Review
Microbiology
Bryn Short, Stephen Carson, Anna-Claire Devlin, James A. Reihill, Anne Crilly, William MacKay, Gordon Ramage, Craig Williams, Fionnuala T. Lundy, Lorcan P. McGarvey, Keith D. Thornbury, S. Lorraine Martin
Summary: Haemophilus influenzae is a common cause of bacterial infection in the lungs of COPD patients, leading to acute exacerbations. Its ability to adhere to host epithelial cells, form biofilms, and persist through immune evasion and antibiotic tolerance plays a crucial role in the pathogenesis of COPD.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Immunology
Mary A. Brown, Sophie B. Morgan, Gillian E. Donachie, Katie L. Horton, Ian D. Pavord, Carolina V. Arancibia-Carcamo, Timothy S. C. Hinks
Summary: Type-2 low asthma or COPD is potentially caused by persistent bacterial colonization of the lower airways by bacteria such as non-encapsulated Haemophilus influenzae (NTHi), which is a commensal of the upper airways. The extent of NTHi invasion and activation of proinflammatory cytokines in airway epithelial cells is not fully understood. This study found that NTHi can be internalized transiently by airway epithelial cells and induce inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Jake R. Weeks, Karl J. Staples, C. Mirella Spalluto, Alastair Watson, Tom M. A. Wilkinson
Summary: Non-typeable Haemophilus influenzae (NTHi) is a common pathogen in COPD patients, but its impact varies among different cohorts. Other bacteria may also contribute to acute exacerbations in COPD. The biofilm phase of NTHi could play a significant role in COPD, exhibiting extreme antimicrobial tolerance and synergistic interactions with other lung pathogens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Anna Carrera-Salinas, Aida Gonzalez-Diaz, Rachel L. Ehrlich, Damaris Berbel, Fe Tubau, Xavier Pomares, Junkal Garmendia, M. Angeles Dominguez, Carmen Ardanuy, Daniel Huertas, Alicia Marin, Conchita Monton, Joshua Chang Mell, Salud Santos, Sara Marti
Summary: The immunomodulatory properties of azithromycin reduce the frequency of exacerbations and improve the quality of life of COPD patients. However, long-term administration may alter the respiratory microbiota, such as Haemophilus influenzae, an opportunistic respiratory colonizing bacteria that play an important role in exacerbations. This study contributes to a better understanding of COPD progression by characterizing the clinical evolution of H. influenzae in a cohort of patients with prolonged azithromycin treatment. The emergence of macrolide resistance during the first months, combined with the role of Haemophilus parainfluenzae as a reservoir and source of resistance dissemination, is a cause for concern that may lead to therapeutic failure. Furthermore, genetic variations in cell wall and inorganic ion metabolism coding genes likely favor bacterial adaptation to host selective pressures. Therefore, the bacterial pathoadaptive evolution in these severe COPD patients raise our awareness of the possible spread of macrolide resistance and selection of host-adapted clones.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Shengsen Chen, Xinyun Zhang, Cheng Yang, Shi Wang, Hao Shen
Summary: This study established a mouse model of bacterium-induced acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) and found that the IL-17 gene is essential for the development of AE-IPF.
Article
Environmental Sciences
Lewis J. Williams, Stephen G. Tristram, Graeme R. Zosky
Summary: Exposure to geogenic particulate matter (PM) is associated with increased prevalence of respiratory infections in Australian Indigenous communities. The concentration of iron in geogenic PM is linked to its respiratory health effects, and haematite has the greatest impact on the invasiveness of bronchial epithelial cells by non-typeable Haemophilus influenzae (NTHi).
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Raza Ul Mohsin, Christian Kjer Heerfordt, Josefin Eklof, Pradeesh Sivapalan, Mohamad Isam Saeed, Truls Sylvan Ingebrigtsen, Susanne Dam Nielsen, Zitta Barrella Harboe, Kasper Karmark Iversen, Jette Bangsborg, Jens Otto Jarlov, Jonas Bredtoft Boel, Christian Ostergaard Andersen, Henrik Pierre Calum, Ram B. Dessau, Jens-Ulrik Staehr Jensen
Summary: This study found that the use of inhaled corticosteroids (ICS) in outpatients with chronic obstructive pulmonary disease (COPD) is associated with an increased risk of acquiring Haemophilus influenzae infection, and this risk is dose-dependent, indicating that caution should be exercised when using high-dose ICS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Yonathan Arfi, Carole Lartigue, Pascal Sirand-Pugnet, Alain Blanchard
Summary: Mycoplasmas are small, genome-reduced bacteria with the ability to colonize a wide range of host species. They can exist as commensal microbiota or cause pathogenic inflammatory diseases. These bacteria have evolved strategies to evade the host's immune response, including the expression of immunoglobulin-binding proteins to prevent antibody-antigen interaction. Understanding these immune evasion mechanisms is crucial for studying mycoplasma diseases and improving vaccine efficacy.
Review
Virology
Ashley N. Della Fera, Alix Warburton, Tami L. Coursey, Simran Khurana, Alison A. McBride
Summary: Persistent infection with oncogenic human papillomavirus (HPV) types contributes to approximately 5% of human cancers. The HPV infectious cycle and viral proteins manipulate cellular proliferation and differentiation, increasing the risk of carcinogenesis in infected cells.
Article
Microbiology
Rabeb Dhouib, Marufa Nasreen, Dk Seti Maimonah Pg Othman, Daniel Ellis, Simon Lee, Ama-Tawiah Essilfie, Philip M. Hansbro, Alastair G. McEwan, Ulrike Kappler
Summary: Molybdenum-containing enzyme DmsABC plays a crucial role in infection by H. influenzae, affecting intracellular survival and interactions with the host.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Xiao Wu, Runfeng Li, Yunceng Weng, Hongxia Zhou, Haiming Jiang, Jin Zhao, Bin Liu, Ruifeng Chen, Xinxin Chen, Weimin Yang, Zifeng Yang, Xinhua Wang
Summary: Primary influenza virus infection can predispose hosts to secondary infection with Haemophilus influenzae, which increases disease severity and mortality. Sequential infection with influenza A virus and Haemophilus influenzae induced lethal synergy in a mouse model, possibly due to increased bacterial loads and lung damage. Analysis showed a correlation between specific adhesion molecules and bacterial growth in secondary pneumonia following primary viral infection.
MICROBES AND INFECTION
(2021)
Article
Infectious Diseases
Shuxian Wen, Ying Mai, Xu Chen, Kun Xiao, Yongping Lin, Zhenbo Xu, Ling Yang
Summary: This study investigates the molecular epidemiology and antibiotic resistance of Haemophilus influenzae in Guangzhou, China. A total of 80 H.influenzae isolates were collected from patients in a hospital from January 2020 to April 2021. The majority of H. influenzae strains were found to be non-typeable H. influenzae, and they showed relative susceptibility to certain antibiotics. The genotyping results revealed high genetic diversity among the isolates.
Article
Microbiology
Kati Karvonen, Jonna Nykky, Varpu Marjomaeki, Leona Gilbert
Summary: The study investigated the infection processes of B. burgdorferi in two human cell lines, revealing differences in infection patterns, dose-dependent responses, and morphological variations between the cell lines. The findings suggest a mechanism of immune evasion for the bacteria through invading non-phagocytic cells and lack of cytopathic effects onto the host cells.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Young June Choe, Mi Seon Han, Youn Young Choi, Young Joo Sohn, Ye Kyung Kim, Kyung Min Kim, Ji Young Park, Hyun Mi Kang, In Ae Yoon, Jae Hong Choi, Chi Eun Oh, Eun Young Cho, Hyunju Lee, Eun Hwa Choi
Summary: The study in Korea between 2014 and 2019 found that the carriage rates of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children varied, with a significant increase in carriage of serotype 23A of S. pneumoniae. Children who had received pneumococcal conjugate vaccines had a lower risk of vaccine-type carriage. Continuous surveillance is necessary to evaluate the long-term effects of PCVs on the carriage dynamics of these bacteria.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Ying Zhang, Hongbo Wang, Yanqiu Zhang, Peiliang Zhao, Yanan Li
Summary: Non-typeable Haemophilus influenzae (NTHi) outer membrane vesicles (OMVs) may play a role in the pathogenesis of neutrophilic asthma. It was found that NTHi OMVs induced inflammatory responses and immune-related signaling pathways, resulting in neutrophilic asthma.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Mary C. Gallo, Charmaine Kirkham, Samantha Eng, Remon S. Bebawee, Yong Kong, Melinda M. Pettigrew, Herve Tettelin, Timothy F. Murphy
INFECTION AND IMMUNITY
(2018)
Article
Multidisciplinary Sciences
Melinda M. Pettigrew, Christian P. Ahearn, Janneane F. Gent, Yong Kong, Mary C. Gallo, James B. Munro, Adonis D'Mello, Sanjay Sethi, Herve Tettelin, Timothy F. Murphy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Immunology
Timothy F. Murphy, Aimee L. Brauer, Melinda M. Pettigrew, Eric R. LaFontaine, Herve Tettelin
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Immunology
Yu-Ching Su, Emma Mattsson, Birendra Singh, Farshid Jalalvand, Timothy F. Murphy, Kristian Riesbeck
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Chemistry, Medicinal
Livia Shehaj, Santosh K. Choudary, Kamlesh M. Makwana, Mary C. Gallo, Timothy F. Murphy, Joshua A. Kritzer
ACS INFECTIOUS DISEASES
(2019)
Article
Immunology
C. P. Ahearn, C. Kirkham, L. D. Chaves, Y. Kong, M. M. Pettigrew, G. T. F. Murphy
INFECTION AND IMMUNITY
(2019)
Article
Biotechnology & Applied Microbiology
Adonis D'Mello, Christian P. Ahearn, Timothy F. Murphy, Herve Tettelin
Article
Multidisciplinary Sciences
Soumi Ghosh, Christian P. Ahearn, Christine R. Isabella, Victoria M. Marando, Gregory J. Dodge, Helen Bartlett, Robert L. McPherson, Amanda E. Dugan, Shikha Jain, Lubov Neznanova, Herve Tettelin, Rachel Putnik, Catherine L. Grimes, Stefan Ruhl, Laura L. Kiessling, Barbara Imperiali
Summary: The role of host salivary proteins in maintaining oral health is unclear. A highly expressed gene called ZG16B was found to capture commensal microbes and regulate their growth using a mucin-assisted clearance mechanism, thus influencing the compositional balance of the oral microbiome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Timothy F. Murphy, Charmaine Kirkham, Adonis D'Mello, Sanjay Sethi, Melinda M. Pettigrew, Herve Tettelin
Summary: Chronic obstructive pulmonary disease (COPD) is a common and debilitating disorder that is the third leading cause of death worldwide. This study analyzed the persistence of nontypeable Haemophilus influenzae (NTHi) in COPD airways and found that the NTHi genome undergoes inversion during persistence, resulting in changes in expression of key virulence factors. It was also discovered that the adhesins HMW1 and HMW2 play a critical role in NTHi adherence and invasion of respiratory epithelial cells. These findings provide important insights into the mechanisms of NTHi persistence in COPD airways and may inform the development of novel interventions.
Article
Medicine, Research & Experimental
E. Bengert, L. Towle-Miller, J. Boccardo, G. Mercene, P. J. Ohtake, P. Balkundi, P. L. Elkin, J. Balthasar, T. F. Murphy, K. Noyes
Summary: This study proposes a practical method to track institutional changes in research teamwork and productivity using commonly available electronic databases. The study shows that the extent of interdisciplinary collaboration varies significantly depending on academic unit, faculty appointment, and seniority. Interdisciplinary grants constitute a significant proportion of all grants and have been on the rise in recent years. Departments with more interdisciplinary grants receive more research funding. Further research is needed to improve the efficiency of interdisciplinary collaborations.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Timothy F. Murphy, Rita Hubbard Robinson, Kelly M. Wofford, Alan J. Lesse, Susan Grinslade, Henry L. Taylor, Kinzer M. Pointer, George F. Nicholas, Heather Orom
Summary: The African American population in Buffalo, New York faces significant health disparities due to social determinants of health. A community-university partnership organized the annual Igniting Hope conference series to address these disparities. The series has become the premier conference on health disparities in the region, attracting community members, leaders, university faculty, and trainees. It has led to initiatives such as a new state law, mitigation of COVID-19 fatalities, and the establishment of a university-supported institute.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Microbiology
Elaine M. Mokrzan, Christian P. Ahearn, John R. Buzzo, Laura A. Novotny, Yan Zhang, Steven D. Goodman, Lauren O. Bakaletz
Article
Microbiology
John M. Atack, Timothy F. Murphy, Melinda M. Pettigrew, Kate L. Seib, Michael P. Jennings
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Respiratory System
David M. Jacobs, Katia Noyes, Jiwei Zhao, Walter Gibson, Timothy F. Murphy, Sanjay Sethi, Heather M. Ochs-Balcom
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2018)
Article
Microbiology
John M. Atack, Timothy F. Murphy, Lauren O. Bakaletz, Kate L. Seib, Michael P. Jennings
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2018)