Journal
LIGHT-SCIENCE & APPLICATIONS
Volume 7, Issue -, Pages -Publisher
CHINESE ACAD SCIENCES, CHANGCHUN INST OPTICS FINE MECHANICS AND PHYSICS
DOI: 10.1038/lsa.2017.152
Keywords
interferometric imaging; label-free plasmonic biosensors; lens-free imaging; phase interrogation; point-of-care devices; protein microarray detection
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Funding
- European Union [644956]
- North Atlantic Treaty Organization's Public Diplomacy Division
- Ecole Polytechnique Federale de Lausanne research fund
- Fundacio Privada Cellex
- CERCA Programme/Generalitat de Catalunya
- International PhD fellowship program 'la Caixa'-Severo Ochoa @ ICFO
- International PhD fellowship program 'la Caixa' - Severo Ochoa @ ICFO
- Spanish Ministry of Economy and Competitiveness, through the 'Severo Ochoa' Programme for Centres of Excellence in RD [SEV-2015-0522]
- project OPTO-SCREEN [TEC2016-75080-R]
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Nanophotonics, and more specifically plasmonics, provides a rich toolbox for biomolecular sensing, since the engineered meta-surfaces can enhance light-matter interactions to unprecedented levels. So far, biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes. However, the phase response of the plasmonic resonances have rarely been exploited, mainly because this requires a more sophisticated optical arrangement. Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics. It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path configuration. This unique combination allows the detection of atomically thin (angstrom-level) topographical features over large areas, enabling simultaneous reading of thousands of microarray elements. As the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components, the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes. Our research opens new horizons for on-site disease diagnostics and remote health monitoring.
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