Article
Chemistry, Multidisciplinary
Taiyu Song, Hui Zhang, Zhiqiang Luo, Luoran Shang, Yuanjin Zhao
Summary: Chemotherapy is hindered by tumor heterogeneity in pancreatic cancer patients. This study introduces a microfluidic encapsulated and integrated primary pancreatic cancer cells platform for biomimetic tumor 3D cultivation and clinical drug evaluation. The results demonstrate its potential in clinical drug evaluation.
Article
Chemistry, Multidisciplinary
Hong Chen, Hui Zhang, Yanhong Dai, Haofang Zhu, Guodong Hong, Chengwen Zhu, Xiaoyun Qian, Renjie Chai, Xia Gao, Yuanjin Zhao
Summary: Novel magnetic alpha-lipoic acid (ALA)-conjugated gelatin methacryloyl hydrogel microrobots are developed for inner ear drug delivery and deafness prevention. These microrobots possess slow drug release, targeted movement, and biosafety, generated from microfluidic devices. Pre-injecting them in the middle ear of cisplatin-deafened mice demonstrates the practical value of these smart magnetic hydrogel microrobots in deafness prevention.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yixuan Shang, Yuxiao Liu, Hanxu Chen, Dagan Zhang, Yuzhi Yang, Yuanjin Zhao
Summary: The intelligent microfluidic device with responsive structural color hydro gel microchannels has the capability of controllable fluid manipulation and visual state feedback, showing potential in constructing self-regulating micropumps and supporting oriented sensing analysis.
APPLIED MATERIALS TODAY
(2021)
Review
Marine & Freshwater Biology
Beiyu Hu, Peng Xu, Liang Ma, Dongwei Chen, Jian Wang, Xin Dai, Li Huang, Wenbin Du
Summary: Microbes play a crucial role in influencing the Earth's environment, yet remain poorly understood due to limited capacity. The emerging technology of droplet microfluidics offers promising solutions for microbial studies, enabling high-throughput single-cell cultivation, screening, and sequencing. This review provides an overview of droplet microfluidics techniques for microbial research, focusing on critical steps in the microfluidic system and recent progress in microbiological applications.
MARINE LIFE SCIENCE & TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Valerie L. Harmon, Ed Wolfrum, Eric P. Knoshaug, Ryan Davis, Lieve M. L. Laurens, Philip T. Pienkos, John McGowen
Summary: This study introduces a set of standard metrics for describing the reliability of algae cultivation systems, providing a basis for quantifying pond failures and offering insights into pond management and contaminant mitigation strategies based on measured experimental values.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Engineering, Biomedical
Yin Yao, Yiqiang Fan
Summary: This study introduces a rapid and low-cost method for fabricating open-channel hydrogel-based microfluidic devices using CO2 laser ablation, with detailed investigation on the profiles of laser-ablated microchannels. Additionally, an easy-to-access storage method for hydrogel-based microfluidic devices is proposed.
BIOMEDICAL MICRODEVICES
(2021)
Article
Chemistry, Physical
Lilith M. Caballero Aguilar, Serena Duchi, Carmine Onofrillo, Cathal D. O'Connell, Claudia Di Bella, Simon E. Moulton
Summary: Microfluidic systems show great potential in delivering bioactive agents for tissue engineering applications. The fine-tuning of parameters in microfluidic systems is crucial for maximizing encapsulation efficiency and generating bioactive microspheres.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Pierre-Alexandre Goyette, Etienne Boulais, Maude Tremblay, Thomas Gervais
Summary: The article introduces the pixelated chemical display (PCD) for highly parallel and reconfigurable liquid handling on open surfaces. It creates microfluidic pixels to display dynamic chemical images on surfaces without the need for physical barriers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao
Summary: Erythrocytes, with their unique morphology and cellular composition, have inspired the development of various artificial biomaterials that have broad prospects in biomedical applications. This comprehensive review covers the fabrication and applications of erythrocyte-inspired functional materials, highlighting the synthesis strategies of particles with erythrocyte-inspired morphologies and discussing their practical biomedical applications. The future possibilities of advanced erythrocyte-inspired biomaterials are also explored, with the aim of inspiring researchers to develop novel biomaterials and accelerate their progress towards clinical biomedical applications.
Article
Biotechnology & Applied Microbiology
Marina Mariotto, Sophia Egloff, Ines Fritz, Dominik Refardt
Summary: PHB-producing cyanobacteria can be used as a raw material for bio-based and biodegradable plastics. Scaling up cultivation in open systems and reducing costs by using waste streams as nutrient sources are feasible, but the environmental parameters have a significant impact on PHB yields and must be considered for optimization.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Review
Materials Science, Multidisciplinary
Anthony Beck, Franziska Obst, Denise Gruner, Andreas Voigt, Philipp Jan Mehner, Stefan Gruenzner, Rene Koerbitz, Mohammed Hadi Shahadha, Alexander Kutscher, Georgi Paschew, Uwe Marschner, Andreas Richter
Summary: This article discusses the application of stimuli-sensitive hydrogels in miniaturized, integrated sensor and actuator systems. It focuses on the design parameters of hydrogel-based valves and highlights key developments in the field. The article also provides essential design guidelines and scaling laws for hydrogel-based components.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Daniel A. N. Foster, Dae Kun Hwang
Summary: This article introduces a microfluidic assembly fabrication based on flow lithography for producing polymeric sheets with geometrically complex and selective patterns. The method combines a magnetic clamp with flow lithography, enabling rapid flow-assisted exchanges of multiple compositions and achieving high resolution.
APPLIED MATERIALS TODAY
(2022)
Review
Biochemical Research Methods
Kel S. Hakim, Blanca H. Lapizco-Encinas
Summary: Nonlinear electrokinetics technologies, such as DEP particle trapping and EROT for particle assessments, have been widely applied in the analysis, sensing, and purification of microorganisms. Recent research has made significant advancements in these technologies, showcasing the potential future developments within the field of microscale EK.
Article
Materials Science, Multidisciplinary
Cheng Zhao, Jiahui Guo, Han Zhang, Min Nie, Caihong Yang, Yujuan Zhu, Yuanjin Zhao, Liping Zhong
Summary: In this study, bamboo-inspired gasotransmitter microfibres were generated using microfluidic spinning, allowing for precise control of bubble size and morphology. The microfibres promoted wound healing through the dual effects of drugs and gas, and the addition of responsive materials enabled controlled drug release for continuous effects.
ADVANCED FIBER MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Phillip Lemke, Ahmed E. Zoheir, Kersten S. Rabe, Christof M. Niemeyer
Summary: The study presents a machine-based microfluidic biofilm cultivation and analysis platform, showing its value in spatial analysis of biocatalytically active biofilms. The platform's reproducibility and capability for in-depth spatially resolved studies on biomass growth and productivity make it a valuable tool for investigating biofilms and microbial communities for various technical purposes.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)