Article
Pharmacology & Pharmacy
Guo Dai, Gaiwei Liu, Di Zheng, Qi Song
Summary: Low concentrations of cisplatin can induce EMT-like characteristics in osteosarcoma cells, promote cell mobility, and activate the Notch signaling pathway. Combining cisplatin with a Notch signaling pathway inhibitor effectively inhibits cell migration and invasion, reducing pulmonary metastatic nodules in vivo.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye, Jiacong Hong, Zhongyu Xie, Keng Chen, Yanfeng Wu, Huiyong Shen
Summary: The study demonstrates that CCR9 promotes osteosarcoma lung metastasis by activating the Wnt/beta-catenin signaling pathway, suggesting that CCR9 may be a promising therapeutic target to inhibit lung metastasis and serve as a novel prognostic marker for osteosarcoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Shuang Qu, Xiaoli Huang, Xiaoling Guo, Zhihai Zheng, Tiannan Wei, Biyun Chen
Summary: Through comparative RNA-seq analysis, we identified differential expression of EMT genes in AML patients and constructed a metastasis-related EMT signature (MEMTs). Analysis on different cohorts showed that MEMTs were associated with prognosis and chemotherapy response in AML. Functional experiments demonstrated that CDH2 is a key gene promoting leukemia cell metastasis among the three MEMTs genes. These findings provide potential predictive factors for AML prognosis and chemotherapy response, with CDH2 as a potential therapeutic target.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Cheng Zhang, Yu Liang, Chun-Dong Zhang, Jun-Peng Pei, Kun-Zhe Wu, Yong-Zhi Li, Dong-Qiu Dai
Summary: LINC01235 is significantly over-expressed in gastric cancer cells and tissues, and its high expression is positively correlated with poor prognosis. It can promote cancer cell metastasis through the EMT pathway.
Article
Biochemistry & Molecular Biology
Huiyan Niu, Anna Qu, Chunyan Guan
Summary: The study revealed that miR-188-5p inhibits invasion and migration of lung cancer cells by regulating the MGAT3 gene, thereby suppressing the EMT process, suggesting potential therapeutic value for the management of metastatic lung cancer.
BIOMEDICAL JOURNAL
(2021)
Article
Oncology
Yan Chen, Jun Li, Jia-Kun Xiao, Lei Xiao, Bin-Wu Xu, Chen Li
Summary: Research has shown that the NEAT1/miR-483/STAT3 axis plays an important role in regulating the metastasis of osteosarcoma. Potential therapeutic targeting of this axis could have beneficial effects on osteosarcoma treatment in the future.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jiazhang Wei, Weiming Deng, Jingjin Weng, Min Li, Guiping Lan, Xiang Li, Linsong Ye, Yongli Wang, Fei Liu, Huashuang Ou, Yunzhong Wei, Wenlin Huang, Sifang Xie, Guohu Dong, Shenhong Qu
Summary: CTC classification allows for a better understanding of cellular phenotypic changes responsible for locoregional invasion and distant metastasis in nasopharyngeal carcinoma (NPC), and predicts clinical outcomes in patients with progressive NPC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Di Zheng, Kezhou Xia, Ling Yu, Changtian Gong, Yubo Shi, Wei Li, Yonglong Qiu, Jian Yang, Weichun Guo
Summary: The study identified 6 metastasis-related genes and constructed a novel prognostic signature for predicting overall survival in osteosarcoma patients, with FHIT potentially being a therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yang Song, Weiwei An, Hongmei Wang, Yuanren Gao, Jihua Han, Chenguang Hao, Lin Chen, Shilong Liu, Ying Xing
Summary: LRH-1 plays a crucial role in osteosarcoma, predicting metastatic potential and serving as a potential target for cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal-Egana, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Faergeman, Ole N. Jensen, Rasmus Siersbaek, Kumar Somyajit, Paolo Ceppi
Summary: This study found an inverse association between short-chain fatty acids and EMT in non-small cell lung cancer patients. In vitro experiments showed that propionate treatment enhanced the epithelial transcriptional program and reduced the EMT phenotype in lung cancer cell lines. Animal experiments also confirmed that propionate can reduce lung cancer metastasis and lymph node spread. Further mechanistic investigation revealed that propionate treatment caused chromatin remodeling through p300-mediated histone acetylation.
EMBO MOLECULAR MEDICINE
(2023)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Wen-Hui Hsieh, Shu-Wei Liao, Shun-Ming Chan, Jin-De Hou, Szu-Yuan Wu, Bing-Ying Ho, Kung-Yen Chen, Yu-Ting Tai, Hsu-Wei Fang, Chih-Yuan Fang, Se-Yi Chen, Jui-An Lin
Summary: The effects of clinically relevant concentrations of lidocaine on epithelial-mesenchymal transition (EMT) and associated lung cancer behaviors were investigated. Lidocaine attenuated the inhibitory effect of 5-fluorouracil (5-FU) on cell migration and promoted EMT at clinically relevant concentrations. Lidocaine also induced EMT-associated anoikis resistance in lung cancer cells.
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.