Review
Clinical Neurology
Duriel Hardy, Tanuja Chitnis, Emmanuelle Waubant, Brenda Banwell
Summary: Pediatric-onset multiple sclerosis is a relapsing-remitting neuroinflammatory disease characterized by frequent relapses and high lesion burden on MRI. Current treatment focuses on early initiation of disease-modifying therapies to prevent relapses and slow disability progression. Studying the pediatric MS population allows exploration of early-life exposures that contribute to MS development, including perinatal and environmental risk factors.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Anna Eusebi, Pietro Zara, Ignazio Roberto Zarbo, Silvia Festa, Veronica Dessi, Valentina Pes, Francesca Salis, Giovanni Sotgiu, Alessandra Carta, Stefano Sotgiu
Summary: The study assessed the frequency, characteristics, and future trajectory of monophasic acquired demyelinating syndromes (ADS) associated with conversion to pediatric multiple sclerosis in children from Sardinia. It was found that nearly half of the children with ADS could already be diagnosed with pediatric multiple sclerosis at onset, and 72% of those with ADS will develop pediatric multiple sclerosis after an average of 8 years. The results indicate Sardinia is a high-risk area for ADS in children.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Review
Neurosciences
Steven C. Pike, Nora Welsh, Michael Linzey, Francesca Gilli
Summary: This article introduces the etiology of multiple sclerosis (MS) and the importance of verifying viral hypotheses of MS through the TMEV-IDD model. The main mechanisms of CNS autoimmunity, the contribution of different immune cells to TMEV-IDD, and the sexual dimorphism observed in TMEV-IDD and MS are discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Elisea De Somma, Julia O'Mahony, Robert A. Brown, Brian L. Brooks, E. Ann Yeh, Alonso Cardenas de La Parra, Douglas Arnold, D. Louis Collins, Josefina Maranzano, Sridar Narayanan, Ruth Ann Marrie, Amit Bar-Or, Brenda Banwell, Christine Till
Summary: This study found that cognitive functioning in adolescents with ADS remained stable over a two-year period, but declines were noted in certain cognitive tests such as auditory working memory, symbol digit modalities, and visual matching. Lower normalized brain volume at early stages may predict negative changes in cognitive abilities.
CHILD NEUROPSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Dominic O. Co
Summary: Acquired demyelinating syndromes (ADS) are a group of inflammatory demyelinating conditions that include optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Differentiating between subtypes of ADS is important for optimal patient management, and this can be achieved by considering clinical features, laboratory tests (especially autoantibodies), and MRI findings.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Luciana Midaglia, Ana Felipe-Rucian, Ignacio Delgado Alvarez, Xavier Montalban, Mar Tintore
Summary: This case report presents a 9-year-old girl with subacute symptoms of severe bilateral visual acuity decrease and gait ataxia. Features on MRI and positive anti MOG antibodies in cerebrospinal fluid (CSF) led to the diagnosis of MOG antibody disease (MOGAD) with a neuromyelitis optica spectrum disorder (NMOSD)-like picture. However, during follow-up, new lesions suggestive of pediatric-onset MS (POMS) appeared on brain MRI, leading to the restart of immunosuppressive treatment.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Nikita Malani Shukla, T. Charles Casper, Jayne Ness, Yolanda Wheeler, Tanuja Chitnis, Timothy Lotze, Mark Gorman, Leslie Benson, Bianca Weinstock-Guttmann, Greg Aaen, Moses Rodriguez, Jan-Mendelt Tillema, Lauren Krupp, Teri Schreiner, Soe Mar, Manu Goyal, Mary Rensel, Aaron Abrams, John Rose, Michael Waltz, Tony Liu, Corinne Manlius, Emmanuelle Waubant
Summary: This study describes the demographic features and clinical and radiologic course of pediatric-onset multiple sclerosis (POMS) patients treated with commonly used newer disease-modifying treatments (DMTs) in the US. The data suggests clinical and MRI benefit, as well as high rates of no evidence of disease activity (NEDA-2), in a large number of POMS patients, despite relatively short treatment duration with the DMTs.
PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Giulia Longoni, Robert A. Brown, Ade Oyefiade, Renisha Iruthayanathan, Colin Wilbur, Shahriar Shams, Austin Noguera, Stephanie A. Grover, Julia O'Mahony, Luke Chung, Michael J. Wan, Jean K. Mah, Fiona Costello, Douglas L. Arnold, Ruth Ann Marrie, Amit Bar-Or, Brenda Banwell, Donald Mabbott, Arun Y. Reginald, E. Ann Yeh
Summary: The study found that early episodes of optic neuritis have a significant impact on neuroaxonal structure in pediatric acquired demyelinating syndromes. Non-optic neuritis relapses were also associated with reduced retinal thickness in multiple sclerosis (MS) patients. Additionally, youth with MS showed chronic retinal neurodegenerative changes.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Maria Ruby Rose Q. Castaneda, Adrian Espiritu, Marilyn A. Tan
Summary: This study provides a comprehensive summary of the clinical features of children with PADS at a Philippine tertiary hospital, highlighting the importance of using clinical diagnostic criteria to improve case recognition in low- and middle-income countries. The study also emphasizes the need for international registries with wider geographic representation to develop diagnostic and management guidelines suitable for different levels of care.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Eva Costa-Arpin, Begona Ares, Arturo Gonzalez-Quintela, Jose Prieto-Gonzalez
Summary: A study on the changing prevalence of multiple sclerosis in Santiago de Compostela, Spain, found that the prevalence doubled in 12 years, while the difference in incidence was not significant. The higher mean age in the last study suggests a longer survival of patients with MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Maria Di Gregorio, Valentina Liliana Adriana Torri Clerici, Giuseppe Fenu, Lorenzo Gaetani, Antonio Gallo, Paola Cavalla, Paolo Ragonese, Pietro Annovazzi, Alberto Gajofatto, Luca Prosperini, Doriana Landi, Carolina Gabri Nicoletti, Caterina Di Carmine, Rocco Totaro, Viviana Nociti, Chiara De Fino, Diana Ferraro, Valentina Tomassini, Carla Tortorella, Isabella Righini, Maria Pia Amato, Alessia Manni, Damiano Paolicelli, Pietro Iaffaldano, Roberta Lanzillo, Marcello Moccia, Fabio Buttari, Roberta Fantozzi, Raffaella Cerqua, Sara Zagaglia, Deborah Farina, Giovanna De Luca, Maria Chiara Buscarinu, Federica Pinardi, Eleonora Cocco, Claudio Gasperini, Claudio Marcello Solaro, Massimiliano Di Filippo
Summary: The study found that tumefactive multiple sclerosis (TuMS) primarily affects women with a young onset age, and presents with unique disease characteristics. Some patients require multiple acute-phase treatments, while those with certain risk factors may experience disease progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Jose Fernandez-Velasco, Enric Monreal, Jens Kuhle, Virginia Meca-Lallana, Jose Meca-Lallana, Guillermo Izquierdo, Celia Oreja-Guevara, Francisco Gascon-Gimenez, Susana Sainz de la Maza, Paulette E. Walo-Delgado, Paloma Lapuente-Suanzes, Aleksandra Maceski, Eulalia Rodriguez-Martin, Ernesto Roldan, Noelia Villarrubia, Albert Saiz, Yolanda Blanco, Carolina Diaz-Perez, Gabriel Valero-Lopez, Judit Diaz-Diaz, Yolanda Aladro, Luis Brieva, Cristina Iniguez, Ines Gonzalez-Suarez, Luis A. Rodriguez de Antonio, Jose M. Garcia-Dominguez, Julia Sabin, Sara Llufriu, Jaime Masjuan, Lucienne Costa-Frossard, Luisa M. Villar
Summary: This study aimed to investigate the role of inflammation in the response to ocrelizumab in patients with PPMS. The findings showed that over 60% of patients achieved no evidence of disease activity (NEDA) after one year of treatment, regardless of their baseline characteristics. The baseline inflammation influenced the predominant immunological pathways, with inflammatory B cells playing a pivotal role in Gd+ patients and inflammatory T and innate immune cells in Gd- patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Annarita Del Gatto, Michele Saviano, Laura Zaccaro
Summary: Multiple sclerosis is a progressive and highly debilitating disease, with current treatment strategies showing limitations in preventing disease progression. Peptide-based systems offer new therapeutic opportunities for the treatment of MS.
Editorial Material
Clinical Neurology
David Wynne, Benjamin Kim Hung Ho, Tiew Fong Han
Summary: Tumefactive demyelinating lesions (TDLs) are rare sequelae of idiopathic inflammatory demyelinating diseases, often mimicking tumors and abscesses. This case emphasizes the importance of considering the rare diagnosis of TDL in otherwise healthy young adults with cystic brain lesions on imaging.
WORLD NEUROSURGERY
(2021)
Review
Public, Environmental & Occupational Health
Bruno Kusznir Vitturi, Alfredo Montecucco, Alborz Rahmani, Guglielmo Dini, Paolo Durando
Summary: This study conducted the first systematic review with meta-analysis to investigate the occupational risk factors of Multiple Sclerosis. It found that agricultural workers, offshore workers, hairdressers, individuals exposed to toxic fumes from oil wells, low-frequency magnetic fields, and pesticides had an increased likelihood of being diagnosed with MS, which could potentially influence public policies and calls for future research in this area.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Signe Stelling Risom, Lau Caspar Thygesen, Trine Bernholdt Rasmussen, Britt Borregaard, Marianne Wetendorff Norgaard, Rikke Mols, Anne Vinggaard Christensen, Charlotte Brun Thorup, Lars Thrysoee, Knud Juel, Ola Ekholm, Selina Kikkenborg Berg
Summary: This study aims to describe potential risk factors at discharge and their associations with readmission from 60 days to 1 year after discharge.
JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Clinical Neurology
Johanna Balslev Andersen, Finn Sellebjerg, Melinda Magyari
Summary: This study found no increased association of adverse pregnancy outcomes in newborns with fetal exposure to disease-modifying drugs (DMDs) when compared with either DMD-unexposed pregnancies or the general population.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alessio Signori, Johannes Lorscheider, Sandra Vukusic, Maria Trojano, Pietro Iaffaldano, Jan Hillert, Robert Hyde, Fabio Pellegrini, Melinda Magyari, Nils Koch-Henriksen, Per Soelberg Sorensen, Tim Spelman, Anneke van Der Walt, Dana Horakova, Eva Havrdova, Marc Girard, Sara Eichau, Francois Grand'Maison, Oliver Gerlach, Murat Terzi, Serkan Ozakbas, Olga Skibina, Vincent Van Pesch, Maria Jose Sa, Julie Prevost, Raed Alroughani, Pamela A. McCombe, Riadh Gouider, Saloua Mrabet, Tamara Castillo-Trivino, Chao Zhu, Koen de Gans, Jose Luis Sanchez-Menoyo, Bassem Yamout, Samia Khoury, Maria Pia Sormani, Tomas Kalincik, Helmut Butzkueven
Summary: This study identifies different subgroups of patients with secondary progressive multiple sclerosis (SPMS) based on their longitudinal trajectories of disability. The findings suggest that SPMS patients progress at greatly different rates and the identification of distinct trajectories can guide better patient selection in future clinical trials. Additionally, the distinct trajectories may reflect heterogeneous pathological mechanisms of progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Mathilde Adsersen, Lau Caspar Thygesen, Mette Asbjoern Neergaard, Per Sjogren, Lise Mondrup, Jette Soegaard Nissen, Lars Michael Clausen, Mogens Groenvold
Summary: This nationwide study investigated the association between cancer patients' education and income and admittance to specialized palliative care. The results showed that patients with higher education and income were more likely to be admitted to palliative care services, indicating an inequity that needs to be addressed for patients with lower education and income.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sophie S. Hellmann, Sanne P. Moller, Annette K. Ersboll, Ziggi Santini, Maj Britt D. Nielsen, Morten K. Gronbaek, Ola Ekholm, Lau C. Thygesen
Summary: This study evaluated the association between changes in labor force participation and depression risk during COVID-19 in Denmark. The study found that unemployment, being outside the labor force, and working part-time were associated with an increased risk of depression.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Siri Rosenkilde, Ola Ekholm, Sanne P. P. Moller, Maj Britt D. Nielsen, Lau C. C. Thygesen
Summary: This study aimed to investigate the main reasons for COVID-19 vaccine hesitancy and factors associated with it. A nationwide survey revealed concerns about adverse effects and the belief in natural immunity as the main reasons for hesitancy. Factors associated with hesitancy included female sex, younger age, being divorced, a non-Danish country of origin, lower educational level, unemployment, previous COVID-19 infection, and a greater worry about oneself and others getting infected. Future vaccination programs should target these specific socio-demographic subgroups to reduce hesitancy and increase uptake.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Oncology
Mathilde Adsersen, Lau Caspar Thygesen, Maria Kristiansen, Maiken Bang Hansen, Mette Asbjoern Neergaard, Morten Aagaard Petersen, Mogens Groenvold
Summary: The ageing population of immigrants in Europe will result in an increased demand for specialised palliative care. However, the admittance of immigrants to specialised palliative care in Europe has not been well studied.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Public, Environmental & Occupational Health
Anne Sofie Plum Christensen, Veronica Pisinger, Anne Friis Krarup, Peter Dalum, Lau Caspar Thygesen, Janne Schurmann Tolstrup
Summary: Excessive alcohol consumption among young people is a global public health concern due to its negative impact on short- and long-term well-being. This study investigated the association between weekly alcohol consumption and various measures of poor well-being among students aged 15-25 years in Denmark. The findings revealed a U-shaped relationship, where both non-drinkers and heavy drinkers had higher odds of poor well-being compared to moderate drinkers. Understanding these associations can contribute to reducing alcohol consumption and promoting well-being among young students.
PREVENTIVE MEDICINE REPORTS
(2023)
Article
Oncology
Cecilie Larsen, Kirstine S. Kirchhoff, Lena Saltbaek, Lau C. Thygesen, Randi V. Karlsen, Mads N. Svendsen, Beverley L. Hoeg, Trine A. Horsbol, Pernille E. Bidstrup, Helle G. Christensen, Christoffer Johansen, Susanne O. Dalton
Summary: This study investigates the association between education level and fear of recurrence (FCR) among breast cancer patients, and finds that patients with higher education levels have less FCR compared to those with lower education levels. Self-efficacy only mediates a small part of this association among patients within 5 years since diagnosis.
Article
Public, Environmental & Occupational Health
Nanna Schneekloth Jarlstrup, Lau C. Thygesen, Charlotta Pisinger, Jorgen Vestbo, Morten Gronbaek, Janne S. Tolstrup
Summary: The national smoking ban in Denmark did not have a significant impact on the incidence of smoking-related diseases, and there were no differences observed among socioeconomic groups. Therefore, future tobacco control measures in Denmark should focus on targeting low socioeconomic groups to address the strong socioeconomic inequality in health.
Article
Oncology
Anne Katrine Graudal Levinsen, Trille Kristina Kjaer, Lau Caspar Thygesen, Thomas Maltesen, Erik Jakobsen, Ismail Gogenur, Michael Borre, Peer Christiansen, Robert Zachariae, Peter Christensen, Soren Laurberg, Peter de Nully Brown, Lisbet Rosenkrantz Hoelmich, Christoffer Johansen, Susanne K. Kjaer, Lonneke van de Poll-Franse, Lena Saltbaek, Susanne Oksbjerg Dalton
Summary: There are variations in health-related quality of life (HRQoL) among cancer survivors in Denmark depending on their educational level. Cancer survivors with lower education tend to have more impaired functioning and severe symptoms, emphasizing the need for targeted support and interventions.
Article
Clinical Neurology
Dominika Stastna, Frederik Elberling, Luigi Pontieri, Elisabeth Framke, Dana Horakova, Jiri Drahota, Petra Nytrova, Melinda Magyari
Summary: This study evaluated the difference in relapse occurrence pre- and post-COVID-19 vaccination in Danish patients with relapsing multiple sclerosis. The findings showed that there was no significant increase in relapse activity following the administration of the first dose of the COVID-19 vaccine.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Richard Nicholas, Jeff Rodgers, James Witts, Annalaura Lerede, Tim Friede, Jan Hillert, Lars Forsberg, Anna Glaser, Ali Manouchehrinia, Ryan Ramanujam, Tim Spelman, Pernilla Klyve, Jiri Drahota, Dana Horakova, Hanna Joensen, Luigi Pontieri, Melinda Magyari, David Ellenberger, Alexander Stahmann, Helmut Butzkueven, Anneke Van der Walt, Vladimir Bezlyak, Carol Lines, Rod Middleton
Summary: This study analyzed registry data from multiple countries and found variations in DMT usage, with factors such as gender, disability level, and monitoring influencing the likelihood of receiving DMTs. The study also explored the impact of diagnosis on DMT usage in clinical SPMS.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Substance Abuse
Nanna Schneekloth Jarlstrup, Lau Caspar Thygesen, Morten Kloecker Gronbaek, Morten Hulvej Rod, Janne Schurmann Tolstrup
Summary: The implementation of a national smoking ban in Denmark did not consistently reduce the incidence of smoking-related diseases compared to pre-ban levels.
NICOTINE & TOBACCO RESEARCH
(2023)