Article
Biochemistry & Molecular Biology
Mengzhu Lv, Simeng Zhang, Bo Jiang, Sunrun Cao, Yuqing Dong, Liu Cao, Shu Guo
Summary: The study demonstrated that adipose-derived stem cell therapy can delay replicative senescence and shift metabolic homeostasis, ultimately delaying the aging process by promoting mitophagy and improving mitochondrial quality in cells. The research also showed that ADSC therapy can improve aging-related symptoms and phenotypes through mitochondrial quality control, offering significant potential for future applications in aging-related diseases.
Article
Cell Biology
Xiaoyun Wu, Yongxu Mu, Jingyi Yao, Fuhong Lin, Daocheng Wu, Zhijie Ma
Summary: The study revealed that ADSCs from UC patients exhibited defective immunosuppression, indicating their unsuitability for autologous transplantation in treating UC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Huanmin Kang, Jianing Feng, Yingqian Peng, Yingyi Liu, Yalei Yang, Ying Wu, Jian Huang, Ying Jie, Baihua Chen, Yan He
Summary: This study compared the immunosuppressive capacity of mesenchymal stem cells (MSCs) from human adipose tissue (hAD-MSCs) and human umbilical cord (hUC-MSCs) and explored their effects on graft neovascularization and lymphangiogenesis in corneal transplantation models. The results showed that hAD-MSCs had stronger immunosuppressive effects in vitro, while hUC-MSCs exerted inhibitory effects through cell-cell contact-dependent mechanisms. Systemic administration of a lower dose of hAD-MSCs performed better in prolonging corneal allograft survival, while subconjunctival administration of MSCs was safer and further prolonged allograft survival. Both types of MSCs inhibited corneal neovascularization, but hAD-MSCs showed greater superiority in suppressing graft lymphangiogenesis.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, Research & Experimental
Ahmed Abdelbaset-Ismail, Abeer Tharwat, Ahmed E. Ahmed, Tarek Khamis, Ibrahim H. Abd El-Rahim, Sadeq K. Alhag, Mohamed F. Dowidar
Summary: This study found that rat adipose-derived mesenchymal stem cells (rAD-MSCs) could alleviate diclofenac sodium (DIC)-induced acute liver injury by being transplanted into the injured liver. This treatment method significantly improved survival rate, body weight, and liver function indicators, while reducing inflammation and cell damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Yosuke Niimi, Tuvshintugs Baljinnyam, Satoshi Fukuda, Clark R. Andersen, John R. Salsbury, Jong O. Lee, Donald S. Prough, Perenlei Enkhbaatar
Summary: This study aimed to test the efficacy of nebulized adipose-derived mesenchymal stem cells (ASCs) in a well-characterized ovine model of smoke inhalation injury. The results showed that the PaO2/FiO2 in the ASCs group was significantly higher and the oxygenation index was significantly lower compared to the control group. The viability of ASCs in bronchoalveolar lavage fluid was lower than those exposed to the control solution. Nebulized ASCs moderately improved pulmonary function and delayed the onset of ARDS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Luminita Labusca, Dumitru-Daniel Herea, Anca Emanuela Minuti, Cristina Stavila, Camelia Danceanu, Petru Plamadeala, Horia Chiriac, Nicoleta Lupu
Summary: Iron oxide based magnetic nanoparticles (MNP) have versatile applications in biology and medicine. This study compared the chondrogenic conversion of ADSC-MNP and WJMSC under different conditions, finding that ADSC-MNP displayed superior proliferation and chondrogenic potential, with MF exposure further enhancing chondrogenesis in ADSC-MNP. Loading ADSC with MNP may be a promising approach for cartilage engineering in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Naoki Ishiuchi, Ayumu Nakashima, Satoshi Maeda, Yoshie Miura, Kisho Miyasako, Kensuke Sasaki, Toshio Uchiki, Ayano Sasaki, Shogo Nagamatsu, Naoki Nakao, Masataka Nagao, Takao Masaki
Summary: Fibrosis is a common histological feature in chronic organ injury, leading to organ failure. Adipose-derived mesenchymal stem cells (ASCs) have been studied as a therapeutic tool to prevent organ failure. This study compared the therapeutic effects of ASCs from superficial and deep layers and found that both types of ASCs are equally effective and safe for treating organ injury.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Immunology
Yongcheng Wei, Xiaoyong Chen, Huanxi Zhang, Qun Su, Yanwen Peng, Qian Fu, Jun Li, Yifang Gao, Xirui Li, Shicong Yang, Qianyu Ye, Huiting Huang, Ronghai Deng, Gang Li, Bowen Xu, Chenglin Wu, Jiali Wang, Xiaoran Zhang, Xiaojun Su, Longshan Liu, Andy Peng Xiang, Changxi Wang
Summary: BM-MSCs are tolerable for kidney allograft recipients with cABMR, and combined with immunosuppressive drugs can delay allograft function deterioration by reducing DSA levels and DSA-induced injury. The immunomodulatory effect of MSCs on peripheral B and T cell subsets may be the underlying mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Yang Zhou, Bo Zhao, Xin-Liao Zhang, Yi-jun Lu, Shou-Tao Lu, Jian Cheng, Yu Fu, Lin Lin, Ning-Yan Zhang, Pei-Xin Li, Jing Zhang, Jun Zhang
Summary: This study investigated the potential clinical application roles of human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. The combined administration of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration showed additional benefits in promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Article
Biochemistry & Molecular Biology
Kuo-An Chu, Chang-Ching Yeh, Chun-Hsiang Hsu, Chien-Wei Hsu, Fu-Hsien Kuo, Pei-Jiun Tsai, Yu-Show Fu
Summary: This study compared the effectiveness of human umbilical cord Wharton's jelly-derived mesenchymal stem cells (HUMSCs) versus adipose tissue-derived mesenchymal stem cells (ADMSCs) for reversing pulmonary fibrosis in rats. The results showed that HUMSCs had better effects on lung function improvement and collagen degradation, as well as alveolar regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aniko Kun-Varga, Barbara Guban, Vanda Miklos, Shahram Parvaneh, Melinda Guba, Diana Szucs, Tamas Monostori, Janos Varga, Akos Varga, Zsolt Razga, Zsuzsanna Bata-Csorgo, Lajos Kemeny, Klara Megyeri, Zoltan Vereb
Summary: The proper functioning of mesenchymal stem cells (MSCs) is crucial for the body's homeostasis. Inflammation and infection can alter the function of MSCs, which in turn affects tissue regeneration and immunological status. This study aimed to investigate the response of adipose-derived MSCs (ADMSCs) to HSV infection in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Annalisa Itro, Maria Consiglia Trotta, Roberta Miranda, Marco Paoletta, Annalisa De Cicco, Caterina Claudia Lepre, Umberto Tarantino, Michele D'Amico, Giuseppe Toro, Alfredo Schiavone Panni
Summary: The aim of this systematic review is to provide a clear overview of the current clinical research progress in the use of adipose-derived mesenchymal stem cells (ASCs) as a therapeutic option for tendinopathies. Seven clinical studies met the inclusion criteria and showed the efficacy and safety of ASCs treatment for tendinopathies. However, there is a lack of clear description of the biomolecular mechanisms underlying the beneficial properties of ASCs.
Article
Biotechnology & Applied Microbiology
Hyun-Ho Yun, Seong-Gon Kim, Se-Il Park, Woori Jo, Kyung-Ku Kang, Eun-Joo Lee, Dong-Kyu Kim, Hoe-Su Jung, Ji-Yoon Son, Jae-Min Park, Hyun-Sook Park, Sunray Lee, Hong-In Shin, Il-Hwa Hong, Kyu-Shik Jeong
Summary: Bone regeneration is a complex process influenced by factors like inflammation, tissue interactions, and progenitor cells. Bone grafting is currently the most effective treatment, but it has drawbacks. Adipose-derived stem cells show promise in accelerating bone regeneration.
BIOENGINEERING-BASEL
(2023)
Article
Cell Biology
Furkan Yigitbilek, Sabena M. Conley, Hui Tang, Ishran M. Saadiq, Kyra L. Jordan, Lilach O. Lerman, Timucin Taner
Summary: MSCs from liver and adipose tissue showed similar proliferation and migration properties, but had differences in immunomodulatory and pro-angiogenic abilities. Selecting cell-based therapy according to the specific characteristics of different cell sources may be important for treating certain diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)