Article
Dermatology
Tsung-Yu Tsai, I-Hsin Huang, Yuan-Chen Chao, Hua Li, Tyng-Shiuan Hsieh, Hsiao-Han Wang, Yu-Ting Huang, Chun-Yuan Chen, Ying-Chih Cheng, Po-Hsiu Kuo, Yu-Chen Huang, Yu-Kang Tu
Summary: Systematic review and network meta-analysis indicated that combination therapy with corticosteroids and intravenous immunoglobulin was the only treatment showing significant survival benefits for patients with TEN and SJS/TEN overlap. However, limitations such as heterogeneity and a lack of eligible randomized controlled trials need to be considered. Further studies are required to provide clearer evidence on promising therapies like cyclosporine and etanercept.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hua-Ching Chang, Tsung-Jen Wang, Ming-Hsiu Lin, Ting-Jui Chen
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases caused by drugs. The effectiveness of systemic immunomodulating treatments for SJS/TEN is still controversial, but cyclosporine and biologic anti-TNF-alpha have shown promising results. Combination treatments are also being explored. Large-scale randomized controlled trials are needed for more definitive evidence. Advances in understanding the pathogenesis of SJS/TEN may inspire the discovery of potential therapeutic targets.
Review
Dermatology
I Torres-Navarro, A. Briz-Redon, R. Botella-Estrada
Summary: Some treatments for SJS/TEN demonstrate better performance, such as cyclosporine and the combination of immunoglobulins with corticosteroids. However, there is still insufficient evidence to recommend widespread use in all patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Medicine, General & Internal
Ekaterina A. Nikitina, Daria S. Fomina, Ulyana A. Markina, Sergey S. Andreev, Yuri V. Streltsov, Tatiana S. Kruglova, Marina S. Lebedkina, Alexander V. Karaulov, Maryana A. Lysenko
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare syndromes characterized by necrotic skin and mucosal lesions. Drug-induced mechanisms are the most common cause, with certain drugs posing a higher risk. There is no gold standard treatment, but TNF-α inhibitors have shown promise in SJS/TEN cases.
FRONTIERS IN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Lin Cheng
Summary: Adverse drug reactions, particularly SJS and TEN, are a significant public health concern with high mortality rates and ineffective treatment options. Factors such as infections, mutations in drug metabolic enzymes, and immune responses contribute to SJS/TEN development. Future research directions include epigenetics, metabolites, and regulatory T cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Leangelo N. Hall, Swapna S. Shanbhag, Ramy Rashad, James Chodosh, Hajirah N. Saeed
Summary: The study evaluated the effect of systemic cyclosporine on ocular disease in SJS/TEN patients and found no significant association between the use of systemic cyclosporine and chronic ocular complications in this small cohort.
Article
Dermatology
Ting-Jung Hsu, Hsu-Hang Yeh, Chih-Hung Lee, Kwei-Lan Liu
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal adverse drug reactions. The most common culprit drug is carbamazepine, which has a strong association with HLA-B*15:02. There is no statistically significant correlation between in-hospital stay and the average daily dose of corticosteroids.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
Kevin Phan, Lawrence J. Oh, Andrea Issler-Fisher, Amshuman Rao, Eugene H. Wong, Peter Maitz
Summary: This systematic review and meta-analysis examines the prevalence of mechanical ventilation (MV) in patients with Stevens-Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN), and identifies risk factors associated with this requirement. The results show that about 27.5% of patients require MV, with a higher likelihood for TEN patients compared to SJS patients. Risk factors for the need for MV include bacteremia, shock/organ failure on admission, and total body surface area >30%.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Pan Lv, Jiangxia Huang, Qianru Yang, Ting Yang, Xianwei Cao, Ougen Liu, Zhibin Zhang
Summary: This study analyzed the expression profiles of circRNAs in peripheral blood mononuclear cells of SJS/TEN patients and found a correlation between circRNA expression and disease severity. Specifically, hsa_circ_0083619 was identified as a potential indicator for SJS/TEN severity and a circRNA-miRNA-mRNA network was constructed. The study suggests that the hsa_circ_0083619/miR-18a-5p/BCL2L10 axis may play a role in the pathogenesis of SJS/TEN.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Eri Tsukagoshi, Yoichi Tanaka, Yoshiro Saito
Summary: Drug-related Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare but severe adverse drug reactions, with predicting their onset remaining challenging. Pharmacogenomic information on drug labels may differ among countries, but CPIC guidelines provide a scientifically sound goal for future pharmacogenomic implementation.
FRONTIERS IN MEDICINE
(2021)
Article
Dermatology
Yasmin Chia Chia Liew, Karen Jui Lin Choo, Choon Chiat Oh, Shiu Ming Pang, Yi Wei Yeo, Haur Yueh Lee
Summary: This study evaluated the differences between Mycoplasma-related and drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. The results showed no significant differences in baseline characteristics and extent of involvement, but significant differences in mortality rates between the two groups.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
ShengYang Bertrand Lian, Choon Chiat Oh, Yi Wei Yeo, Haur Yueh Lee
Summary: This case series documents the incidence of various nail changes as a sequelae to Stevens-Johnson syndrome/toxic epidermal necrolysis.
Article
Dermatology
Rokea A. El-Azhary, Somaira Nowsheen, Lawrence E. Gibson, David J. DiCaudo
Summary: This study retrospectively assessed clinical characteristics and mortality rate of patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) who developed disseminated intravascular coagulation (DIC). The incidence of DIC in patients with SJS/TEN was low but associated with increased mortality. Common triggers of SJS/TEN included drugs and infections, and early clinician awareness and aggressive intervention are crucial for preventing death.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
E. J. Roberts, V. Melchionda, G. Saldanha, S. Shaffu, J. Royle, K. E. Harman
Summary: Toxic epidermal necrosis (TEN)-like lupus is a rare condition that occurs in patients with acute severe flares of systemic lupus erythematosus, characterized by epidermal loss and mucosal ulceration. This condition may resemble drug-induced Stevens-Johnson syndrome/TEN, but differs in the absence of a suitable culprit drug and the context of acute lupus, requiring early input from Rheumatologists for appropriate management.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Review
Ophthalmology
Gabor Toth, Andrea Lukacs, Frank Schirra, Gabor L. Sandor, Petra Killik, Otto A. Maneschg, Zoltan Z. Nagy, Nora Szentmary
Summary: The aim of the review article was to summarize the current literature on Stevens-Johnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN). SJS/TEN is a serious multi-system, immune-mediated, mucocutaneous disease with a high mortality rate and potential for ocular complications. Early diagnosis, timely amniotic membrane transplantation, and aggressive topical management are important for preventing long-term eye problems. Ophthalmologists should regularly examine patients in both the acute and chronic phases for comprehensive ophthalmic care.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Urology & Nephrology
Helena U. Zacharias, Michael Altenbuchinger, Ulla T. Schultheiss, Johannes Raffler, Fruzsina Kotsis, Sahar Ghasemi, Ibrahim Ali, Barbara Kollerits, Marie Metzger, Inga Steinbrenner, Peggy Sekula, Ziad A. Massy, Christian Combe, Philip A. Kalra, Florian Kronenberg, Benedicte Stengel, Kai-Uwe Eckardt, Anna Kottgen, Matthias Schmid, Wolfram Gronwald, Peter J. Oefner
Summary: A new risk equation based on laboratory tests can be used to identify patients with CKD who are at high risk of progressing to KFRT.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Editorial Material
Urology & Nephrology
Ulla T. Schultheiss, Peggy Sekula
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Fruzsina Kotsis, Ulla T. Schultheiss, Matthias Wuttke, Pascal Schlosser, Johanna Mielke, Michael S. Becker, Peter J. Oefner, Edward D. Karoly, Robert P. Mohney, Kai-Uwe Eckardt, Peggy Sekula, Anna Koettgen
Summary: In patients with chronic kidney disease, there is a strong association between urine drug metabolite levels and self-reported medication use, indicating under-reporting of some over-the-counter medications.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Azin Kheirkhah, Claudia Lamina, Barbara Kollerits, Johanna F. Schachtl-Riess, Ulla T. Schultheiss, Lukas Forer, Peggy Sekula, Fruzsina Kotsis, Kai-Uwe Eckardt, Florian Kronenberg
Summary: The study found a significant association between higher PCSK9 concentrations and the risk of cardiovascular disease, independent of traditional risk factors including LDL cholesterol levels. This association was stronger in nonstatin users and participants with pre-existing cardiovascular disease at baseline.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Transplantation
Helena Baechle, Peggy Sekula, Pascal Schlosser, Inga Steinbrenner, Yurong Cheng, Fruzsina Kotsis, Heike Meiselbach, Helena Stockmann, Sebastian Schoenherr, Kai-Uwe Eckardt, Olivier Devuyst, Juergen Scherberich, Anna Koettgen, Ulla T. Schultheiss
Summary: This study aimed to explore metabolites associated with uromodulin concentrations and evaluate their association with the progression of chronic kidney disease (CKD) and adverse kidney events. The study found that higher levels of urinary and serum uromodulin were associated with a lower risk of adverse kidney events, suggesting a potential protective role of functional nephrons in CKD outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Inga Steinbrenner, Peggy Sekula, Fruzsina Kotsis, Maja von Cube, Yurong Cheng, Jennifer Nadal, Matthias Schmid, Markus P. Schneider, Vera Krane, Matthias Nauck, Kai-Uwe Eckardt, Ulla T. Schultheiss
Summary: In this study, higher levels of OPN were found to be associated with worsening kidney function markers and an increased risk of adverse outcomes in CKD patients. A larger proportion of KF events could be attributed to higher OPN levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Genetics & Heredity
Yurong Cheng, Yong Li, Nora Scherer, Franziska Grundner-Culemann, Terho Lehtimaki, Binisha H. Mishra, Olli T. Raitakari, Matthias Nauck, Kai-Uwe Eckardt, Peggy Sekula, Ulla T. Schultheiss
Summary: The study identified genetic underpinnings of OPN in a European CKD population, revealing two replicated signals in a Finnish cohort that are associated with OPN production and blood pressure control and inflammation. The findings suggest a potential pathological role of OPN in CKD and emphasize the need for further research to understand its complex role in human physiology.
Article
Medicine, Research & Experimental
Yong Li, Yurong Cheng, Francesco Consolato, Guglielmo Schiano, Michael R. Chong, Maik Pietzner, Ngoc Quynh H. Nguyen, Nora Scherer, Mary L. Biggs, Marcus E. Kleber, Stefan Haug, Burulca Goecmen, Marie Pigeyre, Peggy Sekula, Inga Steinbrenner, Pascal Schlosser, Christina B. Joseph, Jennifer A. Brody, Morgan E. Grams, Caroline Hayward, Ulla T. Schultheiss, Bernhard K. Kraemer, Florian Kronenberg, Annette Peters, Jochen Seissler, Dominik Steubl, Cornelia Then, Matthias Wuttke, Winfried Maerz, Kai-Uwe Eckardt, Christian Gieger, Eric Boerwinkle, Bruce M. Psaty, Josef Coresh, Peter J. Oefner, Guillaume Pare, Claudia Langenberg, Jurgen E. Scherberich, Bing Yu, Shreeram Akilesh, Olivier Devuyst, Luca Rampoldi, Anna Koettgen
Summary: Uromodulin (UMOD) is a major risk gene for kidney disease and is highly abundant in urine. This study identified genetic variants associated with circulating uromodulin and found an upstream variant in the UMOD locus that affects its synthesis in kidney cells. The study also found shared association patterns between UMOD and complex traits like chronic kidney disease. Furthermore, the study revealed the role of glycan marks and their enzymes and receptors in uromodulin glycosylation.
Article
Urology & Nephrology
Inga Steinbrenner, Zhi Yu, Jin Jin, Ulla T. Schultheiss, Fruzsina Kotsis, Morgan E. Grams, Josef Coresh, Matthias Wuttke, Florian Kronenberg, Kai-Uwe Eckardt, Nilanjan Chatterjee, Peggy Sekula, Anna Koettgen
Summary: Chronic kidney disease (CKD) is a global health burden affecting over 10% of the adult population. This study aims to investigate the association between a polygenic predisposition to lower eGFR and adverse outcomes in CKD patients, and determine whether it provides additional predictive information beyond established risk factors.
KIDNEY INTERNATIONAL
(2022)
Article
Genetics & Heredity
Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulca Uluvar, Matthias Wuttke, Yurong Cheng, Arif B. Ekici, Gergely Gyimesi, Edward D. Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F. Gomez, Bing Yu, Morgan E. Grams, Josef Coresh, Eric Boerwinkle, Michael Kottgen, Florian Kronenberg, Heike Meiselbach, Robert P. Mohney, Shreeram Akilesh, Miriam Schmidts, Matthias A. Hediger, Ulla T. Schultheiss, Kai-Uwe Eckardt, Peter J. Oefner, Peggy Sekula, Yong Li, Anna Koettgen
Summary: The kidneys play a critical role in removing waste products and retaining valuable solutes in the body. Genetic studies of plasma and urine metabolites have identified important associations and provided insights into kidney function, such as glycerol transport and protein localization. Shared genetic determinants of metabolite-disease combinations offer potential for understanding metabolic diseases. Expanding genetic studies of the metabolome beyond plasma allows for a better understanding of processes at the interface of body compartments.
Meeting Abstract
Transplantation
Elias Kellner, Jan Lipovsek, Marco Reisert, Martin Buechert, Harald Horbach, Wilfried Reichardt, Maximilian Russe, Christopher Schlett, Fabian Bamberg, Peggy Sekula, Anna Koettgen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Yong Li, Yurong Cheng, Francesco Consolato, Guglielmo Schiano, Michael Chong, Maik Pietzner, Ngoc Quynh Nguyen, Nora Scherer, Mary Biggs, Marcus E. Kleber, Stefan Haug, Burulca Goecmen, Marie Pigeyre, Peggy Sekula, Inga Steinbrenner, Pascal Schlosser, Christina Joseph, Jennifer Brody, Morgan Grams, Caroline Hayward, Ulla T. Schultheiss, Bernhard Kraemer, Florian Kronenberg, Annette Peters, Jochen Seissler, Dominik Steubl, Cornelia Then, Matthias Wuttke, Winfried Maerz, Kai-Uwe Eckardt, Christian Gieger, Eric Boerwinkle, Bruce Psaty, Josef Coresh, Peter Oefner, Guillaume Pare, Claudia Langenberg, Juergen E. Scherberich, Bing Yu, Shreeram Akilesh, Olivier Devuyst, Luca Rampoldi, Anna Koettgen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Jan Lipovsek, Elke Schaeffner, Iris Heid, Anna Koettgen, Peggy Sekula
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Inga Steinbrenner, Zhi Yu, Jin Jin, Ulla T. Schultheiss, Fruzsina Kinga Kotsis, Morgan Grams, Josef Coresh, Kai-Uwe Eckardt, Peggy Sekula, Nilanjan Chatterjee, Anna Koettgen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Inga Steinbrenner, Yurong Cheng, Jennifer Nadal, Matthias Schmid, Fruzsina Kinga Kotsis, Heike Meiselbach, Markus Schneider, Vera Krane, Matthias Nauck, Kai-Uwe Eckardt, Anna Koettgen, Peggy Sekula, Ulla T. Schultheiss
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)