Article
Oncology
Dechuang Jiao, Jingyang Zhang, Jiujun Zhu, Xuhui Guo, Yue Yang, Hui Xiao, Zhenzhen Liu
Summary: Previous studies have shown lower survival rates in inflammatory breast cancer (IBC) patients compared to non-inflammatory local advanced breast cancer (non-IBC) patients. However, the survival rate of IBC and other T4 non-IBC (T4-non-IBC) patients had not been explored. In this study, it was found that patients with IBC and T4-non-IBC had similar breast cancer-specific survival (BCSS) rates in the modern systemic treatment era. Furthermore, it was observed that in IBC patients, the HR-/HER2+ subtype had a better outcome, while the HR-/HER2- subtype had a poorer outcome compared to T4-non-IBC patients.
Article
Endocrinology & Metabolism
Hongyan Yao, Zijing Li
Summary: This study analyzed retinal vessel density and thickness characteristics in patients with diabetic nephropathy (DN) and preclinical diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). The findings suggest that DN individuals have more severe microvascular and microstructural impairment compared to individuals without DN. Additionally, estimated glomerular filtration rate (eGFR) may serve as an indicator for retinal microvascular impairment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rui-Ting Zhang, Yu Liu, Ke-Ke Lin, Wan-Ning Jia, Quan-Ying Wu, Jing Wang, Xiao-Yan Bai
Summary: A risk prediction model for hypoglycemia during hemodialysis was constructed for patients with diabetic nephropathy. The model includes 6 predictors and showed good prediction outcome based on logistic regression analysis.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Medicine, General & Internal
Yi-Hsin Hung, Chin-Chou Huang, Liang-Yu Lin, Jaw-Wen Chen
Summary: This study suggests that hyperuricemia is an independent risk factor for the decline in renal function in patients with hypertension. Uric acid level >= 7.5 mg/dL may be considered as the optimal cutoff value for predicting the development of renal impairment.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Lingling Liu, Ke Zuo, Weibo Le, Manman Lu, Zhihong Liu, Weiwei Xu
Summary: This study found that nondiabetic urine glucose is closely related to proteinuria and can be used as a marker to predict renal function.
Article
Public, Environmental & Occupational Health
Joshua Stevenson-Hoare, Ganna Leonenko, Valentina Escott-Price
Summary: This study found that metformin therapy has short-term benefits on longevity in patients with type 2 diabetes, but these benefits are outweighed by the negative effects of diabetes in the long term.
Article
Endocrinology & Metabolism
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen
Summary: This study used Mendelian randomization analysis to determine the causal relationship between cystatin C and diabetic nephropathy. The study found that cystatin C is an independent risk factor for diabetic nephropathy in patients with diabetes, regardless of BMI and SBP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Kunihiro Ishioka, Sumi Hidaka, Naoki Fujiwara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi
Summary: This study investigated the association between zinc deficiency and aorta stiffness in non-diabetic HD patients. The results showed that patients in the zinc deficiency group were older and had higher levels of CRP and hypoalbuminemia. They also had higher levels of baPWV and lower levels of ABI. After adjusting for malnutrition and inflammation, multivariate analysis indicated that age and zinc level were independent predictors of baPWV.
Article
Multidisciplinary Sciences
Min Wang, Hsin-Chiao Hsu, Mei-Ching Yu, I-Kuan Wang, Chien-Chang Huang, Ming-Jen Chan, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu, Lan-Mei Huang, Frederick W. K. Tam, Tzung-Hai Yen
Summary: This study found that small kidney size on starting hemodialysis is not associated with an increased risk of death in diabetic patients receiving hemodialysis.
Review
Medicine, General & Internal
Xiaoyun He, Gaoyan Kuang, Yi Zuo, Shuangxi Li, Suxian Zhou, Chunlin Ou
Summary: Diabetic nephropathy (DN) is a major complication of diabetes that involves oxidative stress. Non-coding RNAs (ncRNAs) play a significant role in the occurrence and development of DN, offering new insights into therapeutic approaches for DN.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Barbara Di Camillo, Lucia Puricelli, Elisabetta Iori, Gianna Maria Toffolo, Paolo Tessari, Giorgio Arrigoni
Summary: Protein turnover rate is crucial for cellular functions and dysregulation of protein degradation can lead to various diseases. Studying protein synthesis and degradation rates is important to understand the pathophysiology of diseases. This study used a dynamic-SILAC approach to investigate protein turnover and abundance in a cellular model of diabetic nephropathy, identifying several proteins with altered turnover and abundance between diabetic nephropathic subjects and controls. These proteins could potentially serve as biomarkers or therapeutic targets for diabetic complications. The data obtained also provide valuable information on protein half-lives in human fibroblasts and contribute to basic cell biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Dong-Yuan Chang, Meng-Rui Li, Xiao-Juan Yu, Su-Xia Wang, Min Chen, Ming-Hui Zhao
Summary: In this study, it was found that compared to proteinuric DN patients, nonproteinuric DN patients had lower frequency of diabetic retinopathy (DR) and better renal outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Min Yi, Ting He, Kaijin Wang, Yonggang Wei
Summary: This study compared the efficacy and safety of gefitinib in combination with chemotherapy versus gefitinib alone in patients with advanced Non-Small Cell Lung Cancer (NSCLC) through a meta-analysis of clinical studies. Results showed that the combination therapy was more effective in improving objective response rate, disease control rate, progression-free survival, and overall survival compared to gefitinib alone. However, the combination therapy also had a higher risk of complications. These findings suggest that the combination therapy can provide better outcomes for patients with advanced NSCLC.
Article
Multidisciplinary Sciences
Abdul Baset Abbas, Alia Hazeb, Rawan Al-Badani, Boshra Al-Thmary, Rasha Mokaram, Somayah Al-Najjar, Shifa Mothna, Aziza Kssiam, Abeer Esmail, Ali Al-Rashidi
Summary: The study found significant differences in hematological indices between diabetic patients and the healthy control group, with diabetic patients having higher levels of mean corpuscular volume, white blood cells, eosinophils, platelets, and erythrocyte sedimentation rate.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Chao Tang, Han Ouyang, Jian Huang, Jing Zhu, Xiaosong Gu
Summary: Patients with DN undergoing HD tend to have worse LV diastolic function and are more likely to have heart valve problems. LV diastolic dysfunction and E/e '>13 are predictors of death in DN patients.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)