroos, Chunlei Han, Francisco R. Lopez-Picon, Hechun Xia
Summary: The study showed that OEC transplantation reduced spinal cord inflammation and modulated neuroinflammation by secreting IL-1Ra. This therapeutic approach has high effectiveness in treating spinal cord injury by reducing neuroinflammation through IL-1Ra secretion.
Article
Cell & Tissue Engineering
Olga V. Stepanova, Anastasia D. Voronova, Anastasiia O. Sosnovtseva, Aleksei A. Stepanenko, Andrey V. Chadin, Ekaterina K. Karsuntseva, Grigorii A. Fursa, Marat P. Valikhov, Alevtina S. Semkina, Pavel O. Vorobyev, Igor V. Reshetov, Vladimir P. Chekhonin
Summary: Research on therapeutic efficiency of human olfactory ensheathing cells (OECs) transduced by adenoviral vectors encoding mature BDNF in treating posttraumatic spinal cord cysts showed promising results regarding cyst reduction, but limited effects were seen in functional tests.
STEM CELLS AND DEVELOPMENT
(2022)
Article
Neurosciences
Yan Zhang, Yu-shen Yang, Wei-can Chen, Cong-mei Wang, He-fan He
Summary: This study used bioinformatics analysis and experimental verification to elucidate the hub genes associated with spinal cord injury (SCI) and to discover the underlying molecular mechanisms of cell intervention. Differential gene expression analysis and network construction were performed, and key genes and pathways were identified. Experimental validation showed differences in Cd4, Tp53, Rac2, and Akt3 between transplanted and control groups, indicating their essential role in olfactory ensheathing cell transplantation. Furthermore, the toll-like receptor signaling pathway was significantly enriched, and the expression differences of associated molecules were verified. Additionally, a regulatory network was constructed for the central genes. This study provides new insights for cell therapy in SCI treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Jon Prager, Daisuke Ito, Darren R. Carwardine, Prince Jiju, Divya M. Chari, Nicolas Granger, Liang-Fong Wong
Summary: The study demonstrates that genetically modified canine olfactory mucosal OECs can provide sufficient chABC to drive modest functional improvement in a rat SCI model. Animals transplanted with cOEC-chABC showed superior performance in behavioral testing and gait compared to the other two groups, with potential mechanisms of recovery observed.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
Selin Ursavas, Hakan Darici, Erdal Karaoz
Summary: SCI repair candidate cells include OECs, with successful results in animal models but limited clinical trials due to difficulties in cell acquisition. Insufficient information exists on mechanisms of action, adverse effects, application methods, effective subtypes, and cell sources for OECs.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Cell & Tissue Engineering
Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li, Xue-wen Kang
Summary: SCI often leads to serious motor and sensory dysfunction of the limbs below the injured segment, causing physical, psychological harm and economic burden. MSC therapy for SCI has shown promise but faces challenges like low survival rate and immune rejection, while exosomes derived from MSCs have great potential in the treatment of SCI.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Yufeng Shang, Haotong Guan, Fuling Zhou
Summary: Umbilical cord mesenchymal stem cells (UC-MSCs) have the characteristics of inhibiting tumor cell proliferation and migration, supporting hematopoietic microenvironment, and suppressing the immune system, showing great potential in the treatment of hematologic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Fangzheng Yu, Peifeng Li, Shenghu Du, KoonHei W. Lui, Yutian Lin, Lumin Chen, Qi Ren, Jian Wang, Jin Mei, Jian Xiao, Junyi Zhu
Summary: This study aimed to evaluate whether decellularized scaffolds carrying olfactory ensheathing cells could better promote axon growth, with promising results indicating improved axon regeneration and functional recovery in animal experiments.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Xiaohui Wang, Chao Jiang, Yongyuan Zhang, Zhe Chen, Hong Fan, Yuyang Zhang, Zhiyuan Wang, Fang Tian, Jing Li, Hao Yang, Dingjun Hao
Summary: The present study aimed to investigate the pro-angiogenic potential of OECs activated by CCM and LPS and the underlying mechanisms. The activated OECs were found to effectively promote proliferation, migration, and vessel-like structure formation of vascular endothelial cells. Several pro-angiogenic growth factors were significantly elevated in the conditioned medium (CM), and the PI3K/Akt signaling pathway was involved in these pro-angiogenic events. Transplantation of activated OECs improved angiogenesis and the microenvironment in the injured spinal cord.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Liliana Rytel, Joanna Wojtkiewicz, Anna Snarska, Anita Mikolajczyk
Summary: This study investigated the impact of a low dose of Salmonella Enteritidis LPS on duodenal enteric neurons immunoreactive to substance P (SP), vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating peptide (PACAP-27), and cocaine- and amphetamine-regulated transcript (CART) using a double immunofluorescence technique. The findings suggest that even a low dose of LPS can affect the number of enteric neurons containing these neuropeptides, with changes dependent on the type of enteric plexus. The mechanisms behind these fluctuations are unclear but may be related to the pro-inflammatory and neurotoxic activity of LPS.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Biographical-Item
Clinical Neurology
Karol Wisniewski, Joanna Wojtkiewicz
JOURNAL OF NEUROLOGY
(2021)
Editorial Material
Medicine, General & Internal
Karol Wisniewski, Joanna Wojtkiewicz
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Environmental Sciences
Ignacy Gonkowski, Slawomir Gonkowski, Ewa Dzika, Joanna Wojtkiewicz
Summary: The study found that BPA has an impact on CB-positive enteric neuronal cells in the caecum, with low doses increasing cell numbers in certain plexuses and high doses increasing cell numbers in all plexuses. This indicates that CB in the ENS has adaptive and protective functions.
Article
Agriculture, Dairy & Animal Science
Liliana Rytel, Ignacy Gonkowski, Waldemar Grzegorzewski, Joanna Wojtkiewicz
Summary: The enteric nervous system (ENS) located in the gastrointestinal tract regulates stomach and intestine functions. Nitric oxide (NO) synthesized by enteric neurons is involved in intestinal regulation. Inflammation leads to an increase in nitrergic nerve structures, suggesting NO's involvement in pathological processes in the bowel.
Article
Biochemistry & Molecular Biology
Natalia Nowicka, Kamila Szymanska, Judyta Juranek, Kamila Zglejc-Waszak, Agnieszka Korytko, Michal Zalecki, Malgorzata Chmielewska-Krzesinska, Krzysztof Wasowicz, Joanna Wojtkiewicz
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unclear pathogenesis. RAGE and its ligands have been found to play an important role in the pathogenesis of ALS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Tomasz Antonowski, Karol Wisniewski, Piotr Podlasz, Adam Osowski, Joanna Wojtkiewicz
Summary: In high doses, inositol may have toxic effects on zebrafish, but low doses may have some benefits. In the presence of ethanol, inositol does not show a significant protective effect on the hepatocytes of zebrafish larvae.
Article
Biology
Julia Jaroslawska, Agnieszka Korytko, Kamila Zglejc-Waszak, Tomasz Antonowski, Andrzej S. Pomianowski, Krzysztof Wasowicz, Joanna Wojtkiewicz, Judyta K. Juranek
Summary: The study compared the effects of experimentally induced type 1 or type 2 diabetes on mouse peripheral nerves. Both T1D and T2D mice showed similar characteristics of peripheral nerve damage, including deficits in nerve conduction velocity, reduced fiber numbers, irregular shapes, and oxidative-nitrosative stress. Non-hyperglycemic effects of diabetes, such as dyslipidemia, were also found to be important in the development of diabetic neuropathy.
Article
Environmental Sciences
Slawomir Gonkowski, Manolis Tzatzarakis, Elena Vakonaki, Krystyna Makowska, Aristidis M. Tsatsakis, Joanna Wojtkiewicz
Summary: This study evaluated TCS concentration levels in residents of Olsztyn, northeastern Poland, using liquid chromatography-mass spectrometry. The results showed that TCS was present in the majority of samples, with concentration levels ranging from 37.9 pg/mg to 3386.5 pg/mg. The study revealed that people living in northeastern Poland are exposed to TCS to a large degree.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Katarzyna Podhorodecka, Pawel Radkowski, Paulina Boniecka, Joanna Wojtkiewicz
Summary: This study examined the psychological distress among anesthesiologists in Poland after the COVID-19 pandemic. The results showed that the majority of participants experienced burnout and believed that the pandemic had a negative impact on their level of burnout. It is important to emphasize the significance of supporting the mental health of healthcare workers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Janusz Sadowski, Ryszard Targonski, Piotr Cyganski, Paulina Nowek, Magdalena Starek-Stelmaszczyk, Katarzyna Zajac, Judyta Juranek, Joanna Wojtkiewicz, Andrzej Rynkiewicz
Summary: Current data suggests that heart failure (HF) is associated with inflammation, microvascular dysfunction, and remodeling. This study compared structural changes in retinal arterioles and carotid arteries between HF patients and patients without heart failure. The results showed that HF patients had higher arterial thickness and wall-to-lumen ratio compared to non-HF patients, and there was a correlation between retinal arterioles and carotid arteries.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Karol Wisniewski, Tomasz Antonowski, Judyta Juranek, Piotr Podlasz, Joanna Wojtkiewicz
Summary: Epilepsy, affecting about 70 million people worldwide, poses a significant challenge to medicine. In this study, the potential antiepileptic properties of scyllo-inositol (SCI) were tested in zebrafish larvae with seizures induced by pentylenetetrazol. Short-term exposure to SCI reduced larva motility, while long-term exposure did not produce similar results, possibly due to insufficient concentration of SCI. These findings highlight the potential of SCI in epilepsy treatment and call for further clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Michael Thoene, Ewa Bejer-Olenska, Joanna Wojtkiewicz
Summary: Articular cartilage has low regenerative ability and requires therapy for significant joint injuries. This article reviews the causes of osteoarthritis and its treatment using traditional methods and the latest stem cell technology. The use and potential risks of mesenchymal stem cells for tissue regeneration and implantation are discussed, along with applications in treating osteoarthritis in humans after using canine animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Maria Derkaczew, Piotr Martyniuk, Adam Osowski, Joanna Wojtkiewicz
Summary: The aim of this paper is to explore the potential of using Myo-inositol and its derivatives for treating neurodegenerative disorders. The researchers focus on common diseases like Alzheimer's, Parkinson's, Huntington's, and Spinocerebellar ataxias, as well as other rare diseases. Although research on this topic has been ongoing for years, further examination is still needed for the use of Myo-inositol and methods altering its metabolism.
Article
Biology
Adam Osowski, Iryna Hetmaniuk, Olena Fedchyshyn, Mykhailo Sas, Yuliia Lomakina, Nataliia Tkachuk, Olena Budarna, Volodymyr Fik, Larisa Fedoniuk, Joanna Wojtkiewicz
Summary: This study investigated the effects of severe burn injuries on the cardiovascular system, specifically the atria and auricles of the heart, and evaluated the potential benefits of using lyophilized xenodermotransplants as a treatment option. The results showed that third-degree burns caused significant ultrastructural changes in atrial cardiomyocytes, leading to long-term destructive changes in the structural components of the atria. However, the use of lyophilized xenodermotransplants had a positive effect on the atrial ultrastructure over time.
