Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Boquan Qin, Shizhou Wu, Hongxian Dong, Shu Deng, Yunjie Liu, Wanli Zhang, Guoying Feng, Lei Lei, Huiqi Xie
Summary: This study developed a dual-layered sodium alginate/carboxymethyl chitosan (SA/CMCS) adhesive film cored with an SA-bFGF microsphere-loaded small intestine submucosa (SIS) hydrogel composite dressing with a graphene oxide (GO)-based antisense transformation system to promote infected diabetic wound healing and bacterial eradication.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Zhenghua Sun, Hao Xiong, Tengfei Lou, Weixuan Liu, Yi Xu, Shiyang Yu, Hui Wang, Wanjun Liu, Liang Yang, Chao Zhou, Cunyi Fan
Summary: Treating chronic wounds, especially in diabetes mellitus cases, is challenging due to prolonged inflammatory responses. Macrophage polarization and the use of Quercetin (QCT) have shown potential in promoting wound healing and inhibiting inflammation. However, the limited solubility of QCT restricts its applicability. Small intestinal submucosa (SIS) has been studied as a carrier for tissue regeneration and wound healing. Researchers have developed a biosafe hydrogel dressing with self-healing, water-absorbable, and immunomodulatory properties by combining SIS and QCT. In in vivo experiments, the hydrogels significantly increased wound repair rate and showed promising results in promoting wound healing.
Article
Public, Environmental & Occupational Health
Sohail Akhtar, Mujahid Latif, Omer Shabbir Ahmed, Aqsa Sarwar, Ayisham Alina, Muhammad Imran Khan
Summary: This study explores the prevalence of foot ulcers among diabetic patients in Punjab, Pakistan and identifies associated factors. The results indicate a relatively high prevalence of foot ulcers in Punjab, highlighting the need for better strategies and preventive measures to address this epidemic.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, Research & Experimental
Yujia Zhang, Jing Zhang, Zhou Xu, Deju Zhang, Panpan Xia, Jitao Ling, Xiaoyi Tang, Xiao Liu, Rui Xuan, Meiying Zhang, Jianping Liu, Peng Yu
Summary: Non-coding RNA (ncRNA) is a significant component of the human genome, controlling various biological processes. It plays a crucial role in the onset and development of diabetes-related complications, such as diabetic foot ulcer (DFU). Understanding the mechanism and progress of ncRNA-protein binding in DFU can contribute to the early diagnosis and targeted intervention of DFU.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Yi Xu, Kang Han, Yongming Zhou, Jian Wu, Xin Xie, Wei Xiang
Summary: Diabetic foot ulcers (DFUs) are common complications of diabetes. Recent advancements in computerized classification based on deep learning methods have shown promising results for identifying infection and ischemia in DFUs. This study proposes the use of class knowledge banks (CKBs) to improve the performance of DFU infection and ischemia classifications by effectively extracting and representing class knowledge.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Jean-Baptiste Bonnet, Ariane Sultan
Summary: The diabetic foot ulcer (DFU), a common and serious complication of diabetes, is influenced by the individual's social environment and access to healthcare. Financial insecurity and social protection systems play a significant role in DFU prognosis, while the relationship between socioeconomic and socio-educational deprivations and DFU is more complex. Understanding the correlation between DFU risk and social deprivation depends on how social deprivation is calculated and how questions about the relationship are framed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Pingnan Jiang, Qianhang Li, Yanhong Luo, Feng Luo, Qingya Che, Zhaoyu Lu, Shuxiang Yang, Yan Yang, Xia Chen, Yulan Cai
Summary: Diabetic foot ulcer (DFU) is a serious complication of diabetes that can lead to amputation and death. Proper management includes surgical treatment, topical dressings, vascular assessment, and glycemic control. Among these, dressings play a crucial role in protecting the wound and promoting healing.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Sujit Kumar Das, Pinki Roy, Prabhishek Singh, Manoj Diwakar, Vijendra Singh, Ankur Maurya, Sandeep Kumar, Seifedine Kadry, Jungeun Kim
Summary: Diabetes is a chronic condition caused by uncontrolled blood sugar levels, and early diagnosis of complications such as diabetic foot ulcers (DFUs) can help prevent severe consequences. The use of deep learning, machine learning, and computer vision techniques provides promising solutions for assisting clinicians in diagnosing DFUs. This article provides a comprehensive overview of the current status of automatic DFU identification and highlights the dominance of CNN-based solutions in the field. It emphasizes the importance of combining traditional ML and advanced DL techniques for more reliable and efficient diagnostic decisions.
Editorial Material
Biochemistry & Molecular Biology
Alisha R. Oropallo, Thomas E. Serena, David G. Armstrong, Mark Q. Niederauer
Summary: Oxygen therapy, including HBOT and TOT, is commonly used to enhance wound healing in diabetic foot ulcer patients by promoting angiogenesis and inflammation regulation. Molecular biomarkers can be utilized to predict patient response to specialized treatments.
Article
Biophysics
Haotian Xu, Shiqi Li, Xiaoxuan Ma, Tingting Xue, Fang Shen, Yi Ru, Jingsi Jiang, Le Kuai, Bin Li, Hang Zhao, Xin Ma
Summary: This review comprehensively assesses recent studies on cerium oxide nanoparticles (CONPs) in treating diabetic foot ulcer (DFU). The research found that CONPs have significant therapeutic effects in reducing oxidative stress and improving microbial abundance, providing a promising avenue for the treatment of DFU. Additionally, the review summarizes the wound healing process, ceria synthesis, and the incorporation of CONPs with other materials.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Dermatology
Liu He, Ya-Qing Xia, Cai-Feng Yang, Jia-Li He, Xian-Yu Tang
Summary: A meta-analysis was conducted to evaluate the management of diabetic foot wound ulcers (DFWUs) using laser therapy (LT). The results showed that LT had a significant effect on reducing ulcer size and promoting complete healing in individuals with DFWUs compared to control. However, caution should be exercised in interpreting the results due to the small sample size of the selected studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Julian F. Guest, Graham W. Fuller, Peter Vowden
INTERNATIONAL WOUND JOURNAL
(2018)
Article
Multidisciplinary Sciences
Julian F. Guest, Andy Ingram, Nadia Ayoub, Christian J. Hendriksz, Elaine Murphy, Yusof Rahman, Patrick McKiernan, Helen Mundy, Patrick Deegan
Article
Dermatology
Julian F. Guest, Heenal Singh, Karan Rana, Peter Vowden
JOURNAL OF WOUND CARE
(2018)
Article
Dermatology
Julian F. Guest, Heenal Singh, Peter Vowden
JOURNAL OF WOUND CARE
(2018)
Article
Medicine, General & Internal
Julian F. Guest, Graham W. Fuller, Peter Vowden, Kathryn Ruth Vowden
Article
Medicine, General & Internal
Julian F. Guest, Heenal Singh
CURRENT MEDICAL RESEARCH AND OPINION
(2019)
Article
Health Care Sciences & Services
Julian F. Guest, Graham W. Fuller
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2019)
Article
Medicine, General & Internal
Julian F. Guest, Tomas Keating, Dinah Gould, Neil Wigglesworth
Article
Medicine, General & Internal
Julian F. Guest, Tomas Keating, Dinah Gould, Neil Wigglesworth
Article
Medicine, General & Internal
Julian F. Guest, Graham W. Fuller, Jacky Edwards
Article
Medicine, General & Internal
Julian F. Guest, Graham W. Fuller, Peter Vowden
Article
Dermatology
Julian F. Guest, Leanne Atkin, Christopher Aitkins
Summary: The study estimated the cost-effectiveness of using dHACM allografts as an adjunct to standard care for non-healing DFUs in secondary care in the UK. It found that within a certain price range, this intervention is cost-effective for the NHS.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Dermatology
Julian F. Guest, Karen Staines, Nina Murphy
Summary: The study suggests that thigh-administered IPC in combination with standard care can improve healing probabilities and health-related quality of life for hard-to-heal VLUs, potentially providing cost-effective treatment for the NHS.
JOURNAL OF WOUND CARE
(2021)
Article
Dermatology
Julian F. Guest, Valter Deanesi, Arrigo Segalla
Summary: The study evaluated the cost-effectiveness of using the topical debriding agent Debrichem in the management of hard-to-heal venous leg ulcers. The results showed that the addition of Debrichem increased the probability of healing and improved patients' health-related quality of life. Furthermore, using Debrichem had the potential to reduce the overall cost of wound management for the healthcare system.
JOURNAL OF WOUND CARE
(2022)
Article
Medicine, General & Internal
Julian F. Guest, Graham W. Fuller
Summary: This retrospective cohort analysis examined the impact of the COVID-19 pandemic on the management of venous leg ulcers in the UK. The study found that the healing rate of venous leg ulcers decreased by 16% in 2020 and 42% in 2021 compared to 2019, with a significant increase in healing time. COVID-19 infection rates were estimated at 3% in both years, and there was an increased risk of amputation and sepsis among patients. The study also observed a significant reduction in healthcare resources and a decrease in the use of compression therapy and wound care products.