Article
Clinical Neurology
Seong Ho Jeong, Hyun-Jae Jeong, Mun Kyung Sunwoo, Sung Soo Ahn, Seung-Koo Lee, Phil Hyu Lee, Yun Joong Kim, Young H. Sohn, Chae Jung Park, Seok Jong Chung
Summary: The volume of the choroid plexus (CP) is associated with cognitive decline and dementia conversion risk in patients with Parkinson disease (PD). A larger CP volume is correlated with lower baseline frontal/executive function scores and higher risk of dementia conversion. The effect of CP volume on dementia conversion is completely mediated by frontal/executive function.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Hanna Johansson, Urban Ekman, Linda Rennie, Daniel S. Peterson, Breiffni Leavy, Erika Franzen
Summary: This study examined the difficulties PD patients face during DT walking, factors influencing DT costs, and the impact of cognitive status on strategies used during DT paradigms. The results showed that PD MCI patients had larger DT costs on gait and different strategies compared to PD non-MCI patients.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Sygrid van der Zee, Martijn L. T. M. Muller, Prabesh Kanel, Teus van Laar, Nicolaas I. Bohnen
Summary: This study investigated the relationship between cognitive functioning and regional cholinergic innervation in patients with PD, utilizing [F-18]Fluoroethoxybenzovesamicol positron emission tomography imaging. The results showed partial overlapping topography across cognitive domains, with most robust correlations in the domains of memory, attention, and executive functioning. The findings confirm and expand on previous observations of cholinergic system involvement in cognitive functioning in PD, reflecting a combination of disease-specific and aging effects.
MOVEMENT DISORDERS
(2021)
Article
Multidisciplinary Sciences
Joan Forns, J. Bradley Layton, Jennifer Bartsch, Mary Ellen Turner, Colleen Dempsey, Mary Anthony, Mary E. Ritchey, George Demos
Summary: The study evaluated the risk of falls and fractures in patients with Parkinson disease with psychosis (PDP) compared to those without psychosis at similar disease stages. The results showed that PDP patients had a slightly higher risk of falls and fractures, particularly in falls, compared to PD patients without psychosis.
Article
Clinical Neurology
Bendix Labeit, Inga Claus, Paul Muhle, Liesa Regner, Sonja Suntrup-Krueger, Rainer Dziewas, Tobias Warnecke
Summary: This study explored the impact of cognitive and motor dual-task interference on oropharyngeal swallowing in patients with Parkinson's disease (PD). The results showed that oropharyngeal swallowing in PD patients is not only reflexive but also requires mental capacity, highlighting the importance of attentional resources in the central control of swallowing as a compensatory mechanism for PD-related dysphagia. The proposed dual-task protocol may be useful for challenging swallowing functional reserve.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Seok Jong Chung, Han Soo Yoo, Hye Sun Lee, Yang Hyun Lee, KyoungWon Baik, Jin Ho Jung, Byoung Seok Ye, Young H. Sohn, Phil Hyu Lee
Summary: The study indicates that baseline cognitive function in PD patients is related to long-term motor outcomes such as levodopa-induced dyskinesia, wearing-off, freezing of gait, and longitudinal increases in levodopa-equivalent dose.
JOURNAL OF NEUROLOGY
(2021)
Letter
Clinical Neurology
Tomoyuki Kawada
Summary: The study revealed that high baseline dietary antioxidants such as vitamin E and vitamin C were inversely associated with Parkinson's disease, while there was no significant association between estimated intake of dietary beta-carotene or NEAC and Parkinson's disease.
Article
Clinical Neurology
Avril Metcalfe-Roach, Adam C. Yu, Ella Golz, Mihai Cirstea, Kristen Sundvick, Daniel Kliger, Liam H. Foulger, Melissa Mackenzie, B. Brett Finlay, Silke Appel-Cresswell
Summary: This study found a strong correlation between adherence to the MIND diet and age of onset of Parkinson's disease, especially in female patients. Additionally, adherence to the Greek Mediterranean diet was also associated with later onset of PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
A. V. Nagy, G. Leschziner, S. H. Eriksson, A. Lees, A. J. Noyce, A. Schrag
Summary: Cognitive impairment is more prevalent in individuals at higher risk of PD, especially those with REM-sleep behaviour disorder.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Tamara Schejter-Margalit, Rachel Kizony, Noam Ben-Binyamin, Roni Hacham, Avner Thaler, Inbal Maidan, Anat Mirelman
Summary: This study explored changes in prefrontal cortex activation during the performance of CDT in participants with PD compared to healthy controls, and found correlations between PFC activation and CDT performance. The results indicated slower PFC activation in participants with PD, which correlated with behavioral measures, highlighting the importance of performing the CDT copy task to detect early cognitive decline in PD participants.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
H. Bejr-kasem, F. Sampedro, J. Marin-Lahoz, S. Martinez-Horta, J. Pagonabarraga, J. Kulisevsky
Summary: In this study, 35.1% of PD patients developed minor hallucinations during follow-up. These patients showed increased prevalence of subjective cognitive decline at 5 years, but not formal cognitive impairment. Additionally, they exhibited differences in gray matter volume at baseline in certain brain regions. Further longitudinal analyses may be needed to determine whether these findings indicate a higher risk of future cognitive deterioration.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Psychiatry
Eren Halac, Remzi Ogulcan Ciray, Serkan Turan, Mustafa Tuncturk, Nilay Agac, Fatma Nur Elmas, Stella Rosson, Cagatay Ermis
Summary: Upon conducting a systematic review and meta-analysis, it was discovered that youth with pediatric bipolar disorder (PBD) exhibit significant impairments in social cognition, specifically in emotion recognition (ER) and theory of mind (ToM). The results of the meta-analysis indicated that deficits in social cognitive abilities might be an illness-related trait of PBD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Alexandra K. Gold, Michael W. Otto
Summary: Comorbid substance use disorders are common in bipolar disorder and associated with worse outcomes. Psychosocial treatments have limited effectiveness for comorbid presentation, suggesting a need for novel treatments. This study identified delay discounting as a potential mechanistic target for reducing clinical risk behaviors among individuals with bipolar disorder with and without substance use disorders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Gulay Kenangil, Mehmet Demir, Esma Tur, Fusun Domac
Summary: This study investigated the relationship between alexithymia, cognition, and depression in patients with Parkinson's disease (PD). The results showed that alexithymia is common in PD patients and is associated with cognitive impairment and depression.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Yu Wang, Li -Peng Bai, Wei Liu, Xiao-Dong Zhu, Xiang -Yang Zhang
Summary: This study found that PD patients with depressive symptoms have lower BDNF levels and poorer cognitive function. BDNF independently contributes to immediate memory, language, and overall cognitive function in patients with depressive symptoms.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Psychiatry
Corby L. Dale, Ethan G. Brown, Melissa Fisher, Alexander B. Herman, Anne F. Dowling, Leighton B. Hinkley, Karuna Subramaniam, Srikantan S. Nagarajan, Sophia Vinogradov
SCHIZOPHRENIA BULLETIN
(2016)
Article
Clinical Neurology
Ethan G. Brown, Vanja C. Douglas
SEMINARS IN NEUROLOGY
(2015)
Editorial Material
Clinical Neurology
Maxime O. Baud, Ethan G. Brown, Neel S. Singhal, J. Claude Hemphill
Article
Neurosciences
Leighton B. N. Hinkley, Elysa J. Marco, Ethan G. Brown, Polina Bukshpun, Jacquelyn Gold, Susanna Hill, Anne M. Findlay, Rita J. Jeremy, Mari L. Wakahiro, A. James Barkovich, Pratik Mukherjee, Elliott H. Sherr, Srikantan S. Nagarajan
JOURNAL OF NEUROSCIENCE
(2016)
Article
Geriatrics & Gerontology
Ethan G. Brown, S. Andrew Josephson, Noriko Anderson, Mary Reid, Melissa Lee, Vanja C. Douglas
Article
Immunology
Jeffrey R. Vitt, Ethan G. Brown, Daniel S. Chow, S. Andrew Josephson
JOURNAL OF NEUROIMMUNOLOGY
(2017)
Article
Health Care Sciences & Services
Ethan G. Brown, S. Andrew Josephson, Noriko Anderson, Mary Reid, Melissa Lee, Vanja C. Douglas
BMC HEALTH SERVICES RESEARCH
(2018)
Editorial Material
Clinical Neurology
Ethan G. Brown, Samuel M. Goldman, Caroline M. Tanner
PARKINSONISM & RELATED DISORDERS
(2018)
Article
Psychiatry
Corby L. Dale, Ethan G. Brown, Alexander B. Herman, Leighton B. N. Hinkley, Karuna Subramaniam, Melissa Fisher, Sophia Vinogradov, Srikantan S. Nagarajan
SCHIZOPHRENIA RESEARCH
(2020)
Editorial Material
Clinical Neurology
Ethan G. Brown, Samuel M. Goldman
Article
Neurosciences
Lana M. Chahine, Iris Chin, Chelsea Caspell-Garcia, David G. Standaert, Ethan Brown, Luba Smolensky, Vanessa Arnedo, Daisy Daeschler, Lindsey Riley, Monica Korell, Roseanne Dobkin, Ninad Amondikar, Stephen Gradinscak, Ira Shoulson, Marissa Dean, Kevin Kwok, Paul Cannon, Kenneth Marek, Catherine Kopil, Caroline M. Tanner, Connie Marras
JOURNAL OF PARKINSONS DISEASE
(2020)
Article
Multidisciplinary Sciences
Luba Smolensky, Ninad Amondikar, Karen Crawford, Scott Neu, Catherine M. Kopil, Margaret Daeschler, Lindsey Riley, Ethan Brown, Arthur W. Toga, Caroline Tanner
Article
Neurosciences
Roseanne D. Dobkin, Ninad Amondikar, Catherine Kopil, Chelsea Caspell-Garcia, Ethan Brown, Lana M. Chahine, Connie Marras, Nabila Dahodwala, Sneha Mantri, David G. Standaert, Marissa Dean, Ira Shoulson, Kenneth Marek, Andrea Katz, Monica Korell, Lindsey Riley, Carolin M. Tanner
JOURNAL OF PARKINSONS DISEASE
(2020)
Article
Clinical Neurology
Ethan G. Brown, Ian O. Bledsoe, Nijee S. Luthra, Svjetlana Miocinovic, Philip A. Starr, Jill L. Ostrem
MOVEMENT DISORDERS CLINICAL PRACTICE
(2020)
