Article
Ophthalmology
Marina Knudsen Kirkegaard
Summary: Ocular adnexal lymphoma is a relatively rare malignancy, consisting of four main subtypes. Early diagnosis and analysis of clinical and genetic features of each subtype are crucial for predicting prognosis and guiding treatment.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Marina Knudsen Kirkegaard, Marthe Minderman, Lene Dissing Sjo, Steven T. Pals, Patrick R. G. Eriksen, Steffen Heegaard
Summary: This study aimed to reclassify ocular adnexal large B-cell lymphomas (OA-LBCLs) and investigate the prevalence and association of MYD88 and CD79B mutations with clinical parameters. The results revealed that OA-LBCL mainly consists of two subtypes, and MYD88 mutations, as well as cMYC/BCL2 double-expressor DLBCL, are associated with poor prognosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Stine Dahl Vest, Sarah E. Coupland, Bita Esmaeli, Paul T. Finger, Gerardo F. Graue, Hans E. Grossniklaus, Tine Gadegaard Hindso, Frederik Holm, Santosh G. Honavar, Jwu Jin Khong, Marina Knudsen Kirkegaard, Penelope A. McKelvie, Lauge Hjorth Mikkelsen, Kaustubh Mulay, Peter Kristian Rasmussen, Volkert Siersma, Lene Dissing Sjo, Matthew C. Sniegowski, Bradley A. Thuro, Geeta K. Vemuganti, Steffen Heegaard
Summary: The specific location of ocular adnexal lymphoma (OAL) and the AJCC TNM tumour stage are prognostic factors for mortality in different OAL subtypes. Eyelid lymphoma has the highest disease-specific mortality in all subtypes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuqing Hou, Xiaoyang Xie, Jixin Chen, Peng Lv, Shijie Jiang, Xiaowei He, Lijuan Yang, Fengjun Zhao
Summary: The BOF-based radiomics is effective in differentiating between OAL and IOI. The method shows potential for improved differentiation when combined with data augmentation, and performs better compared to human radiological diagnosis.
EUROPEAN RADIOLOGY
(2021)
Article
Pathology
Junpeng Xu, Peifeng Li, Jia Chai, Kangjie Yu, Tianqi Xu, Danhui Zhao, Yixiong Liu, Yingmei Wang, Kaijing Wang, Jing Ma, Linni Fan, Qingguo Yan, Shuangping Guo, Hualiang Xiao, Qilin Ao, Zhaoming Wang, Weiping Liu, Sha Zhao, Weihua Yin, Yuhua Huang, Yaqin Li, Miaoxia He, Rong Liang, Mingyang Li, Zhe Wang
Summary: This study presented 17 cases of sinusoidal large B-cell lymphoma (SLBCL) with distinct pathological features. The patients had a median age of 57 years, with approximately equal numbers of male and female patients. The majority of patients exhibited aggressive disease and poor outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyang Xie, Lijuan Yang, Fengjun Zhao, Dong Wang, Hui Zhang, Xuelei He, Xin Cao, Huangjian Yi, Xiaowei He, Yuqing Hou
Summary: This study demonstrates the value of deep learning in combining multimodal radiomics and clinical and imaging features for differentiating ocular adnexal lymphoma (OAL) from idiopathic orbital inflammation (IOI). The DL model using combined features outperformed those using only multimodal radiomics features or clinical and imaging features, indicating the benefit of combining multiple modalities for more accurate diagnosis.
EUROPEAN RADIOLOGY
(2022)
Article
Ophthalmology
Bita Esmaeli
Summary: This article summarizes an invited lecture topic on the mechanism of action, indications, and clinical experience with immune checkpoint inhibitors in patients with locally advanced ocular adnexal squamous cell carcinoma. The authors share several successful cases of using PD-1 directed immune checkpoint inhibitors to treat locally advanced conjunctival, eyelid, and lacrimal sac/duct squamous cell carcinoma. The immune checkpoint inhibitors present a new strategy for the treatment of locally advanced squamous cell carcinoma of the ocular adnexa and orbit.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Oncology
Yuanzheng Liang, Rui-ying Fu, Xue-lin Liu, Xin-di Liu, Ying-shi Piao, Jian-min Ma, Liang Wang
Summary: This study investigated the associations between disease characteristics, treatment strategies, and long-term outcomes in patients with primary ocular adnexal extranodal marginal zone mucosa-associated lymphoid tissue lymphoma (OAML). The results showed that bilateral involvement was associated with poor prognosis, and further treatment after surgery improved survival. Some patients may experience disease progression or relapse more than five years after initial treatment.
Article
Ophthalmology
Yu Yang, Xuelian Jin, Yujiao Wang, Ruixin Ma, Weimin He
Summary: This study provides a description of the clinical characteristics and treatment outcomes of secondary ocular adnexal lymphoma (OAL), highlighting the importance of timely biopsy and systemic evaluation for diagnosis and treatment. Secondary OAL is a rare disease with a poor prognosis, often associated with more aggressive pathological types, although indolent lymphoma is not uncommon. Pathological differences between OAL and previously diagnosed systemic lymphoma may exist in some patients. Prompt excision biopsy and thorough systemic evaluation are recommended for patients suspected of having secondary OAL.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Oncology
Jiahao Shi, Tianyu Zhu, Huimin Lin, Zhen Liu, Min Zhou, Ziyao Yu, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Xianqun Fan, Yixiong Zhou
Summary: In this study, the proteotranscriptome landscape of Ocular adnexal B-cell lymphoma (OABL) was investigated. The results revealed high global protein-mRNA concordance as a novel characteristic of OABL, which is related to recurrence. The study also identified the oncogenic role of ADAR and DNAJC9 as a potential biomarker for OABL.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Ophthalmology
Asad Loya, Vignesh Ramachandran, Talha Ayaz, Christina Y. Weng
Summary: A retrospective study investigated the risk of second primary malignancies in patients with ocular adnexal lymphoma, finding a higher incidence of secondary malignancies, predominantly non-Hodgkin's lymphoma. Patients had an increased risk of developing secondary malignancies within the first year and 1-5 years following lymphoma diagnosis. Different patterns of site-specific and overall secondary malignancy risk were observed among various ocular adnexal lymphoma subtypes.
Letter
Oncology
Nobuhiko Nakamura, Senji Kasahara, Junichi Kitagawa, Hiroshi Nakamura, Michio Sawada, Kenji Fukuno, Yuhei Shibata, Yuto Kaneda, Takeshi Hara, Nobuhiro Kanemura, Hisashi Tsurumi, Masahito Shimizu
Summary: This study aimed to evaluate the efficacy and safety of BRAC combination therapy in patients with relapsed or refractory follicular lymphoma or mantle cell lymphoma. The results showed that BRAC therapy had a good response rate but also caused significant hematological toxicity.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Dongfeng Zeng, Yu Fang, Yue Fei, Rong Liang, Haige Ye, Yun Liang, Xiuhua Sun, Michael Wang, Huiqiang Huang, Lugui Qiu, Yuxuan Che, Panpan Liu, Yi Wang, Tao Pan, Yao Lv, Jintai Deng, Shuhua Yi, Yizi He, Ling Xiao, Huijuan Lv, Jiangfang Feng, Huilai Zhang, Hui Zhou, Dehui Zou, Qingqing Cai
Summary: A real-world multicenter study conducted in China evaluated treatment patterns and outcomes in newly diagnosed MCL patients treated with BTK inhibitors. The study found that non-HD-AraC chemotherapy combined with BTK inhibitors may be a viable therapeutic strategy for younger patients, and anti-HBV prophylaxis should be implemented in patients with resolved hepatitis B.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijuan Yang, Huachen Zhang, Xiaoyang Xie, Shijie Jiang, Hui Zhang, Xin Cao, Yuqing Hou, Xiaowei He, Junming Wang, Tao Zhang, Fengjun Zhao
Summary: This study developed and validated an MRI-based radiomics nomogram for the individual diagnosis of ocular adnexal lymphoma (OAL) versus idiopathic orbital inflammation (IOI). The nomogram showed good diagnostic performance and revealed the association between radiomics features and the individual risk of developing OAL.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Hematology
Estelle Bourbon, Delphine Maucort-Boulch, Juliette Fontaine, Claire Mauduit, Pierre Sesques, Violaine Safar, Emmanuelle Ferrant, Camille Golfier, Dana Ghergus, Lionel Karlin, Anne Lazareth, Fadhela Bouafia, Gian Matteo Pica, Frederique Orsini-Piocelle, Clement Rocher, Francois-Xavier Gros, Marie Parrens, Arthur Dony, Cedric Rossi, Herve Ghesquieres, Emmanuel Bachy, Alexandra Traverse-Glehen, Clementine Sarkozy
Summary: This retrospective study reported 70 cases of EBV(+) diffuse large B-cell lymphoma, with a median age of 68.5 years. Patients were mainly treated with immunochemotherapy or chemotherapy. Older age and HLH were associated with shorter PFS and OS.
Article
Ophthalmology
Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivela, Ashwin Mallipatna, Chengyue Zhang, Junyang Zhao, Matthew Wilson, Rachel Brennan, Michala Burges, Jonathan Kim, Jesse L. Berry, Rima Jubran, Vikas Khetan, Suganeswari Ganeshan, Andrey Yarovoy, Vera Yarovaya, Elena Kotova, Denis Volodin, Yacoub Yousef, Kalle Nummi, Tatiana L. Ushakova, Olga Yugay, Vladimir G. Polyakov, Marco Antonio Ramirez-Ortiz, Elizabeth Esparza-Aguiar, Guillermo L. Chantada, Paula Schaiquevich, Adriana C. Fandino, Jason C. Yam, Winnie W. Lau, Carol P. Lam, Phillipa Sharwood, Sonia Moorthy, Quah Boon Long, Vera Adobea Essuman, Lorna A. Renner, Ekaterina Semenova, Jaume Catala-Mora, Maria Correa Llano, Elisa Carreras
Summary: This study analyzed data from 1054 RB eyes from 18 ophthalmic oncology centers worldwide and found that eyes with diffuse intraocular distribution of RB seeds had a higher risk of local treatment failure compared to eyes with focal seeds. Therefore, further subclassification of AJCC RB category cT2b into focal and diffuse seeds can improve prognostication for eye salvage.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Raksha Rao, Santosh G. Honavar, Sumeet Lahane, Kaustubh Mulay, Vijayanand Palkonda Reddy
Summary: This study evaluated the safety and efficacy of ruthenium-106 (Ru-106) plaque brachytherapy in managing invasive ocular surface squamous neoplasia (OSSN). The results showed that the treatment was effective in tumor regression and eye salvage, with no significant complications or metastasis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Muhammed Jawad, Krishna Yamini, Ziyaad Sultan, Sarah Coupland, James Hsuan, Austin McCormick
Summary: This article presents a case of retained intraorbital grease, discussing the clinical and radiological findings, as well as the management approach.
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2023)
Article
Ophthalmology
Stine Dahl Vest, Sarah E. Coupland, Bita Esmaeli, Paul T. Finger, Gerardo F. Graue, Hans E. Grossniklaus, Tine Gadegaard Hindso, Frederik Holm, Santosh G. Honavar, Jwu Jin Khong, Marina Knudsen Kirkegaard, Penelope A. McKelvie, Lauge Hjorth Mikkelsen, Kaustubh Mulay, Peter Kristian Rasmussen, Volkert Siersma, Lene Dissing Sjo, Matthew C. Sniegowski, Bradley A. Thuro, Geeta K. Vemuganti, Steffen Heegaard
Summary: The specific location of ocular adnexal lymphoma (OAL) and the AJCC TNM tumour stage are prognostic factors for mortality in different OAL subtypes. Eyelid lymphoma has the highest disease-specific mortality in all subtypes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Katharina Eibenberger, Rumana Hussain, Yamini Krishna, Sarah E. Coupland, Heinrich Heimann
Review
Ophthalmology
Lindsay A. McGrath, David A. Ryan, Sunil K. Warrier, Sarah E. Coupland, William J. Glasson
Summary: Conjunctival lymphoma is an ocular malignancy derived from clonal proliferation of lymphocytes. The majority of cases are extranodal marginal zone B-cell lymphoma, but other subtypes also exist. Clinical manifestations are nonspecific, but typically present as painless conjunctival lesions. Treatment approaches focus on local immunomodulation. Recent advancements in sequencing technologies have improved clinicians' ability to predict disease recurrence and systemic involvement.
Article
Medicine, General & Internal
Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O'Connell, Josep M. Piulats, Valerie O'Neill, Noel Horgan, Sarah E. Coupland, Jacintha O'Sullivan, William M. Gallagher, Alberto Villanueva, Breandan N. Kennedy
Summary: A study found that high expression of CysLT(1) is associated with poor prognosis in primary uveal melanoma (UM). Additionally, quininib and 1,4-dihydroxy quininib drugs were able to alter cancer hallmarks of UM cell lines in vitro. The study also highlighted the diagnostic and therapeutic potential of CysLT(1) and ATP5F1B in UM.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Paul T. Finger, Robert Stewart, Mark J. Rivard, Raymond J. Beers, Jacob Kamen, Shyam Lama, Kimberly J. Chin, Kyle Mohney, Toby S. Welles, Wolfgang A. G. Sauerwein, Kenneth Rosenzweig
Summary: This study investigates the application of high-dose-rate (HDR) yttrium-90 (Y-90) brachytherapy in medical physicists, radiation oncologists, and ophthalmic surgeons. The dose calibration and target delineation methods were established to evaluate radiation safety. The results demonstrate the feasibility and effectiveness of HDR Y-90 brachytherapy in clinical practice.
Article
Oncology
Helena Robinson, Antonio Eleuteri, Joseph J. Sacco, Rumana Hussain, Heinrich Heimann, Azzam F. G. Taktak, Bertil Damato, Alexander J. Thompson, Thomas Allen, Helen Kalirai, Sarah E. Coupland
Summary: This study compares the accuracy of different prognostic systems for targeting surveillance programs in uveal melanoma patients. It suggests that the Liverpool Uveal Melanoma Prognosticator Online III (LUMPOIII) offers greater specificity and provides guidance for its use. This study provides valuable information for revising the clinical guidelines for surveillance in uveal melanoma.
Article
Chemistry, Medicinal
Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuni, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud
Summary: Given the rarity of uveal melanoma and the lack of effective treatments, researchers have developed a method to collect and preserve limited tissue samples from primary tumors and metastases for advanced research and drug screening.
Article
Cell Biology
Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Felix B. Engel, B. E. Snaar-Jagalska
Summary: This study established a patient-derived animal model for metastatic UM and identified ferroptosis induction as a possible therapeutic strategy for the treatment of UM patients.
CELL DEATH DISCOVERY
(2023)
Editorial Material
Ophthalmology
Tatyana Milman, Hans E. Grossniklaus, Gabrielle Goldman-Levy, Tero T. Kivela, Sarah E. Coupland, Valerie A. White, Hardeep Singh Mudhar, Charles G. Eberhart, Robert M. Verdijk, Steffen Heegaard, Anthony J. Gill, Martine J. Jager, Aberlardo A. Rodriguez-Reyes, Bita Esmaeli, Jennelle C. Hodge, Ian A. Cree
Summary: The 5th edition of the WHO Classification of Tumours of the Eye and Orbit is a significant step in standardizing diagnostic practices globally. It introduces new chapters and consolidates sections, highlighting recent advances in etiology, pathogenesis, and diagnosis of eye and orbital tumors. This edition also includes updates on classification schemes and newly identified tumors. The editorial summarizes the major changes and specific updates in each taxonomic category, focusing on advances in understanding tumor pathogenesis, diagnostic criteria, and molecular markers.
OCULAR ONCOLOGY AND PATHOLOGY
(2023)