Article
Cell Biology
Gang Xu, Ying Li, Shengyuan Zhang, Haoran Peng, Yunyun Wang, Dekang Li, Taijie Jin, Zhuohao He, Yilun Tong, Chunting Qi, Guowei Wu, Kangyun Dong, Jizhou Gou, Yang Liu, Tongyang Xiao, Jing Qu, Liang Li, Liang Liu, Ping Zhao, Zheng Zhang, Junying Yuan
Summary: The study found evidence of RIPK1 activation in lung samples of COVID-19 patients and SARS-CoV-2 infected lung organoids, while inhibition of RIPK1 reduced viral load. The results suggest that targeting RIPK1 may offer a therapeutic option for COVID-19 treatment.
Article
Biology
Jing Zhang, Di Zhao, Lingyuan Zhang, Yuanfan Xiao, Qingnan Wu, Yan Wang, Jie Chen, Qimin Zhan
Summary: This study demonstrates that the inhibition of Src activity by ponatinib suppresses malignant phenotypes of ESCC while not affecting normal esophageal epithelial cells. Src interacts with Fyn and Lyn to form heterodimers, which contribute to the development of ESCC. Inhibition of Src activity also blocks critical tumor-promoting pathways. Src/Fyn and Src/Lyn heterodimers may be potential targets for ESCC treatment.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Cell Biology
Juanjuan Xiao, Lu Zhang, Huijun Yi, Ling Zou, Jianmei Mo, Feng Xue, Jinhua Zheng, Yingze Huang, Hui Lu, Hansheng Wu, Peipei Xue, Xin Zhang, Lifei He, Zhaoxin Li, Shigui Pang, Guibin Qiao, Qiuhong Duan, Feng Zhu
Summary: This study reveals the role of T-LAK cell-oriented protein kinase (TOPK) in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). The researchers found that TOPK is highly expressed in ALK-positive NSCLC and identified ALK as an upstream kinase of TOPK. Moreover, they showed that inhibiting TOPK enhances tumor sensitivity to an ALK inhibitor, and the combination of alectinib and a TOPK inhibitor suppresses tumor growth and promotes apoptosis of ALK-positive NSCLC cells.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Haifeng Wu, Xiuqing Yan, Liang Zhao, Xiang Li, Ximing Li, Yi Zhang, Changping Gu, Fan Yang, Jingting Yan, Yalin Lou, Yufei Li, Li Yang, Xiaofeng Qin, Yuelan Wang
Summary: p120 is a positive regulator of type I interferon (IFN-I) production, promoting phosphorylation of IRF3 by stabilizing the TBK1-IRF3 complex. Knockdown of p120 expression increases susceptibility to VSV infection, with higher tissue viral titers, decreased IFN-I production, and increased immune cell infiltration.
MOLECULAR IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Andrii Slonchak, Xiaohui Wang, Julio Aguado, Julian D. J. Sng, Harman Chaggar, Morgan E. Freney, Kexin Yan, Francisco J. Torres, Alberto A. Amarilla, Rickyle Balea, Yin Xiang Setoh, Nias Peng, Daniel Watterson, Ernst Wolvetang, Andreas Suhrbier, Alexander A. Khromykh
Summary: sfRNA plays an important role in the transmission of Zika virus, facilitating the virus to pass through the placenta and infect the fetal brain. It also induces apoptosis of neural progenitor cells in human brain organoids. In infected human placental cells, sfRNA inhibits multiple antiviral pathways and promotes apoptosis, with STAT1 identified as a key factor. Phosphorylation and nuclear translocation of STAT1 are reduced due to sfRNA binding to and stabilizing viral protein NS5.
Article
Immunology
Yihua Zhang, Bowen Xin, Yinan Liu, Wenyi Jiang, Wendong Han, Jian Deng, Peihui Wang, Xiaowu Hong, Dapeng Yan
Summary: This study reveals a previously unknown mechanism by which the SARS-COV-2 protein NSP9 promotes cytokine storm and tissue damage. NSP9 interacts with and activates TBK1, leading to increased cytokine production. Additionally, NSP9 is ubiquitinated and degraded by MID1, but virus infection inhibits this degradation process. These findings provide insights into the pathogenesis of COVID-19 and present a potential target for therapeutic intervention.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Salvatore Rizza, Luca Di Leo, Chiara Pecorari, Paola Giglio, Fiorella Faienza, Costanza Montagna, Emiliano Maiani, Michele Puglia, Francesca M. Bosisio, Trine Skov Petersen, Lin Lin, Vendela Rissler, Juan Salamanca Viloria, Yonglun Luo, Elena Papaleo, Daniela De Zio, Blagoy Blagoev, Giuseppe Filomeni
Summary: Nitric oxide (NO) production in the tumor microenvironment contributes to cancer development. This study reveals that S-nitrosylation, a post-translational modification mediated by NO, plays a role in sustaining tumorigenesis. The enzyme GSNOR, which deactivates S-nitrosylation, is found to be hypo-expressed in various human malignancies. GSNOR deficiency leads to S-nitrosylation of focal adhesion kinase 1 (FAK1), enhancing its autophosphorylation and promoting cancer cell survival in suspension. GSNOR-deficient tumor models are highly sensitive to FAK1 inhibitors, suggesting GSNOR as a potential therapeutic target.
Article
Pharmacology & Pharmacy
Alan Alfano, Jin Xu, Xi Yang, Dhanraj Deshmukh, Yun Qiu
Summary: Tubulin is a vital component of the cytoskeleton and plays crucial roles in cellular signaling, maintenance, and division. Increased expression of TUBB3, a type of beta-tubulin primarily found in neural cells, is associated with taxane resistance and poor prognosis. Here, we discovered that TUBB3 is phosphorylated at Tyrosine 340 (Y340) by c-Src in prostate cancer cells. Phosphorylation at Y340 regulates TUBB3 protein stability and subcellular localization. Inhibition of SRC kinase activity affects spindle stability in mitotic cells due to the lack of TUBB3 Y340 phosphorylation. Understanding the posttranslational regulation of TUBB3 could serve as potential biomarkers for disease recurrence and treatment failure.
Article
Multidisciplinary Sciences
Mariko Morii, Sho Kubota, Chizu Hasegawa, Yumi Takeda, Shiori Kometani, Kyoko Enomoto, Takayuki Suzuki, Sayuri Yanase, Rika Sato, Aki Akatsu, Kensuke Hirata, Takuya Honda, Takahisa Kuga, Takeshi Tomonaga, Yuji Nakayama, Noritaka Yamaguchi, Naoto Yamaguchi
Summary: The Src-family tyrosine kinases (SFKs) accumulate in the centrosome region at the beginning of mitosis and phosphorylate PRC1 and kinastrin, leading to their delocalization from microtubules during mitosis.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Rulu Pan, Yan Yu, Haiyan Zhu, Wenyi Zhang, Yuan Qin, Lin Ye, Juji Dai, Ren Huang, Xinyan Peng, Siqi Ye, Ziqi Lin, Shishun Huang, Shuyi Chong, Liting Lu, Xincheng Lu
Summary: RSPO2 promotes the growth and metastasis of ovarian cancer through the activation of FAK/Src signaling cascades. It prevents the endocytic degradation of LGR4 and promotes LGR4-mediated translocation of Src to the plasma membrane. In addition, it directly binds to integrin beta 3 and enhances the stability of integrins. High expression of RSPO2 is associated with poor prognosis in ovarian tumors.
Article
Multidisciplinary Sciences
Seoyun Yum, Minghao Li, Yan Fang, Zhijian J. Chen
Summary: This study shows that STING can function independently of type I interferons and autophagy, and that TBK1 recruitment to STING is essential for antiviral and antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Jiutao Wang, Ning Yao, Yamei Hu, Mingjuan Lei, Meixian Wang, Lu Yang, Satyananda Patel, Xiang Li, Kangdong Liu, Zigang Dong
Summary: This study identified the potential mechanism of how Ras is activated in glioblastoma multiforme (GBM) through the interaction between Ras and PHLDA1. The overexpression of PHLDA1 promoted cell proliferation and tumor growth by regulating the Ras/Raf/Mek/Erk signaling pathway. In addition, Src phosphorylated Ras at tyrosine 32 to enhance its GTPase activity. PHLDA1 competed with Src for binding to Ras, inhibiting Ras phosphorylation by Src and rescuing Ras activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Zhongmin Lin, Yu Zhao, Qijia Li, Xingyuan Ci, Xiaoxian Ye, Guorong Chen, Quanmei Tu, Weixu Feng, Pengfei Jiang, Shanli Zhu, Xiangyang Xue, Nicholas A. Saunders, Lifang Zhang, Xueqiong Zhu, Kong-Nan Zhao
Summary: This study reveals that HPV16 E7 oncoprotein is continuously expressed and interacts with AKT/Src signaling to promote the initiation and progression of cervical cancer.
Article
Microbiology
An Fang, Yueming Yuan, Baokuen Sui, Zhihui Wang, Yuan Zhang, Ming Zhou, Huanchun Chen, Zhen F. Fu, Ling Zhao
Summary: This study reveals a novel function of miRNA-200b-3p in negatively regulating IFN-I production during viral infection through MAPK pathway. Application of miR-200b-3p inhibitors exhibits potent antiviral effects. These findings provide fresh insight into host-virus interactions and reveal a potential therapeutic target for common antiviral intervention.
Review
Hematology
Yotis A. Senis, Zoltan Nagy, Jun Mori, Sophia Lane, Patrick Lane
Summary: SFKs, originally discovered as proto-oncogenes, play vital roles in platelet research by initiating and amplifying signals from major receptors, providing insights into self-regulation through phosphorylation of their C-terminal tyrosine residues, and offering potential therapeutic targets for regulating platelet functions.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2021)
Editorial Material
Cell Biology
Zhou Yu, Taoyong Chen, Xuetao Cao
Article
Immunology
Songqing Tang, Taoyong Chen, Mingjin Yang, Lei Wang, Zhou Yu, Bin Xie, Cheng Qian, Sheng Xu, Nan Li, Xuetao Cao, Jianli Wang
CELLULAR & MOLECULAR IMMUNOLOGY
(2017)
Editorial Material
Immunology
Zhou Yu, Taoyong Chen, Xuetao Cao
CELLULAR & MOLECULAR IMMUNOLOGY
(2016)
Article
Immunology
Mingjin Yang, Taoyong Chen, Xuelian Li, Zhou Yu, Songqing Tang, Chen Wang, Yan Gu, Yanfang Liu, Sheng Xu, Weihua Li, Xuemin Zhang, Jianli Wang, Xuetao Cao
Article
Biology
Zhou Yu, Taoyong Chen, Xuelian Li, Mingjin Yang, Songqing Tang, Xuhui Zhu, Yan Gu, Xiaoping Su, Meng Xia, Weihua Li, Xuemin Zhang, Qingqing Wang, Xuetao Cao, Jianli Wang
Article
Biochemistry & Molecular Biology
Xuelian Li, Mingjin Yang, Zhou Yu, Songqing Tang, Lei Wang, Xuetao Cao, Taoyong Chen
Article
Oncology
Taoyong Chen, Mingjin Yang, Zhou Yu, Songqing Tang, Chen Wang, Xuhui Zhu, Jun Guo, Nan Li, Weiping Zhang, Jin Hou, Haibo Liu, Chaofeng Han, Qiuyan Liu, Yan Gu, Cheng Qian, Tao Wan, Long Cui, Minghua Zhu, Weiqiang Zheng, Xuetao Cao
Article
Genetics & Heredity
Donghua He, Taoyong Chen, Mingjin Yang, Xuhui Zhu, Chen Wang, Xuetao Cao, Zhen Cai
JOURNAL OF MOLECULAR MEDICINE-JMM
(2011)
Article
Multidisciplinary Sciences
Songqing Tang, Taoyong Chen, Zhou Yu, Xuhui Zhu, Mingjin Yang, Bin Xie, Nan Li, Xuetao Cao, Jianli Wang
NATURE COMMUNICATIONS
(2014)
Editorial Material
Immunology
Taoyong Chen, Xuetao Cao
Summary: Living organisms have developed conserved mechanisms for detecting and responding to molecular patterns from invading viruses, with cGAS-like receptors being a newly identified family of PRRs specifically for viral nucleic acids.
TRENDS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xuelian Li, Zhou Yu, Qian Fang, Mingjin Yang, Jiaying Huang, Zheng Li, Jianli Wang, Taoyong Chen
Summary: This study reveals the important role of TRIM13, a transmembrane ER-associated E3 ubiquitin ligase, in restraining the inflammatory response triggered by pathogenic DNAs. TRIM13 interacts with STING, catalyzing its poly-ubiquitination and regulating its stability.
Article
Biotechnology & Applied Microbiology
Na Zhao, Xiao Gui, Qian Fang, Rui Zhang, Weiye Zhu, Haorui Zhang, Qing Li, Yukun Zhou, Jiawei Zhao, Xiao Cui, Guangping Gao, Huipeng Tang, Ni Shen, Taoyong Chen, Hongyuan Song, Wei Shen
Summary: The study found that Graphene Quantum Dots (GQDs) are biocompatible nanomaterials that can inhibit proliferation, migration, tube formation, and sprouting of human umbilical vein endothelial cells in a dose-dependent manner, and can inhibit pathological retinal neovascularization in an oxygen-induced retinopathy model. The data suggest that GQDs disrupt the periostin/ERK pathway and subsequent cell cycle regulation. This signaling pathway was confirmed in an OIR mouse model.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ha Zhu, Kun Chen, Yali Chen, Juan Liu, Xiaomin Zhang, Yumei Zhou, Qiuyan Liu, Bingjing Wang, Taoyong Chen, Xuetao Cao
Summary: This study identifies ZCCHC4 as a potential therapeutic target and predictor of poor prognosis in multiple types of cancer. ZCCHC4 promotes chemoresistance and inhibits apoptosis in cancer cells through its interaction with AL133467.2. Furthermore, ZCCHC4 blocks the interaction between AL133467.2 and gamma H2AX, leading to increased chemoresistance. These findings provide mechanistic insights into the roles of RNA-binding proteins in cancer progression and treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhou Yu, Xuelian Li, Mingjin Yang, Jiaying Huang, Qian Fang, Jianjun Jia, Zheng Li, Yan Gu, Taoyong Chen, Xuetao Cao
Summary: TRIM41 plays a crucial role in innate antiviral response by facilitating pathogenic nucleic acids-triggered signaling pathway, interacting with BCL10 and modifying its polyubiquitylation to activate NF-kappa B and TBK1-IRF3 pathways. The deficiency of TRIM41 leads to impaired immune response against viruses, suggesting its potential as a universal E3 ubiquitin ligase in innate antiviral defense mechanism.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)