Article
Biochemistry & Molecular Biology
Konstantinos Loukelis, Foteini Machla, Athina Bakopoulou, Maria Chatzinikolaidou
Summary: This study investigates the impact of kappa-carrageenan on dental pulp stem cells and reveals that its integration in scaffolds significantly enhances the odontogenic potential of DPSCs, supporting dentin-pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Karina Mitchell, Sreejith S. Panicker, Calista L. Adler, George A. O'Toole, Katherine R. Hixon
Summary: Honey has been used for centuries to reduce bacterial infection, and Manuka honey with Unique Manuka Factor (UMF) possesses additional antibacterial properties. This study investigated the incorporation of Manuka honey into chitosan-gelatin cryogels and hydrogels, finding that lower concentrations showed improved bacterial clearance while higher concentrations resulted in cell death.
Article
Materials Science, Multidisciplinary
Tansza Setiana Putri, Devi Rianti, Priyawan Rachmadi, Anita Yuliati
Summary: A composite scaffold was successfully fabricated using beta-tricalcium phosphate (beta TCP) extracted from limestone, mixed with chitosan and gelatin. The study optimized the fabrication process and evaluated the effect of glutaraldehyde on scaffold characteristics. Results showed that lower porosity led to higher compressive strength in the cross-linked scaffolds.
Article
Biochemistry & Molecular Biology
Fatemeh Eftekhari-Pournigjeh, Mahdi Saeed, Sarah Rajabi, Maryam Tamimi, Mohamad Pezeshki-Modaress
Summary: In this study, chitosan/gelatin composite scaffolds reinforced by centrifugally spun PLA chopped nano/microfibers were successfully prepared. The results showed that scaffolds reinforced with 2% PLA-CFs had enhanced mechanical properties and better cell penetration and distribution.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Soroush Ahmadi, Ahmad Hivechi, S. Hajir Bahrami, Peiman B. Milan, Seyedeh Sara Ashraf
Summary: This study developed chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The incorporation of CE enhanced the properties of the nanofibers, including degradation behavior, antibacterial activity, and biocompatibility. The extract release profile showed a burst release in the first 6 hours, followed by a controlled release in the next 138 hours.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Zhengyue Li, Xiuqiong Chen, Chaoling Bao, Chang Liu, Chunyang Liu, Dongze Li, Huiqiong Yan, Qiang Lin
Summary: The combination of alginate with bacterial cellulose nanocrystals-chitosan-gelatin composite scaffolds showed regular 3D morphologies and well-developed pore structures, with the addition of BCNs effectively controlling the swelling and biodegradation behavior. This composite scaffold exhibited good cytocompatibility, making it potentially suitable for bone tissue engineering applications.
Article
Polymer Science
Dania Adila Ahmad Ruzaidi, Mohd Muzamir Mahat, Zarif Mohamed Sofian, Nikman Adli Nor Hashim, Hazwanee Osman, Mohd Azizi Nawawi, Rosmamuhamadani Ramli, Khairil Anuar Jantan, Muhammad Faiz Aizamddin, Hazeeq Hazwan Azman, Yee Hui Robin Chang, Hairul Hisham Hamzah
Summary: This study successfully synthesized PEDOT:PSS hydrogels and characterized the performance of Cs-Gel-Agar porous hydrogels through various analysis methods. The results demonstrated the optimum electrical conductivity of the hydrogels at a 1% PEDOT:PSS mixing ratio.
Review
Polymer Science
Gamal Abdel Nasser Atia, Hany K. Shalaby, Mehrukh Zehravi, Mohamed Mohamady Ghobashy, Hager Abdel Nasser Attia, Zubair Ahmad, Farhat S. Khan, Abhijit Dey, Nobendu Mukerjee, Athanasios Alexiou, Md. Habibur Rahman, Joanna Klepacka, Agnieszka Najda
Summary: This article examined and summarized the current developments in chitosan-based materials, focusing on the modification of chitosan and its use in periodontal regeneration. The study critically reviewed various preparation and modification techniques to enhance chitosan performance and discussed the uses of chitosan-based products in depth.
Article
Nanoscience & Nanotechnology
Xuanwen Xu, Yi Zhou, Kai Zheng, Xinyu Li, Lu Li, Yan Xu
Summary: Periodontitis is a chronic inflammatory disease that affects people worldwide and has an uncertain prognosis with surgical treatment. In this study, a three-dimensional scaffold made of electrospun polycaprolactone/gelatin fibrous membranes was developed to overcome the challenges of periodontal treatment. The scaffold showed good properties and promoted adhesion and proliferation of human periodontal ligament stem cells. In vivo experiments confirmed that the scaffold could guide cellular orientation and potentially facilitate periodontal regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Georgia Vagropoulou, Maria Trentsiou, Anthie Georgopoulou, Eleni Papachristou, Oleg Prymak, Aristeidis Kritis, Matthias Epple, Maria Chatzinikolaidou, Athina Bakopoulou, Petros Koidis
Summary: This study demonstrates the potential of hybrid chitosan/gelatin/nanohydroxyapatite scaffolds to support viability and proliferation of dental pulp stem cells, inducing odontogenic differentiation and in vitro biomineralization without the addition of any inductive factors. The results suggest a promising strategy for tissue engineering of mineralized dental tissues.
Article
Biotechnology & Applied Microbiology
Elisa Roldan, Neil D. Reeves, Glen Cooper, Kirstie Andrews
Summary: This study evaluated the suitability of gelatin as the sole material to manufacture tissue engineering scaffolds. The gelatin-based electrospun scaffolds exhibited comparable mechanical properties to various human tissues, suggesting their potential application in tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Applied
Farnoush Sadat Rezaei, Fariborz Sharifianjazi, Amirhossein Esmaeilkhanian, Ehsan Salehi
Summary: Chitosan has shown unparalleled characteristics for regenerative medicine applications, offering biocompatibility, biodegradability, and film-forming capabilities. Recent advances in chitosan films and scaffolds in tissue engineering, wound healing, and drug delivery fields have been surveyed and discussed.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, Research & Experimental
JiUn Lee, Dongyun Kim, Chul Ho Jang, Geun Hyung Kim
Summary: This study attempted to fabricate a 3D printed scaffold with excellent mechanical properties and recoverable behavior, using human placental extracts as bioactive components. In vitro and in vivo results suggested that the G/H/hPE scaffold is a potential candidate for use in bone tissue engineering.
Article
Polymer Science
Parya Bahrami Miyanji, Dariush Semnani, Abdolkarim Hossein Ravandi, Saeed Karbasi, Aref Fakhrali, Sajjad Mohammadi
Summary: Chitosan-gelatin/single-walled carbon nanotubes functionalized by COOH (SWNTs-COOH) nanocomposite scaffolds were fabricated through electrospinning in this study. The addition of SWNTs-COOH improved the mechanical properties, stability, and cell viability of the scaffolds, making them suitable for cartilage tissue engineering applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Engineering, Biomedical
Abudureheman Maihemuti, Han Zhang, Xiang Lin, Yangyufan Wang, Zhihong Xu, Dagan Zhang, Qing Jiang
Summary: In this study, a three-dimensional printed porous multilayer scaffold made of cold-water fish skin gelatin was developed for osteoarticular cartilage regeneration. The scaffold mimics the structure of native cartilage, allowing chondrocytes to adhere, proliferate, and communicate, as well as transport nutrients and prevent further joint damage. Moreover, the gelatin scaffolds were found to be nonimmunogenic, nontoxic, and biodegradable. Implanting the scaffold into rat cartilage defects resulted in satisfactory repair outcomes in an animal model. Therefore, cold-water fish skin gelatin scaffolds have promising applications in regenerative medicine.
BIOACTIVE MATERIALS
(2023)