Article
Biotechnology & Applied Microbiology
Zeyuan Li, Bo Peng, Shilian Chen, Jiaping Li, Kai Hu, Lijuan Liao, Qiuli Xie, Mei Yao, Lixing Liang, Stephen Tomlinson, Guandou Yuan, Songqing He
Summary: This study compared the different mechanisms of liver regeneration and injury between partial hepatectomy (pHx) and extended hepatectomy (eHx) using transcriptome and metabolome analysis. The results showed that eHx caused more severe liver injury and lower survival rates compared to pHx. Analysis of differentially expressed genes (DEGs) and differentially produced metabolites (DPMs) suggested that cholesterol metabolism and insulin resistance pathways might be important for liver regeneration and mouse survival post-PHx and -eHx.
Review
Biotechnology & Applied Microbiology
Yi Wu, Ning Li, Xinyu Shu, Wang Li, Xiaoyu Zhang, Dongyuan Lu, Mian Long
Summary: The liver is a complex organ with vital functions and regenerative capacity after tissue injury. Mechanical cues play a significant role in liver regeneration, including changes in hemodynamics and mechanical forces within the liver. Understanding the mechanotransductive pathways and mechanocrine responses can contribute to a comprehensive understanding of liver regeneration. Proper adjustment of mechanical loading may serve as an effective therapy for liver injury and diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sinan Efe Yazici, Mustafa Emre Gedik, Can Berk Leblebici, Kemal Kosemehmetoglu, Gurcan Gunaydin, Ahmet Bulent Dogrul
Summary: In this study, the researchers investigated the mechanisms of liver regeneration and found that Vegf, endocan, endostatin, and eEF2K play important roles in the process of liver regeneration after partial hepatectomy. Specifically, endocan may serve as a useful biomarker for clinical prognosis.
MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Hong Liu, Anqi Zhou, Zhiwen Fan, Xi Zhu, Xiulian Miao
Summary: This study investigated the role of ubiquitin-specific peptidase 47 (USP47) in liver regeneration. The results showed that USP47 expression was up-regulated in hepatocytes isolated from mice subjected to partial hepatectomy or exposed to HGF treatment. E2F1 was identified as the primary regulator of USP47 transcription. USP47 was found to play an essential role in liver regeneration, as its inhibition impaired liver regeneration in mice and its over-expression enhanced hepatocyte proliferation in vitro and promoted liver regeneration in mice. A positive correlation between USP47 expression and hepatocyte proliferation was also observed in patients with acute liver failure.
Article
Dentistry, Oral Surgery & Medicine
Che-Chang Tu, Zhao-Cheng Zheng, Nai-Chen Cheng, Jiashing Yu, Wei-Chiu Tai, Yi-Xuan Pan, Po-Chun Chang
Summary: This study evaluated the potential of alveolar mucosal cell (AMC) spheroids for promoting extraction socket healing and calvarial osseous defect regeneration. The results showed that AMC spheroids can accelerate wound healing and bone tissue regeneration. The effects of socket healing and bone defect regeneration can be further enhanced by promoting osteogenesis of AMC.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Cell Biology
Yuan-E Lian, Yan-Nan Bai, Jian-Lin Lai, Ai-Min Huang
Summary: The study found that aberrant autophagy in fibrotic liver leads to impaired liver regeneration. Enhancement of autophagy improves hepatocyte proliferative capacity and restricts cellular hypertrophy and binuclearity ratio.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Runbin Sun, Haokai Zhao, Shuzhen Huang, Ran Zhang, Zhenyao Lu, Sijia Li, Guangji Wang, Jiye Aa, Yuan Xie
Summary: The study investigated the dynamic metabolic changes during liver regeneration in mice using a metabolomic approach and regression analysis with different machine learning methods. The random forest method showed the best performance in predicting liver index, with several amino acid metabolic pathways and glucose metabolism pathway being the most influenced during liver regeneration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Neety Sahu, Pranay Agarwal, Fiorella Grandi, Michela Bruschi, Stuart Goodman, Derek Amanatullah, Nidhi Bhutani
Summary: The study demonstrates that co-culturing patient-derived OA cartilage explants with alginate-encapsulated MSC microbeads can lead to improved proteoglycan distribution, increased sGAG content, cell proliferation, elevated levels of cytokines such as IL-10, HGF, and sFAS, increased TIMP1 levels, and a decrease in apoptotic cells. This indicates that the paracrine factors secreted by MSC microbeads create a conducive microenvironment for anabolic, proliferative, and anti-apoptotic processes in patient-derived OA cartilage, ultimately promoting endogenous regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Saisai Wei, Qiang Zheng, Yu Pan, Yunwan Xu, Jiacheng Tang, Xiujun Cai
Summary: The study revealed that liver regeneration leads to reprogramming of gene expression profiles, while core clock genes' rhythm remains stable. Performing partial hepatectomy in the evening may result in retarded liver regeneration due to the accumulation of DEC1.
Article
Gastroenterology & Hepatology
Genis Camprecios, Aina Anton, Anna Oncins, Carla Montironi, Maria Ruart, Rosa Montanes, Hector Garcia-Caldero, Joan Carles Garcia-Pagan, Virginia Hernandez-Gea
Summary: Liver sinusoidal endothelial cells (LSEC) are key elements in regulating the liver response to injury and regeneration. Endothelial autophagy plays a crucial role in protecting cells from injury-induced oxidative stress and fibrosis. However, this study found that endothelial autophagy is not essential for liver regeneration after partial hepatectomy (PHx).
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Lais A. de Paula Simino, Marina Figueiredo Fontana, Thais de Fante, Carolina Panzarin, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Mina Desai, Michael G. Ross, Adriana Souza Torsoni
Summary: Obesity during pregnancy increases the risk of non-alcoholic fatty liver disease in offspring. However, the offspring of obese dams are able to overcome epigenetic changes and regenerate liver tissue after partial hepatectomy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Qinhui Liu, Qin Tang, Xinchun Liu, Min Tian, Xiandan Jing, Zongyun Feng, Xuping Yang
Summary: Studies have demonstrated the positive effect of highland barley ss-glucan (HBBG) on various liver diseases, including acute liver injury and liver regeneration. In this study, the researchers investigated the beneficial impact of HBBG on liver regeneration following partial hepatectomy (PH) using mouse models. They found that HBBG promoted hepatocyte proliferation and liver regeneration after PH by activating the STAT3-CyclinD1 signaling pathway. Furthermore, the intervention of HBBG decreased hepatocyte apoptosis in a liver injury model induced by CCl4.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Genetics & Heredity
Jian Zhao, Shi-Zhe Yu, Qiang Cai, Duo Ma, Long Jiang, Ling-Peng Yang, Zhi-Yong Yu
Summary: Key genes involved in cell cycle, DNA replication, and p53 signaling pathway were identified in the early stage of liver regeneration in mice after partial hepatectomy (PH). Ube2c was found to play a crucial role in regulating hepatocyte proliferation by modulating genes such as Ccna2, Cdkn1a, Chek1, and Mcm5.
FRONTIERS IN GENETICS
(2021)
Article
Gastroenterology & Hepatology
Mohammad H. Fard-Aghaie, Andras Budai, Noemi Daradics, Gergo Horvath, Karl J. Oldhafer, Attila Szijarto, Andras Fulop
Summary: Physical prehabilitation (PP) plays a beneficial role in liver regeneration, mitochondrial function, and inflammatory response after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). It can accelerate regeneration rate, improve mitochondrial biogenesis, and reduce inflammatory response in a rodent model.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)