Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder

(2017) Ryan K C Yuen et al.   NATURE NEUROSCIENCE

An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability

(2016) Jonathan D. J. Labonne et al.   HUMAN GENETICS

Innate Color Preference of Zebrafish and Its Use in Behavioral Analyses

(2016) Jong-Su Park et al.   MOLECULES AND CELLS

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior

(2016) Zohar Ben-Moshe Livne et al.   PLoS Genetics

Sexually dimorphic neuronal responses to social isolation

(2016) Laura Senst et al.   eLife

Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A

(2015) Lucas M Bronicki et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DYRK1A mutations in two unrelated patients

(2015) Lyse Ruaud et al.   European Journal of Medical Genetics

Genetic dissection of the Down syndrome critical region

(2015) Xiaoling Jiang et al.   HUMAN MOLECULAR GENETICS

ZC4H2, an XLID gene, is required for the generation of a specific subset of CNS interneurons

(2015) Melanie May et al.   HUMAN MOLECULAR GENETICS

Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID

(2015) B W M van Bon et al.   MOLECULAR PSYCHIATRY

Development of social behavior in young zebrafish

(2015) Elena Dreosti et al.   Frontiers in Neural Circuits

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

(2014) Ulf Soppa et al.   CELL CYCLE

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene Dyrk1a

(2014) A. Thomazeau et al.   JOURNAL OF NEUROSCIENCE

Social behavior of zebrafish: From synthetic images to biological mechanisms of shoaling

(2014) Robert Gerlai   JOURNAL OF NEUROSCIENCE METHODS

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

Zebrafish as an emerging model for studying complex brain disorders

(2014) Allan V. Kalueff et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Induction of Social Behavior in Zebrafish: Live Versus Computer Animated Fish as Stimuli

(2014) Meiying Qin et al.   Zebrafish

DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson’s disease

(2014) M J Barallobre et al.   Cell Death & Disease

Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae

(2013) Ulrich Herget et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Autism

(2013) Meng-Chuan Lai et al.   LANCET

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Dissociating the effects of habituation, black walls, buspirone and ethanol on anxiety-like behavioral responses in shoaling zebrafish. A 3D approach to social behavior

(2013) Hans Maaswinkel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Developing zebrafish models of autism spectrum disorder (ASD)

(2013) Adam Michael Stewart et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function

(2013) Matthew O. Parker et al.   Frontiers in Neural Circuits

Translocations Disrupting PHF21A in the Potocki-Shaffer-Syndrome Region Are Associated with Intellectual Disability and Craniofacial Anomalies

(2012) Hyung-Goo Kim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effects of nicotine and alcohol on zebrafish (Danio rerio) shoaling

(2012) Noam Miller et al.   BEHAVIOURAL BRAIN RESEARCH

Automated high-throughput neurophenotyping of zebrafish social behavior

(2012) Jeremy Green et al.   JOURNAL OF NEUROSCIENCE METHODS

An affective disorder in zebrafish with mutation of the glucocorticoid receptor

(2012) L Ziv et al.   MOLECULAR PSYCHIATRY

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant

(2012) Christelle Golzio et al.   NATURE

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

DYRK1A: A master regulatory protein controlling brain growth

(2012) Fayçal Guedj et al.   NEUROBIOLOGY OF DISEASE

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

17α-Ethinyl estradiol affects anxiety and shoaling behavior in adult male zebra fish (Danio rerio)

(2011) Nasim Reyhanian et al.   AQUATIC TOXICOLOGY

Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly

(2011) BWM van Bon et al.   CLINICAL GENETICS

Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice

(2011) G. Murakami et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Three-Dimensional Neurophenotyping of Adult Zebrafish Behavior

(2011) Jonathan Cachat et al.   PLoS One

Identification of a brain center whose activity discriminates a choice behavior in zebrafish

(2011) B. Y. B. Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WDR11, a WD Protein that Interacts with Transcription Factor EMX1, Is Mutated in Idiopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome

(2010) Hyung-Goo Kim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

(2010) Evan Elliott et al.   NATURE NEUROSCIENCE

Measuring behavioral and endocrine responses to novelty stress in adult zebrafish

(2010) Jonathan Cachat et al.   Nature Protocols

Shoaling develops with age in Zebrafish (Danio rerio)

(2010) Christine Buske et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish

(2009) Rupert J. Egan et al.   BEHAVIOURAL BRAIN RESEARCH

Analyzing habituation responses to novelty in zebrafish (Danio rerio)

(2009) Keith Wong et al.   BEHAVIOURAL BRAIN RESEARCH

Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice

(2009) Glòria Arqué et al.   NEUROBIOLOGY OF DISEASE

Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly

(2008) Rikke S. Møller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The social zebrafish: Behavioral responses to conspecific, heterospecific, and computer animated fish

(2008) Cristina Saverino et al.   BEHAVIOURAL BRAIN RESEARCH

Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

(2008) Glòria Arqué et al.   PLoS One

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols